What if cancer drugs could find the tumor – and go nowhere else? What if this meant you could get potent therapy directly to the tumor, sparing healthy cells? That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed. We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects. Our Operating Principles - We move fast because speed matters to cancer patients. - We aim to communicate openly and challenge ideas regardless of job title. - We are bold, take risks, and push boundaries being led by science. - We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes. If that fires you up, come build the future of cancer therapy with us! You’re the right fit for Shasqi if you.. - Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment. - Can balance scientific rigor with a fast-paced environment. - Are comfortable with ambiguity and making decisions in the face of uncertainty. - Operate with a strong sense of agency and invite feedback and advice. - Can challenge convention and think of creative solutions that meet the needs of the company. - Are a doer, hands-on, resourceful, and do not hesitate to step up. - Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it. Position Summary We are seeking a highly motivated and experienced Executive Director of Protein Engineering and Chemistry to build and lead our CAPAC (Click Activated Protodrugs Against Cancer) pre-targeting therapeutic engineering platform and team. This is a critical leadership role responsible for driving molecular design, optimization, and biologic CMC of our pipeline from early discovery through IND-enabling studies and into the clinic. This position requires deep expertise in protein engineering, strong knowledge of chemistry and biologic CMC, and demonstrated success advancing therapeutics into clinical development. Required qualifications: Education and Experience - Ph.D. in Biochemistry, Protein Engineering, Chemistry, Chemical Biology, or related discipline. - Minimum 12+ years of relevant industry experience working in therapeutic discovery and development of either: - Biologics and small molecules, or - Small molecule-biologic conjugates. - Minimum 5+ years of leadership experience managing scientific teams. - Demonstrated track record of advancing biologic-based therapies into clinical development. - Direct experience supporting biologic CMC development, IND submissions, and clinical-stage programs is required. Technical Expertise - Small format biologic discovery and protein engineering. - Experience with chemical biology or medicinal chemistry. - Targeted therapies. - Structure-based design and protein optimization. - Biophysical and biochemical characterization methods. - Developability assessment and manufacturability considerations. - Protein chemistry, conjugation, and modification strategies. Experience with one or more of the following is highly desirable: - Antibody-drug conjugates (ADCs). - Bioorthogonal click chemistry. - Protein conjugation and linker chemistry. Leadership and Professional Skills - Proven ability to build and lead high-performing teams. - Strong strategic thinking and decision-making skills. - Excellent communication and presentation skills. - Demonstrated ability to work cross-functionally with a highly collaborative organization. - Ability to manage multiple programs in a fast-paced environment. Responsibilities including but not limited to the following: Scientific Leadership and Hands-On Contribution - Lead the protein engineering and chemistry teams toward design, discovery, engineering, and optimization of therapeutic candidates, including biologic binders, chemical payloads, and technologies to enable pre-targeting with click chemistry. - Personally contribute to molecular design strategy, candidate selection, and developability assessment for both biologic binders and chemical payloads. - Guide strategy for protein characterization, including biophysical, biochemical, and functional evaluation. - Establish and implement strategies for lead optimization, focusing on affinity, specificity, stability, manufacturability, and developability. CMC Strategy and Development Integration - Ensure candidates are designed with manufacturability, scalability, and regulatory requirements in mind. - Lead internal team working with CDMOs and CROs to advance: - Cell line development - Process development - Analytical development - GMP Manufacturing - Regulatory requirements - Contribute to IND-enabling activities and regulatory documentation. Strategic and Organizational Leadership - Build, lead, manage, and mentor a high-performing protein engineering and chemistry team. - Lead team toward defining departmental goals and strategy aligned with research and company goals. - Lead team to manage internal and external collaborations, including CROs and academic partners. - Serve as a scientific leader and key contributor to portfolio strategy and candidate selection decisions. Innovation and External Engagement - Maintain awareness of emerging technologies in protein engineering, novel payloads, and pre-targeting. - Identify and implement new tools and platforms to enhance engineering capabilities. - Represent the company at scientific conferences and external meetings as appropriate. How We Work: - We are a remote-first company, with occasional travel for in-person team meetings or scientific conference attendance. - Core collaboration window: 9:00am–3:00pm Pacific Time. You are expected to be available during this time for meetings and real-time collaboration. - Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected. - Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours. - You should be comfortable working across common tools including Zoom, Google Workspace, Microsoft 365, Slack, and similar platforms. Benefits & Eligibility Compensation at Shasqi - Competitive base salary as part of a broader total rewards package. - Equity: Included as port of total compensations. - Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. - Flexible PTO and a WFH stipend to support remote work. - Ongoing growth opportunities, professional development, and mentorship. Salary Range - The anticipated base salary range for this role is $250-$300K USD. - Final compensation will depend on location, experience, skills, education, and internal equity. - Our ranges are intentionally broad to reflect market conditions and the specialized nature of our work. Eligibility - U.S.-based employees only. - Must be authorized to work in the United States. - We are not currently sponsoring visas. About Shasqi Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027. You can learn more about our company at www.shasqi.com Please Note: At this time, Shasqi is not partnering with external recruiting agencies. We kindly ask that agencies refrain from contacting us regarding this role. Shasqi is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.

Think of TEKsystems Global Services (TGS) as the growth solution for enterprises today. We unleash growth through technology, strategy, design, execution and operations with a customer-first mindset for bold business leaders. We deliver cloud, data and customer experience solutions. Our partnerships with leading cloud, design and business intelligence platforms fuel our expertise. We value deep relationships, dedication to serving others and inclusion. We drive positive outcomes for our people and our business, and we stay true to our commitments and act in harmony with our words. We exist to create significant opportunity for people to achieve fulfillment through career success. Ready to join us? Here’s what the opportunity supported through our TGS Talent Acquisition Team requires: This position is responsible for analyzing, designing, documenting, and implementing the components, software, and layers required for complex software implementations based on requirements and design specifications. As part of the team in charge of building and delivering a solution, this person will perform tasks including analysis, design, testing, architecture, planning, estimation, coding, debugging and knowledge transfer. Team members identify needs, estimate and commit to delivering on those tasks, and track the status of those tasks to completion. Key Accountabilities and Priorities: • Analyze and understand user and computer systems requirements as well as design solutions and write specifications for computer programs. • Participate in software development lifecycle activity; estimating, planning, designing, coding, documenting and testing of software applications. • Participate in technical code reviews and provide guidance to junior developers. • Assist in development of user stories, including feature design and acceptance criteria. • Align with senior and lead developers on delivering features that meet the documented requirements. Required Education and/or Experience: • 4+ years of experience in Object Oriented analysis, design, development and integration of software products in a company recognized for software development capability. • 3+ years development experience with Python (packages, modules, Flask, Jinja templates, etc). • 2+ years development experience with SQL Alchemy or other Python ORM library. • 2+ years development experience with Front-End web development (React, Angular, Vue, JavaScript, TypeScript). • Experience using software best practices like test driven development (TDD) and continuous integration. • Experience working with Agile methods and iterative development, such as SCRUM, Kanban, Extreme Programming (XP), and pair programming. • Experience with design patterns, refactoring and unit testing and object oriented analysis/design. • Familiarity with relational databases, preferably PostgreSQL, Oracle or SQL Server. Desirable Experience • Experience parsing and analyzing yaml, json and csv files • 2+ years development experience with Java (j2EE, Hibernate, Spring, etc.) • 2+ years Cloud experience (AWS, Azure, GCP) Requisite Abilities and/or Skills: • Excellent communication skills - must be strong enough for customer facing situations. • Demonstrate problem solving skills to deal with complex situations while providing creative solutions. • Strive for continuous improvement and personal development, proactively encouraging the same from team members. Skills Python Top Skills Details Python Additional Skills & Qualifications • Analyze and understand user and computer systems requirements as well as design solutions and write specifications for computer programs. • Participate in software development lifecycle activity; estimating, planning, designing, coding, documenting and testing of software applications. • Participate in technical code reviews and provide guidance to junior developers. • Assist in development of user stories, including feature design and acceptance criteria. • Align with senior and lead developers on delivering features that meet the documented requirements. Job Type & LocationThis is a Permanent position based out of Baltimore, MD. Pay and BenefitsThe pay range for this position is $81100.00 - $121700.00/yr. We reserve the right to pay above or below the posted wage based on factors unrelated to sex, race, or any other protected classification. Additional earnings may be available through incentive programs like annual bonuses, profit sharing, etc. Our full-time, internal employment benefits include the following: • Medical, Dental, and Vision • Critical Illness, Accident, and Hospital • 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available • Life Insurance (Voluntary Life and AD&D for employee and dependents) • Short and Long-Term Disability • Health Spending Account (HSA) • Transportation Benefits • Employee Assistance Program • Time Off/Leave (PTO, Vacation or Sick Leave) Workplace TypeThis is a fully remote position. Application DeadlineThis position is anticipated to close on Apr 28, 2026. h4>About TEKsystems: We're partners in transformation. We help clients activate ideas and solutions to take advantage of a new world of opportunity. We are a team of 80,000 strong, working with over 6,000 clients, including 80% of the Fortune 500, across North America, Europe and Asia. As an industry leader in Full-Stack Technology Services, Talent Services, and real-world application, we work with progressive leaders to drive change. That's the power of true partnership. TEKsystems is an Allegis Group company. The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law. About TEKsystems and TEKsystems Global Services We’re a leading provider of business and technology services. We accelerate business transformation for our customers. Our expertise in strategy, design, execution and operations unlocks business value through a range of solutions. We’re a team of 80,000 strong, working with over 6,000 customers, including 80% of the Fortune 500 across North America, Europe and Asia, who partner with us for our scale, full-stack capabilities and speed. We’re strategic thinkers, hands-on collaborators, helping customers capitalize on change and master the momentum of technology. We’re building tomorrow by delivering business outcomes and making positive impacts in our global communities. TEKsystems and TEKsystems Global Services are Allegis Group companies. Learn more at TEKsystems.com. The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

CrazyGames is a leading web games platform with 50 million monthly users. We grew from a hobby project to a 50-person product team redefining how millions discover and play games — and now we're going native mobile. We're looking for a product-minded engineer to help build our apps into the core of the CrazyGames experience. You'll work across the stack: native iOS/Android, React, custom Capacitor plugins, Node backends, and Terraform infrastructure. You don't need to be an expert in all of them — but you should be eager to dive into any of them. This role lets you shape what we build, not just how. Key outcomes for the role: - Within 1 month you are familiar with the codebase, fix bugs, and contribute to larger changes for our 40M users. - Within 3 months, you implement user-facing features end-to-end and conduct experiments to improve core metrics. - Within 6 months, you take ownership of adding features to our app, such as implementing the possibility to play games while offline while ensuring that progress within games is transferred between devices when the device gets internet access. - Within 12 months, you fully understand the high-level architecture of the codebase so that you can work together with your Team Lead to specify and coordinate large new user-facing features that encompass multiple code projects. What we offer: - Top-notch engineers as colleagues. We like to hire experts. - A modern tech stack: Node.js, React, TypeScript, GraphQL. Terraform infrastructure on AWS. - A lot of responsibility and freedom. We hire only experts and trust them to deliver excellent results. - Flexible working hours and location. The results are what count! - Team weeks: we organize a week somewhere in Europe once or twice per year. We pay for transport and accommodation so you can have fun with the team. - The opportunity to play games and claim it's work. This role can be performed fully remotely if your timezone is between GMT-2 and GMT+6, or hybrid if you live close to Leuven, Belgium. Reach out if: - A Bachelor’s, Master’s, or PhD degree in Computer Science/Engineering/… or at least 3 years of relevant experience. - You have good software engineering skills and knowledge of technical concepts in the context of the web. - You are happy to bounce around different technologies on a daily basis. - You can think in terms of users, can judge and prioritize features, and can convert them into technical requirements. - You have an eye for detail and for the big picture. - You combine knowledge of software development with a business sense, an interest in UX, and strong analytical skills.

Job Family: SAAS/PAAS/Cloud Consulting Travel Required: Up to 25% Clearance Required: Ability to Obtain Public Trust What You Will Do: We are looking for a hands-on software engineer with deep knowledge of Microsoft Power Apps, including basic Microsoft Dynamics 365 understanding. An expert on Power Apps to design, configure and develop custom solutions in Microsoft Power platform. The candidate will take an active role in supporting and building on the MPP application. The candidate will have excellent presentation, communication, leadership, and client development skills to effectively present information to C-level management, public groups, and/or the board of directors. The candidate should have excellent organizational and multi-tasking skills, attention to quality, self-motivation and a strong desire to succeed. Responsibilities: - Drive Microsoft Power Platform implementations through all project phases including discovery, definition, build, test, and deploy - Identify the client's sales, marketing, and customer service requirements through discovery meetings - Delivering services and solutions for clients using Microsoft’s PowerApps, Power BI, SharePoint, Power Automate, Microsoft Teams, custom development, and data integrations - Provide hands-on technical expertise to design and implement Power Platform based solutions satisfying customer requirements. - Conduct end-user training and create and maintain knowledge transfer documentation - Automate business processes with Power Apps and Power Automate; outputs will include data visualization and low code applications - Develop and continue to refine Power Platform implementation standards and tools - Present tailored demonstrations of the technology solution - Responsible for high quality, bug-free development as per the coding standards in close collaboration and interaction with other members of the development/QA team - Participate in daily project scrum meetings and provide a daily personal status report - Collaborate with stakeholders and project team members to design and implement the enterprise Microsoft Dynamics solution ensuring high quality, reliable - Serve as Microsoft Power Platform Subject Matter Expert (SME), with technical expertise including system architecture, solution design, system configuration, and security management - Help create design documentation for new solutions and functions - Work with the support team to resolve production support issues - Will be proactive in staying up to date on the latest updates to the Power Platform, as well as future roadmap features announced in Microsoft’s wave plans What You Will Need: - Must have a minimum of THREE (3) years of professional experience - Selected Candidate must be able to commute onsite to the client as needed depending on location - Must be able to OBTAIN and MAINTAIN a Federal or DHS "PUBLIC TRUST"; candidates must obtain approved adjudication of their PUBLIC TRUST prior to onboarding with Guidehouse. Candidates with an ACTIVE PUBLIC TRUST or SUITABILITY are preferred. - US Citizenship is contractually required - Must have a Bachelor’s degree (4yr college degree) - Hands-on experience with SharePoint 2013 or newer to include both on-premise and SharePoint Online, SharePoint Designer to include creating custom workflow solutions, and PowerApps / Power Automate (M365 Suite of Products) - Experience in designing complex common data models - Intermediate to advanced knowledge of relational database concepts - Experience in using OOTB connectors for Power Apps and Power Automate - Experience in design and development of Canvas and Model-driven Power Apps by utilizing Microsoft Dataverse, SharePoint, or other databases as the backend data storage model - Knowledge and experience with writing technical requirements, test scripts and knowledge of software programming languages and technologies. - Experience in a Software as a Service (SaaS) environment - Experience customizing SharePoint lists and disparate systems with PowerApps - Experience developing PowerApps model - Ability to communicate technical information clearly and concisely to technical and nontechnical users - Ability to initiate majority of relevant tasks, specify and plan activities for task accomplishments and notify supervisor of variances. Prior experience working in a non- governmental organization (NGO) - Hands-on experience with Power Apps and Power Platform technical solutions - Work experience with Software as a Service (SaaS) and/or Platform as a Service (PaaS) environments - Core Skills: C#, SQL, .Net, Power Apps, SharePoint, Microsoft DataVerse (CDS), Power Automate - Experience with and a good understanding of the Power Platform CoE and governance components What Would Be Nice To Have: - Experience in “Big 4” or equivalent established consulting firm and/or Microsoft Gold partner highly desired - BA/BS degree in Business, Computer Science or Engineering - Experience with public sector clients preferred - Experience with Agile or Hybrid-Agile methodology The annual salary range for this position is $102,000.00-$170,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs. What We Offer: Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace. Benefits include: - Medical, Rx, Dental & Vision Insurance - Personal and Family Sick Time & Company Paid Holidays - Position may be eligible for a discretionary variable incentive bonus - Parental Leave and Adoption Assistance - 401(k) Retirement Plan - Basic Life & Supplemental Life - Health Savings Account, Dental/Vision & Dependent Care Flexible Spending Accounts - Short-Term & Long-Term Disability - Student Loan PayDown - Tuition Reimbursement, Personal Development & Learning Opportunities - Skills Development & Certifications - Employee Referral Program - Corporate Sponsored Events & Community Outreach - Emergency Back-Up Childcare Program - Mobility Stipend About Guidehouse Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation. Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco. If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation. All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process. If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties. Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.