Shasqi

What if cancer drugs could find the tumor – and go nowhere else? What if this meant you could get potent therapy directly to the tumor, sparing healthy cells? That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed. We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects. Our Operating Principles - We move fast because speed matters to cancer patients. - We aim to communicate openly and challenge ideas regardless of job title. - We are bold, take risks, and push boundaries being led by science. - We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes. If that fires you up, come build the future of cancer therapy with us! You’re the right fit for Shasqi if you.. - Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment. - Can balance scientific rigor with a fast-paced environment. - Are comfortable with ambiguity and making decisions in the face of uncertainty. - Operate with a strong sense of agency and invite feedback and advice. - Can challenge convention and think of creative solutions that meet the needs of the company. - Are a doer, hands-on, resourceful, and do not hesitate to step up. - Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it. Position Overview We are seeking an experienced and hands-on Principal Scientist, ADME/PK to lead and contribute to pharmacokinetics, biodistribution, and translational modeling efforts for a next-generation tumor targeting technology based on a click chemistry enabled pre-targeting. You will work at the interface of chemistry, biology, and translational sciences to design and interpret studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment. Key Responsibilities Strategy & Leadership - Define and execute ADME/PK strategies for pre-targeted therapeutics that consist of biologics and small molecules. - Lead PK/PD and biodistribution strategy to support platform validation and pipeline programs. - Partner cross-functionally with chemistry, protein engineering, bioanalytical, and pharmacology/toxicology teams to optimize delivery efficiency and exposure. - Serve as the subject matter expert on PK for pre-targeting systems and click chemistry-enabled therapeutics. Preclinical Development - Design, analyze, and interpret PK, biodistribution, and mass balance studies across components of the technology to guide therapeutic design, validation, and development. - Collaborate with bioanalytical assay development team to support assay development. Modeling & Translation - Build and apply PK/PD and mechanistic models to predict human dosing and scheduling. - Translate preclinical data into clinical hypotheses and first-in-human strategies. Collaboration & Communication - Work closely with CMC and analytical teams to ensure bioanalytical readiness. - Partner with toxicology and regulatory teams to support IND-enabling studies. - Present data and strategy to leadership, investors, and external collaborators. Required Qualifications - PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field. - 4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs. - Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics). - Strong experience designing and interpreting in vivo PK and biodistribution studies. - Demonstrated experience with QSP and PK/PD modeling. - Experience with modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar). Preferred Qualifications - Experience with pre-targeting approaches, multi-component therapeutics, or bioorthogonal chemistry systems. - Familiarity with click chemistry reactions (e.g., tetrazine–TCO) in biological systems. - Background in oncology, targeted therapeutics, or drug delivery platforms. - Experience with imaging-based biodistribution (e.g., PET/SPECT, fluorescence). - Knowledge of regulatory expectations for PK/ADME in IND filings. - Strong publication record and presentation skills. How We Work: - We are a remote-first company, with occasional travel for in-person team meetings or scientific conference attendance. - Core collaboration window: 9:00am–3:00pm Pacific Time. You are expected to be available during this time for meetings and real-time collaboration. - Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected. - Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours. - You should be comfortable working across common tools including Zoom, Google Workspace, Microsoft 365, Slack, and similar platforms. Benefits & Eligibility Compensation at Shasqi - Competitive base salary as part of a broader total rewards package. - Equity: Included as port of total compensations. - Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. - Flexible PTO and a WFH stipend to support remote work. - Ongoing growth opportunities, professional development, and mentorship. Salary Range - The anticipated base salary range for this role is $150K–$180K USD - Final compensation will depend on location, experience, skills, education, and internal equity. - Our ranges are intentionally broad to reflect market conditions and the specialized nature of our work. Eligibility - U.S.-based employees only. - Must be authorized to work in the United States. - We are not currently sponsoring visas. About Shasqi Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027. You can learn more about our company at www.shasqi.com Please Note: At this time, Shasqi is not partnering with external recruiting agencies. We kindly ask that agencies refrain from contacting us regarding this role. Shasqi is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.

What if cancer drugs could find the tumor – and go nowhere else? What if this meant you could get potent therapy directly to the tumor, sparing healthy cells? That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed. We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects. Our Operating Principles - We move fast because speed matters to cancer patients. - We aim to communicate openly and challenge ideas regardless of job title. - We are bold, take risks, and push boundaries being led by science. - We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes. If that fires you up, come build the future of cancer therapy with us! You’re the right fit for Shasqi if you.. - Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment. - Can balance scientific rigor with a fast-paced environment. - Are comfortable with ambiguity and making decisions in the face of uncertainty. - Operate with a strong sense of agency and invite feedback and advice. - Can challenge convention and think of creative solutions that meet the needs of the company. - Are a doer, hands-on, resourceful, and do not hesitate to step up. - Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it. Position Summary Shasqi is hiring a Director, Clinical Operations to build and lead our clinical operations function for our oncology program. We’re looking for an individual who’s not afraid to get hands-on in the early days but is ready to spread their wings and help shape something much bigger as we grow. You will be the first hire shaping this function from the ground up, delivering high-quality, on-time, on-budget execution for a single Phase 1/2 study while designing it to scale across multiple programs. We are seeking a capable leader with the ability to deliver operational excellence and meet aggressive clinical milestones. The Director of Clinical Operations will report directly to the Chief Medical Officer (CMO). Required qualifications: - 10+ years pharma/biotech experience, with 5+ years in oncology clinical operations (must include Phase 1 and 2 studies). - Experience scaling ops from a first in class program to multiple programs in a biotech startup environment. - Proven track record building and leading clinical ops teams, including direct hiring, mentoring, and performance management - Hands-on experience leading global Phase 1/2 oncology studies end-to-end, from study startup to database lock - Strategic thinker who translates vision into actionable plans and proactively mitigates risks- knows what can go wrong and how to proactively prepare for all possible outcomes. - Strong vendor/CRO management: selection, oversight, issue resolution at executive level - Expertise in financial planning, budgeting, forecasting, and resource allocation for clinical programs - Advanced analytical skills; Excel/MS Project/Smartsheet expert for timelines, trackers, risk registers - Highly organized, detail-oriented, autonomous yet collaborative - Tech-savvy with passion for tools/processes driving efficiency - Cross-functional leadership in matrixed organizations, influencing without authority - Excellent communicator (written/verbal); comfortable presenting to C-suite/executives Responsibilities including but not limited to the following: - Lead operational delivery of Shasqi's lead oncology clinical program, ensuring on-time/on-budget execution while building scalable processes - Serve as hands-on leader: roll up sleeves for critical tasks (study startup, site management, monitoring oversight) - Build and scale clinical ops function: hire/ train first team members, establish SOPs, systems for growth - Own clinical budgeting, forecasting, resource planning; achieve fiscal targets with <4% variance - Select/manage CROs/vendors; negotiate contracts, oversee performance, resolve escalations - Drive risk management, scenario planning, contingency strategies for study milestones - Collaborate cross-functionally with others in the organization for integrated program success - Provide strategic input to clinical development strategy; represent ops on leadership team - Travel to sites as needed to meet with investigators, estimated 10% travel. How We Work: - We are a remote-first company, with occasional travel for in-person team meetings or scientific conference attendance. - Core collaboration window: 9:00am–3:00pm Pacific Time. You are expected to be available during this time for meetings and real-time collaboration. - Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected. - Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours. - You should be comfortable working across common tools including Zoom, Google Workspace, Microsoft 365, Slack, and similar platforms. Benefits & Eligibility Compensation at Shasqi - Competitive base salary as part of a broader total rewards package. - Equity: Included as port of total compensations. - Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. - Flexible PTO and a WFH stipend to support remote work. - Ongoing growth opportunities, professional development, and mentorship. Salary Range - The anticipated base salary range for this role is $200-$240K USD - Final compensation will depend on location, experience, skills, education, and internal equity. - Our ranges are intentionally broad to reflect market conditions and the specialized nature of our work. Eligibility - U.S.-based employees only. - Must be authorized to work in the United States. - We are not currently sponsoring visas. About Shasqi Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027. You can learn more about our company at www.shasqi.com Please Note: At this time, Shasqi is not partnering with external recruiting agencies. We kindly ask that agencies refrain from contacting us regarding this role. Shasqi is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.

What if cancer drugs could find the tumor – and go nowhere else? What if this meant you could get potent therapy directly to the tumor, sparing healthy cells? That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed. We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects. Our Operating Principles - We move fast because speed matters to cancer patients. - We aim to communicate openly and challenge ideas regardless of job title. - We are bold, take risks, and push boundaries being led by science. - We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes. If that fires you up, come build the future of cancer therapy with us! You’re the right fit for Shasqi if you.. - Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment. - Can balance scientific rigor with a fast-paced environment. - Are comfortable with ambiguity and making decisions in the face of uncertainty. - Operate with a strong sense of agency and invite feedback and advice. - Can challenge convention and think of creative solutions that meet the needs of the company. - Are a doer, hands-on, resourceful, and do not hesitate to step up. - Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it. Position Summary We are seeking a highly motivated and experienced Executive Director of Protein Engineering and Chemistry to build and lead our CAPAC (Click Activated Protodrugs Against Cancer) pre-targeting therapeutic engineering platform and team. This is a critical leadership role responsible for driving molecular design, optimization, and biologic CMC of our pipeline from early discovery through IND-enabling studies and into the clinic. This position requires deep expertise in protein engineering, strong knowledge of chemistry and biologic CMC, and demonstrated success advancing therapeutics into clinical development. Required qualifications: Education and Experience - Ph.D. in Biochemistry, Protein Engineering, Chemistry, Chemical Biology, or related discipline. - Minimum 12+ years of relevant industry experience working in therapeutic discovery and development of either: - Biologics and small molecules, or - Small molecule-biologic conjugates. - Minimum 5+ years of leadership experience managing scientific teams. - Demonstrated track record of advancing biologic-based therapies into clinical development. - Direct experience supporting biologic CMC development, IND submissions, and clinical-stage programs is required. Technical Expertise - Small format biologic discovery and protein engineering. - Experience with chemical biology or medicinal chemistry. - Targeted therapies. - Structure-based design and protein optimization. - Biophysical and biochemical characterization methods. - Developability assessment and manufacturability considerations. - Protein chemistry, conjugation, and modification strategies. Experience with one or more of the following is highly desirable: - Antibody-drug conjugates (ADCs). - Bioorthogonal click chemistry. - Protein conjugation and linker chemistry. Leadership and Professional Skills - Proven ability to build and lead high-performing teams. - Strong strategic thinking and decision-making skills. - Excellent communication and presentation skills. - Demonstrated ability to work cross-functionally with a highly collaborative organization. - Ability to manage multiple programs in a fast-paced environment. Responsibilities including but not limited to the following: Scientific Leadership and Hands-On Contribution - Lead the protein engineering and chemistry teams toward design, discovery, engineering, and optimization of therapeutic candidates, including biologic binders, chemical payloads, and technologies to enable pre-targeting with click chemistry. - Personally contribute to molecular design strategy, candidate selection, and developability assessment for both biologic binders and chemical payloads. - Guide strategy for protein characterization, including biophysical, biochemical, and functional evaluation. - Establish and implement strategies for lead optimization, focusing on affinity, specificity, stability, manufacturability, and developability. CMC Strategy and Development Integration - Ensure candidates are designed with manufacturability, scalability, and regulatory requirements in mind. - Lead internal team working with CDMOs and CROs to advance: - Cell line development - Process development - Analytical development - GMP Manufacturing - Regulatory requirements - Contribute to IND-enabling activities and regulatory documentation. Strategic and Organizational Leadership - Build, lead, manage, and mentor a high-performing protein engineering and chemistry team. - Lead team toward defining departmental goals and strategy aligned with research and company goals. - Lead team to manage internal and external collaborations, including CROs and academic partners. - Serve as a scientific leader and key contributor to portfolio strategy and candidate selection decisions. Innovation and External Engagement - Maintain awareness of emerging technologies in protein engineering, novel payloads, and pre-targeting. - Identify and implement new tools and platforms to enhance engineering capabilities. - Represent the company at scientific conferences and external meetings as appropriate. How We Work: - We are a remote-first company, with occasional travel for in-person team meetings or scientific conference attendance. - Core collaboration window: 9:00am–3:00pm Pacific Time. You are expected to be available during this time for meetings and real-time collaboration. - Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected. - Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours. - You should be comfortable working across common tools including Zoom, Google Workspace, Microsoft 365, Slack, and similar platforms. Benefits & Eligibility Compensation at Shasqi - Competitive base salary as part of a broader total rewards package. - Equity: Included as port of total compensations. - Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. - Flexible PTO and a WFH stipend to support remote work. - Ongoing growth opportunities, professional development, and mentorship. Salary Range - The anticipated base salary range for this role is $250-$300K USD. - Final compensation will depend on location, experience, skills, education, and internal equity. - Our ranges are intentionally broad to reflect market conditions and the specialized nature of our work. Eligibility - U.S.-based employees only. - Must be authorized to work in the United States. - We are not currently sponsoring visas. About Shasqi Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027. You can learn more about our company at www.shasqi.com Please Note: At this time, Shasqi is not partnering with external recruiting agencies. We kindly ask that agencies refrain from contacting us regarding this role. Shasqi is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.

What if cancer drugs could find the tumor – and go nowhere else? What if this meant you could get potent therapy directly to the tumor, sparing healthy cells? That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed. We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects. Our Operating Principles - We move fast because speed matters to cancer patients. - We aim to communicate openly and challenge ideas regardless of job title. - We are bold, take risks, and push boundaries being led by science. - We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes. If that fires you up, come build the future of cancer therapy with us! You’re the right fit for Shasqi if you.. - Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment. - Can balance scientific rigor with a fast-paced environment. - Are comfortable with ambiguity and making decisions in the face of uncertainty. - Operate with a strong sense of agency and invite feedback and advice. - Can challenge convention and think of creative solutions that meet the needs of the company. - Are a doer, hands-on, resourceful, and do not hesitate to step up. - Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it. Position Overview We are seeking a strategic and hands-on Principal Scientist, Toxicology & Pharmacology to contribute to strategy and execution of nonclinical safety and pharmacology for our next-generation targeted therapy technology based on pre-targeting enabled by click chemistry. You will work together with chemistry, biology, and ADME/PK teams to design, lead, and interpret toxicology and pharmacology studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment. Key Responsibilities Nonclinical Safety Strategy - Contribute to and execute toxicology strategy for pre-targeted therapeutics, including IND-enabling studies. - Design GLP and non-GLP toxicology studies. - Identify, characterize, and mitigate safety risks. - Establish safety margins and therapeutic index for candidate molecules. Pharmacology & Translational Science - Contribute to pharmacology strategy to demonstrate proof of mechanism and proof of concept. - Design and interpret in vivo efficacy studies including model selection/characterization, study design, working with CROs to execute the study, and data analysis/presentation. - Define exposure-response relationships. - Collaborate on dose and schedule optimization. Cross-Functional Integration - Partner with ADME/PK to integrate pharmacokinetics, biodistribution, and exposure-response modeling. - Work closely with chemistry and protein engineering teams to guide design toward safer and more effective molecules. - Collaborate with CMC and analytical teams to ensure appropriate characterization of each therapeutic component. - Support regulatory strategy, including authoring and reviewing IND sections (e.g., nonclinical overview, tox summaries). Risk Assessment & Decision Making - Develop safety assessment frameworks tailored to our pre-targeting approach. - Drive candidate selection by balancing efficacy, exposure, and safety. - Present findings and recommendations to leadership, board members, and external partners. Required Qualifications - PhD, DVM, or equivalent in Toxicology, Pharmacology, or related discipline. - 4+ years of industry experience in nonclinical safety and/or pharmacology. - Demonstrated experience leading IND-enabling toxicology programs. - Strong background in small molecules, biologics, or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics). - Experience designing and interpreting in vivo toxicology and pharmacology studies. - Familiarity with regulatory expectations (FDA/ICH) for nonclinical development. Preferred Qualifications - Experience with pre-targeting strategies. - Familiarity with bioorthogonal click chemistry (e.g., tetrazine–TCO systems). - Background in oncology or other areas involving targeted therapies. - Experience evaluating on-target vs. off-target toxicities in complex systems. - Knowledge of safety considerations for reactive intermediates or payload-driven toxicity. - Experience integrating PK/PD and tox data for translational modeling. - Strong publication record and presentation skills. How We Work: - We are a remote-first company, with occasional travel for in-person team meetings or scientific conference attendance. - Core collaboration window: 9:00am–3:00pm Pacific Time. You are expected to be available during this time for meetings and real-time collaboration. - Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected. - Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours. - You should be comfortable working across common tools including Zoom, Google Workspace, Microsoft 365, Slack, and similar platforms. Benefits & Eligibility Compensation at Shasqi - Competitive base salary as part of a broader total rewards package. - Equity: Included as port of total compensations. - Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. - Flexible PTO and a WFH stipend to support remote work. - Ongoing growth opportunities, professional development, and mentorship. Salary Range - The anticipated base salary range for this role is $150K–$180K USD. - Final compensation will depend on location, experience, skills, education, and internal equity. - Our ranges are intentionally broad to reflect market conditions and the specialized nature of our work. Eligibility - U.S.-based employees only. - Must be authorized to work in the United States. - We are not currently sponsoring visas. About Shasqi Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027. You can learn more about our company at www.shasqi.com Please Note: At this time, Shasqi is not partnering with external recruiting agencies. We kindly ask that agencies refrain from contacting us regarding this role. Shasqi is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.