Solid Biosciences

• Develop and maintain peer-to-peer scientific relationships with key opinion leaders, investigators, and multidisciplinary care teams. • Execute regional medical engagement plans aligned with Global Medical Affairs strategy. • Represent Solid at scientific congresses, advisory boards, investigator meetings, and other external forums. • Provide scientific education and exchange regarding Solid’s research and development programs. • Gather insights to inform protocol design, endpoint selection, and development strategy. • Support future launch preparedness through deep understanding of regional care pathways and treatment landscapes. • Capture, synthesize, and communicate actionable medical insights. • Identify opportunities for real-world evidence generation, natural history collaborations, and investigator-sponsored research. • Support scientific communication and publication priorities through stakeholder engagement. • Contribute to the development of Solid’s U.S. field medical organization. • Support recruitment, onboarding, and mentoring of future MSL team members. • Establish best practices for scientific engagement and insight gathering. • Transition into regional leadership responsibilities as the MSL organization expands.

• Design and implement the Medical Affairs operating model, governance structure, and annual planning processes. • Develop scalable processes, SOPs, and best practices to support organizational growth. • Drive operational excellence across all Medical Affairs activities. • Develop departmental dashboards, KPIs, and performance metrics. • Establish mechanisms to measure Medical Affairs impact and effectiveness. • Lead Medical Affairs annual planning, goal setting, and business reviews. • Translate medical insights and operational metrics into strategic recommendations. • Manage Medical Affairs budgets, forecasting, and resource allocation. • Oversee grant, sponsorship, congress, publication, and vendor budgets. • Lead implementation and optimization of Medical Affairs technologies and platforms. • Establish performance metrics and oversight processes for external partners.

• Develop and maintain integrated Scientific Communication Platforms (SCPs) across all programs. • Translate scientific and clinical data into compelling, evidence-based scientific narratives. • Ensure consistency of messaging across publications, congresses, medical education, and stakeholder engagements. • Partner with cross-functional teams to align scientific and business priorities. • Lead global publication planning processes across the portfolio. • Develop annual and multi-year publication strategies aligned with development milestones. • Oversee manuscript, abstract, poster, and oral presentation development. • Manage publication agencies, medical writers, and external vendors. • Ensure adherence to ICMJE, GPP, and publication ethics standards. • Lead scientific congress planning and content strategy. • Coordinate development of congress materials and scientific presentations. • Support advisory boards, investigator meetings, and scientific exchange activities. • Develop scientific narratives that communicate the differentiated value of Solid’s platforms and programs. • Support preparation of scientific materials for internal and external stakeholders.

• Develop and maintain peer-to-peer scientific relationships with key opinion leaders, investigators, and multidisciplinary care teams. • Execute regional medical engagement plans aligned with Global Medical Affairs strategy. • Represent Solid at scientific congresses, advisory boards, investigator meetings, and other external forums. • Provide scientific education and exchange regarding Solid’s research and development programs. • Support site identification, evaluation, activation, and expansion for clinical studies. • Collaborate with Clinical Operations to optimize site performance and enrollment readiness. • Gather external feedback to inform protocol design, endpoint selection, and development strategy. • Support future launch preparedness through deep understanding of regional care pathways and treatment landscapes. • Capture, synthesize, and communicate actionable medical insights. • Identify opportunities for real-world evidence generation, natural history collaborations, and investigator-sponsored research. • Support scientific communication and publication priorities through stakeholder engagement. • Contribute to the development of Solid’s U.S. field medical organization. • Support recruitment, onboarding, and mentoring of future MSL team members. • Establish best practices for scientific engagement and insight gathering. • Transition into regional leadership responsibilities as the MSL organization expands.

Role Description We are seeking a Vice President, Head of Data Science & Biostatistics to provide strategic and operational leadership for data sciences across late-stage clinical development for multiple Phase 3 gene trials as well as early stage clinical studies focused on neuromuscular and cardiac diseases. This role will partner cross-functionally to ensure the integrity, rigor, and translational value of clinical data, enabling decisive regulatory, clinical, and commercial outcomes. This leader will oversee a team of biostatisticians and serve as the accountable executive for statistical strategy, data science innovation, and biostatistics integration across clinical programs. The VP will play a critical role in advancing registrational studies, regulatory filings, and lifecycle management while building scalable capabilities to support commercialization and post-marketing evidence generation. Reporting to the Chief Medical Officer, the role will be flexible based on location and alignment with the CMO. Key Position Responsibilities - Define and execute the company’s data science, biostatistics, and biostatistics strategy aligned to Phase 3 execution and regulatory success. - Serve as a core member of the Clinical Leadership Team and partner with the CMO on clinical strategy. - Lead statistical design and execution of Phase 3 trials, including SAPs, protocols, and interim analyses. - Ensure compliance with GCP, ICH guidelines, and regulatory expectations. - Support regulatory submissions (BLA/MAA) and health authority interactions. - Integrate biost and multi-omics data into clinical development. - Advance modern data science approaches, including modeling and AI/ML where appropriate. - Lead and develop a team of 4 biostatisticians. - Lead and develop a team of 3 database managers. - Manage CROs and external partners. - Partner cross-functionally across Clinical, Regulatory, Medical Affairs, and Commercial. Qualifications - Master’s degree or higher in Biostatistics, Statistics, or related field. - 15+ years in biotech/pharma with late-stage clinical experience. - Proven success supporting regulatory submissions and FDA/EMA interactions. - Experience in gene therapy, rare disease, or neuromuscular/cardiac indications preferred. - Expertise in clinical trial design, statistical methods, and regulatory standards. - Strong leadership and communication skills. Key Position Attributes - Strategic Judgment with Clinical Impact: Translates complex data into clear, decision-ready insights and anticipates risks in trial design, endpoints, and data interpretation. Balances scientific rigor with speed in a late-stage environment. - Executive Communication & Influence: Distills statistical complexity into concise messaging for the CMO, ELT, and Board; effectively represents the company with regulators and external stakeholders. - Ownership & Accountability: Operates as the single point of accountability for statistical strategy and data integrity; drives critical milestones with urgency and accountability. - Hands-On Leadership in a Lean Environment: Functions as a player-coach, willing to engage deeply in technical work while leading a small, high-impact team and prioritizing effectively. - Talent Development & Team Leadership: Builds, mentors, and retains a high-performing team of biostatisticians; elevates technical rigor, communication, and execution standards. - Cross-Functional Integration: Seamlessly integrates clinical, biostatistics, and translational data; aligns stakeholders across Clinical, Regulatory, and Technical functions. Compensation The base compensation range for this role is: $288,275 - $377,128. Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. Benefits - Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs. - 401(k) program participation with competitive company matched contributions. - Eligibility to participate in Solid’s Employee Stock Purchase Plan. - Mobile phone subsidy for eligible employees. - Tuition Reimbursement. - Vision Coverage. - Life Insurance. - Voluntary Pet Insurance. - Employee Discount Program on Travel, Entertainment, and Services. - Daily Subsidized Lunch Delivery (onsite @ Hood Park). - Free Onsite Full-Service Gym (onsite @ Hood Park). - Employee Parking (onsite @ Hood Park).

• Develop and execute a global KOL engagement strategy for Friedreich’s Ataxia • Build relationships with neurologists, cardiologists, geneticists, and FA experts globally • Map treatment centers, hospitals, and academic institutions • Partner with Medical Affairs and Opinion Leader Programming to generate actionable insights • Execute advisory boards and scientific engagements • Represent Solid at global congresses • Support clinical site identification and readiness • Ensure compliance with global regulatory standards

• Partner with the Company Team including Manufacturing, Quality, AD/QC, Regulatory, and PD as a manufacturing SME for our clinical manufacturing processes and provide direct Person-in-Plant on-site support during, minimally, all critical cell culture, purification, and drug product unit operations at CMO production locations. • Drive GMP Compliance and evaluate all aspects of ongoing production and understand when to intervene on company’s behalf and when to escalate more significant issues for resolution. • Work in close collaboration with the CDMO and internal teams to support manufacturing investigations and change controls. • Provide assessments of product and process impact and contribute to the identification of root cause and determination and development of appropriate action plans. • Review and/or approve CDMO manufacturing documentation including manufacturing bill of materials, production master batch records, and executed production record review. • Communicate routine production manufacturing status to company stakeholders and assist as necessary with process data retrieval, processing, analysis, through written, verbal, and presentation at various company meeting forums. • Author key technical documentation supporting manufacturing activities including technical risk assessments, manufacturing protocols, campaign reports, and descriptions of manufacturing process and controls. • Author supporting documentation for relevant CMC manufacturing content of various regulatory submissions as needed.

Associate Director, Human Resources Business Partner - Solid Biosciences Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich's ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid's mission is to improve the daily lives of patients living with devastating rare diseases. We are seeking a Human Resources Business Partner who will strategically guide and partner with our Senior Leaders across all Solid Biosciences Business Units. This role will be the key advisor to Senior Leadership on organizational planning, team dynamics and effectiveness, individual and team performance, and proactive planning for the future needs of their organizations. This role will report Vice President, Head of Human Resources and will be based in Solid's Corporate Headquarters located in Hood Park in Charlestown, MA and will work in a hybrid capacity and a target of averaging 3 days per week onsite closely partnering with leaders. Key Position Responsibilities - Build a cadence of proactive partnership touchpoints with senior functional leaders across Solid, ensuring a partnership model is established to regularly guide and advise key organizational planning and decisions - Thoughtfully prompt active review of team and individual performance to directly align HR partnership to business outcomes and key organizational objectives - Embed across Solid's scientific, clinical, manufacturing, technology, and corporate functions to develop a deep comprehension of the science and business of Solid to inform partnership priorities - Lead key organizational processes such as performance management and advancement calibration across the business, aligning closely with the VP, Head of Human Resources on strategy and approach - Serve as a key strategic contributor and co-architect of Solid's employees and leader development programming, linking organizational development to the company's growth trajectory and organizational future - Lead and execute strategic projects across Solid's broader HR Strategy, maturing solid's HR infrastructure such as job architecture and salary bands, alignment with Quality Assurance for Audit and Inspection Readiness, and driving organizational culture initiatives that tangibly align with business priorities Experience Requirements - A bachelor's (BS/BA) degree is anticipated and preferred for this role, while candidates with highly relevant experience in lieu of academic credentials will be given consideration - Candidates with an advanced degree in Business Administration, Human Resources Management, or Organizational Psychology will be given additional consideration - At least 10 years of professional experience is expected for this level of role, with at least 8 years of specific experience within Human Resources targeted. Candidates with most of this experience specifically serving as an HR Business Partner will be given preferred consideration - Specific experience within biotechnology or life sciences companies, while not required, is preferred, as a key aspect of this role will be quickly comprehending the nuance of Solid's research and clinical development work Key Position Attributes - Human Resources expertise with Business / Science Orientation: We are seeking a candidate who will actively immerse themself in understanding the nuance of Solid's science and business - Adaptive curiosity: we seek someone who is eager to learn and adaptive in approach and thought - Credible humility: because of its opportunity for impact, this position will require a level of experience and expertise that will credibly advise Senior Leaders at the VP/SVP level, and balancing experience and expertise with humility will best position this role to build the requisite level of trust and partnership we aim to establish with leaders and within the HR team - Personal accountability with a team orientation: we seek someone who is personally driven and accountable, while having an orientation to partner within the HR team and across the organization as a positive colleague. Compensation The base compensation range for this role is: $160,525 - $201,469 Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid's long term company performance. Benefits and Solid Advantages At Solid Biosciences we offer a highly competitive total rewards and benefits package, intended to support all aspects of our employees' lives and well-being. Additionally, for those employees working onsite at our Hood Park Headquarters, we offer a variety of onsite resources to support those working in our offices. - Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs - 401(k) program participation with competitive company matched contributions - Eligibility to participate in Solid's Employee Stock Purchase Plan - Mobile phone subsidy for eligible employees - Tuition Reimbursement - Vision Coverage - Life Insurance - Voluntary Pet Insurance - Employee Discount Program on Travel, Entertainment, and Services - Daily Subsidized Lunch Delivery (onsite @ Hood Park) - Free Onsite Full-Service Gym (onsite @ Hood Park) - Employee Parking (onsite @ Hood Park)

Role Description We are seeking an accomplished Director of Regulatory Strategy to provide strategic, hands-on regulatory leadership for our clinical-stage gene therapy programs in neuromuscular and cardiac rare diseases. This position will require deep expertise in European regulatory policy, advanced understanding of gene therapy science, and proven experience shaping regulatory strategy through early and mid-stage clinical development. The Director will serve as a key regulatory thought partner to Clinical Development, CMC, science, commercial, and medical affairs teams with a strong focus on EMA, MHRA, and other European regulatory authorities. This role will report to the Vice President of Regulatory Strategy & Intelligence and will be a remote, EU-based role. Key Position Responsibilities - Regulatory Strategy & Leadership - Develop and drive European and global regulatory strategies for clinical-stage neuromuscular and cardiac gene therapy programs. - Serve as regulatory strategy lead for assigned programs collaborating with functional colleagues across CMC, Clinical, and science. - Act as an internal subject-matter expert on European ATMP regulatory policy. - Regulatory Agency Engagement - Lead regulatory interactions with EMA, MHRA, and EU national authorities in partnership with VP, Regulatory Strategy and SVP, Regulatory CMC. - Prepare and manage scientific advice, protocol assistance, pediatric investigational plans, orphan drug applications, etc. - Contribute to global regulatory strategy alignment with US based programs. - Work closely with the health economics team to drive and execute joint HTA and regulatory engagements. - Submissions & Development Support - Provide strategic and hands-on input for CTAs and GMOs in the EU and UK. - Support orphan designation, accelerated pathways, and regulatory filings. - Partner cross-functionally to ensure regulatory readiness. - Scientific & Therapeutic Expertise - Maintain expertise in gene therapy platforms (e.g., AAV). - Apply knowledge of neuromuscular and cardiac disease biology to regulatory strategy. - Monitor evolving EU and UK gene therapy regulations. Qualifications - PhD, MD, PharmD, or equivalent in life sciences required. - 10+ years of regulatory affairs experience required with at least 3 years in gene therapy. - Demonstrated experience and expertise navigating European Regulatory agencies. - Deep expertise in EMA and MHRA processes. Requirements - Ability to work autonomously balanced with effective collaboration and coordination across regional and functional barriers. - Nimble adaptability in working for a smaller scale organization (~125 employees) driving work independently while also evolving processes and systems to mature the regulatory function. Compensation - The base compensation range for this role is: $209,757 - $249,831. - Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. - Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. Benefits - Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs. - 401(k) program participation with competitive company matched contributions. - Eligibility to participate in Solid’s Employee Stock Purchase Plan. - Mobile phone subsidy for eligible employees. - Tuition Reimbursement. - Vision Coverage. - Life Insurance. - Voluntary Pet Insurance. - Employee Discount Program on Travel, Entertainment, and Services. - Daily Subsidized Lunch Delivery (onsite @ Hood Park). - Free Onsite Full-Service Gym (onsite @ Hood Park). - Employee Parking (onsite @ Hood Park).