• Statistical leadership for ASO programs (Phase 1/2 to PoC readiness): Serve as the lead statistician for GondolaBio's ASO assets, owning statistical strategy from early FIH through proof-of-concept. • Develop and defend fit-for-purpose statistical analysis plans (SAPs) that account for small sample sizes, placebo and open-label designs, and high inter-patient variability. • Seizure endpoint strategy: Design robust statistical approaches for seizure frequency and responder analyses in Developmental and Epileptic Encephalopathy populations, where within-patient variability, seizure clustering, and non-normality require non-standard methods. • Partner with clinical colleagues to define scientifically credible and regulatorily acceptable primary and secondary endpoints. • Rare disease-adapted trial design: Apply specialized methods appropriate for small N studies including Bayesian frameworks, adaptive designs, n-of-1 elements, and natural history benchmarking. • Proactively identify and mitigate risks from high variability, missing data, and limited statistical power, communicating trade-offs clearly to program leadership. • Regulatory statistical support: Prepare and contribute to statistical sections of INDs, briefing documents, and FDA/EMA meeting packages. Support pre-IND and Type B/C meetings, and respond to agency questions on statistical methodology. • Biomarker and exploratory analysis: Collaborate with Pharmacology, Translational, and Clinical teams to develop analysis plans for PD biomarkers, target engagement endpoints, and patient stratification. Apply appropriate multiplicity controls and exploratory frameworks to preserve interpretability. • Cross-functional collaboration: Partner closely with Clinical Development, Regulatory, Clinical Operations, and external CROs/vendors to ensure statistical considerations are embedded early in protocol development, CRF design, data management, and study conduct. Represent Statistics in cross-functional program team meetings.

Role Description Reporting to the Senior Director, US Patient Services Operations Lead, the Director, Program Delivery is responsible for the leadership, execution, and optimization of day-to-day operations supporting the US Patient Services team across patient access, affordability, and service delivery. This role ensures seamless coordination between internal teams, external vendors, and cross-functional partners to deliver a high-quality, compliant patient and provider experience. This individual will have three direct reports. - Maximize operational efficiency using available data, on the ground learnings, and market research while optimizing both internal and external service partner measures. - Execute ongoing audits of launch analytics and reporting for Alnylam Assist, Field Reimbursement and Channel functions and ensuring appropriate data capture in custom CRM. - Design and build of new dashboards to support ongoing and future product launches. - Delivery of all financial services programs offered by Alnylam Assist. - Surveilling competitive marketplace for new patient-facing and HCP initiatives and external customer service offerings. - Conceive, develop and implement internal and external programs that drive resolution of complex issues (e.g., prior authorization issues, coordination between Alnylam Assist and channel distribution partners, need for additional patient or healthcare provider education and associated collateral, etc.). - Ensuring internal and external stakeholder satisfaction of US Patient Services through regular communication, satisfaction surveys, and execution of both internal and external key performance indicators. - Support scalable development of launch capabilities, technology, and business process. - Collaborates with legal, regulatory, and compliance stakeholders to ensure compliant development and execution of US Patient Services & Channel initiatives. Qualifications - BS/BA degree (science or business degree preferred). - 10 years business experience, with 8 years of experience in one or more of the following: Patient Services, Reimbursement, or operations within the pharmaceutical or biotech industry. - Proven track record of executing strategic and tactical plans that have delivered strong commercial results. - Strong desire to assess the competitive marketplace and develop/implement new patient programs and services. - Flexible and stimulated by fast-paced environment. - Experience in rare diseases desirable. - Proven ability to influence without authority and work with cross-functional teams in the development and delivery of brand strategic imperatives. - Excellent interpersonal and communication skills. - Ability to travel up to 20% as necessary. - Clear alignment with Alnylam Core Values: - Commitment to People - Innovation and Discovery - Sense of Urgency - Open Culture - Passion for Excellence Requirements - U.S. Pay Range: $198,100.00 - $268,000.00. - This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Benefits - Comprehensive benefits including medical, dental, and vision coverage. - Life and disability insurance. - A lifestyle reimbursement program. - Flexible spending and health savings accounts. - 401(k) with a generous company match. - Paid time off, wellness days, holidays, and two company-wide recharge breaks. - Generous family resources and leave.

Role Description This is your chance to be part of a Revenue Management Consolidated Center (RMCC) that is offering owned, managed, and franchised Hilton hotels world-class revenue management talent and tools. As an Assistant Director, you will support the team that's helping hotels consistently grow market share and outperform competitors. On the Managed Team reporting to the Director, you will accomplish this by: - Developing revenue Managers. - Providing feedback and corrective action on hotel performance. - Communicating RMCC information to the workgroup. - Collaborating on additional RMCC projects. What you'll do during a typical day: - Lead the development of direct reports in your workgroup by providing direction and offering feedback on the performance of their duties and staffing activities. - Be a resource, with continuing efforts to streamline processes, fine-tune efficiencies, and assist others in developing their revenue management skills. - Assess actual hotel performance for hotels in the workgroup to determine if hotels are on target to reach goals, taking corrective action where needed. - Directly support one hotel within the dedicated region. How you'll collaborate with others: - Influence your team to accomplish our objectives through communication, group dynamics, and leadership. - Lead project teams to achieve department initiatives and goals and coordinate resources and collaboration across departments. - Ensure communication from the RMCC VP and Directors is carried out; communicate information, strategies, new programs, and assignments to direct reports and the hotels they support. Deliverables you'll take ownership of: - Conduct weekly, monthly, and quarterly business reviews for hotel performance. - Analyze trends and provide strategic recommendations to achieve revenue and profit objectives. Qualifications - Five (5) years of work experience in Revenue Management. - Proficient in Revenue Management systems, hotel property management systems, and industry-related reports. - Experience handling hotel rates and inventory. - Experience writing forecasts of hotel room revenue weekly and monthly. - Travel up to 15%. Requirements - Full-Service revenue management experience. - Knowledge of Hilton's Revenue Management systems. - Multiple hotel revenue management experience. - Supervisory or team management experience. Benefits - Incredible travel perks – Enjoy 110 nights of deeply discounted travel, with room rates as low as $40/night at our world-class hotels through our Go Hilton travel program. - Own a piece of Hilton – Through our employee stock purchase program (ESPP), you can invest in Hilton shares at a 15% discount to help build your financial future. - Paid parental leave – Because family matters. We offer paid leave for eligible Team Members, including partners and adoptive parents. - Personalized caregiving support – Access dedicated caregiving concierge services to help navigate caregiving for yourself and your loved ones. - Crisis concierge – In times of loss, our Crisis Concierge offers a single, compassionate point of contact for both practical support and emotional care. - Mental health resources – Your wellbeing comes first. Eligible Team Members can access free counseling and support through our best-in-class Employee Assistance Program (EAP). - Generous paid time off (PTO) – Recharge, relax, and take time for what matters most. - Health & welfare benefits – From checkups to dental cleanings to new glasses, we offer a variety of health plans that keep you and your family covered. - Financial security for your future – Our retirement plans make it easier to save for what's next.

Role Description The Senior Director, AI Enablement & Transformation is a senior leadership role within the Technology Services organization responsible for defining and driving the strategic transformation roadmap across IT Infrastructure, Database Operations, Platform Engineering, and Cloud Engineering. This role serves as a key leader in modernizing Technology Services by establishing long-term strategy, guiding architectural direction, aligning transformation initiatives to business objectives, and ensuring successful execution across multiple technology domains. The Senior Director partners closely with technology leaders, Principal Architects, program managers, and enterprise stakeholders to translate strategic objectives into measurable outcomes that improve operational efficiency, reliability, scalability, service quality, and organizational effectiveness. As part of advancing Technology Services capabilities, the role evaluates and responsibly leverages emerging technologies, including Artificial Intelligence (AI), Generative AI, automation, and data-driven insights, to accelerate transformation and drive business value. Location This is a remote opportunity open to candidates located in the U.S. Main Responsibilities - Define and drive the Technology Services transformation strategy across Infrastructure, Database Operations, Platform Engineering, and Cloud Engineering, aligning priorities with organizational and enterprise objectives. - Develop and maintain multi-year transformation roadmaps with clear milestones, success metrics, business outcomes, and value realization targets. - Partner with technology leaders, Principal Architects, and program managers to identify modernization opportunities and define target-state architectures, technology patterns, operating models, and transformation priorities. - Translate strategic objectives into executable initiatives and team-level workstreams, ensuring roadmap goals are incorporated into delivery plans and technology backlogs. - Establish governance processes, executive reporting, and review cadences to monitor progress, manage dependencies, address risks, and ensure accountability for transformation outcomes. - Serve as a trusted advisor to senior technology leaders on modernization strategies, technology investments, operating model evolution, and organizational change initiatives. - Collaborate with Enterprise Architecture, AI Platform, AI Governance, Security, Privacy, and other shared-services teams to ensure alignment with enterprise standards, architectural principles, governance requirements, and security expectations. - Promote the responsible use of AI, Generative AI, automation, analytics, and other emerging technologies to improve operational efficiency, service reliability, workforce productivity, and decision-making. - Evaluate industry trends and emerging technologies to identify opportunities that accelerate innovation and enhance Technology Services capabilities. - Build alignment and influence across stakeholder groups without direct authority while fostering a culture of accountability, collaboration, continuous improvement, and operational excellence. Qualifications - Bachelor's degree in Computer Science, Engineering, Information Systems, or a related field, or equivalent practical experience. - 12+ years of experience in technology leadership roles within enterprise IT, infrastructure, cloud, platform, or operations environments. - 5+ years of experience leading large-scale technology strategy, architecture, or transformation initiatives. - Demonstrated ability to define strategy and translate it into roadmaps, milestones, and measurable outcomes, with executive-level reporting. - Proven experience influencing senior stakeholders and driving alignment across multiple technology organizations without direct authority. - Hands-on experience prototyping, piloting, or operationalizing AI / Generative AI solutions, with working knowledge of model lifecycle considerations (evaluation, monitoring, and responsible use). - Strong understanding of enterprise architecture principles and experience partnering with senior architects. Compensation This information reflects the anticipated base salary range for this position based on current national data. Minimums and maximums may vary based on location. Individual pay is based on skills, experience and other relevant factors. - $174,876 - $233,168 in these states: AL, AR, AZ, FL, GA, IA, ID, IN, KS, KY, LA, ME, MO, MS, MT, ND, NE, NM, OH, OK, PA, SC, SD, TN, UT, VT, WI, WV, WY - $183,621 - $244,827 in these states: CO, HI, MI, MN, NC, NH, NV, OR, RI - $192,364 - $256,486 in these states: AK, CA, CT, DC, DE, IL, MA, MD, NJ, NY, TX, VA, WA Benefits - Lumen offers a comprehensive package featuring a broad range of Health, Life, Voluntary Lifestyle benefits and other perks that enhance your physical, mental, emotional and financial wellbeing. Equal Employment Opportunities We are committed to providing equal employment opportunities to all persons regardless of race, color, ancestry, citizenship, national origin, religion, veteran status, disability, genetic characteristic or information, age, gender, sexual orientation, gender identity, gender expression, marital status, family status, pregnancy, or other legally protected status (collectively, “protected statuses”). We do not tolerate unlawful discrimination in any employment decisions, including recruiting, hiring, compensation, promotion, benefits, discipline, termination, job assignments or training.