Alnylam Pharmaceuticals

Role Description Reporting to the Senior Director, US Commercial Training & Development, the Associate Director, US Commercial Training & Development – TTR Franchise is responsible for leading the commercial capability strategy for the TTR business. This role partners closely with Commercial Leadership to identify capability gaps, develop learning strategies, and implement scalable solutions that accelerate business performance and prepare the organization for future growth. The Associate Director serves as the strategic learning partner for the TTR Franchise and is responsible for translating business priorities into measurable capability-building initiatives. This individual leads the design, implementation, and continuous improvement of onboarding, launch readiness, leadership development, sales capability, coaching, and continuous learning programs while ensuring alignment with commercial objectives. This leader will manage and develop members of the Commercial Training team while collaborating across Marketing, Medical, Market Access, Business Operations, Commercial Excellence, HR, Compliance, Legal, and external partners to drive a high-performing learning culture. Qualifications - Bachelor's degree required; advanced degree preferred. - 8+ years of pharmaceutical or biotechnology commercial experience. - 5+ years of commercial training, capability development, learning and development, or sales leadership experience. - Demonstrated experience leading cross-functional initiatives in a complex matrix organization. - Experience managing and developing learning professionals or cross-functional project teams. - Strong strategic thinking with the ability to align learning solutions to business priorities. - Exceptional communication, facilitation, executive presence, and influencing skills. - Proven ability to build trusted relationships across all organizational levels. - Strong project management and organizational skills. Requirements - Rare disease or specialty pharmaceutical experience. - Commercial launch experience. - Sales leadership or field sales experience. - Experience developing commercial capability frameworks. - Experience with leadership development and coaching programs. - Experience utilizing learning analytics and business performance metrics. - Experience implementing AI-enabled learning technologies and digital learning platforms. - Familiarity with CRM platforms, digital adoption tools, LMS technologies, and virtual learning environments. - Demonstrated ability to lead organizational change and capability transformation initiatives. Benefits - Comprehensive medical, dental, and vision coverage. - Life and disability insurance. - Lifestyle reimbursement program. - Flexible spending and health savings accounts. - 401(k) with a generous company match. - Paid time off, wellness days, and holidays. - Two company-wide recharge breaks. - Generous family resources and leave.

Role Description The Senior Manager, Medical Writing will collaborate with project teams on the development of clinical documents in accordance with all applicable regulations, Good Clinical Practices, and Standard Operating Procedures (SOPs) and will oversee the work of contract writers on the clinical program. - Produce high quality and on-time writing deliverables - Independently plan, write, edit, and format key documents, including clinical protocols, investigator brochures, clinical study reports, integrated safety and efficacy summaries and related documents - Facilitate/manage efficient review and finalization process for documents produced internally and/or externally by consultants, contractors and vendors - Represent Medical Writing on multiple early phase project teams or on specific late phase project teams and collaborate with the Director of Medical Writing to ensure proper planning and resourcing for upcoming project writing deliverables - Collaborate effectively with Biometrics, Clinical Operations, Clinical Development, Regulatory Affairs, Pre-Clinical Development, Program Management, Research, Quality, and Corporate Communications, as well as with external stakeholders - Serve as subject matter expert for clinical documents and their production - Contribute to SOP and template development and maintenance Qualifications - Bachelor's degree in Life Science with relevant writing expertise or in English/Communications with relevant science expertise; advanced degree and/or professional certification/credentials preferred - 6+ years of experience as a medical writer in the sponsor and/or CRO setting; experience with regulatory submissions (CTA/IND/NDA/BLA) and knowledge of eCTD formatting is a plus - In-depth knowledge of Good Clinical Practices, FDA regulations, ICH guidelines, and the drug development process - Successful track record of managing multiple projects in a fast-paced and deadline-driven environment with impeccable attention to detail and ability to complete writing assignments in a timely manner - Experience overseeing the work of contract writers is a plus; must be proficient with Microsoft Windows, Word, Excel, and PowerPoint - Ability to travel approximately 10% is required; demonstrate clear alignment with Alnylam Core Values including Commitment to People, Fiercely Innovative, Purposeful Urgency, Open Culture, and Passion for Excellence Requirements - U.S. Pay Range: $146,100.00 - $197,700.00 - This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Benefits - Comprehensive benefits including medical, dental, and vision coverage - Life and disability insurance - Lifestyle reimbursement program - Flexible spending and health savings accounts - 401(k) with a generous company match - Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks - Generous family resources and leave

Role Description We are seeking an experienced Medical Science Liaison (MSL) to join the TTR team and support Alnylam’s commitment to advancing the science and care of patients with transthyretin (TTR) amyloidosis. Patients often experience prolonged diagnostic journeys; this role is an opportunity to help elevate disease understanding and support evidence-based clinical decision-making through high-quality scientific exchange. The MSL will be principally responsible for building and sustaining scientific partnerships with key opinion leaders (KOLs), investigators, and other healthcare professionals within an assigned geography. The MSL will identify and address unmet medical education needs, deliver balanced scientific information (including mechanism of action and emerging clinical data), and gather actionable medical insights to inform internal stakeholders. Success in this role is grounded in Alnylam’s core values—our unwavering commitment to people, purposeful urgency, passion for excellence, fiercely innovative, and an open culture—while upholding the highest standards of integrity and compliance. This position partners closely with cross-functional colleagues (including Medical Affairs, Clinical Development, Market Access, and Patient Advocacy) to support strategic medical priorities for the TTR franchise and reports to the geographically aligned Field Medical Director. Key Responsibilities - Partner closely with investigators and internal stakeholders to drive patient accrual. - Identify key opinion leaders and cultivate a network of experts for key Alnylam disease areas. - Develop, maintain, and execute US KOL and US Institution plans within respective geography. - Conduct and implement a comprehensive disease awareness tactical plan within the respective geography. - Collaborate with health care professionals to identify opportunities for the development of algorithms and guidelines to facilitate early diagnosis. - Provide in-depth drug mechanism of action and emerging clinical information to health care providers in the respective geography. - Serve as a liaison to health care professionals and professional organizations and disease state advocacy groups. - Support the efforts of patient support groups and educational foundations. - Provide medical and scientific input into the planning and execution of advisory boards and work with experts to review speaker presentations and provide additional medical background where requested. - Contribute to Alnylam's achievement of Company objectives for pre-approved products. - Provide educational meeting support at scientific congresses. - Coordinate required medical, legal, and regulatory review and approval of all field documents for distribution or presentation. - Require 60-70% travel. Qualifications - PhD, PharmD, DNP or MD with 3 to 5 years’ industry experience. - Proven clinical background to enable engagement of Health Care Professionals in a scientifically meaningful exchange. - Prior experience in cardiology and rare disease strongly preferred. - Experience in clinical research, patient recruitment, and investigator-sponsored trials. - Experience in medical education and KOL management. - Effective communication of evidence based scientific information. - Ability to work collaboratively and cross-functionally. - Capable of managing shifting priorities in a rapidly changing environment. - Decision-making and accountability. Requirements - U.S. Pay Range: $187,700.00 - $253,900.00. - Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. - This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Benefits - Comprehensive benefits including medical, dental, and vision coverage. - Life and disability insurance. - A lifestyle reimbursement program. - Flexible spending and health savings accounts. - 401(k) with a generous company match. - Paid time off, wellness days, holidays, and two company-wide recharge breaks. - Generous family resources and leave.

Role Description The Director, Clinical Data Management is responsible for the oversight of data management activities in support of Alnylam studies across all stages of clinical drug development. This position reports to the head of the Clinical Data & Insights group. - Direct and grow internal data management expertise area, including management of direct reports; - Direct and establish standards for data management CRO outsourcing strategy and deliverables, including the CRO selection process and the governance of CRO performance; - Oversee the successful execution of all data management activities in support of Alnylam clinical studies in partnership with CROs, including eCRF development, database build, data collection, data coding, cleaning, database lock and archiving; - Supervise the execution of cross-functional, internal data review plans by direct reports across all Alnylam clinical studies; - Partner with internal and external partners, including Biostatistics, Statistical Programming, Clinical Operations, Medical, Quality Assurance, Clinical Pharmacology and Pharmacometrics, Bioanalytical, Safety & Risk Management (SRM) and Regulatory Affairs; CROs, central and local laboratories, and other vendors; - Lead development and implementation of data collection standards, consistent with industry best practice; - Lead data management contributions to the development of clinical protocols, clinical study reports and other regulatory documents, e.g. DSURs, Briefing Documents, etc. - Oversee development of department workflows, and infrastructure strategy and implementation, such as preferred provider initiatives, SOPs, and templates; - Collaborate with Statistical Programming and external vendors to ensure compliance of SDTM clinical datasets, consistent with CDISC standards; - Collaborate with Clinical Operations and Quality Assurance to certify the integrity and traceability of all clinical data sources, compliant with 21 CFR Part 11 standards; - Direct Data Management GCP inspection readiness efforts; function as a leader for Data Management in GCP inspections; - Represent Data Management at internal cross-functional meetings and external vendor leadership meetings; - Demonstrate clear alignment with Alnylam Core Values including, Commitment to People, Fiercely Innovative, Purposeful Urgency, Open Culture and Passion for Excellence. Qualifications - BS/BA in scientific discipline, MS or equivalent preferred, with at least 15 years of clinical data management experience in a pharmaceutical/biologics/biotechnology company, with at least 5 years in a leadership capacity; - Extensive experience managing global studies utilizing an outsourced CDM model from start-up through close-out; - Extensive experience managing direct reports and providing performance reviews and career development guidance; - Understanding of ICH GCP as well as general knowledge of industry practices and standards; - Knowledge and understanding of regulatory requirements and expectations for clinical data systems including 21 CFR Part 11; - Expert knowledge of eClinical processes, efficient design/build of an EDC data management system and other Clinical Trial data/Data Management Systems; - Expert knowledge and understanding of regulations and industry-adopted data standards, such as CDISC-SDTM and CDASH; - Experience using standardized medical terminology, including MedDRA and WHODrug; - Experience working with Medidata Rave EDC systems; - Experience working with elluminate or other data visualization systems a plus; - Experience working with MS Office Suite (Excel, Word and PowerPoint) familiar with MS Project; - Excellent written and oral communication skills; - Highly motivated and flexible, with excellent organizational skills; - Ability to work independently and as part of a multi-disciplinary team. Requirements - U.S. Pay Range: $197,200.00 - $266,800.00 - The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. - This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Benefits - Comprehensive benefits including medical, dental, and vision coverage; - Life and disability insurance; - A lifestyle reimbursement program; - Flexible spending and health savings accounts; - 401(k) with a generous company match; - Paid time off, wellness days, holidays, and two company-wide recharge breaks; - Generous family resources and leave.

Role Description We are seeking an experienced Associate Medical Director to join our dynamic team in the United States. This pivotal role will support the strategy and execution of comprehensive medical plans in the US, with focus on the ATTR space. The ideal candidate will support the development and execution of plans through various channels, including our field medical team and collaborating closely with cross-functional partners to advance patient care and support healthcare professionals in the diagnosis and management of ATTR. - Support strategic planning by leading the development and refinement of the US Medical Education strategic roadmap, ensuring alignment with broader Medical Affairs and cross-functional objectives. - Lead the development and management of comprehensive project and materials development plans, ensuring seamless coordination among matrixed teams including Medical Affairs, Commercial, Materials Review Boards, Compliance, and external partners. - Oversee the execution of US Medical Education plans, ensuring cohesive, multi-channel dissemination of accurate, timely, and impactful scientific messaging and educational resources tailored to key healthcare professional (HCP) audiences. - Support data-driven refinement of the US Medical Educational Plan, content and messages through analysis of KPI related to knowledge, attitudes and practices of US stakeholders through advisory boards, structured insight generation activities, CME reporting analysis and insights from professional medical associations. - Support the planning and execution of medical education activities at national and regional scientific congresses, including symposia, booth activities, and peer-to-peer engagement opportunities. - Ensure all educational initiatives adhere to regulatory requirements, industry best practices, and internal policies, upholding the highest standards of ethical and professional conduct in all medical affairs activities. Qualifications - Advanced degree (PharmD, PhD, MD) with strong preference for candidates with specialization or experience in cardiology. - Minimum of 5 years of experience in medical affairs within the pharmaceutical or biotech industry, including experience in field medical roles and strategy development. - Proven ability to develop and execute medical strategies and effectively communicate complex scientific information to diverse audiences. - Experience in developing and/or pulling through Medical Education Messages from concept to execution is an asset. - Strong educational communication skills, with the ability to guide field medical teams. - Excellent interpersonal, communication, and collaboration skills, with the ability to engage effectively with internal and external stakeholders. - Solid understanding of the US regulatory environment. - Ability to travel as needed to fulfill job responsibilities. Requirements - U.S. Pay Range: $194,100.00 - $262,500.00 - This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Benefits - Comprehensive benefits including medical, dental, and vision coverage. - Life and disability insurance. - A lifestyle reimbursement program. - Flexible spending and health savings accounts. - 401(k) with a generous company match. - Paid time off, wellness days, holidays, and two company-wide recharge breaks. - Generous family resources and leave.

Role Description The Medical Science Liaison Lead is a professional in charge of leading, managing and monitoring a team of Medical Science Liaisons in Italy and reporting into the Country Medical Director for Italy. He/she will act as a scientific and clinical expert, supporting the medical and scientific objectives of Alnylam’s portfolio in TTR. The MSL Team Lead will be responsible to co-create a comprehensive field medical plan and supporting KOL relationships within Italy. He/she will be accountable also to communicate the science and clinical application of RNAi to Healthcare Practitioners (HCPs). In addition, MSL Team Lead is expected to build strong cross-functional relationships with colleagues in Medical Affairs, Patient Advocacy and Commercial, while maintaining full compliance with all relevant company, industry, legal, and regulatory requirements. Finally, the MSL Lead will be in charge of providing medical and scientific input into the planning and execution of Medical projects. Key Responsibilities - People Leadership Responsibilities - Build and foster an inspiring team environment with a strong culture of open communication and collaboration - Lead and drive the performance, effectiveness, and impact of the MSL team - Define and execute the MSL team strategy, including the development and implementation of territory plans and clear team objectives - Partner closely with the Country Medical Director and Medical Affairs leadership to ensure strong alignment and cross-functional collaboration - Monitor, analyze, and act on performance metrics to continuously enhance team effectiveness - Provide regular updates and insights on medical activities and projects in collaboration with the Medical Director - Lead talent development and succession planning for the MSL team - Set clear priorities, delegate responsibilities, and ensure timely delivery of team objectives - Coach, mentor, and develop team members to strengthen capabilities and drive engagement - Lead recruitment and onboarding of new MSL team members - Scientific expert in TTR - Provide accurate and fair-balanced scientific and medical information (clinical data, development, publications ...) upon request, according to the needs of experts or healthcare professionals, through individual interviews or scientific meetings. - Participate in regional events, national and international congresses as agreed with Medical Director and governance. - Management of national & regional medical projects (IIS, Research collaborations, other) - Maintain a level of expertise in the evolving scientific / therapeutic area and in competitor medicines. - Non-promotional communication with healthcare professionals, respecting the principles of separation of promotional and non-promotional activities defined by the promotional information charter. - Good Clinical Practices - Be compliant to Ethics, Compliance and internal policies Qualifications - Scientific Degree and proven basic science and/or clinical background to enable engagement of Health Care Professionals in a scientifically meaningful exchange - Previous people management experience is preferred - Experience as MSL in biotech, speciality and rare disease is preferred - Experience in clinical research, patient recruitment, and investigator-sponsored trials is a plus - Experience in medical education and KOL management - Effective communication of evidence based scientific information - Ability to work collaboratively and cross-functionally - Decision-making and accountability - Hard-working, energetic and passionate about making a meaningful difference for patients and their caregivers - Outstanding interpersonal skills, including building strong working relationships, and managing and resolving conflict - Demonstrated ability to work effectively in a highly matrixed environment; strongly team oriented - Superb communication skills; oral and written, including presentation skills in Italian & English - An unwavering commitment to upholding the highest ethical, legal, regulatory and scientific standards Requirements - Italy Pay Range: €99,500 to €134,600 gross per annum - The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. - Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills and education. - This role is eligible for an annual short-term incentive award (e.g. bonus or sales incentive), an annual long-term incentive award (e.g. equity) and competitive benefits. Company Description Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Our culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity.

Role Description The Director, Field Medical Affairs is a national leadership role responsible for defining and executing the Field Medical strategy for the community segment, aligned to US Medical Affairs and enterprise priorities. This role leads a team of Medical Science Liaisons (MSLs) and is accountable for translating strategy into disciplined execution, measurable outcomes, and sustained scientific impact. This leader demonstrates strong executive presence and leadership credibility, serving as a trusted voice of Field Medical in cross-functional and Medical Affairs leadership forums. The Director ensures medical and scientific priorities are effectively and compliantly integrated into regional and national plans, while influencing senior stakeholders and shaping enterprise decisions. Success in this role requires a balance of strategic thinking and execution rigor, along with the ability to lead through influence, drive alignment across stakeholders, and elevate field medical impact at scale. The Director also plays a critical role in driving performance through KPIs, strengthening coaching and capability development, and building a high-performing national MSL organization. Key Responsibilities - Lead and develop a national team of MSLs, fostering a high-performance culture grounded in accountability, continuous development, and strong scientific engagement. - Define and execute the Field Medical strategy for the community segment, ensuring alignment to US Medical Affairs priorities and enterprise objectives. - Translate strategy into clear field medical plans, execution frameworks, and measurable outcomes across regions. - Establish and drive KPIs and performance metrics to assess field impact, ensure execution quality, and enable data-driven decision-making. - Ensure consistent, high-quality, and compliant execution of field medical activities across the organization. - Provide ongoing coaching, performance feedback, and leadership development to enhance MSL effectiveness, strategic thinking, and engagement quality. - Represent and lead the Field Medical voice in cross-functional forums, demonstrating executive presence and influencing stakeholders to ensure appropriate and compliant integration of medical priorities into regional and national plans. - Shape cross-functional strategies by incorporating field insights, scientific perspectives, and medical priorities, ensuring alignment with US Medical and enterprise strategy. - Ensure all cross-functional engagement and planning are conducted with strong compliance, scientific integrity, and adherence to Medical Affairs governance standards. - Serve as a strategic liaison across Medical Affairs and cross-functional partners, proactively aligning priorities, removing barriers, and strengthening coordinated execution. - Lead national account planning approaches and field deployment strategies to optimize engagement with key healthcare systems and providers. - Demonstrates resilience, determination, and follow-through in the face of complexity, setbacks, or resistance; maintains focus on strategic priorities; and drives initiatives. - Oversee budget planning and resource allocation, ensuring disciplined investment aligned to strategic priorities. - Represent Field Medical in Medical Affairs leadership discussions, bringing forward field insights and strategic perspectives to influence enterprise decisions. Qualifications - Advanced degree (PharmD, PhD, MD, or DO) - 12+ years of Medical Affairs experience, including field medical leadership - Proven ability to lead and develop high-performing MSL teams at scale - Demonstrated strength in executive presence, influencing senior stakeholders, and operating effectively in leadership forums - Strong track record of strategy development, execution, and cross-functional leadership - Experience with KPI-driven performance management, coaching, and organizational leadership - Experience in cardiology, rare disease, or specialty biopharma preferred - Willingness to travel (~50–60%) Benefits - Comprehensive benefits including medical, dental, and vision coverage - Life and disability insurance - Lifestyle reimbursement program - Flexible spending and health savings accounts - 401(k) with a generous company match - Paid time off, wellness days, holidays, and two company-wide recharge breaks - Generous family resources and leave Company Description We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

Role Description We are looking for an experienced Regional Business Director (RBD) to support the promotion of AMVUTTRA® (vutrisiran). The U.S. Food and Drug Administration (FDA) recently approved the supplemental New Drug Application (sNDA) for AMVUTTRA® (vutrisiran). The approval expands the indication for AMVUTTRA, which now becomes the first and only therapeutic approved by the FDA for the treatment of ATTR-CM and the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults. The RBD will be principally responsible for leading and managing a high-performing team of Business Account Executives, focusing on disease awareness and product education among healthcare professionals managing hATTR amyloidosis patients. This is an incredible opportunity to build a team and shape a market in support of patients, caregivers, and the hATTR amyloidosis community. The RBD will provide coaching to help ensure every BAE meets or exceeds target. He/she will be critical in the assessment and improvement of field and selling processes. RBDs will also need to provide insights to inform commercial strategy, given their proximity to the market, and ultimately meet and exceed performance targets. The RBD will also need to embody Alnylam values: our commitment to people, sense of purposeful urgency, passion for excellence, innovation & discovery, and open culture as well as our unwavering commitment to integrity. Additionally, an RBD will be responsible for the creation of a customer-oriented climate that focuses on an understanding of patient and customer needs, value-added services, and seamless execution. Through the building of best-in-class teams, talent development, and regular monitoring and coaching, the RBD will foster a culture of accountability. The position reports to the Executive Sales Lead role. Key Responsibilities - Lead and manage a high-performing team of Business Account Executives, focusing on disease awareness, product education among healthcare professionals managing hATTR amyloidosis patients. - Utilize strong sales management, strategic planning skills, financial acumen, and analytical capabilities to align sales execution with overarching product strategies and market needs. - Analyze market and proactively develop a forward-thinking action plan, rather than solely reacting to past events. - Coach and develop team members to exceed performance targets, emphasizing compliance and effective local business management through strategic business planning and cross-functional alignment. - Leverage proximity and familiarity of their market to provide insights that help inform the commercial strategy. - Attract, manage, and retain top sales talent with a demonstrated experience in diverse specialties. - Hold the team accountable to sustaining a customer-oriented culture that prioritizes understanding and meeting patient needs, delivering seamless execution and value-added services. - Allocate and manage regional resources effectively that support targeted strategic and operational excellence. - Align people, processes, structure, information, and communication systems within a complex ecosystem – both within and across functions. - Inspire and motivate the team by clearly articulating the strategy and vision for the future. Qualifications - Bachelor’s degree required: science focus strongly preferred; MBA/PhD is a plus. - 7+ years in sales, marketing, commercial operations, and/or account management experience in commercial healthcare organizations (i.e., Biotech, Med Device or Specialty Pharmaceuticals). - 3+ years of experience in leading teams, experience building out field sales teams preferred. - Rare/orphan disease experience preferred. - Experience training and managing BAEs to effectively promote multiple specialties. - US product launch experience is helpful. - In-depth reimbursement knowledge of Buy/Bill and expertise of Part B & D, working with in-house patient support services team required. - Hospital / Institution knowledge and expertise with the P&T process. - Deep experience in Neurology and Cardiology is preferred. - Knowledge and experience with “site-of-care” development. - Experience in working in various departments, managing multiple teams (sales, marketing, market access, patient services). - Demonstrated leadership in working in a matrix environment and influencing management decisions. - Effective planning, prioritization, management, and organizational skills. - Must be familiar with relevant legal and regulatory environments in biotech/pharmaceutical industry. - Significant domestic/regional travel is required (approximately 60 – 70%). - Valid Driver’s license required. - Demonstrated commitment to ethics and integrity. Requirements - Significant domestic/regional travel is required (approximately 60 – 70%). - Valid Driver’s license required. Benefits - Comprehensive benefits including medical, dental, and vision coverage. - Life and disability insurance. - Lifestyle reimbursement program. - Flexible spending and health savings accounts. - 401(k) with a generous company match. - Paid time off, wellness days, holidays, and two company-wide recharge breaks. - Generous family resources and leave.

Role Description The Senior Manager, Medical Science Liaison is responsible for executing field medical activities that support the Medical Affairs strategy for marketed products and/or development compounds. The role applies strong clinical knowledge and field expertise to gather insights from the external healthcare environment and communicate these internally to support decision-making. The Senior Manager builds and maintains relationships with key external stakeholders and contributes to the identification of scientific and clinical trends within the therapeutic area. Working under the guidance of the Medical Affairs Lead and/or Medical Affairs Manager, the role supports the delivery of medical plans, contributes to the identification of data gaps, and helps ensure stakeholder information needs are met through appropriate scientific exchange. The successful candidate will demonstrate solid scientific expertise, effective stakeholder engagement skills, and a good understanding of the disease area and product landscape. Key Responsibilities - Develop and maintain professional relationships with key opinion leaders (KOLs) within assigned therapeutic areas - Identify potential investigator-initiated study (IIS) opportunities and support interactions with investigators as appropriate - Gather and communicate field insights, including emerging clinical and scientific trends - Support the development and execution of advisory boards, symposia and publication activities - Contribute to the development and implementation of local Medical Affairs plans under guidance (e.g. Medical Activity Plans) - Support review of promotional and non-promotional materials (e.g. MRCP) in collaboration with the Medical team - Collaborate effectively with cross-functional colleagues, including Medical and Commercial teams, to support aligned execution of plans - Provide accurate, balanced and timely scientific information in response to external and internal requests - Support scientific presence at conferences and external meetings - Escalate and respond to medical enquiries in line with company processes - Maintain up-to-date knowledge of the therapeutic area, product data and competitor landscape - Ensure compliance with all relevant legal, regulatory and company policies Qualifications - Degree in medical, clinical or life sciences (PhD, MD or equivalent preferred) - Relevant experience in the healthcare industry; prior MSL or similar field medical experience preferred - Understanding of clinical research and working knowledge of GCP is beneficial - Experience reviewing and interpreting scientific literature - Strong communication and presentation skills - Ability to manage territory and prioritise workload effectively - Willingness to travel (approximately 50–60%) Company Description Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality. Our culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential.

Role Description The Key Account Manager (KAM) is a field-based expert, that strategically drives the commercial objectives of Alnylam’s transthyretin amyloidosis (ATTR). The KAM will be primarily accountable for developing and implementing key account plans in their designated territory to optimize care for patients. Reporting to Area Sales Manager, the KAM is expected to develop territory specific strategic account plans in the context of the overall product strategy and in close alignment and collaboration with other functions such as Medical Affairs, while ensuring full compliance with all relevant company, industry, legal, regulatory and ethical standards. Key Responsibilities - Presents a positive image of the company and develops/reinforces awareness about RNAi platform to relevant customer groups. - Develop and Lead Regional/Hospital Market Access. - Develops, owns, and drives territory and account plan, including customer targeting, in line with country strategy in partnership with the Commercial and Medical Affairs team. - Achieves pre-launch and post-launch KPIs. - Performs detailed analysis of the assigned territory to identify, assess, and support the development of relevant centers for diagnosis and treatment. - Drives patient identification, diagnosis, and referral rates by executing against a territory strategy and account specific plans. - Develops trusted relationships with a portfolio of customers to ensure competitive advantage, after developing a thorough understanding of key customer needs and requirements. - Ensures the correct products and services are delivered to customers in a timely manner by collaborating with internal stakeholders (commercial, supply chain, and compliance) and external centers. - Establishes and maintains contact with key customers and provides commercial and scientific services to ensure access at site of care, and that logistics are in place to administer product. - Manages and executes local meetings to drive diagnosis and treatment rates, in collaboration with the Medical Affairs Team for physicians and other healthcare professionals. - Represents Alnylam at local and national events and congresses. - Serves as the link of communication between key customers and internal teams. - Liaises and collaborates with relevant internal staff (Medical Affairs, Commercial Leads, Marketing and Business Operations Manager), as required. - Timely and accurate reporting and continuous diligent maintenance of the CRM database. - Conducts all activities to the highest ethical standards in accordance with country code of practice and local laws and regulations. - Steers regular local alignment meetings with other field-based functions to ensure proper implementation and outcomes against the committed territory and account plans. Qualifications - University degree in a relevant scientific field, compliant with Italian regulatory requirements (D.Lgs. 219/2006). Equivalent qualifications as recognized by the Ministry of Health will also be considered. - 5+ years of Sales and Key Account Management experience in bio/pharmaceutical sales. - Ability to gain consistent access and develop strong & professional relationships for product promotion with healthcare providers in reference centers and the community. - Effective communication and influencing skills to engage with professionals at all organizational levels. - Strong business acumen to add value to the existing healthcare structures. - Ability to draw on previous experiences and insights to generate and maintain appropriate awareness and timely access to treatment. - Excellent organizational and project management skills. - Fluent in Italian and English, both written and verbal preferred. - Ability to travel within a territory on a regular basis (80% of the time). Company Description Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.