• Day-to-day operations & cross-functional interface • Primary point of contact for Support, Customer Success, Development and Sales • Communication bridge between all departments; ongoing internal process optimization • Independent decision-making in Support/Success (e.g., refunds) on important cases • Consultation with the Founder; otherwise coordinate with the team • Temporary team-lead role in departments during critical situations • Responsibility for Moss (expense monitoring, approvals, account monitoring) • Responsibility for accounting, including communication with the tax advisor • Responsibility for Factorial (leave requests, time tracking, submission of sick notes to health insurance, etc.) • Processing sales reps' compensation and invoicing customers • Collections coordination • Planning team events, team calls and workations • Weekly reporting directly to the Founder & CEO — covering all topics • Communication with lawyers, legal insurance, tax advisors and freelancers (e.g., independently managing website projects) • Review and update of Terms & Conditions and privacy policy as needed • Responsibility for the info@ inbox, assessing important legal matters and managing them — you are the first point of contact for all legal inquiries • You step in during urgent situations and conduct initial interviews for new operational roles • You prepare all operational and technical elements for new onboardings and are also responsible for employee offboarding • Technical onboarding of new employees, central point of contact for questions • Screening and initial interviews for Ops hiring, supervision of trial days in Sales

Manager, R&D Operations Cambridge, MA Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity We are seeking an R&D Operations Manager to lead operational planning and execution across our preclinical research and development organization. This role serves as a key business partner to scientific leadership, enabling efficient execution of toxicology, bioanalytical, translational, and research activities through strong operational oversight, vendor management, financial planning, and process optimization. The R&D Operations Manager will be responsible for driving operational excellence across a growing preclinical organization, ensuring studies, vendors, budgets, contracts, and critical deliverables are managed proactively and efficiently. This position offers broad visibility across R&D and significant interaction with scientific leaders, external CROs, Finance, Procurement, Legal, and Quality. Responsibilities Operational Leadership - Support  operational planning and execution activities supporting preclinical, toxicology, bioanalytical, and translational research programs. - Partner with scientific leadership to develop and maintain integrated study plans, timelines, milestones, and operational deliverables. - Support identification of operational risks, develop and maintain program level risk tracker, and proactively work with scientific teams to develop mitigation strategies to support successful study execution. - Establish, implement, and continuously improve operational processes, tools, templates, and governance frameworks that increase organizational efficiency and scalability. - Support the Department Head with scheduling and executive assistant-based activities with approximate 15% time allocation. Vendor and CRO Management - Serve as the primary operational lead for CROs, laboratories, consultants, and other external vendors supporting preclinical programs. - Manage vendor onboarding, contract initiation, statements of work, purchase orders, amendments, and vendor performance tracking. - Partner closely with Procurement, Legal, Finance, and Quality to ensure timely execution of agreements and vendor-related activities. - Monitor vendor deliverables, timelines, and budget performance, escalating issues as needed. Study and Portfolio Operations - Facilitate department-level and cross-functional meetings, lead meeting notes and tracking of decisions, action items, and deliverables with clear documentation and tracking to completion. - Maintain operational oversight of study documentation, ensuring protocols, reports, contracts, and associated records are inspection-ready and appropriately archived. Financial and Resource Management - Manage operational budgets for preclinical and toxicology activities, including purchase order management, invoice reconciliation, accrual tracking, and spend forecasting in partnership with the department head. - Partner with Finance to support annual budget planning and quarterly forecasting activities. - Develop reporting and dashboards that provide visibility into program level and study level costs, vendor spend, and resource utilization. Continuous Improvement - - Develop metrics and key performance indicators to measure operational effectiveness across preclinical programs. - Identify opportunities to streamline workflows, reduce cycle times, and improve collaboration across internal and external stakeholders. - Champion a culture of operational excellence, accountability, and continuous improvement. Required Qualifications - Bachelor’s degree in Life Sciences, Business, Operations, or a related field. - 6+ years of experience in biotechnology, pharmaceutical, CRO, or life sciences environments. - 3+ years of experience supporting preclinical development, toxicology, translational research. - Demonstrated experience managing vendors, CROs, contracts, budgets, and operational processes. - Experience partnering cross-functionally with scientific, finance, procurement, legal, and quality organizations. - Strong project management and organizational skills with the ability to manage multiple complex priorities simultaneously. - Excellent written and verbal communication skills and the ability to influence stakeholders across all levels of the organization. - Proficiency with Microsoft Office and common business systems; experience with NetSuite, LinkSquares, Smartsheet, or project management platforms is preferred. Work Location and Conditions - At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. - You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. - You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $123,000 - $138,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

• Manage, optimize, and implement systems and processes to provide high-level support across the company and portfolio • Drive operational excellence and efficiency across the organization by developing relationships with employees • Provide cross-functional collaboration to achieve strategic goals • Aid in the end-to-end execution of critical projects and initiatives that drive effective implementation and adoption of standards • Create and introduce operations processes, templates, tools, job aids, reports, and dashboards • Develop and document standard operating procedures (SOPs) for system-related workflows • Assist in the development, implementation, and optimization of operational systems and technologies • Provide high-level peer-to-peer technical and operational support across all departments • Lead system conversions for all acquisitions and dispositions • Audit, monitor, and ensure compliance with regulatory requirements

• Leads daily IT operations to ensure system stability, availability, and performance • Drives incident and problem management in alignment with ITIL best practices • Participates in Batch Operations to ensure the timely, accurate, and reliable execution of business-critical workloads • Assists management in the selection, training and developing of new employees • Oversees 24x7 IT operations, system performance, and service availability • Leads incident lifecycle management • Oversees daily Incident and Problem Management activities • Leads major incident response efforts and coordinate technical teams • Conducts root cause analysis and track long-term fixes for recurring issues • Maintains clear communication with leadership, technical teams, and business partners • Ensures alignment with ITIL and IT service management best practices • Participates in Batch Operations activities • Ensures SLA adherence and ticket queue performance • Monitors service metrics and identify improvement opportunities • Maintains ITIL-aligned processes, runbooks, and documentation • Assists the manager in monitoring team performance, staffing, and development • Collaborates with IT and business stakeholders • Ensure accurate documentation of incidents, problem records, and changes within ITSM tools • Provide guidance and mentorship to junior team members • Support on-call rotations and lead in major incident response efforts • Contribute to continuous improvement initiatives aligned with ITIL best practices