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Founder in Residence, Unlocking systemic drug delivery for brain & CNS disease
Location
United States
Posted
12 days ago
Salary
£4.2K / month
Seniority
Mid Level
No structured requirement data.
Job Description
Founder in Residence, Unlocking systemic drug delivery for brain & CNS disease
Deep Science Ventures
Role Description Join us to build: we’re seeking entrepreneurially-minded scientists with deep technical expertise, who are eager to solve one of the most durable and consequential challenges in medicine through venture building. This role offers a unique opportunity to work at the forefront of CNS drug delivery, leading a company that makes it fundamentally easier, safer and more broadly applicable to get therapeutics into the brain. The role is full-time, remote initially until venture incorporation and spin-out (circa end of 2027), location TBD. The Opportunity - CNS diseases represent one of the largest and most persistent unmet needs in medicine. - Over 1 billion people worldwide live with a neurological condition. - Current disease-modifying treatments remain elusive for the vast majority. - The failure rate in CNS drug development is among the highest of any therapeutic area. - The inability to reliably deliver drugs across the blood-brain barrier (BBB) is a central reason for this failure. - Fewer than 2% of small molecules cross the BBB in meaningful quantities. - Almost no large-format biologics reach the brain parenchyma without specialised delivery mechanisms. - Emergence of receptor-mediated transcytosis (RMT) as a BBB delivery strategy represents a genuine step forward. - Challenges with RMT include haematotoxicity, receptor saturation, inefficient endosomal sorting, and receptor downregulation. - There is a compelling scientific and commercial opportunity to redesign BBB drug delivery from first principles. Working in Partnership with Medicines Discovery Catapult This role sits within a formal partnership between Deep Science Ventures (DSV) and Medicines Discovery Catapult (MDC). Driven by a shared conviction in the urgent need to unlock CNS drug delivery, DSV and MDC have partnered to scope and create a new venture at the intersection of protein engineering, cell biology, and drug development. The Role You will join DSV’s venture creation programme as a Founder-in-Residence and work closely with the DSV and MDC teams to spin out the new company. During the programme you will refine, improve and complement existing scoping work on: - The technical thesis for approaches that dramatically improve the efficiency, safety, and modality breadth of drug delivery across the blood-brain barrier. - IP strategy, differentiation, competition. - Market, value capture, techno-economics (value proposition). - Regulatory strategy & positioning. - Fundraising strategy & pitching. - Optimising company strategy for the most rapid and de-risked path to Series A. Preparation for Investment Committee (IC) will involve fulfilling our investment criteria, recruiting advisory and co-founding team members, and parallel fundraising for additional expansion funds. Assuming success at IC, you will receive pre-seed investment and spin out the company end of 2027. You and your co-founders will own a significant stake in the business and continue receiving support post-spinout. Qualifications - Deep expertise in at least two of the following four areas: - Protein Engineering - Biologics Drug Development - Cell Biology & Neurobiology - Medicinal Chemistry Requirements - Track record of translating scientific concepts from discovery through to in vivo proof-of-concept or IND. - Experience managing CRO/CDMO or Pharma programmes and building regulator- or investor-ready data packages. - Highly motivated by unsolved challenges in CNS drug delivery. - Impact driven, take initiative, and can think from a first principles perspective. - Clear entrepreneurial spirit and mindset, demonstrated through impactful innovation. - Collaborative nature, with the ability to work effectively in cross-functional teams. Preferred - Nice to Have - CNS preclinical or clinical drug development experience. - Single-cell transcriptomic data analysis. - Target & biomarker identification. - Deep understanding of IP - FTO and patentability. - Track record of publications and/or thought leadership in CNS delivery or related fields. - Previous biotech founder or C-suite leadership experience. - Previous fundraising experience (VC, dilutive or non-dilutive). - Experience building and leading successful scientific or cross-functional teams. - Network across CNS pharma, biotech, or relevant academic institutions. Benefits - Initial £250k (~$330k / €290k) investment governed by our Investment Committee. - Minimum guaranteed income of £4,166 per month (fixed), paid to each Founder as a consultancy fee until the company is launched. - Continuous support post spin-out, including fundraising, commercial partnerships, recruitment, and team-building. - Access to a unique resource of other Founders currently at DSV across sectors.
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