• The Associate Director/ Director of Health Economics and Outcomes Research (Early Stage Pipeline) will be responsible for defining and executing early evidence generation strategies and deliverables across multiple programs. • Support HEOR/COA endpoint strategy from Phase 1 to 3 clinical studies ensuring inclusion of patient-centric, clinically meaningful, and economically relevant outcomes. • Contribute to commercial and global market access strategy to influence trial designs that meet expectations from multiple stakeholders. • Lead development of HTA-grade cost-effectiveness and budget-impact models to support early decision-making, identify value drivers, pricing, value dossiers, and individual country-specific submissions. • Partner with Global/US Market Access and Regulatory to ensure pivotal studies capture relevant endpoints.

• Own the development and execution of integrated U.S. payer strategies across the Ionis commercial portfolio. • Establish long-range access vision, coverage objectives, and reimbursement strategies aligned with brand and corporate priorities. • Shape and implement enterprise-level access frameworks that can scale across current and future launches. • Identify, quantify, and proactively mitigate access risks and reimbursement barriers. • Provide forward-looking analysis of payer landscape shifts, policy changes, and competitive access dynamics. • Lead U.S. access readiness strategy from pre-launch planning through lifecycle optimization. • Oversee development of payer-facing and field access materials. • Ensure alignment of clinical and economic evidence generation with payer requirements in partnership with HEOR and Medical Affairs. • Influence economic modeling, value frameworks, and budget impact strategies to support coverage negotiations. • Oversee pull-through strategies to accelerate coverage adoption and minimize patient access friction. • Lead and develop a high-performing U.S. Value & Access organization and drive team execution to achieve measurable access outcomes. • Establish clear strategic priorities and ensure alignment of resources against enterprise objectives. • Build scalable capabilities to support portfolio expansion and future product launches. • Foster a culture of collaboration, accountability, and continuous improvement. • Partner closely with Brand, Medical Affairs, HEOR, Regulatory, Government Affairs, Pricing, Field Access, and Sales leadership to ensure cohesive execution. • Integrate payer insights into brand planning, evidence strategies, and lifecycle investment decisions. • Provide executive-level recommendations to senior leadership on reimbursement strategy and payer engagement.

• Lead end-to-end implementation efforts from contract execution through go-live and transition to steady-state operations • Drive the transformation and standardization of implementation methodologies, tools, templates, and governance models • Identify and implement improvements to reduce implementation cycle time, risk, and cost while improving quality and client satisfaction • Establish scalable implementation frameworks that support growth across multiple states and programs • Partner closely with Sales leadership to manage the implementation pipeline, demand forecasting, and delivery readiness • Serve as a senior implementation leader for key clients, ensuring alignment on scope, timelines, risks, and success criteria • Coordinate cross-functional teams including Technology, Data Management, Operations, Analytics, Product, and Shared Services • Lead, mentor, and develop implementation managers, project managers, and delivery staff • Establish implementation governance, escalation paths, and delivery assurance processes • Monitor implementation performance through KPIs, milestones, and risk indicators

• Provide strategic leadership and end-to-end accountability for all IT workstreams related to mergers, acquisitions, divestitures, and strategic transactions, ensuring timely, secure, and value-driven integration execution. • Lead IT due diligence efforts in partnership with Corporate Development, Security, Finance, Legal, and executive leadership, assessing technical environments, operational maturity, risks, cost structures, and integration complexity to inform deal decisions. • Develop and maintain a scalable, flexible IT M&A playbook that defines governance models, integration standards, Day 1 readiness criteria, 30-60-90 day milestones, and long-term transformation objectives. • Own the planning and execution of Day 1, Day 30, and Day 90 integration milestones, ensuring business continuity, secure access provisioning, endpoint and asset visibility, collaboration tooling alignment, and service support readiness. • Serve as the senior IT integration leader across all acquired entities, acting as the primary liaison between acquired leadership teams and internal IT functions to drive alignment, clarity, and accountability. • Establish clear integration governance structures including steering committees, workstream cadences, risk logs, decision frameworks, and executive reporting mechanisms. • Drive rapid stabilization of acquired IT environments, identifying operational gaps, tooling redundancies, contract inefficiencies, and security exposures, and executing remediation plans with urgency and discipline. • Partner with IT Operations, End User Services, ITAM, Service Management, Security, and Engineering teams to coordinate seamless integration across endpoint management, service desk, collaboration platforms, identity alignment, and vendor transitions. • Lead IT separation planning and execution for divestitures, including TSA design and negotiation support, transition roadmaps, service carve-outs, and risk mitigation planning. • Own post-close integration budgeting, cost tracking, synergy realization measurement, and financial transparency across all M&A-related IT initiatives. • Identify opportunities for platform consolidation, vendor rationalization, process standardization, and operating model optimization to accelerate value realization and reduce long-term technical debt. • Ensure acquired environments are aligned to corporate security standards, compliance requirements, asset management policies, and operational controls in partnership with Security and Risk teams. • Drive organizational readiness planning including communication strategies, onboarding workflows, support model transitions, and change management to ensure minimal employee disruption. • Build and lead a high-performing IT M&A team, defining clear roles, expectations, and performance standards while fostering a culture of accountability, urgency, and execution excellence. • Provide executive-level reporting on integration progress, risks, resource constraints, and business impact, enabling informed decision-making and risk ownership. • Operate effectively in high-ambiguity, fast-paced environments where multiple acquisitions may run in parallel and priorities must be dynamically balanced.