Ionis Pharmaceuticals, Inc.

• The Clinical Account Specialist (CAS) is a field-based role responsible for the launch of Ionis’s first wholly owned commercial product within their respective territory and will possess a deep understanding of the healthcare market and the Familial Chylomicronemia Syndrome (FCS) community, including the key customers and accounts treating cardiovascular and lipid related diseases. • The CAS will be responsible for driving performance and working with cross-functional partners and external customers to support Ionis goals and come together to help patients in need. • The CAS will understand the unique objectives and needs of each customer in their pursuit of improved patient outcomes, and will achieve this by building, maintaining, and leveraging networks and relationships in the local healthcare system to develop and execute effective business plans to meet customer and Ionis goals. • The CAS will serve as a cross-functional teammate: building trust and collaborating with a diverse team of people with deep functional and therapeutic area expertise operating with integrity and in compliance with Ionis Code of Ethics and Business Conduct continuing our efforts for the FCS community. • Educate HCPs and office staff to raise FCS disease state awareness, educate on diagnostic pathway, and instill an urgency to treat familial chylomicronemia syndrome (FCS). • Create positive prescribing experience through valuable added resourcing and hcp/patient support materials and programs. • Participate in conferences, congresses, and other scientific meetings to educate HCPs on FCS disease state and treatment. • Gather insights to profile accounts and provide feedback to field leadership and marketing to inform product sales & marketing strategy. • Understand local referral networks, including primary treaters, secondary treaters, and referral patterns for FCS patients. • Identify, validate, and document potential HCPs treating FCS patients to inform commercial strategy.

• Responsible for the launch of Ionis’s first wholly owned commercial product within their respective territory • Build, maintain, and leverage networks and relationships in the local healthcare system • Develop and execute effective business plans to meet customer and Ionis goals • Serve as a cross-functional teammate, building trust and collaborating with a diverse team • Educate HCPs and office staff to raise FCS disease state awareness • Create a positive prescribing experience through value-added resourcing • Participate in conferences and other scientific meetings to educate HCPs on FCS • Execute brand strategic plans by developing customer-focused territory strategic account plans • Adjust strategies to meet business goals in an assigned region

• The Clinical Account Specialist (CAS) is a field-based role responsible for the launch of Ionis’s first wholly owned commercial product within their respective territory • Understand the unique objectives and needs of each customer in their pursuit of improved patient outcomes • Achieve this by building, maintaining, and leveraging networks and relationships in the local healthcare system to develop and execute effective business plans to meet customer and Ionis goals • Serve as a cross-functional teammate: building trust and collaborating with a diverse team of people with deep functional and therapeutic area expertise • Educate HCPs and office staff to raise FCS disease state awareness • Create positive prescribing experience through value added resourcing and HCP/patient support materials and programs • Participate in conferences, congresses, and other scientific meetings to educate HCPs on FCS disease state and treatment • Gather insights to profile accounts and provide feedback to field leadership and marketing to inform product sales & marketing strategy • Understand local referral networks, including primary treaters, secondary treaters, and referral patterns for FCS patients • Identify, validate, and document potential HCPs treating FCS patients to inform commercial strategy • Execute the brand strategic plans by developing and executing customer focused territory strategic account plans to maximize business opportunities and customer satisfaction • Partner with cross-functional teammates to understand and address the unique needs of their customers.

• Building and managing long-term relationships with physicians, Centers of Excellence (COEs) and other customers for the accounts in their assigned territory • Providing access/reimbursement support and product/disease education to the accounts • Delivering key promotional messages to advocate on behalf of people suffering from Alexander disease (AxD) • Representing the organization in the AxD community educating external Healthcare Professionals (physicians, nurses, billing managers, pharmacists, office/hospital staff and other account stakeholders) about the approved indication and clinical information in relation to the AxD disease state • Supporting healthcare provider offices with access & reimbursement support in a compliant manner • Building, maintaining, and leveraging networks and relationships in the local healthcare system to develop and execute effective business plans to meet customer and Ionis goals • Collaborating effectively and compliantly with other Account Specialists and other field teams (e.g., Patient Education Managers, Field Medical Directors) in pursuit of customer/account success

Role Description This position reports to the Assistant Director, Compliance Operations, Systems & Process Lead. The Compliance Operations Manager or Senior Manager supports the day-to-day execution of Ionis’ Healthcare Compliance Operations activities, including: - HCP engagement operations - Transparency reporting - Compliance systems - Operational data quality - Reporting and dashboards - Business process execution This role serves as a key operational partner for core workflows, collaborating across various departments to support compliant, scalable, and efficient operations. The position also supports operational excellence through: - Systems support - Training assistance and coordination - Technology enablement - Continuous improvement This is a remote role for candidates in the U.S., with preference given to individuals located in or near the Boston, MA area to enable periodic on-site collaboration. Responsibilities - Provide daily Healthcare Compliance Operations support and triage for operational inquiries, including compliance mailbox management, request routing, follow-up tracking, and timely resolution. - Support the full HCP engagement lifecycle, including business needs assessments, due diligence, FMV tiering, contracting, and payment documentation. - Administer HCP engagement and other compliance systems, including user support, configuration coordination, testing, troubleshooting, and issue resolution. - Support transparency reporting operations, including data collection, processing, reconciliations, validation, remediation, and reporting readiness for timely and accurate submissions under U.S. federal, state, and ex-U.S. disclosure requirements. - Manage operational data quality initiatives and partner with stakeholders to resolve data issues, monitor trends, and strengthen process controls. - Develop and maintain SOPs, business rules, process maps, work instructions, FAQs, job aids, training materials, and related communications for HCP engagement and transparency reporting processes and systems; deliver end-user training and onboarding. - Coordinate user acceptance testing, system implementations, upgrades, enhancements, and change management activities for compliance-related technologies and workflows. - Track KPIs, operational metrics, dashboards, recurring reports, and trends; recommend corrective actions and process improvements. - Develop operational reports and presentation materials using HCP engagement and transparency data. - Identify automation and emerging digital tools, including AI-enabled workflow solutions, to reduce manual effort, improve user experience, and strengthen controls. - Support audit readiness, inspections, internal monitoring activities, and regulatory inquiries by maintaining accurate, complete, audit-ready documentation, system records, and evidence of key controls. - Support broader Compliance Operations priorities, cross-functional projects, and other day-to-day operational needs as required (e.g., training and communications, compliance ambassador program, etc.). Qualifications - Bachelor’s degree required. - For the Manager position, at least 2 years of related experience in pharmaceutical, biotechnology, medical device healthcare compliance operations with a Bachelor’s degree. - For the Senior Manager position, at least 5 years of related experience in pharmaceutical, biotechnology, medical device healthcare compliance operations with a Bachelor’s degree (or 3+ years with an advanced degree). - Direct experience with HCP engagement, transparency reporting, and compliance systems administration. - Strong understanding of HCP engagement lifecycle activities, including business needs assessments, FMV tiering, due diligence, contracting, payment documentation, and related process controls. - Experience working with data from multiple systems to identify trends, resolve issues, and generate operational insights. - Experience with aggregate spend and transparency reporting, including U.S. federal, state, and ex-U.S. disclosure requirements. - Knowledge of healthcare compliance requirements and industry guidance, including the Anti-Kickback Statute, FCPA, PhRMA Code, OIG guidance, and PDMA. - Experience implementing, administering, or supporting compliance technologies and digital workflow solutions including AI-enabled tools and other operational technologies. - Experience with process improvement, system implementation, reporting, or cross-functional initiatives. - Strong Excel skills, plus Power BI, Tableau, or similar dashboarding and visualization tools. - Ability to translate regulatory requirements into practical, system-enabled processes. - High level of integrity and ability to protect proprietary and confidential information. - Occasional domestic travel of up to 20%. What We Seek in a Candidate - Self-motivated with strong analytical, organizational, and communication skills and able to work independently and collaboratively in a team environment. - Ability to convey complex information clearly to diverse audiences. - Comfortable managing multiple priorities in a fast-paced, dynamic environment. - Agile and willing to take on new projects and additional responsibilities as needed. Compensation - The pay scale for this position is $72,800 to $129,967. - The pay scale for the Manager position is $72,800 to $106,562. - The pay scale for the Senior Manager position is $90,310 to $129,967. Benefits Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits Application Process Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition # IONIS004065. NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

• Develop and lead U.S. market access strategies aligned with brand and portfolio objectives across a 3+ year horizon. • Define value proposition and access roadmap from pre-launch through lifecycle management. • Shape and implement integrated evidence plans, in partnership with HEOR and Medical Affairs to support access and payer negotiations • Serve as the enterprise subject matter expert on access, payer dynamics, and policy trends across the landscape and within specialty and rare disease • Oversee development of AMCP dossiers, payer communication tools (including Pre-approval Information Exchange and Payer Value Proposition) and field access tools (including product coverage, prior authorization criteria and patient support options). • Guide economic modeling and budget impact analyses to support payer discussions • Collaborate and partner closely with Commercial to align access strategy with brand strategy. • Engage with Government Affairs on policy implications and advocacy priorities. • Represent the organization in external advisory boards and industry forums. • Monitor payer landscape, competitive dynamics, and regulatory changes to inform strategy. • Lead, coach, and develop high-performing Market Access professionals. • Select and retain agency partners, holding full budget authority for access strategies • Drive cross-functional alignment in matrixed environments.

• Support day-to-day U.S. import compliance activities in accordance with CBP and applicable PGA requirements • Review and approval of import documentation, HTS classifications, valuation, country of origin, and end-use documentation • Review, audit, and maintain import documentation, including commercial invoices, packing lists, customs entry records, and FDA-related import documentation • Coordinate and communicate with customs brokers, freight forwarders, carriers, and internal stakeholders to ensure timely customs clearance and delivery • Monitor international shipments and proactively resolve customs clearance or transportation issues • Assist with HTS classification and country-of-origin determinations by coordinating with internal stakeholders and external trade compliance resources as needed • Support import audit readiness and compliance reporting activities • Ensure compliance with FDA, USDA/APHIS, Fish & Wildlife Service, and other PGA import requirements • Track logistics and import compliance metrics, shipment status, transportation performance, and broker KPIs • Partner with Supply Chain, Procurement, Finance, Quality, Regulatory, and external logistics providers to improve operational efficiency • Support and lead process improvement initiatives related to trade compliance and logistics operations • Support commercial launch activities involving FTZ operations, FDA import coordination, and temperature-controlled international shipments.

Role Description The Supply Chain Operations and Logistics Specialists will play a critical role in the growth of Ionis and its transformation into a fully integrated biotechnology organization, by ensuring continued access to Ionis marketed products. This individual will be responsible for managing and assisting with the operations and logistics associated with the delivery of our U.S marketed products from our US 3PL partner to our authorized distributors. An ideal candidate will have extensive knowledge of key ERP systems, contract portals, payment portals such as COUPA, and the ability to network efficiently cross functionally. This position will report to the Executive Director, Global Commercial Trade lead and may be located at our corporate headquarters in Carlsbad California, or remote, with preference to the middle-United States region. Responsibilities - Assist with managing the movement of commercially released finished goods throughout the U.S distribution ecosystem; this would be in conjunction with our 3PL partner, contracted Specialty Pharmacies and Distributors. - Assume administrative responsibilities for the creation and maintenance of new business partners in the Ionis ERP Ecosystem (SAP S4/Hana) and the subsequent management of managing customer set ups with our 3PL partner. - Integrate into the Order to Cash (OTC) team; creating strong cross functional partnerships with internal Ionis functions within Accounting, Tax, Supply Chain, and IT. - Create strong collaboration work streams with key workstreams in Ionis’s Commercial Quality Affairs, Commercial, US Marketed Access, Patient Services/Commercial Trade and Distribution, Commercial Analytics, Finance, Accounting. - Assist as directed with the maintenance and oversight of the required US Pharmacy State License renewals and updates as required. - Collaborates closely with all Supply Chain, Demand Planning, and Global Logistics leads to ensure validated and compliant means are used to deliver and transport our finished goods to authorized distributors. - Expand relationship with U.S Commercial distribution to efficiently manage key provisions of executed Distribution and Purchase agreements; such as required notice/notice periods, Accounts Receivable reconciliation activities, Return Goods processes and other contractual obligations as required. - Be a trusted Supply Chain and Operations/Logistics specialist acting as the point person to the various field teams—providing necessary support to maximize their productivity in a compliant manner. - Assume key roles within the OTC Module as assigned (Shipping Specialist, Sales Manager, Sales Clerk, etc.) - Attend and represent Ionis as key industry and customer meetings. - Represent Supply Chain on key internal cross functional product/project teams providing oversight on key logistics capabilities. Qualifications - Preferred Bachelors’, Associate, or other relevant post-secondary degree or significant industry experience. - Bio/pharmaceutical experience of minimum of 5 years with previous experience working within a commercial ecosystem and developing strong cross functional partnerships. - Strong operational and administrative oversight with a keen eye on details such as performance against KPIs and SLAs, leveraging Ionis SAP capabilities to lead decision making, and managing the Purchase Order and Invoicing for assigned vendors. - General Knowledge of the U.S Distribution ecosystem. - Strong leadership skills and ability to partner effectively and collaborate across functions to gain alignment, hold external partners accountable, and improve business performance. - Demonstrated ability and proven history of assisting with assigned projects and initiatives to completion. - Highly organized and detail oriented, with strong project management and presentation and writing skills, proactive communications. Benefits - Ionis offers an excellent benefits package! - Highly competitive benefits. Company Description For more information about Ionis and to apply for this position; reference requisition # IONIS004036. The pay scale for this position is $21.44/hour to $30.55/hour. NO PHONE CALLS PLEASE. PRINCIPALS ONLY. Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

• Define and lead Ionis’ channel operations strategy across Specialty Pharmacies, Specialty Distributors, and other key distribution channel accounts in support of current brands, launches, and future portfolio growth. • Own the design, governance, and continuous improvement of the end-to-end distribution channel operating model, including forecasting, inventory management, allocation, reporting, partner management, and issue escalation with assigned accounts. • Serve as the senior Trade & Distribution lead for U.S Commercial Distribution operations in S&OP/IBP, launch readiness, and cross-functional business planning forums, ensuring channel considerations are incorporated into enterprise decisions. • Own short-, mid-, and long-range distribution channel demand forecasting and support product and account level forecasting through integration of channel data, launch assumptions, access dynamics, and commercial insights. • Establish distribution channel inventory strategies, targets, and guardrails, and lead recommendations on allocation decisions by balancing patient need, contractual commitments, service expectations, and commercial priorities. • Provide strategic oversight of distribution channel inventory, ordering patterns, service performance, and other operational KPIs, and lead cross-functional action plans to address emerging risks and performance gaps. • Develop and maintain executive-level reporting, dashboards, and business reviews that translate distribution channel performance, demand signals, and market developments into clear, actionable recommendations. • Build and sustain senior-level relationships with external distribution channel partners and key accounts, representing Ionis as a strategic and effective manufacturer partner. • Lead governance with distribution channel partners, including business reviews, performance management, service issue resolution, and expectations related to data, reporting, and operational execution. • Influence channel-related contracting strategy by providing operational, service-level, inventory, and reporting perspectives during contract discussions and renewals. • Partner closely with Supply Chain, I&A, Finance, FP&A, Brand, Market Access, Sales, Marketing, and Patient Services leaders to align distribution channel strategy with commercial objectives and business plans. • Define policies, standards, and decision frameworks for channel operations that improve consistency, control, scalability, and readiness across products and channels. • Apply deep understanding of the operational implications associated with pharmacy benefit and medical benefit products, including specialty pharmacy, buy-and-bill, site-of-care, and patient journey considerations. • Lead the ongoing development of Distribution Channel Operations as a capability, including organizational structure, process design, talent strategy, and succession planning. • Lead through direct and matrix influence to strengthen accountability, execution, and collaboration across internal stakeholders and external partners. • Ensure distribution channel operations decisions and actions support compliance expectations, operational rigor, and Ionis’ commitment to patient access and business continuity. • Manage work and decisions with a longer-term view, recognizing the impact of channel strategy on launches, product performance, patient experience, and enterprise results.

• Provides safety science and pharmacovigilance support to assigned molecules within Ionis portfolio • Ensures high quality of aggregate report production • Develops risk management documents in collaboration with Drug Safety Physicians • Coordinates safety review meetings • Conducts signal detection activities and evaluates emerging safety data • Authors key sections of periodic safety reports and other PV documents