• Support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making • Conduct PBPK and/or QSP modeling directly and/or work with external partners to integrate preclinical, in vitro, biomarker, and early clinical data into predictions • Help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights • Contribute to scientific review and provide input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners • Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy • Draft, develop and review program‑level quantitative analysis plans • Communicate modeling results clearly to project teams, supporting decision-making and governance discussions • Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs) with increasing independence • Support departmental objectives, mentor junior staff as appropriate

• Ensure that the Market Access Early Pipeline team forecasting model assumptions are kept current • Catalogue market trends to ensure completeness and effective communication across the organization • Work with Directors to support ongoing market analyses • Draft and communicate updates to the US Market Access Outlook • Gather and maintain a catalogue of above-brand initiatives • Present findings from analyses at various levels across the organization • Participate in development of relevant market research • Organize the annual business planning process for the team

• Actively manage and optimize the value of the relationship between Sumitomo Pharma and assigned corporate partners • Work with SMPA leadership in all functional areas, as well as assigned corporate partners to set the direction and scope for the partnership annually • Oversee the governance of the partnership agreement, including participating in governance committees, working group meetings and facilitating decision making • Serve as a central point of contact to streamline communication and meetings between functional areas within SMPA and across assigned corporate partners • Develop and cultivate strong relationships directly and through Sumitomo leadership with key contacts at assigned corporate partners to create cross-company alignment and resolve disputes • Monitor adherence to agreement obligations and deliverables and take appropriate action to ensure execution • Liaise with legal, finance and functions to ensure that key contract milestones, financial transactions, and progress reports are handled appropriately and provide information/updates/reports as needed • Participate in partner contract negotiations as appropriate and provide input into partnership execution terms of the contract

• Define and execute the global technology strategy aligned with business objectives and regulatory requirements. • Establish governance frameworks for technology services, ensuring compliance with data privacy/residency laws, GxP and other industry standards. • Partner with senior business and technology leaders to drive digital transformation initiatives and operational efficiency. • Lead global support services, including Microsoft 365 administration, end user computing, enterprise collaboration platforms, and communication tools. • Oversee global helpdesk operations, ensuring high-quality, timely support for end-users across all regions. • Manage IT Service Management (ITSM) processes and platforms, driving continuous improvement and automation. • Ensure reliable conference room technology and site support services for global offices and facilities. • Drive the deployment of ServiceNow to support enhanced ITSM process and procedures.