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Discovering drugs for endocrine diseases and endocrine-related tumors. #acromegaly #crinetics #CarcinoidSyndrome
Associate Director, Pharmacometrics
Location
California
Posted
120 days ago
Salary
$154K - $192K / year
Seniority
Senior
Job Description
Associate Director, Pharmacometrics
Crinetics Pharmaceuticals
• Support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making • Conduct PBPK and/or QSP modeling directly and/or work with external partners to integrate preclinical, in vitro, biomarker, and early clinical data into predictions • Help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights • Contribute to scientific review and provide input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners • Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy • Draft, develop and review program‑level quantitative analysis plans • Communicate modeling results clearly to project teams, supporting decision-making and governance discussions • Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs) with increasing independence • Support departmental objectives, mentor junior staff as appropriate
Job Requirements
- Pharm.D/Ph.D. or MS in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a strong understanding of clinical pharmacology principles
- Significant industry experience (Associate Director: MS and 8 years of experience; PhD/PharmD with 5 years of experience) in clinical pharmacology data analysis and interpretation
- Experience with PBPK modeling, QSP modeling, and/or integration of AI/ML into clinical pharmacology decision-making
- Experience interpreting and overseeing population PK and exposure–response analyses
- Familiarity with all stages of clinical drug development, including experience in the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects
- Experience working in a cross functional team and matrix environment
- Strong written, presentation and verbal communication skills
- Ability to influence business leaders at all levels
- Critical thinker with strong problem-solving skills
- Demonstrated ability to apply quantitative methods to complex problems with growing independence
Benefits
- discretionary annual target bonus
- stock options
- ESPP
- 401k match
- top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance
- 20 days of PTO
- 10 paid holidays
- winter company shutdown
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