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Crinetics Pharmaceuticals logo
Crinetics Pharmaceuticals

Discovering drugs for endocrine diseases and endocrine-related tumors. #acromegaly #crinetics #CarcinoidSyndrome

Associate Director, Pharmacometrics

DirectorDirectorOtherRemoteSeniorTeam 201-500Since 2015H1B No SponsorCompany SiteLinkedIn

Location

California

Posted

120 days ago

Salary

$154K - $192K / year

Seniority

Senior

Postgraduate Degree8 yrs expEnglish

Job Description

Associate Director, Pharmacometrics

Crinetics Pharmaceuticals

• Support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making • Conduct PBPK and/or QSP modeling directly and/or work with external partners to integrate preclinical, in vitro, biomarker, and early clinical data into predictions • Help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights • Contribute to scientific review and provide input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners • Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy • Draft, develop and review program‑level quantitative analysis plans • Communicate modeling results clearly to project teams, supporting decision-making and governance discussions • Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs) with increasing independence • Support departmental objectives, mentor junior staff as appropriate

Job Requirements

  • Pharm.D/Ph.D. or MS in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a strong understanding of clinical pharmacology principles
  • Significant industry experience (Associate Director: MS and 8 years of experience; PhD/PharmD with 5 years of experience) in clinical pharmacology data analysis and interpretation
  • Experience with PBPK modeling, QSP modeling, and/or integration of AI/ML into clinical pharmacology decision-making
  • Experience interpreting and overseeing population PK and exposure–response analyses
  • Familiarity with all stages of clinical drug development, including experience in the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects
  • Experience working in a cross functional team and matrix environment
  • Strong written, presentation and verbal communication skills
  • Ability to influence business leaders at all levels
  • Critical thinker with strong problem-solving skills
  • Demonstrated ability to apply quantitative methods to complex problems with growing independence

Benefits

  • discretionary annual target bonus
  • stock options
  • ESPP
  • 401k match
  • top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance
  • 20 days of PTO
  • 10 paid holidays
  • winter company shutdown

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