Crinetics Pharmaceuticals

• Support the development and execution of Crinetics' endocrinology portfolio as part of a multidisciplinary development team • Contribute to the concise clinical development plan (CCDP) • Support the design and conduct of clinical trials across assigned therapeutic areas • Provide medical and scientific input to publications • Support Medical Affairs • Help represent Crinetics to academic, regulatory, and patient organizations • Partner with the cross-functional team to shape a concise Clinical Development Plan (CCDP) for the indication of interest, building consensus toward Executive Team approval and maintaining the plan over time • Lead the design, planning and implementation of clinical trials consistent with this CCDP • Provide scientific and clinical direction for the development of clinical protocols (and, in early stages, clinical trial outlines [CTOs] and synopses), amendments, and related documents (e.g., informed consent) • Work with Medical Writing to ensure content accuracy and medical integrity • Provide medical monitoring for clinical studies in collaboration with CRO medical monitors • Ensure that clinical trials are conducted according to GCP and all applicable regulatory requirements • Provide clinical and scientific input to HEOR-led Patient Reported Outcome research across the studies • Provide medical and scientific oversight needed to support enrollment feasibility and protocol-driven eligibility • Participate in ongoing and formal data analyses and review for CSR completion and planned/actual filing activities • Contribute to the development of clinical sections of regulatory documents such as Investigators' Brochures, briefing books, safety updates, IND/BLA submission documents, responses to Health Authorities questions • Lead trial-related advisory boards, investigator meetings, protocol training meetings • Collaborate with Medical Affairs and Commercial members to develop effective working relationships with key investigators, key opinion leaders and patient advocates to optimize scientific quality/innovation of clinical study design, execution, reporting and publication • Provide medical/clinical expertise to publications planning and drafting • Provide oversight of clinical programs across planning, execution, and completion of clinical trials, ensuring compliance with all applicable regulations and guidance, ICH/GCP, and Crinetics SOPs, in partnership with Clinical Operations • Attend conferences and remain current with relevant therapeutic area information • Serve as the external clinical "face" of Crinetics in interactions with development partners, and leading clinical discussions at advisory boards, as needed.

• Clinical leader of one or more endocrinology programs, being integral to developing the clinical strategy and plans • Member of global project team(s) and development sub team(s) • Contribute as the Clinical Research expert to the conception and regular modifications of the Target Product Profile (TPP) • Lead the development of the Clinical Development Plan (CDP) for each indication being pursued, using the TPP as guidance • Define the scientific rationale and design captured in the Clinical Study Outline for each study in the CDP • Lead the discussions and oversee the writing of the study synopsis, study protocol and its amendments • Review or oversee the review of the data input in the EDC for events of interest or needing further investigation • Provide senior-level medical monitoring and safety oversight in cooperation with pharmacovigilance • Collaborate with other departments in all topics related to the conduct and analysis of clinical study results • Use the findings and other analyses to contribute to trial-related advisory boards, lead investigator meetings, protocol training meetings • Support advisory boards, key opinion leader engagement, and external scientific collaborations • Contribute to the development of relevant sections of regulatory documents such as amendments to protocols and responses to Health Authorities questions

• Own PRO/COA strategy development and execution for Crinetics' pipeline programs • Own the full COA development lifecycle for pipeline programs • Serve as the in-house PRO/COA subject-matter expert and consultant for late-stage assets • Set and maintain PRO/COA methodological and regulatory standards across the function • Partner with Clinical Development and Biometrics on COA endpoint selection • Lead FDA and EMA interactions on outcome measures for pipeline programs • Direct translation and cultural adaptation for global trials and submissions • Lead patient preference and treatment-burden studies for pipeline programs • Contribute PRO/COA evidence to integrated evidence plans • Manage external COA vendors and academic partners while building in-house capability • Provide leadership, career management, coaching, and mentoring as the COE scales

• Own the acromegaly HEOR/RWE evidence strategy across the product lifecycle • Serve as the primary HEOR/RWE point of contact for acromegaly franchise stakeholders • Translate franchise evidence questions into prioritized, executable plans • Contribute the acromegaly HEOR/RWE narrative to integrated evidence plans, value dossiers, AMCP and global value dossiers, and HTA submissions • Partner with Market Access on payer value propositions, budget impact, and access strategy for acromegaly • Align acromegaly evidence generation to launch, access, and lifecycle milestones • Represent the acromegaly evidence story to KOLs, payers, HTA bodies, and at scientific congresses • Support the Senior Director in maintaining a coherent franchise value story • Monitor the competitive and treatment landscape in acromegaly and translate implications into evidence strategy • Ensure compliance with corporate policies and US healthcare laws governing evidence generation and communication

• Design and execute real-world studies for the atumelnant program (CAH adult, CAH pediatric, Cushing's disease) • Own and steward Crinetics' CAH real-world data assets—ensuring continuity, documentation, and reusability of cohorts, code lists, and analytic datasets • Lead analyses using large healthcare databases (insurance claims, EHRs, registries, linked datasets) and primary RWD collection (chart reviews, surveys) • Develop study protocols, statistical analysis plans, and feasibility assessments; perform database selection and confirm that patient counts and study variables exist in available data • Ensure continuity of atumelnant RWE through launch, maintaining institutional knowledge of CAH RWE assets and program evidence needs • Translate evidence priorities set by HEOR/RWE TA Leads, under direction from the RWE COE Head, into executable analyses tied to launch and lifecycle milestones • Apply rigorous epidemiologic and outcomes-research methods, including appropriate causal-inference and bias-control techniques for observational data • Lead and mentor external analysts supporting in-house RWE analytics projects—scoping the work, directing analyses, and reviewing deliverables for methodological quality • Oversee RWE study vendors when analyses are outsourced—managing CRO/data-vendor execution against scope, timelines, budget, and deliverable quality • Contribute RWE outputs to integrated evidence plans, value dossiers, and HTA submissions in partnership with TA Leads and cross-functional stakeholders • Collaborate with the RWE Center of Excellence, Modeling & Simulation, Biometrics, and external data and analytics partners on study design and execution • Prepare manuscripts, abstracts, and congress presentations communicating RWE findings • Ensure compliance with corporate policies and US healthcare laws and regulations governing real-world data use • Other duties as assigned.

• Support global and regional clinical trial operations (CTO) and Clinical Monitoring management in the conduct and oversight of clinical site management and monitoring activities performed by Crinetics or an outsourcing partner. • Conduct Clinical Monitoring visits for assigned Crinetics studies. • Lead monitoring activities on assigned studies, including review of protocols, CRFs, completion guidelines, and study manuals. • Author or review Clinical Monitoring Plan in collaboration with CTO and ensure CRA compliance to current plan. • Manage CRA monitoring visit schedule for each assigned study ensuring visit frequency and scheduled time on site aligns with risk-based indicators and site metrics. • Review and finalize visit reports for regional CRAs managed by Crinetics according to study timelines. • Maintain and act on metrics related to CRA performance or site status. • Support development and manage Clinical Monitoring budget requirements for assigned studies.

• Set the strategic direction for clinical science and operational execution across the endocrine clinical development portfolio • Drive alignment across cross-functional teams to anticipate and resolve risks before they impact program timelines or quality • Build and develop a high-performing team, including Clinical Scientists, consultants, and Clinical Research Project Coordinator • Own clinical data oversight and ensure clean data, analysis, and interpretation • Drive the scientific execution of through contribution of key regulatory documents • Oversee strategic partnerships with CROs • Identify, escalate, and drive resolution of program and portfolio risks in a timely and structured manner • Drive continuous improvement and transformation initiatives across the Clinical Science team

• Support the development and execution of market access strategies • Lead all operational activities for Market Access contracts • Collaborate with Director, Pricing and Contracting to submit accurate pricing and contracting information • Stay up to date with federal and state laws and regulations related to Market Access • Manage gross-to-net discount rate forecasting models and processes • Analyze data from channel partners and third-party data/service vendors • Maintain, execute, and update Standard Operating Procedures (SOPs) for pricing, contracting, and government reporting

• Develop comprehensive market research plans • Lead the execution of various market research projects • Lead cross-functional efforts with Marketing, Market Access, Sales, Medical Affairs, and Corporate Affairs teams • Create global market research frameworks • Work with partners to understand key business needs across therapeutic targets • Align organization on research initiatives' scope, timing, and objectives • Ensure market research conclusions are objective and supported by data • Develop and deliver compelling presentations • Identify qualified suppliers for market research studies and manage engagement processes • Ensure compliance with financial and ethical guidelines

• Manage GLP/GCLP bioanalytical CROs and CLIA clinical testing labs • Develop appropriate biomarker analysis strategy • Apply fit-for-purpose biomarker validation approach • Review and finalize method validations protocols, stability studies, and bioanalytical reports • Participate in the periodic audit of bioanalytical CROs • Work with cross-functional colleagues in various programs • Manage and negotiate scopes of work, budget, and payment schedules • Review invoices against vendor contracts • Contribute to bioanalytical reports and regulatory documents • Lead preparation of bioanalytical sections in regulatory submissions • Lead bioanalytical function on written responses to health authority bioanalytical queries