Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. Praxis is looking for a talented and experienced leader for a key program expected to advance best in class or first-in-class products for areas of high unmet medical need. The ideal candidate is a strong, multi-faceted leader who thrives in environments with high ambiguity, limited hierarchy, and real ownership of outcomes as the program continues its rapid trajectory of transformational patient impact. This results-oriented individual will be characterized by a strong strategic mind, a collaborative nature and intellectual curiosity, and will credibly and enthusiastically work across the spectrum of research, development, technical operations, and commercialization. They will lead a cross-functional program team and be responsible and accountable for Praxis’ program strategy, driving decision-making, and ensuring efficient and high-quality execution. Praxis is committed to a high-energy, fast-pace and flat organization where individuals work as peers with singular objective to bring drugs to patients. This role is not about coordinating consensus; it is about building alignment, deeply understanding all aspects of the development activities for the product and driving the program forward. The Program Lead must embrace and exemplify this way of working. Primary Responsibilities - Internally and externally communicate a shared and bold vision for the program. - Lead, manage, and maintain the Program Team, partnering with functional leads to ensure team effectiveness and operational excellence while retaining clear accountability for program-level decisions. - Lead the creation and execution of the program strategy and integrated development plan(s). - In collaboration with the Program Team, define and deliver against program OKRs. - Provide strategic oversight for program budgets and resourcing, actively shaping—not just tracking—investment decisions. - Architect scenarios to inform decision making and program planning; ensure that the right skills and capabilities exist on the team to effectively execute on the program plan. - Be a role model for Praxons: inspire ambitious goals, give and receive direct feedback, and build trust through transparency and follow-through. - “Roll up sleeves and get hands dirty” for the benefit of the team and the program; wear multiple hats, step into gaps, and hold yourself to the same standards as the team. - Serve as the primary integration point with corporate processes without creating unnecessary bureaucracy. Qualifications - Demonstrated drug development experience with a strong track record of cross-functional leadership; experience across the full development lifecycle strongly preferred. - Strong holistic understanding of the drug development process across functions. - Ability to translate strategy into execution, driving decisions that create value under real-world constraints. - Clear, compelling communicator across internal and external stakeholders. What Sets Successful Praxons Apart - Comfort operating with limited hierarchy and high personal accountability. - Learning agility and intellectual curiosity; ability to rapidly develop deep understanding of new therapeutic areas. - Willingness to challenge assumptions, surface risks early, and engage in healthy debate in service of the best outcome. - Demonstrated ability to balance urgency with rigor in fast-moving environments. Requirements - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. - You'll need comfort with screen work, basic hand coordination, and focus. - Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Compensation & Benefits - World-class benefits package including 99% of the premium paid for medical, dental and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions, long-term stock incentives, and ESPP. - Discretionary quarterly bonus, flexible wellness benefit, generous PTO, paid holidays, and company-wide shutdowns. - Annualized base salary compensation in the range of $285,000 — $325,000 USD. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. - Core Values: Trust, Ownership, Curiosity, and Results. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com. Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.

• Own end-to-end GTM programs, translating strategy into coordinated execution plans across Sales, Marketing, Product, Enablement, RevOps, and Customer teams • Drive cross-functional alignment and accountability, serving as the central owner for GTM planning, priorities, timelines, and launch readiness • Orchestrate complex, multi-stream initiatives (product launches, enablement rollouts, pricing/packaging changes, campaigns) • Establish and lead GTM operating cadences, including weekly execution tracking, monthly business reviews, and quarterly/annual planning cycles • Partner with functional leaders to manage resources and capacity • Build scalable GTM processes, templates, playbooks, and documentation to improve speed, consistency, and repeatability • Define, track, and report GTM success metrics in partnership with RevOps • Proactively manage risks and lead post-program retrospectives to drive continuous improvement

• Work with the team to develop project plans and execute those plans to timelines and budget • Adapt plans to changing customer needs and/or changes in analysis approach as new findings are revealed • Serve as a primary contact point for the customer, ensuring timely response and communication • Ensure appropriate and timely decision-making • Support data collection from customers and collaborators, and ensuring compliance to data onboarding protocols • Ensure compliance with operating procedures and standards for data extraction processes, visualization and data governance • Document and organize requirements, success criteria, milestones and deliverables for projects

• Act as the primary point of contact for the program and aligns Sales, Presales, Engagement Management, Services Management and the customer for the program, including across countries. • Drive customer to realize value from Digital Enterprise Solutions and guide the customer through required value realization plan changes. • Together with Engagement Management, identify and create additional opportunities within and beyond the ongoing program. • Plan the program according to the value realization plan and initiate the required projects to achieve the program vision.