• Reporting to the CEO and serving on the Executive Leadership Team, lead Engineering, Test, IT Operations, and Deployment teams. • Drive Medrio’s AI-first engineering strategy, deliver software that customers trust, and build a high-performance team. • Own architecture, security posture, delivery standards, and the engineering organization’s culture, talent, and operational health. • Drive adoption of AI-assisted development across the engineering organization. • Own cloud-native architecture decisions across a multi-product SaaS platform. • Optimize the development lifecycle by eliminating bottlenecks and automating workflows. • Own Medrio’s security posture and ensure on-time renewal of compliance. • Interact with customers, strategic partners, and the Board to shape opportunities and roadmaps. • Lead a mixed org of engineering directors, senior managers, and senior ICs simultaneously.

• Support project teams with research, data analysis, and documentation related to energy and sustainability initiatives • Assist with gathering, organizing, and summarizing technical, market, or policy information • Help prepare reports, presentations, and written deliverables for internal teams and external clients • Participate in team meetings and collaborate with staff on active projects • Assist with project coordination tasks such as tracking action items, timelines, and deliverables • Perform ad-hoc analysis or administrative support as needed to advance project goals

Role Description Lattice’s Engineering team is continuously working to better both our product and our craft. We use a modern, cutting-edge tech stack and love experimenting with new technologies. We strive for maintainable, robust, and performant code. We’re highly collaborative and continuously iterative, and work closely with designers and product managers. We prioritize not only great technical architecture, but also an amazing product experience. You’ll be responsible for building software to help companies build cultures in which their employees thrive. - You’ll partner with other engineers to build products across a modern tech stack. Our current stack includes Typescript, React, Relay Modern, GraphQL, Node.js, PostgreSQL, and AWS. - You’ll help us build and test experiments, many of which require tight cross-functional collaboration with product managers and designers, as well as cross-team collaboration between engineers. - You will identify and evangelize improvements to improve our team output. - You will help maintain high-quality technical documentation based on feedback from relevant stakeholders. - You will focus on improving our user experience and find creative ways to reduce user pain points. Qualifications - You are passionate about software development and have 2+ years of professional experience writing and maintaining production-level applications. - You have production-level experience in TypeScript, React, GraphQL, Node.js, and are passionate about learning and using any new technologies that are required at the job. - Prior experience within data-driven teams is a plus, not a requirement. - You are efficient in SQL and know how to model data and write performant queries in a relational database like PostgreSQL. - You love to take on challenges that require coordination with multiple teams and multiple engineers. - You are always striving towards understanding the codebase inside and out. - You have the ability to understand the nuances of product requirements and translate them into a product experience. - You take care to write code that your colleagues will also own, comprehend, and maintain. - You are clear and concise in explaining your thought process and in enumerating the tradeoffs made in your work. Requirements - This role is open to candidates located in British Columbia or Ontario, Canada. At this time, we are only able to hire employees residing in these provinces. Benefits - The estimated annual cash salary for this role is CAD $90,000- CAD $120,000. - This position is also eligible for incentive stock options, subject to the terms of Lattice’s applicable plans. - Medical insurance - Dental insurance - Life, AD&D, and Disability Insurance - Natural Disaster Support Program - Wellness Apps - Paid Parental Leave - Paid Time off inclusive of holidays and sick time - Working Remotely Stipend - One time WFH Office Set-Up Stipend - Retirement Plan - Financial Planning - Learning & Development Budget

What if cancer drugs could find the tumor – and go nowhere else? What if this meant you could get potent therapy directly to the tumor, sparing healthy cells? That’s the future we’re building at Shasqi, using Nobel Prize-winning science to unleash powerful therapies only where they’re needed. We’re a small, driven team encompassing broad backgrounds and experiences, united by a single mission: make cancer treatments more effective with minimal side effects. Our Operating Principles - We move fast because speed matters to cancer patients. - We aim to communicate openly and challenge ideas regardless of job title. - We are bold, take risks, and push boundaries being led by science. - We operate with humble confidence: meaning we can balance our sense of capability and conviction without ego, while being humble to seek advice and learn from our mistakes. If that fires you up, come build the future of cancer therapy with us! You’re the right fit for Shasqi if you.. - Are mission driven and eager to do the best work of your career, developing novel therapies that will transform cancer treatment. - Can balance scientific rigor with a fast-paced environment. - Are comfortable with ambiguity and making decisions in the face of uncertainty. - Operate with a strong sense of agency and invite feedback and advice. - Can challenge convention and think of creative solutions that meet the needs of the company. - Are a doer, hands-on, resourceful, and do not hesitate to step up. - Willing to collaborate, debate, commit to decisions clearly, and revisit when evidence demands it. Position Summary We are seeking a highly motivated and experienced Executive Director of Protein Engineering and Chemistry to build and lead our CAPAC (Click Activated Protodrugs Against Cancer) pre-targeting therapeutic engineering platform and team. This is a critical leadership role responsible for driving molecular design, optimization, and biologic CMC of our pipeline from early discovery through IND-enabling studies and into the clinic. This position requires deep expertise in protein engineering, strong knowledge of chemistry and biologic CMC, and demonstrated success advancing therapeutics into clinical development. Required qualifications: Education and Experience - Ph.D. in Biochemistry, Protein Engineering, Chemistry, Chemical Biology, or related discipline. - Minimum 12+ years of relevant industry experience working in therapeutic discovery and development of either: - Biologics and small molecules, or - Small molecule-biologic conjugates. - Minimum 5+ years of leadership experience managing scientific teams. - Demonstrated track record of advancing biologic-based therapies into clinical development. - Direct experience supporting biologic CMC development, IND submissions, and clinical-stage programs is required. Technical Expertise - Small format biologic discovery and protein engineering. - Experience with chemical biology or medicinal chemistry. - Targeted therapies. - Structure-based design and protein optimization. - Biophysical and biochemical characterization methods. - Developability assessment and manufacturability considerations. - Protein chemistry, conjugation, and modification strategies. Experience with one or more of the following is highly desirable: - Antibody-drug conjugates (ADCs). - Bioorthogonal click chemistry. - Protein conjugation and linker chemistry. Leadership and Professional Skills - Proven ability to build and lead high-performing teams. - Strong strategic thinking and decision-making skills. - Excellent communication and presentation skills. - Demonstrated ability to work cross-functionally with a highly collaborative organization. - Ability to manage multiple programs in a fast-paced environment. Responsibilities including but not limited to the following: Scientific Leadership and Hands-On Contribution - Lead the protein engineering and chemistry teams toward design, discovery, engineering, and optimization of therapeutic candidates, including biologic binders, chemical payloads, and technologies to enable pre-targeting with click chemistry. - Personally contribute to molecular design strategy, candidate selection, and developability assessment for both biologic binders and chemical payloads. - Guide strategy for protein characterization, including biophysical, biochemical, and functional evaluation. - Establish and implement strategies for lead optimization, focusing on affinity, specificity, stability, manufacturability, and developability. CMC Strategy and Development Integration - Ensure candidates are designed with manufacturability, scalability, and regulatory requirements in mind. - Lead internal team working with CDMOs and CROs to advance: - Cell line development - Process development - Analytical development - GMP Manufacturing - Regulatory requirements - Contribute to IND-enabling activities and regulatory documentation. Strategic and Organizational Leadership - Build, lead, manage, and mentor a high-performing protein engineering and chemistry team. - Lead team toward defining departmental goals and strategy aligned with research and company goals. - Lead team to manage internal and external collaborations, including CROs and academic partners. - Serve as a scientific leader and key contributor to portfolio strategy and candidate selection decisions. Innovation and External Engagement - Maintain awareness of emerging technologies in protein engineering, novel payloads, and pre-targeting. - Identify and implement new tools and platforms to enhance engineering capabilities. - Represent the company at scientific conferences and external meetings as appropriate. How We Work: - We are a remote-first company, with occasional travel for in-person team meetings or scientific conference attendance. - Core collaboration window: 9:00am–3:00pm Pacific Time. You are expected to be available during this time for meetings and real-time collaboration. - Async + sync balance: Outside of core hours, we work asynchronously, but timely communication and follow-through are expected. - Meetings: You should be comfortable joining video calls, sharing availability on calendar and actively participating during core hours. - You should be comfortable working across common tools including Zoom, Google Workspace, Microsoft 365, Slack, and similar platforms. Benefits & Eligibility Compensation at Shasqi - Competitive base salary as part of a broader total rewards package. - Equity: Included as port of total compensations. - Comprehensive benefits: medical, dental, vision, 401(k) match, short- and long-term disability. - Flexible PTO and a WFH stipend to support remote work. - Ongoing growth opportunities, professional development, and mentorship. Salary Range - The anticipated base salary range for this role is $250-$300K USD. - Final compensation will depend on location, experience, skills, education, and internal equity. - Our ranges are intentionally broad to reflect market conditions and the specialized nature of our work. Eligibility - U.S.-based employees only. - Must be authorized to work in the United States. - We are not currently sponsoring visas. About Shasqi Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027. You can learn more about our company at www.shasqi.com Please Note: At this time, Shasqi is not partnering with external recruiting agencies. We kindly ask that agencies refrain from contacting us regarding this role. Shasqi is an Equal Opportunity Employer. We are committed to creating a diverse and inclusive workplace and do not discriminate on the basis of any protected characteristic under applicable law.