• Own end-to-end performance of assigned customer portfolios, including gross and net retention, expansion, churn risk, and revenue predictability • Define portfolio segmentation strategies based on ARR, growth potential, risk profile, industry vertical, and strategic importance • Establish portfolio-level targets, success metrics, and performance benchmarks aligned to corporate objectives • Drive executive-level accountability for portfolio outcomes through structured governance and reporting cadences • Provide strategic leadership over renewal execution in partnership with Sales Renewals and Account Management leaders • Lead proactive churn-risk identification and mitigation strategies across the portfolio • Identify expansion and whitespace opportunities at a portfolio level and influence sales prioritization accordingly • Guide pricing, packaging, and commercial strategy discussions for large or complex portfolios • Serve as the senior point of coordination across Sales, Customer Success, Support, Services, Product, and Finance for portfolio execution • Establish consistent engagement models, escalation paths, and deal strategy across customer segments • Chair regular portfolio reviews with cross-functional leaders to drive alignment, transparency, and action • Influence resource allocation decisions to maximize portfolio performance and efficiency • Own portfolio-level forecasting for renewals, churn risk, and expansion pipeline • Partner with Revenue Operations to ensure data integrity, reporting accuracy, and KPI visibility • Deliver executive-ready reporting and insights on portfolio health, trends, and risks • Use advanced analytics to inform strategic decisions, investment priorities, and GTM adjustments • Define and evolve portfolio management frameworks, playbooks, and best practices • Identify systemic risks, inefficiencies, or coverage gaps and drive corrective action • Partner with Product and Marketing to ensure portfolio insights inform roadmap prioritization and go-to-market strategy • Champion operational excellence and scalability across customer-facing teams • Lead, mentor, and develop Portfolio Managers or matrixed team members as applicable • Establish performance expectations, development plans, and succession readiness within the portfolio management function • Act as a thought leader within MRI on portfolio strategy, customer economics, and revenue optimization

• Support Crinetics’ translational and early clinical programs by applying mechanistic and quantitative modeling to guide decision-making • Conduct PBPK and/or QSP modeling directly and/or work with external partners to integrate preclinical, in vitro, biomarker, and early clinical data into predictions • Help identify quantitative needs at key development milestones and ensure modeling results are translated into clear, actionable insights • Contribute to scientific review and provide input on population PK, PK/PD, and exposure–response analyses performed internally or through CRO partners • Inform efficient study designs using mechanistic and empirical modeling to guide dose selection, sampling, and biomarker strategy • Draft, develop and review program‑level quantitative analysis plans • Communicate modeling results clearly to project teams, supporting decision-making and governance discussions • Contribute modeling content to regulatory submissions (e.g., INDs, NDAs, IBs) with increasing independence • Support departmental objectives, mentor junior staff as appropriate

• Ensure that the Market Access Early Pipeline team forecasting model assumptions are kept current • Catalogue market trends to ensure completeness and effective communication across the organization • Work with Directors to support ongoing market analyses • Draft and communicate updates to the US Market Access Outlook • Gather and maintain a catalogue of above-brand initiatives • Present findings from analyses at various levels across the organization • Participate in development of relevant market research • Organize the annual business planning process for the team

• Actively manage and optimize the value of the relationship between Sumitomo Pharma and assigned corporate partners • Work with SMPA leadership in all functional areas, as well as assigned corporate partners to set the direction and scope for the partnership annually • Oversee the governance of the partnership agreement, including participating in governance committees, working group meetings and facilitating decision making • Serve as a central point of contact to streamline communication and meetings between functional areas within SMPA and across assigned corporate partners • Develop and cultivate strong relationships directly and through Sumitomo leadership with key contacts at assigned corporate partners to create cross-company alignment and resolve disputes • Monitor adherence to agreement obligations and deliverables and take appropriate action to ensure execution • Liaise with legal, finance and functions to ensure that key contract milestones, financial transactions, and progress reports are handled appropriately and provide information/updates/reports as needed • Participate in partner contract negotiations as appropriate and provide input into partnership execution terms of the contract