Faeth Therapeutics

Role Description We are looking for a highly self-motivated Vice President, Program Management to serve as the operational backbone of our pipeline. Reporting to the CEO, this person will be the connective tissue across every function that touches our programs — finance, legal, regulatory, clinical development, clinical operations, CMC, nonclinical, and beyond — ensuring that nothing falls through the cracks, that leadership always has a clear and current view of timelines and risks, and that the decisions that move our programs forward are surfaced early and teed up well. Roughly 80% of the focus will be our lead program, PIKTOR, with the expectation that this person scales into a broader program and portfolio remit as the pipeline grows. - Own the integrated program plan. - Build and maintain a single, authoritative view of timelines, milestones, dependencies, and the critical path across all functions for PIKTOR and, over time, the broader portfolio. - Keep leadership ahead of the program, not behind it. - Serve as the source of truth for where each program stands and what is about to change. - Run the decision-making machinery. - Surface strategy early and prepare the materials to support it. - Be genuinely AI-native. - Manage program budget and resources. - Quarterback business development execution. - Lead through influence, not authority. - Support board and investor readiness. - Set the program-management standard. Qualifications - ~10+ years in biotech/pharma drug development, with meaningful time in a program or portfolio management capacity. - Direct experience taking a program through late-stage development and to approval and/or commercialization. - Demonstrated ability to lead complex, cross-functional programs and influence senior executives without direct authority. - Deep, hands-on command of the integrated drug-development process across functions. - Genuinely AI-native: already using AI tools extensively in your daily work. - Exceptional communication, facilitation, and executive-presentation skills. - Experience supporting business development / corporate development diligence, alliance management, or partnership execution is a strong plus. - Thrives in a small, fast-moving, ambiguous environment. - Experience preparing board- or investor-facing materials is a plus. Requirements - Oncology strongly preferred; familiarity with small-molecule and/or PI3K/AKT/mTOR pathway programs is a plus. - A proven balance of strategic leadership and hands-on execution, with a bias toward execution and closure. Benefits - Competitive salary and equity in a well-funded, clinical-stage biotech. - 100% remote work and flexible schedule. - Health, dental, and vision for you and your dependents. - Flexible time off. - Generous parental leave. - Traditional and Roth 401k. - Mission oriented, remote first culture.

Role Description The HR Lead will own all aspects of Human Resources, People Operations, Compensation, Benefits, Compliance, and Employee Relations. This role is ideal for a proactive HR professional who thrives in a fast-paced biotech environment and enjoys building scalable processes while serving as a trusted advisor to employees and leadership. Reports to: Chief of Staff Location: Remote (U.S.) Responsibilities: - Lead all onboarding and offboarding processes to ensure a seamless employee experience. - Serve as the primary point of contact for employee questions and support. - Manage compensation planning, benchmarking, and market analyses. - Own equity administration and equity planning processes. - Manage annual compensation review cycles and salary adjustments. - Administer employee benefits programs and manage vendor relationships. - Manage and oversee the company’s 401(k) program, including establishment and administration of a 401(k) committee. - Serve as system administrator for HRIS platforms and related people systems. - Manage payroll preparation and coordinate with payroll providers. - Maintain accurate employee records and HR data and ensure compliance with federal, state, and local employment regulations. - Oversee leave administration, including parental, medical, and other protected leaves. - Lead and administer the annual performance review process. - Lead learning and development programs that support employee growth and leadership development. - Lead company-wide communications and employee engagement activities. - Organize and facilitate All Hands meetings, team lunches, happy hours, and company events. Qualifications - Bachelor's degree in Human Resources, Business Administration, or related field. - 5+ years of progressive HR experience in biotechnology, pharmaceutical, or life sciences organizations. - Strong knowledge of employment law, HR compliance, benefits administration, and employee relations. - Experience managing compensation programs, benchmarking, and equity administration. - Experience administering HRIS systems and payroll processes. - Demonstrated ability to manage sensitive and confidential information with discretion. - Excellent interpersonal, communication, and relationship-building skills. - Strong project management and organizational abilities. - Ability to operate effectively in a high-growth, entrepreneurial environment. Requirements - Experience supporting venture-backed or high-growth biotech companies. - Experience with Radford compensation surveys and benchmarking. - Experience working with Boards of Directors and Compensation Committees. - SHRM-CP, SHRM-SCP, PHR, or SPHR certification. - Experience managing immigration processes and employment-related legal matters. Benefits - Competitive salary and equity in a well-funded, clinical-stage biotech. - 100% remote work and flexible schedule. - Health, dental, and vision for you and your dependents. - Flexible time off. - Generous parental leave. - Traditional and Roth 401k. - Mission oriented, remote first culture.

Role Description The Senior Clinical Scientist is a key scientific leader within the Clinical Development team, responsible for the design, execution, and interpretation of clinical trials across Faeth’s oncology programs. This individual will drive cross-functional collaboration, provide strategic input into clinical development plans, and ensure delivery of high-quality data to support regulatory and scientific objectives. The role requires deep scientific expertise, operational insight, and the ability to influence both internal and external stakeholders. Reports to: CMO Location: Remote (U.S.) Responsibilities: - Lead the design and development of clinical protocols, amendments, and core study documents (e.g., IBs, DSURs, SAPs, CRFs) - Lead ongoing review, monitoring, querying and interpretation of clinical data (safety, efficacy, PK/PD, and biomarker endpoints) - Provide leadership across one or more clinical programs, including lifecycle planning - Oversee execution of Phase 1–3 clinical trials in partnership with Clinical Operations, ensuring quality, timelines, and clinical review of data - Serve as a primary clinical point of contact for CROs, vendors, and investigative sites - Identify and proactively mitigate study risks; drive issue resolution across functions - Drive data quality, including oversight of data cleaning, query resolution, and database lock - Ensure alignment between clinical strategy and translational/biomarker plans - Lead contributions to regulatory submissions (INDs, CTAs, briefing documents, responses to health authorities) - Drive preparation of clinical study reports (CSRs), abstracts, manuscripts, and conference presentations - Represent Clinical Development in internal governance meetings and external interactions Qualifications - 5–8+ years of oncology clinical development experience - Demonstrated experience leading components of interventional clinical trials (Phase 1–3) - Strong expertise in clinical trial design, execution, and data interpretation - Deep understanding of oncology drug development; experience in metabolism, nutrition, or biomarker-driven approaches is a plus - Working knowledge of GCP, ICH guidelines, and global regulatory requirements - Proven ability to lead cross-functional initiatives and influence without authority - Excellent communication, analytical, and problem-solving skills - Comfortable operating in a fast-paced, evolving biotech environment Requirements - Advanced degree (PhD, PharmD, MS, or equivalent) in life sciences, clinical research, or related field Benefits - Competitive salary and equity in a well-funded, clinical-stage biotech - 100% remote work and flexible schedule - Health, dental, and vision for you and your dependents - Flexible time off - Generous parental leave - Traditional and Roth 401k - Mission oriented, remote first culture

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning. We are seeking a Director / Senior Director, FP&A to build and lead the financial planning and analysis function during a pivotal stage of growth and integration. This role will serve as a strategic partner to executive leadership, owning forecasting, budgeting, management reporting and long-range planning while helping guide key business decisions. This is a highly visible, hands-on leadership role for someone who thrives in a fast-paced biotech environment and enjoys translating complex data into actionable insights. Reports to: SVP, Finance Location: Remote (U.S.) Responsibilities: - Lead annual budgeting, quarterly forecasting, and long-range planning processes - Develop and maintain integrated financial models to support strategic decision-making - Drive scenario planning, including cash runway and capital allocation analysis - Partner closely with leaders to manage budgets and track spend - Provide actionable insights on clinical trial costs, program prioritization, and resource allocation - Support leadership with data-driven recommendations across the business - Prepare and deliver monthly and quarterly reporting packages for cost center owners, executive leadership, and the Board - Develop clear, concise presentations that highlight key trends, risks, and opportunities - Support fundraising efforts, including investor materials and financial analysis - Partner on M&A, business development, and strategic transactions as needed - Evaluate pipeline investments and portfolio prioritization - Build and scale FP&A processes, tools, and infrastructure - Improve forecasting accuracy and reporting efficiency - Collaborate with Accounting to ensure alignment between actuals and forecasts and support accrual process - Partner closely with the Legal team to review vendor agreements, support contract negotiations with financial analysis, and ensure purchasing processes align with budget controls and company policies - Review and approve purchase orders (POs), ensuring proper system coding an that expenditures align with approved budgets and company spending policies Requirements: - 10+ years of experience in FP&A, investment banking, consulting, or related fields - Prior experience in biotech, life sciences, or clinical-stage companies strongly preferred - Experience supporting executive leadership and Board-level reporting - Experience with fundraising, M&A, or strategic finance initiatives is a strong plus - Advanced financial modeling and forecasting capabilities - Strong understanding of: - Clinical trial cost structures and R&D spend - Cash flow forecasting and runway analysis - Expertise in Excel and experience with financial planning tools - Strategic thinker with strong business acumen - Hands-on and comfortable operating independently - Excellent communication skills with the ability to influence senior stakeholders - Ability to translate complex financial data into clear, actionable insights Compensation Range: $250,000 - $315,000 (actual compensation may vary based on experience, qualifications and location) Working at Faeth Benefits: - Competitive salary and equity in a well-funded, clinical-stage biotech - 100% remote work and flexible schedule - Health, dental, and vision for you and your dependents - Flexible time off - Generous parental leave - Traditional and Roth 401k - Mission oriented, remote first culture We are an equal opportunity employer, and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. All offers of employment are contingent upon satisfactory completion of a background check and verification of eligibility to work in the United States.

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning. The VP of Investor Relations will be the primary interface between the company and the investment community. This is a senior cross-functional role: you will work directly and frequently with the CEO, Chief Scientific Officer, Chief Medical Officer, and CFO to shape investor messaging, translate science into investment narrative, and ensure the company is consistently well-positioned with institutional investors and sell-side analysts. The ideal candidate brings institutional credibility, an ability to make complex oncology science legible to both specialist and generalist investors, and the organizational discipline to run a high-quality IR program at a lean, fast-moving company. You will own the IR function end-to-end — from investor targeting and conference scheduling to corporate narrative development and capital markets communications. Reports to: CFO Location: Remote (U.S.) Responsibilities: Investor Engagement & Outreach - Build, manage, and continuously optimize a targeted investor outreach program — identifying high-fit institutional investors (long-only, crossover, and healthcare-focused hedge funds) and systematically tracking existing shareholders. - Manage all logistics for investor conferences, roadshows, non-deal roadshows, and one-on-one meetings — ensuring the leadership team is well-prepared, efficiently scheduled, and in front of the right audiences at the right moments. - Develop and maintain relationships with sell-side analysts and buy-side investors; serve as the day-to-day point of contact for inbound investor inquiries. - Proactively sequence the IR calendar around clinical milestones, data readouts, and corporate events so that investor communications are timely, coordinated, and impactful. Narrative Development & Messaging - Partner closely with the CEO, CSO, CMO, and CFO to develop and continuously refine the company's investor narrative — including corporate presentation materials, FAQs, earnings scripts, the annual report, and key message frameworks. - Build and own the investment thesis for PIKTOR, including articulating the multi-node inhibition differentiation story, the competitive landscape, the CELC/gedatolisib read-through, and the company's near-term catalyst path across endometrial, breast, ovarian, and lung cancer indications. - Translate complex PI3K/AKT/mTOR biology and clinical data into clear, accurate, and compelling narratives appropriate for both specialist and generalist investors. - Ensure accuracy and consistency of all investor-facing materials in coordination with legal, regulatory, and compliance teams. Communications & Disclosure - Lead preparation for quarterly earnings calls, including press releases, scripts, Q&A preparation, and post-call investor follow-up. - Manage the company's investor relations website and ensure timely, accurate disclosure of material information in compliance with Reg FD and SEC requirements. - Monitor and synthesize investor perception, consensus estimates, sell-side coverage, trading activity, and competitive intelligence; provide actionable reporting to senior leadership. - Coordinate with any retained external IR advisors and manage deliverables against the company's needs. Cross-Functional Partnership - Serve as a trusted thought partner to the CFO on capital markets strategy — including timing, messaging, and investor targeting for any future financings or transactions. - Collaborate with clinical, regulatory, medical affairs, and legal teams to ensure investor communications around data readouts and regulatory milestones are accurate, appropriately framed, and strategically timed. - Support the board of directors with investor perception updates, competitive positioning, and market intelligence as needed. Requirements: - 8+ years of experience in investor relations, equity research, institutional sales, or a closely related field, with meaningful time spent in the biopharmaceutical or biotechnology sector. - Direct experience owning or managing an IR function at a public biotech or biopharma company, including ownership of conference and roadshow logistics. - Demonstrated ability to communicate complex science to both specialist and generalist investors in written and verbal formats. - Strong existing relationships with healthcare-focused institutional investors and/or sell-side analysts. - Deep understanding of Reg FD, SEC disclosure requirements, and public company IR best practices. - Exceptional organizational and project management skills; comfortable managing multiple priorities in a lean, remote-first environment. - Strong written and asynchronous communication skills appropriate for a distributed team. Preferred - Background in life science investor relations, with experience supporting clinical-stage companies through data readouts, trial initiations, or regulatory milestones. - Prior experience as a biotech buy-side analyst, sell-side analyst, or in equity capital markets at a life sciences-focused bank. - Familiarity with targeted oncology programs, or the competitive landscape in breast or endometrial cancer. - Experience supporting equity financing transactions, including PIPEs, follow-on offerings, or reverse mergers. - Undergraduate or graduate degree in life sciences, finance, or a related field. Compensation Range: $275,000 - $350,000 (actual compensation may vary based on experience, qualifications and location) Working at Faeth Benefits: - Competitive salary and equity in a well-funded, clinical-stage biotech - 100% remote work and flexible schedule - Health, dental, and vision for you and your dependents - Flexible time off - Generous parental leave - Traditional and Roth 401k - Mission oriented, remote first culture We are an equal opportunity employer, and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. All offers of employment are contingent upon satisfactory completion of a background check and verification of eligibility to work in the United States.

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning. The Senior Medical Director will provide strategic and operational medical leadership across the clinical development lifecycle. This individual will serve as the medical monitor and cross-functional medical lead for assigned programs, ensuring scientific rigor, patient safety, and high-quality data generation while working collaboratively to execute efficiently and successfully. This is a lead role in a small, fast-paced biotech where there will be significant opportunities for creativity, problem-solving and contributing to a range of cross-functional activities. Reports to: Chief Medical Officer Location: Remote (U.S.) Responsibilities Medical Monitoring - Serve as the primary Medical Monitor for assigned clinical trials. - Provide ongoing medical oversight to ensure patient safety and protocol compliance. - Review eligibility queries, protocol deviations, and safety data in real time. - Collaborate with Safety/Pharmacovigilance on SAE review, signal detection, and benefit-risk assessments. - Support investigator communications and training related to medical and safety matters. Data Review & Quality Oversight - Lead ongoing clinical data review to ensure integrity, completeness, and scientific validity. - Partner with Clinical Operations and Data Management to ensure high data quality standards. - Identify data trends, inconsistencies, and potential safety or efficacy signals. - Contribute to statistical analysis planning and interpretation of study results. - Ensure readiness for database lock and regulatory submissions. Cross-Functional Clinical Development Leadership - Provide strategic guidance across functions to optimize trial design, recruitment, and execution. - Contribute to translational and biomarker strategies - Collaborate cross-functionally on briefing documents, INDs, NDAs/BLAs, and agency interactions. - Lead medical communications including abstracts, manuscripts, and congress presentations. Qualifications - M.D. degree or PA/NP/PhD - 2+ years as a clinical scientist or medical director in the biotech or pharmaceutical industry. - Prior experience serving as a Medical Monitor for interventional clinical trials. - Experience in clinical data review and ensuring data quality. - Experience leading cross-functional clinical development teams. - Experience with regulatory authority interactions is preferred. - Strong communication, ownership and decision-making skills. - Common sense and flexibility Compensation Range: $325,000 - $400,000 (actual compensation may vary based on experience, qualifications and location) Working at Faeth Benefits: - Competitive salary and equity in a well-funded, clinical-stage biotech - 100% remote work and flexible schedule - Health, dental, and vision for you and your dependents - Flexible time off - Generous parental leave - Traditional and Roth 401k - Mission oriented, remote first culture We are an equal opportunity employer, and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. All offers of employment are contingent upon satisfactory completion of a background check and verification of eligibility to work in the United States.

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning. We are seeking an experienced Senior Vice President, Technical Operations to lead all CMC activities across our portfolio. This role will provide the vision, leadership, strategy and management skills to oversee, lead and further expand the CMC development and manufacturing of the company’s proprietary programs through preclinical, clinical and commercial stages. This individual will collaborate with other senior leaders in the organization to ensure CMC execution is tightly aligned with research, clinical, regulatory, commercial and corporate objectives. The Senior Vice President, Technical Operations is responsible for translating the corporate strategy into global pharmaceutical development and manufacturing strategies (functional areas include chemical development, product development, analytical development, quality control, manufacturing, clinical supply and CMC program management). The SVP will provide technical leadership, strategic direction, risk assessment, and oversight for successful long-range planning and execution across all supporting functions. This individual will manage Contract Development and Manufacturing Organizations (CDMOs) including implementation of strategy, selection, onboarding and relationship management. As a key member of the leadership team, you will interface regularly with executive leadership and the Board, translating complex technical, operational and regulatory topics into clear, concise, and actionable insights that support rapid and informed decision-making. The ideal candidate will be a seasoned pharma/biotech executive with an outstanding record of accomplishment in development and manufacturing of pharmaceuticals with experience in the global submissions and commercialization. This is an exciting opportunity to shape CMC strategy end-to-end and build a world-class CMC organization in a growing, science-driven organization. Reports to: Chief Scientific Officer Location: Remote (U.S.) Responsibilities: CMC Strategy & Leadership - Own and drive the end-to-end CMC strategy across development, clinical supply, scale-up, and commercialization for a portfolio of small-molecule programs - Operate with a high degree of independence and accountability, proactively identifying risks, tradeoffs, and opportunities across the CMC landscape - Anticipate CMC challenges well in advance and lead structured problem-solving efforts, balancing speed, quality, cost, and regulatory expectations - Build scalable CMC roadmaps aligned with clinical milestones, financing events, and long-term corporate strategy - Define CMC organizational requirements and ensure corporate objectives are delivered through internal and external resources. - Select, manage, and hold CROs, CDMOs, and consultants accountable for performance, quality, and timelines - Develop and manage CMC budget - Support business development and evaluation of in licensing opportunities. Development, Manufacturing & Supply - Ensure reliable preclinical, clinical and future commercial supply of safe, high-quality drug products and lead development of manufacturing strategies to ensure capacity for the product portfolio. - Provide senior technical oversight of process development, manufacturing, analytical development, and control strategies - Work collaboratively with Quality and Regulatory to ensure robust, phase-appropriate CMC execution that supports Phase 1 through Phase 3 and commercial readiness - Oversee clinical supply planning, forecasting, and distribution in collaboration with external manufacturers and logistics partners Regulatory & Compliance - Oversee global CMC regulatory strategy, ensuring alignment with FDA, EMA, and other regulatory authorities - Oversee preparation, review, and approval of all CMC-related sections of INDs, NDAs, amendments, and variations - Oversee CMC related regulatory interactions, inspections, and agency meetings - Ensure ongoing compliance with GMP and evolving regulatory expectations Executive & Board Communication - Communicate CMC strategy, risks, and decision points clearly to the executive team and Board of Directors - Synthesize complex technical, regulatory, and operational topics into concise, executive-level summaries and visuals - Provide leadership with clear options, implications, and recommendations to support strategic and financial decisions - Act as a trusted advisor on CMC-related matters impacting valuation, timelines, and investor discussions Requirements: - PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or a related discipline (strongly preferred); Bachelor’s or Master’s with significant relevant experience considered - 15+ years of progressive CMC experience in pharmaceutical development and manufacturing, with demonstrated senior-level ownership of CMC programs with significant small molecule experience - Strong record of accomplishments and successful leadership experience leading and executing CMC development and commercial manufacturing, preferably with experience in an emerging pharmaceutical company that has scaled from early-stage product development to commercial operations. - Demonstrated ability to build a successful technical and operations organizations. - Deep understanding of GMP, regulatory requirements, and small-molecule drug development - Demonstrated ability to work independently, think strategically, and solve problems proactively in fast-moving environments - Strong conflict-resolution and problem-solving skills working with diverse organizations and cultures - Exceptional communication skills, with the ability to distill complex issues into clear, decision-ready messages for senior leadership and boards Compensation Range: $315,000 - $390,000 (actual compensation may vary based on experience, qualifications and location) Working at Faeth Benefits: - Competitive salary and equity in a well-funded, clinical-stage biotech - 100% remote work and flexible schedule - Health, dental, and vision for you and your dependents - Flexible time off - Generous parental leave - Traditional and Roth 401k - Mission oriented, remote first culture We are an equal opportunity employer, and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. All offers of employment are contingent upon satisfactory completion of a background check and verification of eligibility to work in the United States.

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning. We are seeking a Director / Senior Director, FP&A to build and lead the financial planning and analysis function during a pivotal stage of growth and integration. This role will serve as a strategic partner to executive leadership, owning forecasting, budgeting, management reporting and long-range planning while helping guide key business decisions. This is a highly visible, hands-on leadership role for someone who thrives in a fast-paced biotech environment and enjoys translating complex data into actionable insights. Reports to: SVP, Finance Location: Remote (U.S.) Responsibilities: - Lead annual budgeting, quarterly forecasting, and long-range planning processes - Develop and maintain integrated financial models to support strategic decision-making - Drive scenario planning, including cash runway and capital allocation analysis - Partner closely with leaders to manage budgets and track spend - Provide actionable insights on clinical trial costs, program prioritization, and resource allocation - Support leadership with data-driven recommendations across the business - Prepare and deliver monthly and quarterly reporting packages for cost center owners, executive leadership, and the Board - Develop clear, concise presentations that highlight key trends, risks, and opportunities - Support fundraising efforts, including investor materials and financial analysis - Partner on M&A, business development, and strategic transactions as needed - Evaluate pipeline investments and portfolio prioritization - Build and scale FP&A processes, tools, and infrastructure - Improve forecasting accuracy and reporting efficiency - Collaborate with Accounting to ensure alignment between actuals and forecasts and support accrual process - Partner closely with the Legal team to review vendor agreements, support contract negotiations with financial analysis, and ensure purchasing processes align with budget controls and company policies - Review and approve purchase orders (POs), ensuring proper system coding an that expenditures align with approved budgets and company spending policies Requirements: - 10+ years of experience in FP&A, investment banking, consulting, or related fields - Prior experience in biotech, life sciences, or clinical-stage companies strongly preferred - Experience supporting executive leadership and Board-level reporting - Experience with fundraising, M&A, or strategic finance initiatives is a strong plus - Advanced financial modeling and forecasting capabilities - Strong understanding of: - Clinical trial cost structures and R&D spend - Cash flow forecasting and runway analysis - Expertise in Excel and experience with financial planning tools - Strategic thinker with strong business acumen - Hands-on and comfortable operating independently - Excellent communication skills with the ability to influence senior stakeholders - Ability to translate complex financial data into clear, actionable insights Compensation Range: $250,000 - $315,000 (actual compensation may vary based on experience, qualifications and location) Working at Faeth Benefits: - Competitive salary and equity in a well-funded, clinical-stage biotech - 100% remote work and flexible schedule - Health, dental, and vision for you and your dependents - Flexible time off - Generous parental leave - Traditional and Roth 401k - Mission oriented, remote first culture We are an equal opportunity employer, and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. All offers of employment are contingent upon satisfactory completion of a background check and verification of eligibility to work in the United States.

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning. We're looking for a Staff Software Engineer to help shape the architecture and technical direction of our core platform. The product is already in motion, and we need someone who can step in, assess what exists, strengthen the foundation, and drive it forward with the quality, security, and performance it demands. We’re a small, fully remote engineering team (under 20) moving fast. You’ll play a central role in technical decision-making and work alongside experienced engineers to raise the bar across the system. Security and performance aren’t afterthoughts here; they’re core design constraints, and we need someone who treats them that way. This is an early-stage company. That means you’ll wear many hats. Some weeks you’ll be deep in architecture decisions; other weeks you’ll be debugging a deployment pipeline, reviewing a junior engineer’s PR, or jumping into a customer escalation. If you need tightly defined boundaries, this isn’t the right fit. If you thrive when the scope is wide and the impact is direct, keep reading. Reports to: Senior Engineering Manager Location: Remote (India) Responsibilities: - Own and evolve the architecture. Assess the current system, identify what needs to change, and drive the platform’s technical direction - data layer, API surface, frontend application, and deployment infrastructure. - Build across the stack. Write production code daily in React, Node/NestJS, and PostgreSQL on AWS. You’re not directing from the sidelines; you’re in the codebase. - Design for multi-tenancy at scale. Solve hard problems around tenant isolation, data partitioning, role-based access, and per-tenant configuration. - Make security non-negotiable. Bake security into everything - authentication, authorization, data encryption, input validation, API hardening, and compliance readiness. Security isn’t a phase; it’s a design constraint. - Obsess over performance. Profile, benchmark, and optimize across the stack - from database query plans and caching strategies to frontend rendering and bundle size. Build monitoring and alerting so you know when things degrade before users do. - Build for scale. Architect with growth in mind - horizontal scaling, load management, connection pooling, async processing, and infrastructure that doesn’t buckle under increasing tenants and traffic. - Set the engineering standard. Establish patterns, conventions, and quality bars that a growing team will build on top of. Write code that teaches. - Mentor and uplevel. Help mid-level and senior engineers grow. Conduct design reviews, pair on hard problems, and raise the technical bar through collaboration, not gatekeeping. - Champion modern tooling. Actively evaluate and adopt tools that make the team faster - including agentic coding tools like Claude Code. Experiment, form opinions based on evidence, and influence the team through merit, not mandates. - Stay sharp. Keep a pulse on emerging trends in software engineering, AI-assisted development, infrastructure, and developer tooling. Bring what’s relevant back to the team. - Wear whatever hat is needed. Jump into DevOps, debugging, customer support escalations, hiring interviews, or anything else the team needs. We value people who see a gap and fill it. Requirements: - 8+ years of professional software engineering experience with a meaningful portion spent in full-stack roles building web applications at scale. - Experience in high-ambiguity environments. You’ve operated in environments with high ambiguity, limited resources, and shifting priorities, and shipped anyway. - Deep proficiency in modern web stacks. You have deep expertise in at least one modern web stack and are comfortable working across technologies like React, TypeScript, Node.js/NestJS, PostgreSQL, and AWS. You don’t just use these tools - you understand them. - Proven ability to own system architecture. You’ve made foundational technical decisions, evolved existing systems, and lived with the consequences. You know what good (and bad) looks like because you’ve built it and fixed it. - Security-first mindset. You understand OWASP Top 10, know how to prevent common vulnerabilities, and can design authentication and authorization systems that hold up under scrutiny. You think about threat modeling, not just happy paths. - Performance engineering instincts. You can identify bottlenecks, design efficient data access patterns, and build systems that stay responsive under load. You know when to optimize and when it’s premature. - Strong shipping discipline. You balance thoughtful design with pragmatic delivery. You know when to invest in abstraction and when to ship the simple thing. - Enthusiasm for agentic coding and AI-assisted development. You’re already using tools like Claude Code, Copilot, or similar in your workflow and have informed opinions about where they accelerate and where they fall short. - Bias for ownership and action. You default to action. When something is broken or unclear, you step in and fix it without being asked and take responsibility for the outcome. Preferred Requirements: - Experience in healthcare, biotech, or life sciences - particularly with data platforms supporting clinical or research workflows. - Experience with early-stage or growth-stage companies - building quality infrastructure under constraints, limited resources, shifting priorities, and fast release cycles. - Experience designing developer-facing APIs or platform primitives consumed by other engineering teams. - Background in event-driven architectures, CQRS, or domain-driven design. - Familiarity with infrastructure-as-code (Terraform, CDK, or Pulumi) and CI/CD pipeline design. - Experience with penetration testing, security audits, or SOC 2 / ISO 27001 compliance processes. - Track record of evaluating and introducing new tools or frameworks to engineering teams based on measured outcomes. - Contributions to open source or public technical writing that demonstrate how you think.

Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning. We are looking for a Senior Accountant to join our growing finance team and play a key role in supporting day-to-day accounting operations and building scalable processes. This is a hands-on role with strong exposure to leadership, ideal for someone who thrives in a fast-paced biotech environment and enjoys both execution and process improvement. You’ll work closely with the Controller and broader finance team to ensure accurate financial reporting while helping to establish best-in-class accounting practices. Reports to: SVP, Finance Location: Remote (U.S.) Responsibilities: - Support and execute monthly, quarterly, and annual close processes - Prepare journal entries, account reconciliations, and supporting schedules - Maintain the general ledger and ensure accuracy across accounts - Assist in preparation of GAAP-compliant financial statements - Support internal reporting packages for leadership - Help ensure completeness and accuracy of financial data - Support accounting for: - Prepaids, accruals, and fixed assets - Clinical trial accruals and R&D expenses - Take full ownership of the accounts payable cycle – from processing to compliance and reconciliation - Assist with implementation and documentation of accounting policies and procedures - Support external audits and coordinate with auditors - Assist in maintaining internal controls and documentation - Contribute to building SOX-ready processes as the company scales - Identify opportunities to improve efficiency and accuracy in accounting workflows - Support implementation or optimization of accounting systems and tools - Help document and standardize processes across the team Requirements: - 3–6+ years of accounting experience - Combination of public accounting (Big 4 or similar) and/or industry experience preferred - Experience in biotech, life sciences, or high-growth startup environments is a plus - Strong understanding of U.S. GAAP fundamentals - Experience with month-end close and financial reporting - Familiarity with: - Accrual accounting - Financial systems (e.g., NetSuite or similar ERP) - Excel (comfortable working with large datasets) - Detail-oriented with strong organizational skills - Proactive and eager to learn in a fast-paced environment - Strong communication skills and ability to partner cross-functionally - Comfortable working in a hands-on, evolving startup environment Compensation Range: $70,000 - $120,000 (actual compensation may vary based on experience, qualifications and location) Working at Faeth Benefits: - Competitive salary and equity in a well-funded, clinical-stage biotech - 100% remote work and flexible schedule - Health, dental, and vision for you and your dependents - Flexible time off - Generous parental leave - Traditional and Roth 401k - Mission oriented, remote first culture We are an equal opportunity employer, and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. All offers of employment are contingent upon satisfactory completion of a background check and verification of eligibility to work in the United States.