Role Description Join us to build: we’re seeking entrepreneurially-minded scientists with deep technical expertise, who are eager to solve one of the most durable and consequential challenges in medicine through venture building. This role offers a unique opportunity to work at the forefront of CNS drug delivery, leading a company that makes it fundamentally easier, safer and more broadly applicable to get therapeutics into the brain. The role is full-time, remote initially until venture incorporation and spin-out (circa end of 2027), location TBD. The Opportunity - CNS diseases represent one of the largest and most persistent unmet needs in medicine. - Over 1 billion people worldwide live with a neurological condition. - Current disease-modifying treatments remain elusive for the vast majority. - The failure rate in CNS drug development is among the highest of any therapeutic area. - The inability to reliably deliver drugs across the blood-brain barrier (BBB) is a central reason for this failure. - Fewer than 2% of small molecules cross the BBB in meaningful quantities. - Almost no large-format biologics reach the brain parenchyma without specialised delivery mechanisms. - Emergence of receptor-mediated transcytosis (RMT) as a BBB delivery strategy represents a genuine step forward. - Challenges with RMT include haematotoxicity, receptor saturation, inefficient endosomal sorting, and receptor downregulation. - There is a compelling scientific and commercial opportunity to redesign BBB drug delivery from first principles. Working in Partnership with Medicines Discovery Catapult This role sits within a formal partnership between Deep Science Ventures (DSV) and Medicines Discovery Catapult (MDC). Driven by a shared conviction in the urgent need to unlock CNS drug delivery, DSV and MDC have partnered to scope and create a new venture at the intersection of protein engineering, cell biology, and drug development. The Role You will join DSV’s venture creation programme as a Founder-in-Residence and work closely with the DSV and MDC teams to spin out the new company. During the programme you will refine, improve and complement existing scoping work on: - The technical thesis for approaches that dramatically improve the efficiency, safety, and modality breadth of drug delivery across the blood-brain barrier. - IP strategy, differentiation, competition. - Market, value capture, techno-economics (value proposition). - Regulatory strategy & positioning. - Fundraising strategy & pitching. - Optimising company strategy for the most rapid and de-risked path to Series A. Preparation for Investment Committee (IC) will involve fulfilling our investment criteria, recruiting advisory and co-founding team members, and parallel fundraising for additional expansion funds. Assuming success at IC, you will receive pre-seed investment and spin out the company end of 2027. You and your co-founders will own a significant stake in the business and continue receiving support post-spinout. Qualifications - Deep expertise in at least two of the following four areas: - Protein Engineering - Biologics Drug Development - Cell Biology & Neurobiology - Medicinal Chemistry Requirements - Track record of translating scientific concepts from discovery through to in vivo proof-of-concept or IND. - Experience managing CRO/CDMO or Pharma programmes and building regulator- or investor-ready data packages. - Highly motivated by unsolved challenges in CNS drug delivery. - Impact driven, take initiative, and can think from a first principles perspective. - Clear entrepreneurial spirit and mindset, demonstrated through impactful innovation. - Collaborative nature, with the ability to work effectively in cross-functional teams. Preferred - Nice to Have - CNS preclinical or clinical drug development experience. - Single-cell transcriptomic data analysis. - Target & biomarker identification. - Deep understanding of IP - FTO and patentability. - Track record of publications and/or thought leadership in CNS delivery or related fields. - Previous biotech founder or C-suite leadership experience. - Previous fundraising experience (VC, dilutive or non-dilutive). - Experience building and leading successful scientific or cross-functional teams. - Network across CNS pharma, biotech, or relevant academic institutions. Benefits - Initial £250k (~$330k / €290k) investment governed by our Investment Committee. - Minimum guaranteed income of £4,166 per month (fixed), paid to each Founder as a consultancy fee until the company is launched. - Continuous support post spin-out, including fundraising, commercial partnerships, recruitment, and team-building. - Access to a unique resource of other Founders currently at DSV across sectors.

__**Key Responsibilities:**__ **Leading RRAG**RRAG operates as a high‑stakes, low‑volume intelligence environment. Analysts are practitioners, not content producers. The Team Leader sets the bar for rigor, sourcing, and analytic voice. - **Analytical authority:** Uphold rigor, sourcing discipline, and analytic voice across all RRAG products. - **Lean, expert teams:** Build and direct a small bench of contract analysts; serve as connective tissue across analysts, advisors, SMEs, and firm leadership. - **Intellectual ownership:** Set RRAG’s agenda and translate world events into concrete business risk and opportunity. **Research Agenda & Product Line** - Set editorial and analytical direction across advisories, sector briefings, alerts, and subscription deliverables. - Own the publication calendar and quality of every RRAG product. - Maintain consistency of voice, sourcing, and analytical standards. **Published Analysis & Authorship** - Publish sharp, well‑sourced analysis on geopolitical, economic, regulatory, and cross‑domain risk. - Produce decision‑grade work for executive and board audiences. - Write with authority and stand behind published judgment. **Team Building & Leadership** - Recruit, mentor, and manage contract analysts and future domain specialists. - Run weekly editorial planning and product reviews. - Build analytic tradecraft, workflows, and review discipline that scale. **OSINT & Analytic Tradecraft** - Direct primary and open‑source intelligence research across all twelve Nexus domains. - Apply structured analytic techniques to evaluate likelihood, impact, and intersection effects. - Maintain sourcing discipline and analytic traceability. **AI‑Enabled Research Workflows** - Build and refine AI‑assisted research and drafting workflows that increase throughput without compromising rigor. - Govern AI use under strict review standards. **Public Representation** - Anchor the *Risk Apogee* podcast, RRAG webinar series, and RRAG’s LinkedIn presence. - Represent RRAG’s analysis to executive and board‑level audiences.

• Build and refine the overseas payment risk control framework, covering core modules such as merchant onboarding (KYB/KYC), transaction monitoring, fraud detection, chargeback management, and anti-money laundering (AML). • Design differentiated risk control strategies and tiered handling solutions based on country, industry, and transaction characteristics; manage and optimize rule engines, risk scoring, and black/white lists. • Monitor key metrics such as chargeback rates and fraud rates, lead investigations into high-risk merchants and abnormal transactions, and provide disposition recommendations (e.g., transaction limits, delayed settlement, account suspension, etc.). • Collaborate with product and technical teams to drive the functional planning and implementation of risk control systems (rule engines, monitoring alerts, case management). • Stay abreast of the latest anti-fraud and sanctions compliance requirements from international card schemes (Visa/Mastercard) and regulatory bodies to ensure ongoing business compliance. • Periodically produce risk analysis reports, and document typical cases and standardized handling procedures.

Role Description The Team Leader, RRAG is a Senior research and analysis seat for a commercially minded analyst who reads the global landscape with rigor, writes with authority, and builds and runs a team. The Team Leader sets RRAG’s intellectual agenda, owns a published product line, and develops the bench of analysts behind it. This is a generalist leadership role by design — sitting at the intersection of business analysis, applied research, and geopolitical insight. The Team Leader translates complex world events into decision‑grade intelligence for executives and boards. As RRAG grows, the Team Leader will help recruit specialists, including a dedicated cyber analyst, to deepen the bench. Key Responsibilities - Leading RRAG: - Uphold rigor, sourcing discipline, and analytic voice across all RRAG products. - Build and direct a small bench of contract analysts; serve as connective tissue across analysts, advisors, SMEs, and firm leadership. - Set RRAG’s agenda and translate world events into concrete business risk and opportunity. - Research Agenda & Product Line: - Set editorial and analytical direction across advisories, sector briefings, alerts, and subscription deliverables. - Own the publication calendar and quality of every RRAG product. - Maintain consistency of voice, sourcing, and analytical standards. - Published Analysis & Authorship: - Publish sharp, well‑sourced analysis on geopolitical, economic, regulatory, and cross‑domain risk. - Produce decision‑grade work for executive and board audiences. - Write with authority and stand behind published judgment. - Team Building & Leadership: - Recruit, mentor, and manage contract analysts and future domain specialists. - Run weekly editorial planning and product reviews. - Build analytic tradecraft, workflows, and review discipline that scale. - OSINT & Analytic Tradecraft: - Direct primary and open‑source intelligence research across all twelve Nexus domains. - Apply structured analytic techniques to evaluate likelihood, impact, and intersection effects. - Maintain sourcing discipline and analytic traceability. - AI‑Enabled Research Workflows: - Build and refine AI‑assisted research and drafting workflows that increase throughput without compromising rigor. - Govern AI use under strict review standards. - Public Representation: - Anchor the Risk Apogee podcast, RRAG webinar series, and RRAG’s LinkedIn presence. - Represent RRAG’s analysis to executive and board‑level audiences. Qualifications - 6+ years in business analysis, applied research, intelligence analysis, or geopolitical/economic analysis with strong commercial orientation. - Exposure to national‑security, intelligence, military, diplomatic, or regulated‑industry environments. - Strong academic and public writing portfolio; candidates must provide 2–3 published or sanitized samples. - Demonstrated OSINT proficiency and structured analytic techniques. - Evidence of deliberate, effective use of AI tools in research and writing workflows. - Management experience: hiring, mentoring, and leading analysts or small teams. - Bachelor’s degree in a relevant field; advanced degree strongly preferred. Preferred Skills - Familiarity with ERM frameworks (ISO 31000, COSO ERM, FAIR). - Experience in academic, think‑tank, or institutional research. - Experience launching or running subscription‑based intelligence or advisory products. - Experience supporting executive or board‑level audiences. Attributes for Success - Sets a clear intellectual agenda and holds a high bar without micromanaging. - Writes with authority and confidence in published judgment. - Develops people and raises the standard of analysts around them. - Exercises strong judgment, discretion, and sourcing discipline under deadline. - Operates independently in an evolving, distributed environment. Engagement Terms - Engagement Type: Contract role structured toward ongoing leadership. - Term: Initial six‑month engagement; renewal based on performance and product demand. - Work Model: Fully remote (U.S.); occasional travel for client engagements or offsites. - Compensation: Market‑competitive, commensurate with experience and scope. - Work Product: Apogee retains exclusive ownership; standard NDA and IP provisions apply. How to Apply For any questions (OR) to apply, please contact us at careers@apogeeglobalrms.com. Equal Opportunity Statement Apogee Global RMS provides equal opportunity to all applicants and team members without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic information, marital status, veteran status, or any other protected characteristic. As a Service‑Disabled Veteran‑Owned Small Business, we welcome applications from veterans and members of the military community.