Role Description The Global Statistical Lead (GSTATL) for Solid Tumor Oncology is a compound level leader within the Quantitative Science & Evidence Generation (QSEG) organization, accountable for driving the statistical and analytical strategy for a compound or indication across its full development lifecycle. This position leads a cross-functional, integrated quantitative team supporting evidence generation and decision-making, with responsibility spanning: - Clinical trial statistics - Exploratory statistics - Medical affairs statistics - Real-world evidence (RWE) - Safety/pharmacovigilance (PV) statistics - Statistical programming - Biomarker statistics - Advanced analytics The role ensures consistency and scientific excellence across studies, indications, and evidence types—while enabling innovation in statistical methodology, clinical development optimization, and external engagement. The GSTATL plays a key role in regulatory and payer strategy, as well as internal governance and portfolio planning for solid tumor assets. Responsibilities and Accountabilities - Strategic Statistical Leadership: - Serve as the compound-level statistical lead for solid tumor oncology, responsible for end-to-end quantitative strategy supporting clinical development, evidence generation, and regulatory/payer interactions. - Lead development of integrated statistical strategies across all relevant study types and functions (e.g., phase 1b/2 signal-seeking, pivotal, exploratory, RWE, post-marketing). - Align statistical and analytical approaches with the target product profile (TPP), development strategy, and external evidence needs. - Cross-Functional Quantitative Team Leadership: - Lead and coordinate statistical and analytics contributions from a broad QSEG team, including: - Clinical trial biostatisticians - Exploratory oncology statisticians (e.g., tumor burden modeling, subgroup/signal detection) - Medical Affairs statisticians - Statistical programmers - Biomarker/statistical genetics experts in oncology - RWE analysts/statistical epidemiologists - Safety/PV statisticians - Advanced analytics and modeling specialists - Ensure scientific alignment, quality, and integration across all statistical contributions at the compound level. - Regulatory and HTA Engagement: - Represent Astellas on all statistical matters in global regulatory interactions (e.g., FDA, EMA, PMDA). - Guide preparation of statistical content for regulatory submissions, briefing packages, and health technology assessment (HTA) dossiers. - Lead the development of statistical components of payer evidence strategies, including indirect comparisons and external control methodologies. - Innovation and Methodological Excellence: - Champion the use of oncology-appropriate innovations, including Bayesian designs, adaptive trial designs, external controls, tumor-agnostic approaches, and AI/ML tools to enhance study design and signal detection. - Promote exploratory data analysis, modeling, and simulation to support rapid development decisions in Solid Tumor trials. - Integrate clinical, biomarker, safety, and real-world evidence to drive cohesive, data-driven development and access strategies. - Mentorship and Capability Development: - Mentor statisticians and analytics professionals across QSEG, supporting both scientific development and career growth. - Share knowledge and best practices across study teams and therapeutic areas. - Contribute to internal training, methodology development, and talent pipeline initiatives. - Governance and Cross-Functional Influence: - Participate in global asset governance and development team meetings, influencing decisions with rigorous statistical insight. - Collaborate with Clinical Development, Medical Affairs, Regulatory, Market Access, and Commercial to ensure alignment on evidence planning. - Lead or contribute to internal initiatives, including standardization efforts, methodology forums, and innovation networks. Qualifications - Advanced degree (PhD, MD, MBA, or equivalent) in Oncology, Life Sciences, or a related field. - Minimum 8 years of experience in pharmaceutical R&D, external innovation, academic collaboration, or scientific partnering. - Strong understanding of oncology drug discovery, translational science, and modality platforms (e.g., next gen ADCs, engineered biologics, engineered small molecules). - Proven ability to engage with scientific leaders and navigate early-stage biotech and academic ecosystems. - Excellent communication skills with the ability to synthesize complex scientific information into strategic insights. - Prior experience in academic liaison, external innovation, or strategic scouting in pharma/biotech or venture ecosystems. - Familiarity with CI platforms, digital literature monitoring tools, and academic/biotech databases. - A strong network in academia or biotech focused on oncology. - Experience in competitive intelligence, scientific scouting, or innovation strategy within oncology. - Familiarity with academic-industry collaboration models and consortia-based innovation. - High digital literacy and comfort with landscape analytics, scientific intelligence platforms, and conference tracking tools. Preferred Qualifications - PhD (or MSc with equivalent experience) in Biostatistics, Statistics, or a related quantitative discipline. - Minimum of 10 years of experience in oncology clinical development, with proven leadership in statistical strategy and regulatory submissions. - Demonstrated experience leading statistical contributions at the compound level, including regulatory engagement and cross-functional integration. - Broad expertise across clinical trial design, exploratory oncology analytics, biomarker evaluation, RWE, and post-marketing study support. - Broad expertise across clinical trial statistics, exploratory statistics, Medical Affairs statistics, biomarker statistics, safety/PV statistics, real-world evidence (RWE) analytics, and statistical programming. - Strong understanding of the drug development lifecycle, regulatory requirements, and evidence generation for both approval and market access. - Ability to lead and influence cross-functional, global teams within a matrix environment. - Strong communication, collaboration, and stakeholder engagement skills across both technical and non-technical audiences. - Proficiency in statistical software (e.g., SAS, R) and familiarity with simulation tools and modern statistical methods. Location and Working Environment This position is based in Northbrook, IL. Remote work from anywhere in the US is available. At Astellas we recognize the importance of work/life balance, and we are proud to offer a hybrid working solution allowing time to connect with colleagues at the office with the flexibility to also work from home. We believe this will optimize the most productive work environment for all employees to succeed and deliver. Hybrid work from certain locations may be permitted in accordance with Astellas’ Responsible Flexibility Guidelines. Benefits - Medical, Dental and Vision Insurance - Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down - 401(k) match and annual company contribution - Company paid life insurance - Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions - Long Term Incentive Plan for eligible positions - Company fleet vehicle for eligible positions - Referral bonus program

• Develop and execute strategic account plans for national and regional customers. • Establish executive-level relationships with key decision-makers across GPOs, IDNs, health systems, payors, specialty pharmacies, and other partners. • Identify opportunities to expand product access, utilization, and contract penetration. • Represent Cosette as the commercial contact for assigned accounts. • Engage in contract and business discussions with key institutional customers. • Assist with contract renewals, amendments, and business reviews. • Ensure successful implementation and pull-through of customer agreements. • Monitor customer performance and develop action plans to address risks and opportunities. • Partner with other Market Access functions and Contract Strategy teams to align customer needs with potential solutions. • Drive formulary access, account adoption, and utilization objectives. • Support launch readiness and commercialization efforts across institutional channels. • Provide customer insights to support pricing, reimbursement, and access strategies. • Lead internal IDN/systems account planning processes across Commercial, Market Access, Trade, Finance, Supply Chain, Marketing, Medical Affairs, and Legal. • Collaborate with Trade and Distribution teams to support tactical implementation and customer service excellence. • Escalate and resolve customer issues impacting access, supply, pricing, or tactical execution. • Provide leadership and direction to the Director, Contract Strategy & Offer Development.

Role Description Nucleus Global is expanding its footprint in the publication space and is looking for a senior level director to lead the scientific team and provide strategic account oversight. This is an excellent opportunity to help shape the department and grow the publication team and business. The right individual must have strong work experience in the publication space with a focus on lung cancer. This is a client-facing role that requires directing client strategy, staff mentoring/management, leading scientific teams in content creation, and partnering with the VPs of scientific and client services and managing director in business development, among other responsibilities. - Manage scientific team responsible for delivery of a full range of strategic publication focus - Under the guidance of the scientific VP, lead and manage account to ensure the creation of high quality, accurate medical/scientific content with ability to expand management responsibilities as team grows - Develop and grow commercial work partnering with VPs of scientific and client services and managing directors - Identify and develop strategic and tactical business recommendations relevant to client strategy and marketplace needs - Develop/lead/facilitate key strategy workshops - Demonstrate a high level of comfort articulating scientific and therapeutic information in lung cancer - Foster innovation and collaboration across Nucleus to position agency as leader in publication work Qualifications - PhD, PharmD, MD with 10+ years of experience of relevant medical communications experience, with an in-depth understanding of publication oncology work - Track record of successful scientific leadership across several clients/therapeutic categories - US launch experience required; Global experience is a plus - Some travel will be required - Excellent written and verbal communication skills - Experience managing staff/direct reports (potentially based across multiple locations) - This position is open to candidates who are looking for a fully remote or hybrid opportunity based in the United States (east coast preferred) Benefits - Competitive package - Friendly and informal working environment - Excellent opportunities for career and personal development - Robust benefits package including health, dental, vision, 401(K), vacation, holiday, and sick time Company Description Nucleus Global proudly offers an equal opportunity workplace. We are committed to driving a culture of diversity, inclusion and belonging where everyone is able to bring each facet of themselves to work each day. At Nucleus, we believe there is strength in diversity and inclusivity, and that strength is a driver of our success. The base salary range represents the low and high end of the salary range for this position. This range may differ based on your experience and skill set, geographic location, and cost of living considerations. We consider compensation more than just a base salary – that’s why we also offer an exceptional range of flexible benefits, personal support and tailored learning and development opportunities all designed to help you realize your full potential both in life and at work. Don't meet every job requirement? That's okay! Our company is dedicated to building a diverse, inclusive, and authentic workplace. If you're excited about this role, but your experience doesn't perfectly fit every qualification, we encourage you to apply anyway. You may be just the right person for this role or others.

• Macro & Micro Market Analysis: Monitor global hospitality tech trends, macroeconomic shifts, and hospitality buyer behavior to identify emerging threats and new commercial opportunities • Competitive Analysis: Establish a continuous framework for monitoring competitor product launches, feature developments, financial health, M&A activity, and strategic pivots to protect our market positioning. • Win/Loss Analysis: Partner with Sales Operations to conduct rigorous win/loss research. • Executive Briefings: Serve as the trusted internal advisor to the C-suite, Product, and Sales leadership on competitor movements and market shifts • Monetization Architecture: Own the design, execution, and continuous optimization of Revinate’s pricing models • Packaging & Feature Tiering: Lead the cross-functional strategy for packaging new products and bundling existing features to maximize customer lifetime value • Value Metric Discovery: Conduct quantitative research (e.g., Conjoint Analysis) to determine customer willingness-to-pay and discover ideal value metrics • Sales Enablement & Discounting Guardrails: Collaborate with Finance and Revenue Operations to establish pricing calculators that empower Sales while protecting margins • Strategic R&D Input: Synthesize market data and competitive gaps into highly actionable briefings for Product and Engineering leadership.