Role Description The Research and Translational Medicine group at Jade is looking to add a Principal Scientist, Translational Research, to our team. This role will provide scientific leadership across immunology-driven research activities that support Jade’s pipeline programs, including: - Mechanism-of-action studies - Disease biology assessment - Indication evaluation - Translational strategy The Principal Scientist will integrate literature, experimental data, and translational insights to strengthen program rationale, inform clinical development, and identify opportunities for pipeline expansion. This is an exciting opportunity to join a growing, highly collaborative biotech team and contribute to the advancement of potentially best-in-class therapies for autoimmune and inflammatory diseases. This is a fully remote role, preferably based on the U.S. West Coast, with occasional domestic and international travel. The position reports to the Executive Director, Research and Translational Medicine. Qualifications - PhD in Immunology or related field with 8–12+ years of relevant industry experience is required - Deep expertise in immunology and disease biology, particularly in autoimmune and inflammatory disease mechanisms - Strong understanding of drug development, including how preclinical and translational data inform clinical strategy - Experience with immunological assays and platforms (e.g., flow cytometry, ELISA/MSD, cytokine panels, cellular assays); familiarity with advanced platforms (e.g., single-cell, proteomics) is a plus - Experience working in cross-functional teams (e.g., Translational Medicine, Clinical, Nonclinical) - Strong written and verbal communication skills, with a track record of scientific publications and presentations - Ability to operate independently while contributing to a collaborative, fast-paced biotech environment Requirements - Lead immunology-driven research strategy across pipeline programs to support scientific narrative and indication assessment, integrating literature, experimental data, and translational insights - Design and oversee mechanism-of-action studies to elucidate target biology, pathway modulation, and disease relevance across in vitro, ex vivo, and in vivo models, executed in partnership with CROs - Partner closely with Translational Medicine, Clinical Pharmacology, and Nonclinical teams to ensure alignment of preclinical findings with clinical strategy - Generate and interpret complex datasets (e.g., cellular immunology, cytokine profiling, pathway analysis), ensuring rigorous and hypothesis-driven conclusions - Identify and validate new targets and pathways for pipeline expansion, leveraging deep understanding of disease biology, emerging science, and internal platform capabilities - Evaluate and prioritize new indication opportunities, integrating mechanistic rationale, competitive landscape, and translational feasibility - Support external collaborations and CRO activities, providing scientific direction and technical oversight to ensure high-quality data generation - Author and contribute to scientific documents, including study reports, regulatory sections (e.g., IND-enabling rationale), presentations, and publications - Present findings to internal governance teams and external scientific forums - Stay current with advances in immunology, inflammation, and translational science, applying new insights to strengthen program and pipeline strategy Benefits - The anticipated salary range for candidates for this role is $175,000 - $190,000. - The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography.

• Assist with the execution of 3-4 large Future of Medicine screening events per month. • Provide education about the Future of Medicine program, clinical research, and general information about participation in research studies. • Perform the Informed Consent process with event attendees. • Deliver clear, engaging presentations to both individuals and groups. • Be well-versed in Care Access programs to answer participant questions. • Collaborate with internal Care Access teams to strategize and execute community engagement activities. • Support the larger clinical research team, ensuring seamless transitions for participants interested in participating in clinical trials. • Propose suggestions for improving Future of Medicine events based on managerial direction. • Provide support and knowledge sharing to more junior team members on the team.

Role Description The Clinical Trial Manager (CTM) is a key member of the Clinical Operations team and will report into the Clinical Program Manager, Clinical Operations, partnering closely on the start-up and initiation of a global Phase 3 program. The primary responsibilities of the CTM will be regional study management of the EU and vendor management. - With guidance from the Clinical Program Manager, ClinOps, responsibility for day-to-day activities within a region or regions, including site selection, start-up, maintenance, and close-out activities. - May serve as the key operational contact for Braveheart Bio studies aiding in site selection, study implementation, and ongoing coordination of study sites, either directly or via CROs. - Assist Clinical Program Manager, ClinOps with oversight of CRO and set-up of vendors as required, including liaising with Global CRO to ensure timely initiation of study. - Day-to-day contact with counterparts at CRO and/or trial sites, including daily review and identification of potential issues or problems that must be communicated/escalated directly to Clinical Program Manager, ClinOps. - Review site Informed Consent Forms and escalate to appropriate individuals, as needed. - Assist with regulatory submission package review for submissions within region. - Proactively identify potential operational challenges and, in collaboration with senior team members, provide solutions to ensure study execution remains on track. - Perform accompanied visits (PSSVs, SIVs, RMVs) with CRO CRAs to ensure study procedure conduct is in accordance with SOPs and protocol procedures and review routine regulatory documents/files in compliance with protocol, regulatory requirements, SOPs, and Monitoring Plan, as required. - With guidance, may assist in review of protocols, informed consents, and case report forms, monitoring plans, abstracts, presentations, manuscripts and clinical study reports. - May assist in compilation of investigator brochure appendices under close supervision. - Review of trip reports generated by CRO CRAs for trends and quality issues. - Review protocol deviations and monitor for trends. - Coordinate review of data listings and preparation of interim/final clinical study reports, including resolving data discrepancies. - Provide regular study updates to the appropriate internal stakeholders. - Maintain internal Clinical Operations databases and document repositories. - Perform administrative duties in a timely manner as assigned. - Guide and support junior team members, ensuring alignment on deliverables, timelines, and quality standards. Qualifications - At least 4+ years of relevant experience with a BS or BA in a relevant scientific discipline or an RN (2- or 3-year certificate). - Relevant clinical trial experience in the pharmaceutical or health care industry. - Experience as the regional lead for Europe strongly preferred. - Excellent attention to detail, interpersonal and presentation skills are a critical asset. - Excellent organizational, problem-solving and time management skills. - Must be familiar with routine medical/scientific terminology. - Knowledge of FDA and/or EMEA Regulations, ICH Guidelines, and GCPs governing the conduct of clinical trials is desirable. - Must be familiar with Word, PowerPoint, and Excel (intermediate or higher excel proficiency a plus). - Must be able to participate in departmental or interdepartmental strategic initiatives under general supervision. - High energy level, personal productivity, creativity and commitment. - Highly adaptable team-player. - Strong written and verbal communication skills with a collaborative, team-oriented approach. - Ability to thrive in a fast-paced, dynamic environment and remain comfortable with change and ambiguity. - Flexible, proactive, and hands-on mindset with a roll-up-your-sleeves, can-do attitude. Requirements - This position is for remote work and may require domestic or international travel up to 25% (as needed); valid travel documents must be obtainable. Benefits - Salary Range: $140,000 - $170,000. - This role is eligible for a competitive total rewards package, including an annual bonus, equity, and a comprehensive benefits offering. Company Description Braveheart Bio is a clinical-stage biopharmaceutical company focused on developing therapies for patients with hypertrophic cardiomyopathy (HCM) and other serious cardiovascular diseases. Our lead product candidate, BHB-1893, is a next-generation oral small-molecule cardiac myosin inhibitor (CMI) being developed for the treatment of obstructive HCM (oHCM) and non-obstructive HCM (nHCM). Braveheart’s goal is to improve the treatment options for these patients by enhancing speed of onset, depth of gradient response, systolic safety, reversibility and reducing prescribing complexity. With a proven leadership team, a strong financial foundation, and a high-value late-stage asset, Braveheart Bio represents an outstanding opportunity for ambitious, mission-driven professionals to make a tangible impact in a high-profile and rapidly evolving therapeutic area.

Title: Senior Clinical Research Coordinator - Department of Medicine - Office of Research Administration Location: Los Angeles, CA United States Job Description: General Information Press space or enter keys to toggle section visibility. Work Location Los Angeles, CA, USA Onsite or Remote Flexible Hybrid Work Schedule Monday - Friday, 8:00am - 5:00pm Posted Date November 15, 2026 Salary Range $82,105.68 - $133,068.24 Annually Employment Type 2 - Staff Career Duration Indefinite Job 27996 Primary Duties and Responsibilities Press space or enter keys to toggle section visibility. The Senior Clinical Research Coordinator plays a critical role in the overall operational management of clinical research, trial, study activities from design, set up, conduct through closeout. The ideal candidate is an experienced professional or leader who has direct responsibility for the implementation of research activities for one or more studies, which may include multicenter clinical trials, both NIH and industry-sponsored, local investigator-initiated clinical trials, and/or programmatic clinical research activities. Recognize and perform necessary project management tasks and prioritizes work to reach scheduled goals. The Senior Clinical Research Coordinator is a technical leader responsible for ensuring the study protocol and procedures have been completed accurately, safely, and in a timely manner. Work with PIs, departments, sponsors, institutions, and other entities as needed to support and provide guidance on the administration of the compliance, financial, personnel, and other related aspects of studies. Work may be assigned by Senior Management and assignments may be changed on an as-needed basis in order to ensure that studies and patient care needs are handled appropriately and in a timely manner. Travel to other locations may be required. The full annual salary range for this position is: $89,454.77 - $143,904.50 Job Qualifications Press space or enter keys to toggle section visibility Required: • Bachelor’s Degree or three-to seven years of study coordination or clinical research coordination experience • Ability to work efficiently and complete tasks with a high degree of accuracy. • Ability to organize multiple projects for efficiency and cost-effectiveness. • Analytical skills sufficient to work and solve problems. • Ability to work flexible hours to accommodate research deadlines. • Ability to concentrate and focus in a work environment that contains distracting stimuli and competing deadlines. • Ability to be flexible in handling work delegated by more than one individual or in the course of delegating work. • Strong interpersonal communication skills to effectively and diplomatically interact with others, including institutional leadership. • Strong written communication skills, ability to compose advanced correspondence and manage large file systems. • Advanced typing and computer skill/ability including word-processing, use of spreadsheets, email and data entry. • Ability to handle confidential material with judgement and discretion. • Skill in managing diverse, complex tasks and information transfer among multiple constituents. • Sufficient math ability and knowledge of clinical trials budgeting processes to manage the preparation of clinical trial budgets. • Advance knowledge of the clinical research regulatory framework and institutional requirements. • Ability to supervise and delegate clerical work as needed. • Advanced knowledge of Good Clinical Practice (GCP) for clinical research.