Jade Biosciences

About Jade Biosciences Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn.   Role Overview We are seeking a Manager, Accounting to assist in monthly, quarterly, and year-end closing processes focused heavily on R&D accruals (primarily clinical and CMC). The Manager, Accounting will also support the day-to-day functions of the Finance and Accounting team with a focus on streamlining processes and creating efficiencies. The Manager, Accounting will report to the Assistant Controller. Key Responsibilities - Assist in the timely month-end, quarter-end, and year-end closing processes including balance sheet and operating statement account reconciliations, journal entries, and accruals - Work directly with Assistant Controller, Controller, Clinical and CMC teams, and vendors to accurately and efficiently report accruals on a monthly basis - Assist business leaders in preparing clinical and CMC accrual files, inquiring with vendors, and holding monthly inquiries with business owners - Analyze financial statement accounts, identify unusual trends or erroneous entries, and verify accuracy of transactions and balances - Aid in the updating of business process walkthroughs and flow-charts as well as perform periodic controls procedures - Prepare payroll and work closely with HR function to ensure proper reporting and classification - Oversee equity administration and working with HR and Legal functions to accurately report all equity transactions - Potential management of future team members including but not limited to activities of mentoring, training and embodying a continuous improvement mindset - Perform ad hoc projects Qualifications - Bachelor’s degree and 5+ years of related accounting experience, specific experience in Biotech / Life Sciences are required - Experience establishing processes for Clinical and CMC accruals and performing ongoing assessments in line with monthly, quarterly, and annual closes is required - Strong operational accounting skillset and demonstrated success - Master’s degree and CPA certification a plus - Strong understanding of GAAP, and internal controls - Thorough understanding of Sarbanes Oxley and public company requirements - Experience performing and documenting monthly close processes and maintaining supporting documentation for financial transactions - Excellent problem-solving skills, with keen attention to detail and financial analysis knowledge - Stellar collaboration and communication skills and ability to work cross functionally with all levels of the organization - Strong organization and prioritization skills that ensure challenging deadlines are met with high quality output - Ability to critically think through situations and problem solve independently Position Location This is a remote role; periodic travel to team and company events is required. The anticipated salary range for candidates for this role is $130,000 - $140,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography. As part of the I-9 verification of authorization to work in the United States, Jade Bioscience participates in E-Verify. To learn more about E-Verify please review this poster. Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description The Associate Director, Clinical Site Budgets & Payments will architect and lead the company’s global approach to clinical trial site budgeting, investigator grant strategy, transparency compliance, and site/vendor payment governance across our clinical trial portfolio. This leader will define Jade’s global investigator grant philosophy, including structured opening offer and negotiation parameters that ensure speed, fairness, and alignment with global FMV benchmarks. They will establish standards for invoiceables, conditional procedures, pass‑through costs, and country‑specific budgeting norms that apply across all Jade clinical studies. This role oversees a full‑service CRO partner responsible for operational execution of budgets, payments, reconciliation, and study financial controls. It also builds and maintains global site budget forecasts, ensures just‑in‑time CRO funding, and supports accruals, reconciliation, and inspection‑readiness. The successful candidate must be equally fluent in clinical trial protocols and financial statements, highly skilled in influencing cross‑functional and vendor partners, and able to uphold strict compliance with FMV and Sunshine/Open Payments regulations. This is a high‑visibility, individual‑contributor role reporting directly to the Executive Director, Development Outsourcing and operating globally across all Jade studies. The position is remote, with domestic travel up to four times per year. Key Responsibilities - Global Payment Philosophy, Compliance & Governance - Define Jade’s global investigator grant strategy, including opening‑offer tiers, decision and negotiation parameters, aligned with international FMV standards. - Establish and maintain policies for invoiceables, pass‑throughs, conditional procedures, screen‑fail handling, and complex visit structures; ensure global consistency. - Develop and maintain SOPs/WIs governing budgeting, payments, documentation, and global transparency requirements (e.g., U.S. Sunshine/Open Payments and ex‑US equivalents). - Define FMV justification expectations and ensure audit‑ready documentation across all investigator/HCP engagements. - Study‑Level Budget Design & Financial Oversight - Translate clinical protocols into country‑specific and site‑level cost models that accurately reflect procedures, visit schedules, and conditional events. - Build and maintain global study budget forecasts, partnering closely with Clinical Operations and Finance to ensure alignment with development plans. - Implement and monitor just‑in‑time CRO funding, minimizing idle cash at CROs while ensuring on‑time site payments. - Oversee accruals, spend tracking, payment reconciliation, and close‑out documentation for accuracy and inspection readiness. - CRO Governance & Issue Escalation - Serve as Jade’s primary owner of CRO performance for site budgets and payments, including contract expectations, KPIs, and service delivery standards. - Lead the payment‑related components of CRO governance forums, including issue resolution, aging analysis, cycle‑time performance reviews, and payment forecasting. - Resolve escalated site payment issues, driving sustainable root‑cause solutions and process improvements. - HCP/KOL Payment Operations (“White‑Glove” Model) - Implement a high‑touch service model for KOL/HCP payments (consulting, advisory boards, speaking engagements), ensuring accuracy, speed, and FMV alignment. - Streamline administrative burden for external experts by simplifying processes, documentation, and support. - Cross‑Functional Leadership & Decision Support - Partner closely with Clinical Operations, Development Outsourcing, Legal, Compliance, and Finance to ensure budgets and payments reflect protocol intent, operational realities, and compliance needs. - Provide executive‑level visibility into performance metrics such as payment timeliness, disputes, forecast accuracy, and CRO funding utilization. - Serve as Jade’s internal subject‑matter expert for investigator/HCP budgeting and payment strategy across a global two‑program portfolio in Autoimmune disease. Qualifications - Bachelor’s degree in finance, life sciences, business, or related field with 13+ years of experience or an advanced degree (MBA, MS, MPH) with 10+ years of experience. - 10+ years of relevant experience in biotech/pharma or CRO roles with direct responsibility for site budgeting and payment oversight. - Demonstrated ability to interpret clinical protocols and convert them into robust, compliant global site budgets. - Strong understanding of global FMV frameworks and Sunshine/Open Payments transparency requirements. - Proven experience governing a full service CRO, including KPI management, escalation handling, and process improvement. - Ability to analyze financial statements, accruals, and cash flow impacts. - Excellent communication, negotiation, and cross functional influence. - Experience supporting Autoimmune or immune mediated diseases preferred. - Experience managing global payment models across diverse regulatory environments preferred. - Exposure to KOL/HCP engagement processes with FMV and transparency considerations preferred. Position Location - This is a remote role; periodic travel to team and company events is required. - The anticipated salary range for candidates for this role is $170,000 - $190,000. - The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography. Company Description Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development.

About Jade Biosciences Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn.   Role Overview The Director of Program Management (PM) will lead and deliver comprehensive program management support across one or more drug development programs, ensuring alignment with cross‑functional strategic and operational objectives. This individual will serve as the program’s operational leader—driving execution so that all deliverables are met on or ahead of schedule, within budget, and in accordance with organizational goals. Success requires exceptional attention to detail, strong forward‑planning and organizational capabilities, and the ability to effectively engage, influence, and manage stakeholders across diverse teams. This position is fully remote and will report to the VP and Head of Portfolio Strategy and Management (PSM). Periodic travel to team and company events is required. Key Responsibilities - Leads the cross functional development of integrated program plans in partnership with the Program Team Leads, and ensures alignment with the overall program strategy - Collaborates with functional leads to ensure effective teamwork and execution of cross-functional deliverables - Develops and maintains program-level integrated development plans reflective of program strategy, critical path milestones and key interdependencies across functions - Tracks program risks by proactively identifying and resolving issues, and working cross-functionally to develop contingency plans to ensure program success - Drives decision point planning, ensuring the associated deliverables across all functions are met, and contributes to the strategic planning process - Ensures effective, accurate, and timely communication of program information to meet the needs of the program team and stakeholders - Provides cross-functional operational leadership to the team - Partners with the PSM organization to support development and refinement of processes, tools and systems to deliver high quality PM support to the programs and the broader organization Qualifications - Bachelor's degree in a related field required; advanced degree preferred - 15+ years of experience in program, project or alliance management within the biotech or pharmaceutical industry - Strong experience in providing program management to cross-functional teams - Excellent organizational skills and ability to forward-plan - Proven track record of successful project management of complex drug development programs in a fast-paced startup environment - Expertise with project management tools (e.g. Smartsheet, Microsoft Timeline Pro+) - Ability to manage multiple workstreams simultaneously and prioritize effectively in a fast-paced environment - Proactively identify issues and drive resolution; can anticipate key future events and adjust team priorities/plans accordingly - Excellent communication and interpersonal skills with the ability to influence and motivate cross-functional teams, manage a diverse set of stakeholders, and work closely with team leaders - Strong written and oral communication skills with strong attention to detail Position Location This is a remote role; periodic travel to team and company events is required. The anticipated salary range for candidates for this role is $220,000 - $240,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography. As part of the I-9 verification of authorization to work in the United States, Jade Bioscience participates in E-Verify. To learn more about E-Verify please review this poster. Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

About Jade Biosciences Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn.   Role Overview The Executive Director, Program Team Lead, will drive strategic management of one or more drug development programs. This individual will play an integral role in building and leading efficient and collaborative cross-functional teams to achieve program goals. This role requires broad expertise in drug development, strong communication and leadership abilities as well as skillful internal and external stakeholder engagement/management. This is a critical and highly visible role, making a substantial contribution to the company. This position is fully remote and will report to the VP and Head of Portfolio Strategy and Management (PSM). Periodic travel to team and company events is required. Key Responsibilities - Leads a Program Team of cross-functional experts to develop and execute an integrated program strategy to maximize the opportunity of the asset - Builds organizational alignment on program priorities and strategic objectives, ensuring milestones are clearly defined and understood - Synthesizes complex scientific, operational, and business information into clear, big‑picture insights that inform strategic decision‑making and drive results - Critically challenges program plan assumptions, timelines and budget and creates alternative scenarios to enable strategic and operational agility - Continuously incorporates evolving external clinical, regulatory, and commercial insights into the program strategy and adjusts plans as needed - Proactively identifies risks and drives team to develop mitigations - Drive program strategic decision-making; ensures the program is adequately resourced and provides active input/oversight of major budget-impacting decisions - Drives the team to out-of-box thinking and creative issue resolution - Acts as spokesperson for the program and represents program internally and externally Qualifications - Outstanding proven team leadership skills and experience in a complex matrix environment - Masters degree with 15 years of experience or Doctoral degree with 10 years of experience with a scientific and/or business-leadership focus - 15+ years in the life-sciences, biotech and pharmaceutical industry; rare disease and small company experience strongly preferred - At least 10 years equivalent multi-/ cross-functional leadership experience - Experience with development program leadership required; strong preference for candidates who have led teams through registrational trials and market authorization - Excellent relationship building skills and ability to influence to achieve desired outcome - Effective interpersonal and communication skills to bridge between scientific and business stakeholders - Broad and deep understanding of the drug development process and the operational requirements needed to execute it - Ability to objectively interpret and evaluate scientific data and competitive business information - Advanced level of basic science; biologics expertise desired - Foundational financial knowledge, including resource planning and management for headcount and budget Position Location This is a remote role; periodic travel to team and company events is required. The anticipated salary range for candidates for this role is $270,000 - $290,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography. As part of the I-9 verification of authorization to work in the United States, Jade Bioscience participates in E-Verify. To learn more about E-Verify please review this poster. Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

About Jade Biosciences Jade Biosciences is a clinical-stage biotechnology company focused on developing best-in-class therapies that address critical unmet needs in autoimmune diseases. Jade’s lead candidate, JADE101, targets the cytokine APRIL, and is currently being evaluated in a Phase 1 clinical trial for the treatment of immunoglobulin A nephropathy. Jade’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, as well as JADE301, an undisclosed antibody candidate, both currently in preclinical development. Jade was launched based on assets licensed from Paragon Therapeutics, an antibody discovery engine founded by Fairmount. For more information, visit JadeBiosciences.com and follow the Company on LinkedIn.   Role Overview The Executive Director, Clinical Quality Assurance (CQA) will be responsible for all aspects of Quality Assurance focused on Good Clinical Practice (GCP), Good Pharmacovigilance Practices (GPvP) and Good Laboratory Practices (GLP) activities to ensure quality assurance and compliance of Jade sponsored clinical trials with applicable regulations, ICH guidelines, OECD Principles of GLP, Jade procedures and policies, and current industry standards and practices. The Executive Director, Clinical Quality Assurance will perform day-to-day clinical quality operations and compliance activities to support the success of our clinical programs in addition to being a strategic partner to Clinical Development and Operations. This role will maintain and ensure effectiveness of quality programs and documentation to assure compliance and inspection readiness with all applicable quality requirements and regulatory standards. The ideal candidate brings hands-on expertise in GCP, GPvP and GLP QA operations, a proactive approach to problem-solving, and the ability to guide and influence cross-functional teams while upholding the highest standards of quality and compliance. Key Responsibilities - Provide hands on clinical QA oversight and review of protocols, Informed Consent Forms (ICFs), Clinical Study Reports (CSRs), and other clinical trial specific documents. - Provide coaching, Quality decisions and be Quality approver to study teams on protocol deviations, vendor oversight, CAPAs, and issue management. - Act as the primary GCP/GPvP/GLP QA subject matter expert and point of contact for all related matters and issues. - Represent Quality on project teams, service providers and CROs operational meetings, and QA to QA meetings. - Oversee ongoing clinical programs to ensure they are risk‑based, fit‑for‑purpose and in compliance with applicable regulations and guidelines across all phases of development. - Review and approve (as appropriate) procedures, service provider quality agreements, qualification and onboarding forms and regulatory filings. - Develop, implement and execute a risk-based audit strategy and detailed plans for clinical and non-clinical studies. - Establish and maintain GCP/GPvP/GLP QA programs, policies and procedures. - Work collaboratively with the internal Clinical Operations Team and Development Teams to provide leadership and guidance to support study execution, data integrity, and regulatory compliance. - Identify and assess compliance risk and develop and implement risk mitigation measures.Lead the identification, investigation (root cause analysis), and resolution of quality issues through a robust investigation and CAPA process. - Contribute to building a strong quality culture within the organization. - Ensure the timely and effective follow up of all identified or assigned quality issues. - Direct and/or deliver yearly training for internal staff as needed. - Work closely with Development, Clinical Operations, and other functions/departments to drive inspection readiness and support regulatory interactions. - Champion continuous improvement and simplification across clinical quality systems. - Prepare KPIs, metrics and analysis and present status updates as needed. - Provide leadership in inspection preparedness to clinical sites and service providers for regulatory government agencies. - Stay current on global regulations, industry trends, and best practices to ensure continuous improvement and innovation within the QA function. - Apply risk‑based thinking to identify the quality activities that meaningfully influence study outcomes, rather than defaulting to checklists or bureaucracy. - Understand when to escalate, when to intervene, and when to let teams move forward without over engineering processes. - Provide clear, concise guidance that helps teams stay focused, aligned, and inspection ready. Qualifications - Bachelors + 17 or Masters + 15 or PhD + 10 years of related experience Extensive expertise in GCP, GPvP, GLP and ICH clinical requirements, clinical development and methodologies of clinical studies. - Successful track record of translation and implementation of clinical requirements into operational execution. - Extensive knowledge of FDA regulations and practices, ICH guidance, and strong knowledge of global health authority regulations and practices. - A successful track record of working with service providers and CROs. - Ability to make timely and sound quality decisions when faced with complex clinical, compliance, technical and regulatory considerations. Highly skilled in the ability to work with ambiguity and complexity. - Ability to tactically and strategically execute the day-to-day operations to support clinical trials and clinical and non-clinical development activities. - Knowledge of Quality Management Systems; experience in building, implementing and managing quality systems in the pharmaceutical industry. - Expertise in reviewing, revising, and writing Standard Operating Procedures (SOPs). - Effective communication skills (verbal and written) for interactions across functional areas and for interactions with key regulatory agencies. - Strong organizational skills and the ability to participate effectively cross-functionally. - A self-starter and a team player who thrives in a fast-paced dynamic team environment. - Ability to work with minimal supervision, to set priorities to meet timelines, and to motivate and influence others. Prior management experience is required. - Previous experience in successfully leading assigned activities within cross-functional teams. - Proficiency in using SharePoint, Veeva and Microsoft Office applications required (MS Outlook, MS Word, MS Excel, MS PowerPoint). Position Location This is a remote role; periodic travel to team and company events is required. The anticipated salary range for candidates for this role is $265,000 - $300,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography. As part of the I-9 verification of authorization to work in the United States, Jade Bioscience participates in E-Verify. To learn more about E-Verify please review this poster. Jade Biosciences is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

The Senior Director, Clinical Operations is responsible for directing the strategy, management, and oversight of clinical program(s) and functional activities as assigned. Acts as Clinical Operations program lead for assigned program(s) Represents Clinical Operations at the Clinical Development Team and/or Global Program Team Develops and executes program operational strategy Partners closely and effectively with other functions and functional heads to drive program forward Provides strategic and technical recommendations to senior leadership Directs the selection of CROs and other vendors (IxRS, Central Lab, ancillary/tech vendors) Acts as an escalation point for CRO/vendor issues Directs development of vendor Scopes of Work (SOW), scope changes, budgets, and vendor payments Partners with CRO and other vendors to deliver on study execution Creates and tracks clinical program budgets Directs risk mitigation, escalation, and resolution activities both internally as well as with sites and vendors Directs technical and strategic input into the development of clinical documents (protocols, monitoring plans, informed consent forms, investigator brochures, clinical study reports, etc.) Builds relationships with clinical sites, vendors, and key stakeholders Maintains understanding of external landscape and adjusts plans accordingly Represents Clinical Operations in cross-functional activities as assigned Plays a key role in the development and management of the Clinical Operations function; may act as a deputy for the Head of Clinical Operations as assigned Hires, manages, coaches, and mentors staff Contributes to building the organization