• Lead the overall clinical development strategy for oncology programs with primary focus on cholangiocarcinoma and hepatocellular carcinoma from early development through late-stage and registration-enabling studies • Develop and execute integrated clinical development plans aligned with regulatory objectives including study protocol design, execution, and data analysis/interpretation, in conjunction with other relevant functional leaders • Direct study design, protocol development, and execution for Phase 1-3 clinical trials, including pivotal registrational cancer studies • Provide expert oversight of clinical data analysis and interpretation, ensuring data are robust, clinically meaningful, and suitable to support regulatory decision-making • Contribute to pipeline strategy and diligence for new internal and external oncology opportunities, providing senior clinical and regulatory development input • Serve as a clinical development lead for global regulatory interactions, working in close partnership with Regulatory Affairs to define strategy and messaging • Lead and actively participate in meetings with regulatory agencies (e.g., FDA, EMA, MHRA), including scientific advice, End-of-Phase, pre-NDA/BLA, and ad hoc regulatory interactions, from a clinical development perspective • Provide senior clinical oversight and direction for the review of NDA and/or BLA clinical components, including clinical summaries, integrated analyses, and supporting study documentation • Lead the clinical development contribution to responses to health authority questions, including written responses to information requests, major review questions, and post-submission clarifications • Ensure that clinical strategy, trial design, and data presentation are aligned with evolving regulatory guidance and agency feedback throughout the product lifecycle • Ensure the quality, consistency, and regulatory readiness of all clinical documents, including Investigators’ Brochures, protocols, CSRs, safety narratives, and submission-critical documents • Provide senior scientific and clinical input into study-related documentation, including ICFs, CRFs, SAPs, clinical pharmacology analysis plans, and data interpretation narratives

• The Area Vice-President, Sales is a first-line sales leader responsible for launching the NEXCHANGE KIT, Osteal’s lead investigational therapy for periprosthetic joint infection, which has received FDA Breakthrough Therapy, Fast Track, Orphan Drug, and Qualified Infectious Disease designations. This role builds the regional Account Manager team, owns launch execution, surgeon adoption, and translates national strategy into account-level plans. • The AVP partners across Marketing, Market Access, Medical Affairs and Training to deliver an aligned go-to-market strategy and serves as the voice of the field in shaping commercial strategy. • The role demands an entrepreneurial builder with prior launch leadership, deep credibility in orthopedics and the operating room, and the resilience to drive results in a fast-moving, pre-commercial environment. As Osteal builds the commercial organization, this leader will have the opportunity to shape the future field structure, including recruiting and developing District Managers, and growing into broader second-line leadership responsibilities over time.

• Recruit, develop, and lead a high-performing team of Account Managers. • Provide field-based coaching through joint calls and in-hospital support. • Own regional sales forecasting, pipeline management, and performance reporting: conduct ongoing performance management and provide input on compensation plan design and quota setting. • Translate national strategy into actionable regional, territory and account level plans aligned to launch objectives. • Drive regional launch execution including site activation, surgeon adoption, and achievement of quarterly revenue and unit goals. • Identify, develop, and cultivate regional KOLs and centers of excellence in orthopedic infection management. • Partner cross-functionally with Marketing, Market Access, Medical Affairs, Training and Operations to drive aligned execution. • Serve as the voice of the field, bringing insights that inform strategy and decision-making. • Ensure team adherence to all applicable laws, regulations, and company policies.

• Support the Company’s growth initiatives and retail strategies by leading all facets of the real estate process, including market and location strategy, site selection, financial evaluation, lease negotiations, and legal documentation for new and existing stores • Partner with landlords and internal stakeholders to develop and execute negotiation strategies that optimize occupancy costs, enhance store performance, and improve long-term profitability for Genesco, including the successful restructuring and renegotiation of existing leases • Execute on a comprehensive real estate strategy to meet opening objectives for Genesco brands • Assist in meeting targeted financial objectives for all divisions • Promote strong relationships with landlords to enhance overall awareness of company brands and retail concepts • Negotiate and secure favorable lease terms and locations to maximize profitability of each store • Manage the process with Construction and Legal so that approved stores are opened on time and delivered in the manner presented • Oversee preparation of lease documents with legal team • Maintain and update leasing reports for management with clerical staff • Monitor national retail real estate market activity for trends and new developments