Role Description This position may be performed remotely, but requires the flexibility and willingness to travel as needed. Praxis Precision Medicines is entering a pivotal moment as we prepare for commercialization, and how we build and scale capability across the organization will directly impact our success. We are seeking a strategic and visionary Area Vice President of Sales to lead execution and drive commercial performance across key markets. This leader will be responsible for building, scaling, and leading high-performing sales and account management teams while ensuring alignment with enterprise commercial strategy. Working closely with senior leadership, you will help architect a modern, agile field organization that is operationally excellent, customer-focused, and built to support successful product launches and sustained growth. Primary Responsibilities - Lead and develop regional sales and account management teams to deliver strong performance and achieve commercial objectives. - Drive execution of a unified commercial strategy across geographies in alignment with enterprise priorities. - Oversee strategic account engagement, including health systems, IDNs, IPNs, and key payer relationships. - Partner closely with Commercial, Medical Affairs, Patient Services, and Market Access to deliver coordinated customer engagement. - Drive field readiness and execution across pre-launch, launch, and post-launch phases for multiple products. - Ensure sales teams are equipped with the capabilities, tools, and behaviors required for successful product launches. - Build scalable processes, infrastructure, and performance management systems to support growth. - Establish clear metrics to measure effectiveness and drive continuous improvement across the field. - Recruit, develop, and retain top talent while building a high-performance, accountable culture. - Provide insights from the field to inform strategy, execution, and future capability development. How You Work - You think in systems, not silos. - You balance rigor with speed, knowing when each matters most. - You hold a high bar for performance, quality, and accountability. - You collaborate deeply but act with ownership and urgency. - You are passionate about building scalable, sustainable commercial capabilities. Qualifications - 15+ years of progressive experience in pharmaceutical sales and commercial leadership, including direct management of regional or national sales teams. - Prior VP or Director-level experience in rare disease or CNS preferred. - Proven track record of leading strategic account and health system engagement at a national or regional level. - Deep understanding of IDN, IPN, and payer dynamics in rare disease and specialty markets. - Demonstrated experience owning a full national or multi-regional product launch in rare disease, CNS, or specialty pharmaceuticals. - Experience leading cross-functional commercial teams through pre-launch, launch, and post-launch phases. - Background building and leading commercial organizations within biotech or emerging pharmaceutical companies. - Ability to build scalable infrastructure, attract top talent, and deliver results in high-expectation environments. Requirements - The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. - You'll need comfort with screen work, basic hand coordination, and focus. - Reasonable accommodations may be made to enable individuals with disabilities to perform these functions. Benefits - 99% of the premium paid for medical, dental and vision plans. - Company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. - Dollar-for-dollar match up to 6% on eligible 401(k) contributions. - Long-term stock incentives and ESPP. - Discretionary quarterly bonus. - Extremely flexible wellness benefit. - Generous PTO, paid holidays, and company-wide shutdowns. - A collaborative and inspiring team environment. Compensation & Benefits Annualized Base Salary: $270,000 — $320,000 USD. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles. Company Description Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis, we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core values of Trust, Ownership, Curiosity, and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com. Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.

• Research and qualify leads — prioritize the best opportunities together with your Account Executive • Identify the right contacts and bring potential customers into demo calls • Test new outreach formats (cold calls, email sequences, LinkedIn) and iteratively improve them • Actively use AI tools to work faster, more accurately, and more effectively

• Manage the development of new sales leads and service existing customers using the Terex Proven Sales Process • Ongoing research of local market and business activity and identify opportunities • Manage, mentor, and lead the East Region sales team to successfully execute regional goals • Manage discount levels and strive to improve company margins • Manage sales forecasts and secure sales orders according to goals • Manage controlling of expenses per agreed upon budget • Educate sales team on products, service, warranties, and technical support • Ensure sales team has access to parts personnel, field service and other team members as necessary • Demonstrate the Terex Proven Sales Process proper techniques of prospecting, researching, presenting, and quotation and specification writing • Communicate and train the sales team on features and benefits of equipment • Receive feedback on existing products and services, as well as changes, enhancements and new products • Clearly document problems, issues or deviations from standard programs • Support trade shows and customer demonstrations as appropriate

• Make outbound calls to newly issued business to welcome them to the Globe Life Family, ensure their policy(s) are accurate, and assist with any additional information pertaining to their new policy. • Maneuver within our CRM while speaking with recently approved customers to collect the first premium to activate their Life Insurance policy. • Make outbound calls to internet-generated leads to warm up potential customers for our Sales Team. • Be able to explain policy benefits. • Complete necessary paperwork when needed. • Assist with correspondence and error corrections for policy service. • Execute special projects that encompass making numerous outbound calls for special projects/campaigns for our sister companies including AIL & LNL and recording activities requested by/from customers.