Director, Biostatistics Location: Remote, United States Director, Biostatistics Primary Work Location Remote - US Job Code2417 # of openings1 Job Description: Who we are: At Agios, we are fueled by connections to transform rare diseases. We foster an inclusive, collaborative culture – one that sparks bold thinking and strengthens our connections with each other and with the rare disease communities we serve. We embrace diverse backgrounds with respect, active listening, and a commitment to inclusion – because our differences shape how we hire, collaborate, and innovate. Our team’s proven track record of executional excellence, combined with our depth of expertise and dedication, enables us to develop innovative medicines that reflect the priorities of rare disease communities. Our commitment is more than scientific – it’s deeply personal, grounded in the meaningful connections we have built. The impact you will make: Agios Pharmaceuticals is searching for a dynamic Director, Biostatistics, to join our growing Biometrics team. We want someone who cares about this important work, and who’s driven to connect to our mission of helping these patient communities. The Director will serve as the lead statistician for assigned clinical development programs, leading the development and implementation of statistical solutions to support all phases of clinical trials, regulatory filing and facilitating decision-making. The Director will supervise study-level statisticians both in-house and at Contract Research Organizations (CROs), ensuring accountability for all biostatistics deliverables. What you will do: - Contribute to the development of clinical development plans and ensure that clinical development programs meet scientific, regulatory, and quality requirements. - Lead the biometrics team in all aspects associated with regulatory interactions/submission and develop strategies to address health authorities' inquiries pertaining to biometrics. - Provide scientifically rigorous statistical input and review for protocols, statistical analysis plans, interpretation of statistical results, and scientific publications. - Ensure delivery of high-quality, effective, and timely study- or program-level statistical deliverables for assigned projects. - Develop and/or implement innovative statistical approaches to enhance study design, analysis and data exploration methodologies. - Manage and/or mentor junior statisticians to foster their professional growth. - Promote effective collaborations with internal and external stakeholders. - Ensure compliance with relevant regulatory requirements and Agios standards across all study or program-level statistical activities. - Support establishment and maintenance of biometrics standards at Agios. - Serve as a comprehensive resource for clinical development and statistical matters. What you bring: - PhD in Biostatistics or related discipline with 7+ years biopharmaceutical industry experience - Experience in a program/lead statistician role (3+ years) - Experience with regulatory submissions - Experience representing biostatistics in interactions with health authorities - Fluent with statistical software including SAS, R, EAST, and nQuery - Excellent oral and written communication skills Concerned that you don’t check off every box in the requirements listed above? Please apply anyway! At Agios, we value each other’s differences and recognize that teams thrive when everyone brings their unique experiences to the table. We are dedicated to building an inclusive, diverse, equitable, and accessible environment where all employees can bring their whole selves to work. If you’re excited about this role but your previous experience doesn’t align perfectly with the job description, we still encourage you to apply. You may be just the right candidate for this role or another opening! Work Location: Location Agnostic: Work location for this role is based on employee's individual preference. This role has the ability to be either remote in the US or hybrid in our Cambridge Headquarters. Hybrid schedules vary but are generally less than 3 days per week onsite and hybrid employees are expected to live within commutable distance of our Cambridge Headquarters. Remote employees work entirely from home except for attending Company sponsored events/ meetings. For employees who choose to work remotely, travel may be required for certain company events commensurate with the above job description. What we will give you: - Deliberate Development. Your professional growth as one of our top priorities. - Flexibility. We’re all about individual needs. We embrace different perspectives, work styles, health and wellness approaches, care of families and productivity. When you’re at your best, we’re at our best. - Premium benefits package. We invest in the health, wellbeing, and security of our people with a premium benefits package that is well-rounded and flexible to help meet the varied personal and professional needs of every member of our team. For more detail on the benefits we offer at Agios, visit the Inside Agios section of our website. - Competitive and equitable performance-based compensation. This includes base salary and both short- and long-term incentives that are connected to our business strategy and vary based on individual and company performance. - The current base salary range for this position is expected to be between $183,000 and $275,000 annualized; final salary will be determined based on various factors including, but not limited to, years of relevant experience, job knowledge, skills and proficiency, degree/education, and internal comparators. - Psychological safety. We support an environment of fearlessness. We want you to share your ideas, speak candidly and take data-informed risks to help push the boundaries. - Commitment to diversity. We strive to foster a welcoming workplace where everyone can thrive. We’re continuously looking to improve the inclusivity of our workforce. - Commitment to community. We’re an active participant in the communities that surround us – the communities where we live, and the community of people and their loved ones in need of better treatment options for conditions that are often overlooked.

• Define and execute the scientific vision and R&D roadmap aligned with company milestones • Lead the development of XtRNA Bio’s dual tRNA platform (elevation and suppression modalities) • Translate cutting-edge RNA biology into therapeutic strategies with clinical relevance • Oversee lead preclinical programs in focus indications (tRNA elevation in neuromuscular diseases, particularly CMT2D, and tRNA suppression in respiratory diseases, particularly CF) • Guide optimization of AAV-tRNA constructs, including vector design, capsid selection, and delivery strategies • Drive development of synthetic tRNA delivery systems to the respiratory tract • Supervise in vivo and in vitro studies, including rodent and NHP models, biomarker development, and functional endpoints • Drive IND-enabling studies, including biodistribution, toxicology, and dose-finding • Identify and characterize potential clinical applications of the XtRNA platform • Further develop and optimize our delivery modalities • Engage with relevant academic partners for PoC studies • Develop and nurture a dedicated Scientific Advisory Board • Partner with teams in CMC and vector manufacturing, regulatory and clinical strategy, intellectual property and business development • Align scientific execution with fundraising, partnerships, and corporate milestones • Establish a culture of scientific excellence, rigor, and innovation • Interface with external collaborators, KOLs, and Scientific Advisory Board members • Build, mentor, and inspire a high-performing multidisciplinary R&D team in the long term • Present scientific progress to investors, partners, and scientific conferences • Contribute to publications, patents, and company visibility

• Responsible for designing and executing the US Site Engagement strategy aligned to GSK’s clinical development priorities • Focus on accelerating study start‑up, enrollment, and site performance across Oncology, Respiratory, Vaccines, and other therapeutic areas • Ensures high site performance, proactive engagement, and collaboration across the US • Oversight, management and leadership of the country level activities of the Site Engagement Lead (SEL) • Accountable for successful delivery of clinical trials across all therapeutic areas in both pharma and vaccines • Develop and execute a US site engagement strategy to optimize clinical trial site performance • Translate site landscape intelligence, performance data, and external trends into actionable strategies • Responsible for overseeing growth in site relationships and building GSK’s reputation as a “sponsor of choice” for clinical trial sites • Provide strategic input for operational excellence, process efficiency and trial delivery both internally and externally

• Provides leadership, oversight and manages the activities of local delivery leads (LDLs) • Leads a team of LDLs providing training, coaching, mentoring, and performance management • Responsible for effectively managing capacity utilization of LDL resources and contributes to resourcing solutions • Accountable for ensuring the completion of all project management deliverables for all studies assigned to the LOC • Responsible for identifying and sharing best practices, standardizing across the LOC / region • Recruits and develops LDLs and evaluates capabilities of internal staff • Partners with local and central teams to ensure robust study feasibility • Establishes and manages key strategic relationships with external vendors • Ensures that critical study timelines related to study activities are accurately forecasted and achieved