New Leaders Council

• Define and execute the scientific vision and R&D roadmap aligned with company milestones • Lead the development of XtRNA Bio’s dual tRNA platform (elevation and suppression modalities) • Translate cutting-edge RNA biology into therapeutic strategies with clinical relevance • Oversee lead preclinical programs in focus indications (tRNA elevation in neuromuscular diseases, particularly CMT2D, and tRNA suppression in respiratory diseases, particularly CF) • Guide optimization of AAV-tRNA constructs, including vector design, capsid selection, and delivery strategies • Drive development of synthetic tRNA delivery systems to the respiratory tract • Supervise in vivo and in vitro studies, including rodent and NHP models, biomarker development, and functional endpoints • Drive IND-enabling studies, including biodistribution, toxicology, and dose-finding • Identify and characterize potential clinical applications of the XtRNA platform • Further develop and optimize our delivery modalities • Engage with relevant academic partners for PoC studies • Develop and nurture a dedicated Scientific Advisory Board • Partner with teams in CMC and vector manufacturing, regulatory and clinical strategy, intellectual property and business development • Align scientific execution with fundraising, partnerships, and corporate milestones • Establish a culture of scientific excellence, rigor, and innovation • Interface with external collaborators, KOLs, and Scientific Advisory Board members • Build, mentor, and inspire a high-performing multidisciplinary R&D team in the long term • Present scientific progress to investors, partners, and scientific conferences • Contribute to publications, patents, and company visibility