Title: Scientist 2, Separations and Biophysical Characterization Location: Novato, California Category: Technical Development Job Description: Who We Are BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Our manufacturing and process development teams manage the production of our therapies for clinical trials and commercial markets. These engineers, technicians, scientists, and support professionals continually provide quality assurance and ensure we meet all regulatory standards. We have manufacturing facilities in Northern California and in Cork, Ireland. Additionally, our supply chain teams procure the goods and services needed to support manufacturing and worldwide distribution. About Technical Operations BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. SUMMARY The Analytical Sciences group, part of the Technical Development & Services department at BioMarin Pharmaceutical Inc., is seeking a Scientist 2 for the Separations and Biophysics Assays team. This position will focus on biophysical method development and the characterization of protein-based therapeutics - enzymes, conjugated proteins, peptides, emphasizing biochemical and biophysical characterization of these molecules and their degradation products to support CMC product development across early, late-stage, and commercial assets. This includes structure function relationship, solubility profiles, thermodynamics/kinetics and interactions. The ideal candidate will demonstrate strong motivation, critical thinking abilities, effective communication skills, and experience working successfully in multidisciplinary, fast-paced environments. The candidate will be responsible for developing methods utilizing a range of biophysical techniques, including AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS and other relevant technologies. Responsibilities also include managing sample testing, compiling test results, and effectively summarizing findings. The individual should demonstrate exceptional organizational, analytical, and communication abilities, and exhibit initiative and efficiency while collaborating in a dynamic, team-oriented environment. The ideal candidate will have extensive experience and strong expertise in characterizing proteins, peptides, and other modalities using diverse biophysical and analytical methods. Effective communication with cross-functional teams, proactive problem-solving, and collaboration in multidisciplinary settings are essential. Solid knowledge of protein chemistry and biochemistry is required, along with hands-on experience in CMC development of recombinant biologics, peptide and small molecule therapies, and familiarity with ICH guidelines and regulatory submissions. RESPONSIBILITIES - Manage the development, optimization and implementation of biophysical characterization activities within Analytical Sciences for various protein-based therapeutics and other modalities. - Design and conduct studies independently, including but not limited to assess protein structure, structure function relationship, protein-excipient compatibility, solubility, and binding kinetics and affinities. - Use biophysical methods (AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS) to analyze stability and solution properties for various therapeutics. - Develop and qualify biophysical methods for products from early (pre-clinical) to commercial stages. - Manage CDMO partnerships to implement analytical methods or troubleshoot if necessary. - Troubleshoot and optimize methods. - Provide quantitative analysis and interpretations; prepare protocols, reports, and maintain electronic records for inspections. - Present data regularly to teams and leadership. - Write technical reports summarizing study outcomes. - Handle multiple projects and tight deadlines. - Develop external collaborations to advance departmental capabilities. Required Skills: - In-depth understanding of biophysical methods for protein structure and function, protein chemistry, small molecule or oligo chemistry structure, and function. - Subject matter expertise in biophysical methods using AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS, and other areas such as subvisible particulate characterization, microscopy. - Knowledge in standard liquid chromatography methods (e.g. SEC, IEX, RP-HPLC), capillary electrophoresis (CE, cIEF) and detectors: UV, FLD, CAD, and ELSD. - Experience in phase appropriate analytical development supporting drug substance (DS), drug product (DP) assays and supporting formulation development across both early and late phases. - Collaborative skills to work in a cross-functional environment - Excellent writing skills including experimental documentation - Proven data analysis, interpretation and communication, collaboration and scientific communication skills - Proven flexibility and execution skills to deliver in a fast-paced, multi-tasking environment Desired Skills: - CMC knowledge of pharmaceutical development of proteins, peptides, small molecule, gene therapy and/or oligo products and higher order structure characterization and interpretation of data. - Experience in development of methods, designing of experiments using AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS, and other related technologies - Experience in liquid chromatography using SEC, RPLC and capillary electrophoresis (CE, cIEF). - Excellent project management, verbal/written communication, and interpersonal skills. - Prior management experience with ability to lead, mentor and manage direct reports on a daily basis. EDUCATION PhD degree in Biophysics, Biochemistry, Chemistry or related discipline and minimum 5 years of relevant post graduate experience in the industry. (OR) Master’s degree in biochemistry or chemistry or related discipline and minimum 7 years of relevant post graduate experience in the industry. CONTACTS Will report to Sr. Director, Analytical Sciences. Work Environment Hybrid - would require 2-3 days onsite in Novato, CA Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. Equal Opportunity Employer/Veterans/Disabled An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Role Description The primary responsibilities of this role include leading cross-functional projects to drive scientific innovation and excellence in variant classification, gene-disease validity, computational biology, and clinical data analytics. As a member of the Genomic Science Development team, the variant scientist will evaluate the latest scientific advancements to continuously improve the Ambry Classifi™ program and implement new analytical methods and automation tools. The successful candidate will focus on high impact data-driven outcomes to support business goals. - Rigorous analysis of scientific data, whole genome sequencing results, evaluating external published literature and designing internal validation studies - Leadership of cross-functional groups at the team, department, and enterprise level - Demonstrate scientific expertise in molecular genetics, variant science, and gene-disease validity - Develop innovative technologies, software tools, AI/ML to improve the quality and efficiency of variant, gene, disease, and clinical data curation and classification - Develop robust processes to implement scientific advancements meeting all quality assurance standards and documentation requirements while maintaining operational efficiency - Develop educational training modules and methods to ensure broad adoption of all scientific advancements in a high-throughput laboratory environment Qualifications - Excellent written, verbal, and interpersonal communication skills to engage stakeholders and socialize success - Ability to adapt to significant change that is inherent in development and innovation - Ability to work in and contribute to a fast-paced, highly collaborative environment Requirements - At least 3 years of experience in whole genome sequencing (WGS) case analysis and/or variant classification in either a commercial or clinical laboratory setting - Post-doctoral fellowship preferred - Experience in project, program, and change management preferred Benefits - Compensation: $112,000-$120,000 Privacy Notices - To review Ambry’s Privacy Notice, Click here - To review the California privacy notice, California Privacy Notice | Ambry Genetics - To review the UKG privacy notice, California Privacy Notice | UKG Equal Opportunity Employer. This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.

• Lead and contribute to end-to-end research projects using multimodal physiological and behavioral data • Design rigorous studies and analyses to answer challenging scientific questions • Develop and apply advanced statistical and computational models to answer meaningful health questions • Translate evidence and research insights into actionable product solutions • Build and maintain strong working relationships across Health Science, Data Science, and Product squads • Contribute to external scientific dissemination through abstracts, posters, and peer-reviewed manuscripts • Support literature synthesis and help contextualize findings within current evidence

• Work closely with study leads to design client-facing real-world oncology studies with high quality study protocols and statistical analysis plans • Collaborate with statistical programmers to ensure accurate implementation of analyses in accordance with study specifications • Assist in interpretation and presentation of study findings through study reports and presentations to clients • Contribute to discussions with cross-functional stakeholders, including oncologists and project managers, to execute and deliver on projects in an accurate, effective, and timely manner • Continue to develop your understanding of epidemiological and statistical approaches for analyzing observational real-world data and deepen your understanding of cancer biology, therapies, and outcomes across multiple major tumor types