Executive Director, Medicinal Chemistry remote type Remote locations UK - Home-Based US - Home-Based time type Full time job requisition id R011112 Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit www.jazzpharmaceuticals.com for more information. Job Description The Executive Director, Head of Discovery Chemistry is accountable for the scientific leadership, strategic direction, and operational excellence of small‑molecule drug discovery from target validation through candidate nomination and transition into Early Development. The role ensures the delivery of high‑quality, differentiated molecules across Neuroscience and Oncology programs, integrating medicinal, computational, and AI/ML‑enabled drug design approaches to maximize probability of technical and clinical success.  Essential Functions / Responsibilities  - Serve as global head of Discovery Chemistry with end‑to‑end accountability for small‑molecule discovery programs from hit identification through candidate nomination (Decision Point 0), including discovery formulation and synthesis enablement of transfer to Pharmaceutical Development partners  - Define and execute a Discovery Chemistry strategy aligned with portfolio priorities in Neuroscience and Oncology, emphasizing molecule quality, translation, and long‑term value.  - Ensure rigorous molecular design standards addressing potency, selectivity, CNS exposure where applicable, safety margins, and developability.  - Lead and integrate medicinal chemistry, computational chemistry, and structure‑based design capabilities across internal teams and external partners.  - Oversee state of the art and future-facing disciplined use of AI/ML‑enabled drug design platforms to accelerate design cycles, improve decision quality, and reduce technical risk.  - Ensure quality of due diligence activities within chemistry and discovery domain of corporate development evaluations  - Drive timely and high‑confidence candidate nominations, ensuring transfer and chemistry readiness for IND‑enabling activities.  - Represent Discovery Chemistry at the level of Research and Non-Clinical Leadership Team, Scientific Review meetings, and Early Development Portfolio Review Committee governance forums, and development transition reviews.  - Partner with Neuroscience and Oncology Research, Translational Science, DMPK, Toxicology, CMC, Regulatory, Pharmaceutical Development, and Clinical Development to ensure seamless progression into development.  - Provide executive scientific leadership in external collaborations, alliances, and due diligence evaluations for in‑licensing and M&A opportunities.  - Develop, mentor, and retain senior chemistry leaders, fostering a culture of scientific excellence, accountability, and continuous innovation.  - Manage chemistry contributions to Oncology, Neuroscience new target prioritization working teams and process, ensuring med chem, structural information, tractability tools appropriately integrated into target matrix assessments.  - Ensure Chemistry functional and capacity discipline and continuous improvement  Governance & Portfolio Accountability  - Serve as the Discovery Chemistry representative and accountable leader at Early Development Project Review Committee (EDPRC), Development Project Review Committee (DPRC), and other portfolio governance forums as appropriate.  - Prepare, present, and defend Discovery Chemistry strategies, molecular design rationale, candidate quality attributes, and risk assessments at stage‑gate, portfolio, and governance reviews.  - Ensure the timely escalation of scientific, technical, and resourcing risks related to molecule quality, developability, or program execution to EDPRC, DPRC, and senior R&D leadership.  - Partner closely with Co-CSOs, Therapeutic Area Heads, EDTLs, Project Management, Pipeline Innovation, and functional leaders to enable sound portfolio decision‑making, prioritization, and investment allocation across Neuroscience and Oncology programs.  Required Knowledge, Skills, and Abilities  - Executive‑level Discovery Chemistry leader with extensive progressive experience in medicinal chemistry and small‑molecule drug discovery within pharmaceutical and/or biotechnology organizations.  - Demonstrated track record of pipeline impact, including:  - Multiple high‑quality clinical candidate nominations, and  - Documented contributions to late‑stage development assets and/or approved medicines.  - Deep scientific expertise in medicinal chemistry, lead identification and optimization, and structure‑activity relationships across complex target classes relevant to Neuroscience and Oncology, including CNS‑penetrant small molecules.  - Proven experience establishing and enforcing molecule quality standards, including potency, selectivity, pharmacokinetics, CNS exposure where applicable, safety margins, chemical developability, and differentiation versus standard of care.  - Extensive experience leading and integrating computational chemistry, structure‑based drug design, and AI/ML‑enabled drug discovery approaches, with clear understanding of:  - Model validation and limitations  - Data integrity and provenance  - Appropriate application to decision‑making rather than exploratory novelty.  - Demonstrated ability to balance innovation, speed, and scientific rigor in early discovery environments characterized by uncertainty and evolving targets.  - Successful leadership in global, matrixed discovery organizations, with proven ability to influence outcomes and align diverse functional teams toward common objectives.  - Strong strategic and portfolio‑level thinking, with experience shaping discovery strategy to maximize probability of technical success and long‑term patient and business value.  - Established external scientific credibility, with the ability to engage effectively with academic leaders, industry peers, alliance partners, and key opinion leaders.  - Exceptional communication and influencing skills, capable of translating complex scientific data and trade‑offs into clear, actionable recommendations for senior governance bodies and executive leadership.  - Proven commitment to talent development, succession planning, and inclusive leadership, with a track record of building high‑performing, diverse Discovery Chemistry organizations  - Extensive experience with internal discovery as well as externalized operating models through CROs and biotech partnerships.  Required Experience and Qualifications  Experience  - Extensive progressive experience in medicinal chemistry and small‑molecule drug discovery within pharmaceutical and/or biotechnology organizations.  - Demonstrated success in senior scientific leadership roles (Director, Senior Director, Executive Director, or equivalent), with accountability for strategy, delivery, and organizational performance.  - Proven track record of pipeline impact, including:  - Multiple clinical candidate nominations, and  - Clear ownership of molecule quality and developability through discovery and early development transition.  - Significant experience leading discovery programs in Neuroscience and/or Oncology, including complex target classes and, where applicable, CNS‑penetrant small‑molecule design.  - Extensive experience directing and integrating medicinal chemistry, computational chemistry, and structure‑based drug design capabilities within a matrixed R&D environment.  - Demonstrated ability to lead and govern the validated use of computational chemistry and AI/ML‑enabled drug design tools, with clear understanding of their appropriate application, limitations, and impact on decision‑making.  - Experience representing discovery functions in portfolio governance and decision‑making forums (e.g., research review committees, early development or portfolio review committees).  - Proven ability to lead global, cross‑functional organizations, including mentoring senior leaders, setting performance expectations, and building high‑performing teams.  Education  - PhD in Chemistry (Medicinal Chemistry, Organic Chemistry, or closely related discipline) or equivalent scientific degree required.  Preferred Experience and Qualifications  Experience  - Direct contribution to late‑stage clinical development programs and/or approved medicines.  - Experience leading discovery organizations across multiple therapeutic areas, with depth in both Neuroscience and Oncology portfolios.  - Hands‑on or leadership experience establishing molecule quality bars, including CNS exposure, safety margins, physicochemical optimization, and chemistry readiness for IND‑enabling studies.  - Experience serving as a senior scientific leader in Early Development governance bodies (e.g., EDPRC / DPRC equivalents), including preparation and presentation of stage‑gate and portfolio materials.  - Experience with external collaborations and alliances, including joint governance, CRO strategy, and scientific oversight of external partners.  - Participation in or leadership of scientific due diligence activities for in‑licensing, acquisitions, or strategic partnerships.  - Recognized external scientific credibility, demonstrated through publications, patents, invited presentations, or leadership within the broader discovery chemistry community.  Education and Training  - Postdoctoral training in medicinal chemistry, chemical biology, computational chemistry, or a related discipline.  - Formal or experiential training in computational chemistry, data science, or AI/ML applications in drug discovery.  #LI-JC1 #LI-Remote Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law. The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here: https://careers.jazzpharma.com/benefits

• Directs Billing Management and staff to ensure that authorizations, accurate submission of all claims and timely collections occurs in accordance with all third-party contract terms including, Medicare, Medical, managed care, commercial insurance, and direct patient pay. • Establishes and maintains all billing and financial data, including medical billing code tables, rate schedules and payer information. • Analyzes reimbursement from all sources, including carrier reimbursement exception reporting and follow up pending claims analysis and denials management. • Assures maximization of cash collections through diligent and timely monitoring of all authorizations and open accounts receivable balances. • Maintains and enhances billing policies and procedures for each function in the revenue cycle process and ensures staff adherence to policies. • Prepares detailed analyses and reports of prior authorizations, billing, accounts receivable activity and results, including performance matrixes, bad debt expense and AR days outstanding. • Manages for continuous improvements within the prior authorizations and revenue cycle process. • Effectively interacts with various functional areas and provides mentoring, coaching and performance reviews for direct reports. • Manages all outreach billing operations, including hiring, orientation, training, development, coaching, corrective actions, and ongoing monitoring of all staff work-related activities. • Ensures consistent quality of the billing services by distributing and assigning duties and responsibilities to employees, ensuring skill levels are appropriate to the assigned tasks, and monitoring the department’s productivity. • Leads a high performance team responsible for Prior Authorization Billing Operations. • Provides leadership, drives change, and facilitates process improvements. • Actively collaborates with the RCM (Billing) Finance team on analysis of billing activity for monthly financial reporting, the sales and marketing team of new and existing clients, and senior management on performance and new initiatives. • Participates in the Compliance Committee for Coding and Billing related items; establishes and enforces departmental and company policies and procedures. • Develops and monitors operating procedures and, where necessary, implements changes in workflow to improve productivity. • Drafts accurate budgeting and forecasting of headcount and cash receipts.

• Provides strategic leadership and operational oversight for the Delivery Management group • Ensures seamless execution of client-facing projects and services • Oversees project planning, resource management, risk mitigation, and operational excellence • Establishes and implements best practices for delivery management • Leads execution and delivery of multiple global projects • Develops innovative network solutions tailored to clients' needs • Optimizes global resource allocation and workforce planning • Drives continuous improvement efforts to enhance the client experience

Role Description The Scientific Director, Neuro-therapeutics will serve essentially as the early Compound Development Team Leader (eCDTL) for VRI’s second therapeutic program. In this capacity, you will convene and lead a cross-functional team of internal and external experts — spanning bioinformatics, therapeutic design, in vitro biology, in vivo pharmacology, manufacturing, and regulatory affairs — and be accountable for driving the program forward across all of those disciplines simultaneously. This role reports to the Chief Scientific Officer and works in close coordination with VRI’s Executive Director and program leads. What You'll Own - Scientific Strategy & Target Selection - Lead target identification and sequence prioritization for VRI’s therapeutic program, including known causative genes and emerging targets relevant to the disease biology. - Determine therapeutic modality — ASO vs. siRNA, backbone chemistry, modification strategy — with scientific rationale grounded in both biology and practical development considerations. - Evaluate sequence candidates, apply scoring frameworks, and converge on lead molecules most likely to succeed in CNS delivery. - Define Plan B and Plan C candidate strategies to ensure program progress is never contingent on a single compound. - Translate target biology insights into actionable design criteria for the synthesis and screening pipeline. - Oligonucleotide Design & Candidate Advancement - Provide scientific direction for ASO and siRNA design, guiding vendor partners and internal scientists on backbone chemistry, modification strategy, and design tradeoffs. - Lead design reviews, evaluate screening data, and make candidate advancement and termination decisions in coordination with the CSO. - Assess in vitro and in vivo datasets against advancement criteria, identifying signal from noise and recommending next steps. - Stay current on the relevant oligonucleotide literature and competitive landscape, flagging findings that should influence VRI’s strategy. - In Vitro & In Vivo Oversight - Define the scientific questions that in vitro campaigns must answer, including cell-based assays, disease-relevant neuronal models, and functional readouts appropriate to the target biology. - Evaluate in vivo study designs for scientific rigor and IND-relevance; interpret results in context of regulatory requirements. - Provide scientific oversight to external labs and CROs on study design and endpoint validity. - Manufacturing Oversight - Oversee manufacturing of ASO and siRNA candidates, ensuring designs meet research-scale synthesis requirements and can be scaled appropriately toward GMP production. - Bring CMC awareness to program planning, anticipating manufacturing constraints that could affect IND timelines. - Regulatory & IND Scientific Input - Own the scientific content of the IND package: nonclinical study rationale, pharmacology and toxicology summaries, and the scientific narrative that ties target biology to clinical hypothesis. - Make or delegate all scientific judgment calls required for IND sections; what data is sufficient, what gaps require additional studies, and what the FDA will scrutinize on the nonclinical side. - Ensure all nonclinical studies are designed and executed in alignment with IND-enabling standards and FDA expectations for rare disease therapeutics. - Engage with expedited regulatory pathways (Fast Track, Orphan Drug, Expanded Access) as appropriate, and maintain contingency pathway awareness across alternative jurisdictions. Qualifications - Advanced degree (PhD or equivalent) in medicinal chemistry, biochemistry, molecular biology, or a related field. - Direct involvement in oligonucleotide drug development like ASOs, siRNAs, or closely related modalities. - Expertise with oligonucleotide modalities including gapmers, SSOs, siRNA, and saRNA. - Demonstrated experience leading or coordinating cross-functional drug development work, including managing external partners toward shared milestones. Requirements - Direct involvement in IND-enabling programs. - CNS delivery expertise: intrathecal delivery, CNS tissue distribution, and the design implications of targeting the central nervous system with oligonucleotides. - Experience with disease-relevant in vivo models and familiarity with what meaningful efficacy readouts look like in the context of CNS neurodegeneration. - Computational fluency: comfort using bioinformatics tools and sequence design platforms as a normal part of scientific work. - Experience with expedited regulatory pathways (Fast Track, Orphan Drug, Expanded Access) in a rare disease context. Benefits - Competitive compensation based upon experience, qualifications, and role scope. - Full suite of benefits.