• Provides strategic leadership and operational oversight for the Delivery Management group • Ensures seamless execution of client-facing projects and services • Oversees project planning, resource management, risk mitigation, and operational excellence • Establishes and implements best practices for delivery management • Leads execution and delivery of multiple global projects • Develops innovative network solutions tailored to clients' needs • Optimizes global resource allocation and workforce planning • Drives continuous improvement efforts to enhance the client experience

Role Description The Scientific Director, Neuro-therapeutics will serve essentially as the early Compound Development Team Leader (eCDTL) for VRI’s second therapeutic program. In this capacity, you will convene and lead a cross-functional team of internal and external experts — spanning bioinformatics, therapeutic design, in vitro biology, in vivo pharmacology, manufacturing, and regulatory affairs — and be accountable for driving the program forward across all of those disciplines simultaneously. This role reports to the Chief Scientific Officer and works in close coordination with VRI’s Executive Director and program leads. What You'll Own - Scientific Strategy & Target Selection - Lead target identification and sequence prioritization for VRI’s therapeutic program, including known causative genes and emerging targets relevant to the disease biology. - Determine therapeutic modality — ASO vs. siRNA, backbone chemistry, modification strategy — with scientific rationale grounded in both biology and practical development considerations. - Evaluate sequence candidates, apply scoring frameworks, and converge on lead molecules most likely to succeed in CNS delivery. - Define Plan B and Plan C candidate strategies to ensure program progress is never contingent on a single compound. - Translate target biology insights into actionable design criteria for the synthesis and screening pipeline. - Oligonucleotide Design & Candidate Advancement - Provide scientific direction for ASO and siRNA design, guiding vendor partners and internal scientists on backbone chemistry, modification strategy, and design tradeoffs. - Lead design reviews, evaluate screening data, and make candidate advancement and termination decisions in coordination with the CSO. - Assess in vitro and in vivo datasets against advancement criteria, identifying signal from noise and recommending next steps. - Stay current on the relevant oligonucleotide literature and competitive landscape, flagging findings that should influence VRI’s strategy. - In Vitro & In Vivo Oversight - Define the scientific questions that in vitro campaigns must answer, including cell-based assays, disease-relevant neuronal models, and functional readouts appropriate to the target biology. - Evaluate in vivo study designs for scientific rigor and IND-relevance; interpret results in context of regulatory requirements. - Provide scientific oversight to external labs and CROs on study design and endpoint validity. - Manufacturing Oversight - Oversee manufacturing of ASO and siRNA candidates, ensuring designs meet research-scale synthesis requirements and can be scaled appropriately toward GMP production. - Bring CMC awareness to program planning, anticipating manufacturing constraints that could affect IND timelines. - Regulatory & IND Scientific Input - Own the scientific content of the IND package: nonclinical study rationale, pharmacology and toxicology summaries, and the scientific narrative that ties target biology to clinical hypothesis. - Make or delegate all scientific judgment calls required for IND sections; what data is sufficient, what gaps require additional studies, and what the FDA will scrutinize on the nonclinical side. - Ensure all nonclinical studies are designed and executed in alignment with IND-enabling standards and FDA expectations for rare disease therapeutics. - Engage with expedited regulatory pathways (Fast Track, Orphan Drug, Expanded Access) as appropriate, and maintain contingency pathway awareness across alternative jurisdictions. Qualifications - Advanced degree (PhD or equivalent) in medicinal chemistry, biochemistry, molecular biology, or a related field. - Direct involvement in oligonucleotide drug development like ASOs, siRNAs, or closely related modalities. - Expertise with oligonucleotide modalities including gapmers, SSOs, siRNA, and saRNA. - Demonstrated experience leading or coordinating cross-functional drug development work, including managing external partners toward shared milestones. Requirements - Direct involvement in IND-enabling programs. - CNS delivery expertise: intrathecal delivery, CNS tissue distribution, and the design implications of targeting the central nervous system with oligonucleotides. - Experience with disease-relevant in vivo models and familiarity with what meaningful efficacy readouts look like in the context of CNS neurodegeneration. - Computational fluency: comfort using bioinformatics tools and sequence design platforms as a normal part of scientific work. - Experience with expedited regulatory pathways (Fast Track, Orphan Drug, Expanded Access) in a rare disease context. Benefits - Competitive compensation based upon experience, qualifications, and role scope. - Full suite of benefits.

• Articulate the value of the Tanium platform to decision makers and expertly manage the complex sales cycle • Nurture and develop relationships within the assigned territory and/or accounts, presenting to the C-suite the value of the Tanium platform • Work with the Partner and Marketing teams to define and support prospecting and sales efforts within assigned territory and/or accounts • Generate appropriate sales development activity to ensure healthy pipeline management • Accurately forecast, maintaining excellent SFDC hygiene • Conduct online webinars or in-person presentations to generate qualified leads • Travel as needed

• Lead AI vision-setting engagements with top energy accounts, advising CEOs and executive teams on strategic adoption and impact. Cultivate and maintain executive-level relationships with customers, partners, and key industry stakeholders across the EMEA region. • Lead the strategic and operational execution of GTM initiatives across the energy sector in EMEA, including oil and gas, power and utilities, renewables, and mining. Drive pipeline growth and accelerate customer adoption. Define, track, and report on key performance indicators (KPIs) for GTM initiatives, continuously refining plans based on data and field insights. • Build strong alignment with EMEA sales, field engineering, marketing, partnerships, and product teams. Develop and execute industry-specific GTM programs that convert market opportunity into revenue. • Develop and deliver thought leadership through industry publications, conferences, and executive briefings to position Databricks as the platform of choice for the industry. Provide ongoing analysis of market trends, competitive dynamics, and customer needs to sharpen our industry strategy and identify high-value growth opportunities. • Travel regularly to support customer meetings, executive engagements, and industry events.