Calyxo, Inc. is a medical device company headquartered in Pleasanton, California, USA. The company was founded in 2016 to address the profound need for improved kidney stone treatment. Kidney stone disease is a common, painful condition that consumes vast amounts of healthcare resources each year. Our team is led by executives and investors with a proven track record of commercializing paradigm-shifting devices to meet unmet needs within urology. Are you ready to change the future of kidney stone treatment? We are seeking high achievers who want to be part of a dynamic team working in a fun, diverse atmosphere. Summary: Reporting to the Regional Sales Manager, the Territory Sales Manager for our Seattle/Boise territory will live in or around the Seattle or Boise area. This position will drive high CVAC adoption among physicians while meeting or exceeding the monthly and quarterly sales quotas for this territory. This role will effectively communicate CVAC’s value proposition to new and existing customers and will qualify, train, assess, and develop accounts to adopt our technology as an integral part of their kidney stone practice. This role will represent Calyxo with honesty, integrity, and unwavering business ethics. The ideal candidate will be disciplined and have experience conducting product demonstrations. This candidate should be comfortable with frequent travel and be able to generate new sales leads on a regular basis. The candidate should be able to keep track of their sales and effectively communicate with other team members while out in the field. Responsibilities: - Meet or exceed quarterly sales quota for the defined area. - Maintain a monthly and quarterly territory plan that outline territory sales objectives and areas of vulnerability. - Provide monthly forecasts for defined area. - Effectively communicate the value proposition of Calyxo products to customers. - Qualify, train, assess, and develop accounts to adopt Calyxo products as an integral part of their kidney stone practice with the goal of demonstrating high account adoption. - Communicate current market conditions and recommend improvements to the commercial process. - Partner with Professional Education to deliver outstanding clinical and training support to ensure physicians quickly become clinically independent. - Build and maintain relationships with key customers and KOLs within defined region. - Partner closely with the Regional Sales Manager, Sales team, and Marketing team to identify and prioritize customers for higher-level corporate relationships. - Partner with the Customer Service team to meet and exceed customer expectations. - Partner with the Regional Sales Manager and Finance team to ensure all required sales reporting forms are completed and submitted on time. - Provide support for the resolution of product complaints and/or safety issues. - Proactively support organizational goals and objectives, policies and procedures, Good Manufacturing Practices, and FDA regulations, including strict compliance with Calyxo’s Customer Relationship and the Sunshine Act policies. - Maintain a professional and credible image with key physicians, consultants, suppliers, and teammates. - Establish and maintain credentials (via RepTrax, Vendormate, etc) to enter and work in hospitals and other medical facilities as required by facility requirements. - Manage travel and expenses per approved budget. - Perform other duties as assigned. - Contribute to our culture of being collaborative, respectful, transparent, ethical, efficient, high- achieving, and fun! Qualifications: - Education: Bachelor’s degree or equivalent experience - 5+ years of outside sales/sales management experience. Medical device experience preferred - Strong track record of over-delivering revenue versus sales plan - Proficient in navigating and accelerating hospital and ASC product approval processes - Operating room experience required - Thorough knowledge of urology and urology products and strong relationships with local urologists highly desired - Successful track record of launching new and disruptive technologies and well-versed and proficient in complex reimbursement environments - Understanding of the treatment algorithm for patients with kidney stones preferred - Compliance with relevant vaccination county, state, and federal rules At Calyxo, you will be part of a knowledgeable, high-achieving, experienced and fun team. You will work in a diverse work environment with experienced, proven leaders and have an opportunity to shape our company culture. You will experience constant learning and dynamic challenges to help you grow and be the best version of yourself. We also offer a competitive compensation package as follows: - Base salary of $120,000 and variable compensation of $140,000 annualized - Stock options – ownership and a stake in growing a mission-driven company - Employee benefits package that includes 401(k), healthcare insurance and paid vacation Calyxo is deeply committed to fostering an environment where diversity and inclusion are not only valued but also prioritized. We believe a diverse and inclusive community empowers us to act courageously, care deeply, and dream boldly to impact people in big ways. Diverse viewpoints bring diverse capabilities, which strengthen our focus and fuel our growth. Calyxo is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify their identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. Disclaimer: At Calyxo, we prioritize a transparent and structured interview process to ensure the best fit for both our candidates and our team. Please be aware of the following: - Structured Interview Process: Our hiring process includes multiple stages of interviews where you will have the opportunity to communicate directly with Calyxo employees. This ensures that you gain a comprehensive understanding of the role and our company culture. - Verification of Identity: We do not extend job offers without first meeting candidates, either virtually or in person. This step is crucial to maintain the integrity of our hiring process and to ensure mutual alignment. - Beware of Scams: Calyxo will never request sensitive personal information, such as your full name, address, phone number, or identification documents, via email or online forms before an official interview. Calyxo representatives will always contact you using an email format of firstname.lastname@calyxoinc.com. If you receive a request for information from any other domain, please contact us directly at info@calyxoinc.com to verify the legitimacy of the communication. We appreciate your interest in joining Calyxo and look forward to getting to know you through our official channels.

• Translate a project contract into an actionable scope of work for teams to execute. • Understand and prioritize problems to be solved, and adapt effectively as context shifts. • Foster shared definitions of outcomes and success, even as conditions change or new information emerges. • Help teams develop a shared sense of how different parts (people, process, tech) can work together to meet project goals and deliver concrete value. • Use qualitative and quantitative data to inform product decision-making. • Make sure tasks or milestones deliver value to users and meet client and contractual needs. • Use agile methodologies to build momentum, show progress, and learn continuously. • Create clarity, accountability, and structure that enable a team to deliver. • Build trust with the team, ensuring they understand roles, expectations, and deadlines. • Set appropriate expectations and be accountable for the quality of project work. • Align diverse experiences and cross-functional teams around shared goals. • Facilitate well-run meetings and clear asynchronous communication. • Establish collaboration norms that prioritize openness, resilience, and clarity. • Give kind, candid, and constructive feedback to colleagues and clients. • Create a team environment in which people with diverse skills and styles can thrive together, supporting teammates through navigating differences productively. • Communicate effectively with stakeholders and clients about what to expect and when. • Plan and work in the open, sharing work and methodology as widely as possible. • Empower clients through collaboration and deliverables that meet them where they are. • Build trust with clients and stakeholders by translating between different perspectives, navigating misalignment, and enabling decision-making. • Guide teams and clients through key decisions and blockers.

• Serve as the primary advisor to Sales and Customer Success on deal structure, pricing, discounting, and contract terms — especially for complex, non-standard, or enterprise opportunities. • Review and approve deals against internal pricing policies and booking guidelines, ensuring compliance without sacrificing deal velocity • Partner with Sales and Customer Success through the full deal cycle, from initial scoping through close, to shape smart, scalable commercial terms • Act as the escalation point for deal exceptions, offering clear guidance on alternatives and tradeoffs • Build and own AssetWatch's deal desk workflows, approval frameworks, SLA standards, and discount authorization matrices • Drive continuous improvement of the quote-to-cash process in Salesforce and CPQ tools, reducing friction and improving data quality • Develop and maintain a deal desk playbook, contract templates, and booking guidelines tailored to AssetWatch's hardware + SaaS subscription model • Ensure deal data is clean, complete, and structured to support downstream billing, revenue recognition, and forecasting • Partner closely with Finance on revenue recognition, order accuracy, and period-close processes • Develop a set of booking guidelines and policies that balance speed and agility with the need for audit-ready, repeatable revenue measurement • Collaborate with Legal on contract redlines, MSAs, and non-standard commercial terms • Work with RevOps to improve tooling, reporting, and deal desk KPIs (cycle time, discount trends, exception rates) • Provide Sales leadership with regular visibility into deal health and commercial patterns

About Apogee Therapeutics Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally. Apogee Therapeutics is a clinical-stage biotechnology company advancing novel biologics with potential for differentiated efficacy and dosing in the largest I&I markets, Apogee’s antibody programs are designed to overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. Zumilokibart (APG777), the company’s most advanced program, is being initially developed for the treatment of atopic dermatitis (AD), which is the largest and one of the least penetrated I&I markets, as well as asthma. With four validated targets in its portfolio, Apogee is seeking to achieve best-in-class efficacy and dosing through monotherapies and combinations of its novel antibodies. Based on a broad pipeline and depth of leadership and expertise, the company believes it can deliver value and meaningful benefit to patients underserved by today’s standard of care. We are a fast-paced company committed to building an exceptional culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless and a commitment to refusing to stop at “good enough”. If this sounds like you, keep reading! Role Summary We are seeking a Clinical Trial Manger (CTM) to join our growing Clinical Operations team! In this newly created role, you will be accountable for the operational management and execution of global clinical trial programs (Phases I-III). You will be responsible for ensuring adherence to GCPs, SOPs and all regulatory agency guidelines, as well as study operational planning and execution. A key focus is partnership with CROs and other 3rd party vendors to oversee and ensure study milestones and deliverables are achieved according to agreed quality standards and timelines, and that the quality of data is suitable for regulatory submission/inspections. You will have visibility and regular interaction with key internal and external stakeholders communicating project status, escalating issues, and troubleshooting routine inquiries. Key Responsibilities - Oversee study scope, quality, timelines, and budget with the internal functional leads, CRO, and vendors to ensure overall project objectives are met - Initiate and build strong relationships with key opinion leaders and clinical site staff - Partner with the CRO to ensure robust patient enrolment strategies are developed and effectively implemented, on time and within budget for assigned regions - Partner with the CRO to ensure robust ongoing data monitoring strategies are developed and effectively implemented to ensure delivery of high-quality data - Proactively identify and manage study related risks - Develop and manage clinical trial documents, including but not limited to protocols, Case Report Forms (CRFs), and consents - Review and manage study related plans and processes including Investigator agreements (CTA), site budget review, CRFs, CRF guidelines, Statistical Analysis Plans, Pharmacokinetic Analysis Plans, Monitoring plan, Data Management Plan, and Safety Monitoring Plan - Collaborate with Regulatory/CRO team members to assist with completion/review of regulatory submissions - Review CRO and vendor contracts/work orders and specifications to align with study objectives - Review specifications for systems build and participate in User Acceptance Testing (UAT) (eg, IRT, eCOA, EDC) - Participate in data cleaning and manage database lock activities with cross functional team - Oversee review and approve essential document packages to enable timely site activations - Direct investigator performance and adherence to protocol, and proactively addresses conduct issues and enrollment problems, as necessary - Participate in TMF review and ensure quality and completeness throughout end of the study - Ensure the study is always “inspection ready” - Oversee and coach the functional activities of Clinical Trial Associates allocated to the project Ideal Candidate - Bachelor’s degree in life science or equivalent - Minimum of 5 years of clinical trial management experience in conducting international clinical trials in a Sponsor Pharma/Biotech organization. Biotech experience strongly preferred. - Prior phase II and III experience required - A solid understanding of the drug development process, ICH guidelines/GCP and specifically, each step within the clinical trial process - Proven proficiency in overseeing complex studies being managed in house and by a CRO - Demonstrated ability to lead teams and work in a fast-paced, cross functional environment, and able to think critically and creatively - Experience selecting and managing clinical vendors to support study activities - Enjoys building relationships with KOLs and site personnel - Demonstrated ability to build and deliver on patient enrolment strategies - Demonstrates innovation, possesses drive, energy, and enthusiasm to deliver the program objectives - Demonstrated ability to review and comprehend complex scientific concepts and clinical data - Strong planning, time management, and coordination skills - Demonstrated ability to problem solve and use clear judgment in relation to regulatory requirements, interactions with external parties, timelines, and complex clinical programs - Excellent written and oral communication skills - Position requires up to 35%travel, including mandatory in-person attendance at Apogee All Hands meetings typically held twice per year. Travel is also required to attend key Phase 3 meetings, typically held at the Apogee San Francisco office. This position may also require US and international travel to clinical sites and/or medical conferences. The anticipated salary range for candidates for this role will be $145,000- $160,000 per year. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. What We Offer - A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless - Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly - Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits - We provide competitive time off, including three weeks PTO, two one-week company-wide shutdowns a year and dedicated paid sick leave - Commitment to growing you professionally and providing access to resources to further your development - Apogee offers regular all team, in-person meetings to build relationships and problem solve E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster. Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law. To review our privacy policy, click here It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.