This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description Iovance is seeking a Health Economic Value Access (HEVA) Director as a part of the US Market Access function to develop and translate economic evidence into value-based messaging and pricing. This individual will understand payer, hospital, and provider clinic evaluation and financial feasibility to support the US Payer field team with pre-approval market readiness (FDAMA 114), cost of care/site of care, and cost-effectiveness for our key formulary decision makers. - Partner with Policy and Payer Marketing on engagement strategy with external partners and formulary decision-makers. - Build and drive the US value proposition story for AMTAGVI and pipeline therapies. - Incorporate health economics, business analytics, and competitive intelligence into the development of innovative strategies. - Lead development and maintenance of formulary submission packages and economic modeling analyses. - Support field-based cross-functional teams to provide pharmacoeconomic expertise in access engagements. - Compliantly manage operations of Iovance Pricing Committee. - Assess clinical and economic data gaps at key accounts and collaborate with internal stakeholders. - Support Market Access Account team(s) with Payer and Formulary Decision Makers at key congresses. - Work cross-functionally as a liaison with brand teams to ensure alignment within the Market Access team. - Partner with Commercial Strategy on Market Readiness and value evidence creation. - Assist on pipeline products and indications to generate key evidence and value proposition. - Provide strategic support and clinical-economic content expertise in innovation and partnership opportunities. - Operate at the highest level of compliance and professional standards. - Serve as internal point of contact for all health care economic policy. - Travel required, including overnights and some weekends (up to 20%). Qualifications - Advanced Degree in Health Economics, Public Health, Economics, or related field. - 12 plus years of experience in Healthcare or Pharmaceutical Industry with a focus on health economics and market access. - Strong background/experience in pharmacoeconomic, cost-effectiveness, HEOR, and payer interactions. - Strong analytical and qualitative skills, with experience in developing economic models and analyzing real-world data. - Proven ability to develop and maintain relationships with key decision-makers in the US healthcare/economics ecosystem. - Experience in assessing and analyzing clinical and HEOR data gaps. - Must be a strong team player and effectively interface with other internal departments. - Excellent communication and presentation skills. - Strategic thinking and decision-making abilities. - Ability to take initiative and work both independently and in a team environment. Requirements - Doctorate degree (PharmD, MD, DO or PhD) preferred. - Cell therapy, Hematology/Oncology experience preferred. Physical Demands and Activities Required - Must be able to remain in a stationary position standing or sitting for prolonged periods of time. - Must be able to move about inside an office and exert up to 10 pounds of force occasionally. - Must have visual acuity to perform activities such as preparing and analyzing data. - This position requires repetitive motion and substantial movements of the wrist, hands, and/or fingers. - Must be able to communicate with others to exchange information. Mental - Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem-solving, analysis, and discretion. - Ability to handle work-related stress and multiple priorities simultaneously. - Ability to meet deadlines. Work Environment This job operates in a professional workplace or remote office environment and requires standard office equipment and keyboards. Employees who work remotely are expected to maintain their workspace and environment safely and free from safety hazards.

• Lead the global strategy, governance, and performance management of the supplier quality program • Ensure that all external suppliers, CMOs, and contract laboratories meet regulatory, quality, and business requirements • Shape the global supplier quality strategy to align with corporate and quality objectives • Develop and maintain governance models and performance frameworks for supplier oversight across all regions • Oversee processes for tracking, monitoring, and communicating supplier-related risks to Quality, Compliance, and Global • Provide strategic oversight of global audit planning, execution, and follow-up for suppliers, CMOs, and contract labs • Lead response and escalation processes for supplier deviations, OOS, critical defects, and supply-related disruptions • Oversee the ongoing optimization within Master Control Supplier Quality and drive implementation of digital tools for supplier monitoring

• Own Upstart’s branded media and sponsorship strategy from annual planning through in-market optimization. • Lead TV and top-of-funnel media buying, including partner selection, negotiation, budgeting, flighting, and performance evaluation. • Develop and manage strategic brand partnerships, sponsorships, and integrations that extend Upstart’s reach and reinforce brand credibility. • Develop and execute branded activations in partnership with digital, creative, and external partners, ensuring alignment with brand and business goals. • Partner closely with Analytics to define measurement frameworks for brand media, including incrementally testing, lift studies, MMM inputs, and attribution approaches. • Collaborate with Creative and Product Marketing to translate brand strategy into effective media executions and partner activations. • Scale significant annual brand media budgets, balancing reach, frequency, and efficiency while adapting to performance signals and market conditions. • Establish best practices for brand media planning, buying, and measurement as Upstart continues to scale upper-funnel investment.

• Partner with the Mission System business leaders to understand their most important requirements • Help drive appropriate improvement strategies based on current opportunities outlined in Mission Systems Goal Alignment • Work and mentor with a team of selected Operational Excellence Leaders to set short term and long-term goals and objectives for Mission Systems ( MiS ) CORE & Lean maturity • Partner with Missions Engineering and Quality Team members, Operational Excellence Leaders as a change agent on execution of key initiatives to achieve operational results • Lead teams to resolve critical problems that involve consideration of multiple variables across multiple sites/organizations including customers and suppliers • Explain policies, practices, and procedures and influence others • Provide functional knowledge and maintain insight to current industry standard methodologies and how they can be applied • Coach plant leadership to implement the Lean Operating System and assist Operations leaders to develop self- sufficiency within sites • Positively affect KPI change, including, but not limited to: Lead Time (Days to Manufacture) decreases, On Time Start increases, Productivity increases, SRR Reduction, Schedule Stabilization improvement, Inventory reduction/optimization, Percent of parts with a Plan for Every Part