Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS). Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply. The Opportunity We are seeking an experienced Senior Manager, Contracts to help refine and scale our contracting operations as we prepare for a potential drug launch. This role will own the full contract lifecycle process—from intake and template selection through negotiation support, execution, and post execution management. This is a highly visible, customer service oriented role that will serve as the internal subject matter expert and trainer for Amylyx’s contract lifecycle management system (CLMS). The ideal candidate will have a strong background in contract management within the life sciences, biotech, or pharmaceutical industry and thrive in a fast moving, evolving environment. Responsibilities Optimize and implement contracting processes and best practices , ensuring efficient workflows, compliance, and continuity across teams. Manage end-to-end contract lifecycle for a broad set of contracts, e.g. services, confidentiality, research collaborations, and other commercial or operational contracts. Maintain the contract management system and repository , including metadata accuracy, key date tracking, renewal management, obligation monitoring, tags, parties and reporting. Partner closely with internal stakeholders (Legal, Compliance, Finance, Procurement, Clinical, Commercial, and other business partners) to ensure contract terms align with business and compliance needs. Develop, update, and maintain contract templates and playbooks in partnership with Legal advisors. Develop and maintain CLMS training materials and provide new hire and refresher training sessions as well as ad hoc support. Establish and track contracting KPIs , dashboards, and metrics to provide visibility into system performance and contracting volume. Partner with the IT Administrator to drive continuous contracting process improvements , including identifying opportunities to streamline workflows through automation and the use of Artificial Intelligence tools. Required Qualifications Preferred Qualifications Experience with LinkSquares contract lifecycle management system. Demonstrated experience applying AI tools to contract review or process optimization. Industry experience in biotech, pharma, or life sciences . Work Location and Conditions At Amylyx, we proudly support remote work opportunities within the United States. However, due to business considerations related to health insurance coverage and state tax regulations, we are unable to hire employees who reside and/or work in certain states. Currently, we are not considering applicants from Alaska, Arizona, Hawaii Michigan and Tennessee. You will be expected to travel to our corporate location in Cambridge, MA several times a year and attend other company-related events as necessary and requested. You must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.) at your remote location. Compensation The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity. Estimated Pay Range $146,000 — $164,000 USD To stay connected with us, follow Amylyx Pharmaceuticals on LinkedIn. To return to our website please click here. Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know. It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

• Lead federal pursuit strategy, including pre-positioning, capture planning, opportunity evaluation, and Go/No-Go decision support. • Manage end-to-end proposal development for federal opportunities of varying size and complexity, from capture through submission and presentation. • Establish proposal strategies, themes, and win messaging aligned with solicitation requirements and corporate differentiators. • Plan and lead proposal activities and reviews, including kickoff meetings, strategy sessions, color reviews, and final production. • Ensure proposal compliance and quality through solicitation analysis, compliance matrices, reviews, and final submission oversight. • Coordinate technical teams, proposal staff, and subconsultants to deliver cohesive, single-voice submissions. • Allocate proposal resources, forecast workload, and mentor proposal coordinators and contributors. • Participate in client debriefs and lessons-learned activities to continuously improve pursuit and proposal outcomes. • Lead federal marketing initiatives that support business development, brand visibility, and client engagement within the federal market sector. • Collaborate with corporate marketing and partner firms to execute coordinated federal marketing, branding, and communication efforts. • Oversee development and maintenance of federal marketing collateral, including website content, capability statements, presentations, and pursuit-related materials. • Ensure marketing materials are accurate, compliant, and aligned with corporate brand standards. • Support opportunity identification and pursuit development through market intelligence and competitor research. • All other duties as required.

• Oversee the Meadows Institute’s RFP capture, proposal development, and funding lifecycle workflows, ensuring disciplined coordination from opportunity identification through submission and post-award stewardship. • Coordinate early-stage RFP capture activities, including requirements analysis, timeline development, role clarity, and go/no-go support, in close partnership with program teams and Strategic Growth leadership. • Provide oversight to ensure proposals, service contracts, and related deliverables are completed on time, at high quality, and in alignment with institutional priorities. • Oversee post-award funding lifecycle activities, including reporting, renewals, and stewardship deliverables, to ensure funder requirements are met and obligations are fulfilled reliably. • Lead and manage a team of Funding Lifecycle Managers and a Senior Editor that work in close partnership with program teams and major gift officers, creating consistent, trusted working relationships. • Set clear expectations, workflows, and performance standards for the team, fostering accountability, collaboration, and continuous improvement. • Work closely with program team leads to support the translation of programmatic expertise into clear, compelling proposals and funding reports. • Routinely assess RFP capture, proposal development, and funding lifecycle workflows to identify inefficiencies, bottlenecks, and opportunities for improvement. • Partner with the SVP of Strategic Growth to recommend refinements to workflows, templates, roles, and service models as the Strategic Growth function evolves. • Ensure proposals, reports, and funding-related deliverables reflect consistent messaging, structure, and quality across the Institute. • Monitor proposal volume, RFP activity, deadlines, team capacity, and post-award obligations.

• Lead the administrative and organizational aspects of the proposal development process for federal, state, and local government opportunities. • Work closely with Capture Managers, Proposal Managers, and the Proposal Production Team to ensure compliance with Request for Proposal (RFP) requirements. • Analyze RFPs, RFIs, and RFQs, and develop compliance matrices, annotated outlines, and structured templates. • Maintain strict document version control and ensure compliance throughout the proposal lifecycle. • Coordinate color team reviews (Pink, Red, Gold), production phases, and submission deadlines. • Contribute to and monitor proposal schedules to ensure workflows align with submission due dates. • Ensure adherence to page limits, template standards, branding requirements, and corporate document style guides. • Manage final quality checks, PDF optimization, and file naming conventions.