Role Description We are seeking a Vice President, Head of Data Science & Biostatistics to provide strategic and operational leadership for data sciences across late-stage clinical development for multiple Phase 3 gene trials as well as early stage clinical studies focused on neuromuscular and cardiac diseases. This role will partner cross-functionally to ensure the integrity, rigor, and translational value of clinical data, enabling decisive regulatory, clinical, and commercial outcomes. This leader will oversee a team of biostatisticians and serve as the accountable executive for statistical strategy, data science innovation, and biostatistics integration across clinical programs. The VP will play a critical role in advancing registrational studies, regulatory filings, and lifecycle management while building scalable capabilities to support commercialization and post-marketing evidence generation. Reporting to the Chief Medical Officer, the role will be flexible based on location and alignment with the CMO. Key Position Responsibilities - Define and execute the company’s data science, biostatistics, and biostatistics strategy aligned to Phase 3 execution and regulatory success. - Serve as a core member of the Clinical Leadership Team and partner with the CMO on clinical strategy. - Lead statistical design and execution of Phase 3 trials, including SAPs, protocols, and interim analyses. - Ensure compliance with GCP, ICH guidelines, and regulatory expectations. - Support regulatory submissions (BLA/MAA) and health authority interactions. - Integrate biost and multi-omics data into clinical development. - Advance modern data science approaches, including modeling and AI/ML where appropriate. - Lead and develop a team of 4 biostatisticians. - Lead and develop a team of 3 database managers. - Manage CROs and external partners. - Partner cross-functionally across Clinical, Regulatory, Medical Affairs, and Commercial. Qualifications - Master’s degree or higher in Biostatistics, Statistics, or related field. - 15+ years in biotech/pharma with late-stage clinical experience. - Proven success supporting regulatory submissions and FDA/EMA interactions. - Experience in gene therapy, rare disease, or neuromuscular/cardiac indications preferred. - Expertise in clinical trial design, statistical methods, and regulatory standards. - Strong leadership and communication skills. Key Position Attributes - Strategic Judgment with Clinical Impact: Translates complex data into clear, decision-ready insights and anticipates risks in trial design, endpoints, and data interpretation. Balances scientific rigor with speed in a late-stage environment. - Executive Communication & Influence: Distills statistical complexity into concise messaging for the CMO, ELT, and Board; effectively represents the company with regulators and external stakeholders. - Ownership & Accountability: Operates as the single point of accountability for statistical strategy and data integrity; drives critical milestones with urgency and accountability. - Hands-On Leadership in a Lean Environment: Functions as a player-coach, willing to engage deeply in technical work while leading a small, high-impact team and prioritizing effectively. - Talent Development & Team Leadership: Builds, mentors, and retains a high-performing team of biostatisticians; elevates technical rigor, communication, and execution standards. - Cross-Functional Integration: Seamlessly integrates clinical, biostatistics, and translational data; aligns stakeholders across Clinical, Regulatory, and Technical functions. Compensation The base compensation range for this role is: $288,275 - $377,128. Base salary offered is determined through an internal analysis utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short-term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward individual performance and align incentives to Solid’s long term company performance. Benefits - Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs. - 401(k) program participation with competitive company matched contributions. - Eligibility to participate in Solid’s Employee Stock Purchase Plan. - Mobile phone subsidy for eligible employees. - Tuition Reimbursement. - Vision Coverage. - Life Insurance. - Voluntary Pet Insurance. - Employee Discount Program on Travel, Entertainment, and Services. - Daily Subsidized Lunch Delivery (onsite @ Hood Park). - Free Onsite Full-Service Gym (onsite @ Hood Park). - Employee Parking (onsite @ Hood Park).

• Lead the strategy and execution needed to secure broad, sustainable access to the company’s innovative therapies • Develop and implement market access initiatives that help ensure patients can obtain the treatments they need while supporting commercial growth and organizational scale • Oversee the payer, oncology GPO, and trade functions • Develop and execute a comprehensive market access strategy for Catalyst's lead assets • Integrate market access considerations into product development plans, regulatory submissions, and commercialization strategies • Monitor the payer access environment, identify emerging trends and risks, and develop innovative access solutions • Collaborate with HEOR colleagues to shape health economics and real-world evidence strategies • Develop and execute pricing, reimbursement, and contracting strategies • Lead pricing and reimbursement negotiations with payers • Partner with internal stakeholders to develop compelling value propositions • Directly engage with payers, CMS, GPOs, and large oncology practice groups • Manage day-to-day relationships with wholesalers, distributors, and pharmacies • Manage Key Access Vendors

• Lead our delivery practice and become the most trusted face of our firm in client relationships. • Deliver exceptional work, deepen client partnerships, and position the firm as a forward-thinking leader in technology consulting. • Lead a team of consultants across our technology implementation practices. • Serve as the executive sponsor on our most strategic engagements, build trusted advisor relationships with client executives. • Set and maintain the standard for delivery quality across all active technology implementation engagements. • Own utilization, average bill rates, project profitability, and CSAT metrics. • Champion the adoption of AI tools across the consulting practice. • Represent Consulting at the executive leadership table.

• Lead and oversee the company’s Quality Control and Internal Audit functions, ensuring effective execution of audit plans, quality reviews, and risk management initiatives. • Manage and develop a team of Quality Control professionals, including onshore and offshore resources, ensuring proper workload management, performance expectations, and operational efficiency. • Oversee Internal Audit operations, including coordination of onshore and offshore audit resources, to ensure comprehensive risk assessments and audit coverage. • Develop, administer, and maintain a multi-year rotational internal audit plan aligned with company strategy, priorities, and risk assessments. • Plan and execute operational, financial, compliance, and quality control audits using a risk-based methodology; define audit scope, test controls, and develop actionable recommendations to improve processes. • Ensure QC reviews, audit fieldwork, testing, and evidence gathering are thorough, accurate, and support audit conclusions. • Draft impactful audit reports, presenting findings, trends, and recommendations clearly and concisely to executive leadership and the Audit Committee. • Conduct remediation procedures to ensure identified QC and audit findings are addressed appropriately and completed on schedule. • Assist with regulatory compliance, and other investor, agency, and regulatory requirements. • Perform ad hoc investigations, special reviews, and quality assessments as requested by management or the Audit Committee. • Function as a liaison during regulatory examinations and coordinate with external auditors, investors, and third-party review teams as needed. • Provide strategic guidance to management on process improvements, internal controls, loan quality, and risk mitigation opportunities. • Evaluate and enhance internal controls, governance, QC processes, and operational procedures across Non-QM wholesale mortgage operations.