• Serves in an on-call capacity providing, consistent, comprehensive oversight of all organ donation operations including but not limited to donor referral triage, authorization, management, organ allocation, recovery and post-mortem care. Responsible for providing plan of care guidance, and ensuring all case activity proceeds in an effective and efficient manner. • Provides regulatory oversight/verification of critical considerations such as hemodilution, death note(s), and PHS Increased Risk reviews. • Collaborates with DNW Medical Director/Chief Medical Officer (CMO) on setting and upholding donor case plans and interacts with physician consults as needed. • Advises staff in working through operational challenges by providing mentoring, talking points, and on-site support. • Provides on-site staff and operations support for procedures and critical staffing needs (i.e. DCD lead, donor management). • Collaborates with management team on staff development directives. • Drives organ operations, quality assurance, and performance improvement initiatives. Responsible for identifying trends and performance improvement opportunities in collaboration with Chief Medical Officer and Clinical Educator. • Collaborates with CMO to develop and maintain evidenced based donor clinical management guidelines. • Partners with regional management to identify, develop, and implement regional strategies for clinical and hospital education, including but not limited to participating in donor councils, grand rounds, staff meetings and other educational opportunities. • Responsible for identification and implementation of transplant center (TXC) stakeholder engagement strategies. Serves as the primary point of contact for TXC concerns, leads root cause analysis, proposes improvement plans and implements change to address improvement opportunities. Engages stakeholders by participating on abdominal and thoracic transplant program quality meetings. Engages stakeholders to develop resources for infectious disease consulting, echo core diagnostic group, DNW case plans and timing reviews, and overall performance improvement. • Collaborates with Research Program Director on evaluation and implementation of research initiatives, particularly those focused on prospective donor management trials. • Collaborates with referral management team to ensure appropriate resource commitment and process improvement. • Participate in and lead donor performance improvement meetings (QAPI, MAB, educational forum, etc). • Performs additional responsibilities and projects as assigned.

Role Description This is a unique opportunity for the right individual who has innate leadership and organizational skills, technical expertise in clinical oncology drug development in an industry setting, and experience in organizing and running clinical trials. As the Senior Director of Clinical Operations, you will be responsible for the operational design and structure of, and accountable for the execution of, Revolution Medicines early-stage clinical studies in Japan. Specifically, you will be responsible for: - The development, management, and execution of the Clinical Development Plan (CDP) for clinical programs which includes clinical trial timeline estimates, budgets, and resource requirements in Japan. - Oversight over the execution of clinical trials, including CRO selection and site selection in Japan. - Lead the strategic planning, optimization, and deployment of Clinical Operations resources across Japan, ensuring effective alignment with both project and non-project. - Line management responsibilities include hiring, performance management, career development and mentorship. - Lead team meetings and collaborate with other functional groups within the company (e.g., Clinical Development, DMPK, Regulatory, QA, Finance, Legal, etc.) as an ad-hoc member to achieve clinical study goals regulations and International Council for Harmonization (ICH)/ GCP guideline. Qualifications - BS/MS Degree in a scientific discipline with a minimum of 12 years of clinical operations experience in the pharmaceutical or biotech industry. - Minimum of 7 years project and line management experience. - Extensive experience in leading and managing global phase 1-3 clinical trials within designated timelines, resources, and budgets. - Experience in working with cooperative group studies and investigator sponsored trials, preferred. - A demonstrable record of strong leadership and teamwork. - Extensive experience in selection of CROs/ vendors and management of external resources. - Must have a working knowledge of data management, data review and analysis, and drug safety, pharmacovigilance and other related functions to clinical trial conduct. - Strong working knowledge of PMDA/MHLW Regulations, ICH Guidelines and GCPs governing the conduct of clinical trials. - Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high-energy environment. - Excellent written and verbal communication skills both in English and Japanese. - Ability to act as an excellent ambassador for Revolution Medicines in interactions with key opinion leaders, scientific advisors, corporate partners and, where necessary, investors. - Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important. Preferred Skills - Experience in oncology clinical trials. Company Description

• Provide strong, independent leadership for assigned clinical projects, ensuring successful execution. • Serve as the primary point of contact for clients, vendors, and internal stakeholders. • Oversee study management activities, including site selection, initiation, monitoring, and closeout. • Develop and maintain study timelines, budgets, and project plans, ensuring adherence to scope. • Mitigate risks and proactively address challenges to keep projects on track. • Ensure compliance with ICH-GCP, regulatory guidelines, and company SOPs. • Manage vendor relationships and study-specific contracts. • Provide mentorship and guidance to junior project team members. • Support proposal development, bid defense meetings, and business growth initiatives. • Participate in internal and external project team meetings to ensure alignment and success.

• Provide healthcare industry expertise and management consulting support across client engagements within the Healthcare Practice. • Develop practice-wide methodologies that can be applied across account strategies and client plans. • Build and maintain strong account relationships with key client decision-makers. • Identify emerging industry issues and help develop the practice’s strategic response. • Support the development of strategic alliances and relationships across targeted healthcare markets. • Provide delivery assurance and execution support for engagements with priority clients. • Mentor and develop Guidehouse team members while supporting client delivery across engagements. • Demonstrate visible leadership within client accounts and across the broader practice. • Lead consulting engagements by shaping statements of work, developing project plans, writing proposals, presenting to client executives, and facilitating decisions with key stakeholders and influencers.