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Senior Medical Director, Early Clinical Development
Location
United Kingdom
Posted
9 days ago
Salary
0
Seniority
Lead
No structured requirement data.
Job Description
Senior Medical Director, Early Clinical Development
BioMarin Pharmaceutical Inc.
Role Description BioMarin’s Early Clinical Development (ECD) team is seeking an accomplished Senior Medical Director to serve as a senior clinical leader responsible for shaping and executing early clinical development strategies across one or more assets within the early pipeline. This role encompasses end‑to‑end clinical leadership from first‑in‑human studies through demonstration of clinical proof of concept, with accountability for scientific rigor, strategic clarity, and development decision‑making during the highest‑risk phases of development. Leveraging deep expertise in translational clinical research and early‑phase trial design, the Senior Medical Director will: - Lead integrated clinical development planning. - Design and oversee highly informative Phase 1 and Phase 2 studies. - Guide key investment and governance decisions based on emerging safety, pharmacology, biomarker, and efficacy data. - Partner closely with colleagues in Early Clinical Development, Biomarkers, Clinical Pharmacology, Preclinical Safety, Clinical Safety, Regulatory, and Clinical Operations. - Contribute broader portfolio‑level clinical perspective across BioMarin’s early pipeline. - Support evaluation of new internal programs and external business development opportunities. - Provide mentorship and leadership within the ECD organization. - Interact regularly with senior governance bodies, health authorities, and external scientific experts. - Represent BioMarin as a thought leader in early clinical development. Qualifications - Deep expertise in translational clinical research. - Experience in early-phase trial design. - Strong leadership and mentorship skills. - Ability to balance strategic priorities and resource allocation. Requirements - Experience in clinical development plans. - Ability to make recommendations at key development and governance decision points. - Experience with regulatory submissions (pre-IND, IND). - Experience in designing and executing natural history studies. - Ability to partner with Biomarker and Clinical Pharmacology colleagues. Benefits - Opportunity to work with a dedicated team of industry experts. - Engagement in innovative therapies for rare diseases. - Mentorship and leadership opportunities.
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