Role Description We’re looking for a senior Media Director to step into a role and own several client accounts from day one. This person will be responsible for media strategy, planning, execution, and campaign management across their assigned book of business, overseeing planning teams, serving as a primary client contact, and partnering cross-functionally with account, strategy, channel, and analytics teams to deliver strong results. This is a role for someone who operates with a high degree of independence. The right candidate is proactive, relationship-driven, and capable of moving work forward across multiple accounts simultaneously without losing sight of the details. The ability to step into existing client relationships and establish trust and momentum quickly is essential. Experience with branding campaigns for CPG or grocery clients is a meaningful advantage. Key Responsibilities - Account & Campaign Ownership: Serve as the day-to-day media lead across assigned accounts—owning strategy, planning, execution, and ongoing campaign management with accountability for performance and client satisfaction. - Media Strategy & Planning: Develop and oversee media strategies that align with client objectives, translating business goals into channel-appropriate, insight-driven media plans across relevant above-the-line and digital channels. - Planning Team Oversight: Manage and provide direction to assigned planning teams, ensuring work is on strategy, on deadline, and meeting the standards expected. - Primary Client Contact: Own the client relationship for designated accounts, leading status communications, presenting recommendations, addressing concerns proactively, and maintaining the trust and confidence of client stakeholders. - Cross-Functional Collaboration: Partner closely with account management, strategy, media channel specialists, and analytics teams to develop integrated, well-rounded campaigns and ensure seamless execution across workstreams. - Campaign Management & Optimization: Monitor campaign performance, surface insights and optimizations in a timely manner, and communicate implications and recommended actions clearly to both internal teams and clients. - New Business Support: Contribute to new business pitch opportunities as needed bringing strategic media thinking and category knowledge. Qualifications - 7+ years of media planning and strategy experience, with demonstrated experience operating at the Director level or equivalent—owning accounts, leading teams, and managing senior client relationships. - Strong command of media strategy across channels, with experience developing both above-the-line brand campaigns and performance-oriented media plans. - Proven ability to manage multiple accounts simultaneously in a fast-paced agency environment, maintaining quality and client confidence across all of them. - Demonstrated experience leading or overseeing planning teams—setting direction, reviewing work, and developing junior talent. - Client-facing confidence and polish; able to establish credibility quickly with new client contacts and navigate nuanced relationship dynamics with ease. - Highly self-directed and proactive—comfortable operating with limited oversight and knowing when to escalate versus when to resolve independently. - Strong organizational and communication skills; able to manage competing priorities without dropping details or losing momentum on any account. - Agency background required. Benefits - Project Type: Contract - Role: Media Director - Rate: $69/hour - Location: Remote (CST or EST preferred)

• Serve as a trusted analytics partner to Brand teams supporting BEQALZI and BTK CDAC launch planning, execution, and ongoing performance management. • Own customer segmentation strategy and execution, including the development, refinement, and activation of segments to support brand strategy, targeting, and customer engagement. • Lead analytics using secondary data sources to generate actionable insights on customer behavior, market dynamics, patient flow, and brand performance. • Own advanced analytics modeling for the brands, including use cases such as look-alike modeling, program or campaign effectiveness measurement, and other predictive or prescriptive analytics to inform business decisions. • Develop and deliver strategic and tactical analyses to answer key business questions related to launch readiness, brand performance, customer engagement, market evolution, and competitive dynamics. • Partner closely with Brand Teams, GCMT, Medical, GCSO, and other internal teams to integrate multiple data sources into a cohesive view of business performance and opportunity. • Design and maintain launch performance measurement frameworks, dashboards, KPIs, and business reviews to track progress against strategic objectives. • Support development of market assessments, segmentation, patient or customer journey analyses, and performance storytelling for leadership audiences. • Translate analytical findings into clear recommendations that influence strategic decisions and improve launch effectiveness. • Manage projects effectively across multiple stakeholders, ensuring timely delivery, high quality outputs, and alignment with business priorities.

• Support the Director, GVP Quality in implementing GVP Quality Assurance • Ensure Pharmacovigilance activities comply with regulatory standards • Lead audit and inspection activities • Manage quality systems and risk management • Develop and manage quality metrics • Conduct GCP/GVP training as needed

Role Description The Medical Science Liaison Lead is a professional in charge of leading, managing and monitoring a team of Medical Science Liaisons in Italy and reporting into the Country Medical Director for Italy. He/she will act as a scientific and clinical expert, supporting the medical and scientific objectives of Alnylam’s portfolio in TTR. The MSL Team Lead will be responsible to co-create a comprehensive field medical plan and supporting KOL relationships within Italy. He/she will be accountable also to communicate the science and clinical application of RNAi to Healthcare Practitioners (HCPs). In addition, MSL Team Lead is expected to build strong cross-functional relationships with colleagues in Medical Affairs, Patient Advocacy and Commercial, while maintaining full compliance with all relevant company, industry, legal, and regulatory requirements. Finally, the MSL Lead will be in charge of providing medical and scientific input into the planning and execution of Medical projects. Key Responsibilities - People Leadership Responsibilities - Build and foster an inspiring team environment with a strong culture of open communication and collaboration - Lead and drive the performance, effectiveness, and impact of the MSL team - Define and execute the MSL team strategy, including the development and implementation of territory plans and clear team objectives - Partner closely with the Country Medical Director and Medical Affairs leadership to ensure strong alignment and cross-functional collaboration - Monitor, analyze, and act on performance metrics to continuously enhance team effectiveness - Provide regular updates and insights on medical activities and projects in collaboration with the Medical Director - Lead talent development and succession planning for the MSL team - Set clear priorities, delegate responsibilities, and ensure timely delivery of team objectives - Coach, mentor, and develop team members to strengthen capabilities and drive engagement - Lead recruitment and onboarding of new MSL team members - Scientific expert in TTR - Provide accurate and fair-balanced scientific and medical information (clinical data, development, publications ...) upon request, according to the needs of experts or healthcare professionals, through individual interviews or scientific meetings. - Participate in regional events, national and international congresses as agreed with Medical Director and governance. - Management of national & regional medical projects (IIS, Research collaborations, other) - Maintain a level of expertise in the evolving scientific / therapeutic area and in competitor medicines. - Non-promotional communication with healthcare professionals, respecting the principles of separation of promotional and non-promotional activities defined by the promotional information charter. - Good Clinical Practices - Be compliant to Ethics, Compliance and internal policies Qualifications - Scientific Degree and proven basic science and/or clinical background to enable engagement of Health Care Professionals in a scientifically meaningful exchange - Previous people management experience is preferred - Experience as MSL in biotech, speciality and rare disease is preferred - Experience in clinical research, patient recruitment, and investigator-sponsored trials is a plus - Experience in medical education and KOL management - Effective communication of evidence based scientific information - Ability to work collaboratively and cross-functionally - Decision-making and accountability - Hard-working, energetic and passionate about making a meaningful difference for patients and their caregivers - Outstanding interpersonal skills, including building strong working relationships, and managing and resolving conflict - Demonstrated ability to work effectively in a highly matrixed environment; strongly team oriented - Superb communication skills; oral and written, including presentation skills in Italian & English - An unwavering commitment to upholding the highest ethical, legal, regulatory and scientific standards Requirements - Italy Pay Range: €99,500 to €134,600 gross per annum - The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. - Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills and education. - This role is eligible for an annual short-term incentive award (e.g. bonus or sales incentive), an annual long-term incentive award (e.g. equity) and competitive benefits. Company Description Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Our culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity.