• Serve as the primary point of contact for service provider-related operational issues across assigned regions or trades. • Coordinate with account operations teams to resolve service delivery issues, pricing discrepancies, or compliance concerns. • Ensure service provider adherence to standards for service levels, pricing, system usage, and communication protocols. • Monitor key performance indicators (KPIs) for service providers, including response time, service completion, invoice accuracy, and system compliance. • Conduct routine audits to verify delivery against service expectations and agreed terms. • Escalate repeated performance or compliance issues and support implementation of corrective actions or provider replacements. • Maintain strong working relationships with assigned service providers, acting as both a compliance enforcer and a partner in continuous improvement. • Conduct structured performance check-ins and gather field input to inform service provider scorecards and improvement plans. • Support onboarding and readiness for new service providers with greater urgency and efficiency, ensuring clear communication of performance expectations. • Identify outlier pricing or billing patterns through invoice review and data analysis. • Collaborate with the Director to maintain pricing benchmarks and support provider negotiations. • Contribute to efforts that reduce total cost of ownership (TCO) through strategic network optimization and process standardization. • Work closely with NSC colleagues and cross-functional partners (e.g., Finance, Legal, Operations) to align on service provider management objectives and execution. • Provide field-facing support, including training and documentation, on service provider management processes and escalation paths. • Contribute to the refinement of standard operating procedures (SOPs), compliance protocols, and performance monitoring tools.

• Support management of the planning, compilation, QC, and submission of CMC dossier content to clinical and commercial applications, and their amendments. • Prepare and adapt submission documents for use in global clinical and commercial submissions following eCTD specifications and market specific requirements. • May be responsible for independently planning and preparing routine clinical trial application related amendments and commercial submissions (e.g. Annual reports, DSUR, health authority queries). • Independently manages submission trackers for coordination of submissions across multiple products. • Maintains logs of clinical and commercial submissions and correspondence with FDA or other regulatory agencies. • Facilitate communication with Vendors/ CROs for planning and tracking of source documents to ensure high-quality IND, IND amendments, CTA, EU-CTR submissions are delivered in timely manner. • Support the implementation of regulatory strategy for assigned projects and programs for projects in all stages of development (IND through NDA/BLA approval and commercialization). • Works with submission authors and reviewers to ensure that source document planning is complete and that high-quality documents are approved on-schedule in terms of scientific content, organization, clarity, accuracy, format, consistency and adherence to regulatory guidelines, styles and processes. • Prepare and compile effective presentations for external and internal audiences as needed. • Create documents in accordance with eCTD specifications. • Perform miscellaneous duties as assigned.

• Manages the planning, compilation, QC, and submission of Investigational Drug Applications (INDs), Biologics License Applications (BLAs), and their amendments. • Prepares routine IND and CTA amendments. • Work with submission authors and reviewers to ensure that source document planning is complete and that high-quality documents are approved on-schedule. • Represents Regulatory Affairs and provides regulatory expertise to cross-functional teams on specified projects and topics. • Interface with Quality Assurance, clinical manufacturing, commercial manufacturing and other stakeholders to further develop and maintain a robust change control program. • Work with cross-functional project teams to develop CMC regulatory strategy for product changes at all stages of development. • Work within the CMC Regulatory Affairs team to gain consensus on proposed changes. • Negotiate with internal stakeholders to ensure that proposed changes and submission content are aligned with ICH guidelines, country regulations and guidelines, and industry standards. • Participate in risk mitigation by proactively identifying risk, developing options and contingency plans. • Assists in developing and managing Gantt charts (in conjunction with Program Management) and trackers for submissions across the multiple products. • Maintains logs of IND and CTA submissions and correspondence with FDA or other regulatory agencies. • Must adhere to Iovance Biotherapeutics’ core values, policies, procedures, and business ethics. • Perform miscellaneous duties as assigned.

• Support management of the planning, compilation, QC, and submission of CMC dossier content to clinical and commercial applications, and their amendments. • Prepare and adapt submission documents for use in global clinical and commercial submissions following eCTD specifications and market specific requirements. • May be responsible for independently planning and preparing routine clinical trial application related amendments and commercial submissions (e.g. Annual reports, DSUR, health authority queries). • Independently manages submission trackers for coordination of submissions across multiple products. • Maintains logs of clinical and commercial submissions and correspondence with FDA or other regulatory agencies. • Facilitate communication with Vendors/ CROs for planning and tracking of source documents to ensure high-quality IND, IND amendments, CTA, EU-CTR submissions are delivered in timely manner. • Support the implementation of regulatory strategy for assigned projects and programs for projects in all stages of development (IND through NDA/BLA approval and commercialization). • Works with submission authors and reviewers to ensure that source document planning is complete and that high-quality documents are approved on-schedule in terms of scientific content, organization, clarity, accuracy, format, consistency and adherence to regulatory guidelines, styles and processes. • Prepare and compile effective presentations for external and internal audiences as needed. • Create documents in accordance with eCTD specifications.