eClinical Solutions logo
eClinical Solutions

We bring people and data together to support tomorrow’s breakthroughs

Principal Software Engineer

Full-stack EngineerSoftware EngineerFull TimeRemoteLeadTeam 201-500Since 2012H1B SponsorCompany SiteLinkedIn

Location

Massachusetts

Posted

7 days ago

Salary

$152K - $190K / year

Seniority

Lead

Job Description

Principal Software Engineer

eClinical Solutions

• Design, develop, test, and deploy scalable, secure, and highly interactive web applications • Own and evolve core platform modules, from concept through release and support • Influence application and system architecture with a focus on performance, reliability, security, and maintainability • Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions • Collaborate closely with Product Management, QA, and other engineers throughout the SDLC • Provide technical mentorship and guidance to other engineers on the team • Diagnose and resolve complex production issues across distributed systems • Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations • Contribute to technical documentation including design specs, acceptance criteria, and release notes.

Job Requirements

  • Bachelor’s or Master’s degree in Computer Science or equivalent practical experience
  • 10+ years in software design and development using the Microsoft technology stack preferred
  • Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
  • Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
  • Solid understanding of software design principles, patterns, and best practices
  • Experience across the full Software Development Lifecycle (Agile preferred)
  • Proven ability to work independently while collaborating effectively in a fast-paced environment
  • Excellent communication, documentation, and technical leadership skills.
  • Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
  • Experience using Python and/or .NET alongside AI/LLM workflows
  • Familiarity with agent-based or workflow-driven AI architectures is a strong plus
  • Understanding of secure and responsible AI usage in enterprise systems.
  • Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
  • Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
  • Secure development experience, including awareness of common vulnerabilities and mitigations
  • Experience with clinical trial data, life sciences, or regulated SaaS environments
  • Experience building data visualizations or analytics-driven user experiences.

Benefits

  • Health insurance
  • Retirement plans
  • Paid time off
  • Flexible work arrangements
  • Professional development

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