Arvinas is a biotechnology research company that is “propelling the future with targeted protein degradation.” As an employer, the company believes its team members “make the
DMPK Scientist
Location
Connecticut
Posted
35 days ago
Salary
0
Seniority
Mid Level
Job Description
DMPK Scientist
Arvinas
Role Description We have an exciting opening for an experienced DMPK scientist. The incumbent will contribute as a DMPK scientist on project teams from drug discovery through all stages of drug development, with a scientific background on key aspects of DMPK science, including but not limited to: - In vitro and in vivo ADME - Animal PK - Toxicokinetics - Drug metabolism - DME- and transporter-based DDI - 14C-ADME studies - QWBA - Human PK prediction This position reports to the Head of Nonclinical Sciences and may be based at our headquarter location in New Haven, CT or a remote role based within the U.S. Principal Responsibilities - Serve as a project DMPK scientist and advise discovery teams on strategies for early ADMET profiling up to the selection of lead candidate into preclinical development. - Represent DMPK function on company-wide development teams to support the advancement of preclinical and clinical development assets. - Contribute to the in vitro DDI and other in vitro/in vivo DMPK assessment for individual preclinical drug candidates and ensure timely availability of key data as part of the IND enabling activities. - Recommend stage appropriate clinical DDI strategy to the clinical pharmacology function. - Contribute to outsource of DMPK studies and ensure timely and high quality conduct of in vitro and in vivo ADMET studies. - Partner with key CROs to develop and customize ADMET assays to support PROTAC drug discovery and development. - Contribute to the preparation of DMPK component of regulatory documents such as IND, IB, or other documents. - Stay up to date with the scientific advance and regulatory landscape for DMPK science in drug discovery and development. Qualifications - In-depth knowledge or expertise on one or several aspects of DMPK science in drug discovery and/or development, such as biotransformation, bioanalysis, pharmacokinetics, toxicokinetics, DME- and transporter-based drug-drug interaction, PBPK or PK/PD modeling, human PK prediction. - General knowledge of drug discovery and development process. - Experience in representing DMPK function on discovery and development teams. - Ability to integrate DMPK knowledge of individual drugs and prepare DMPK components of regulatory documents. - Hands-on experience and proficiency in PK analysis with PK or modeling software such as Phoenix. - Knowledge of relevant regulatory guidance in areas such as drug-drug interaction, bioanalysis, and GLP. Requirements - Ph.D. in pharmaceutical science, chemistry, biochemistry, or related scientific discipline with ten-plus years of relevant experience in DMPK in the biopharmaceutical industry or CROs supporting pharmaceutical development, preferably with a focus on small molecules. - Direct experience with PROTAC, molecular glue, or ADC highly desirable. - Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for a current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of lab and home office environments. - Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. Benefits - Competitive package of base and incentive compensation. - Comprehensive benefits program designed to support the health, wellness and financial security of employees and their families. - Group medical, vision and dental coverage. - Group and supplemental life insurance. - And much more. Company Description Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. For more information about Arvinas, please visit www.arvinas.com and connect on LinkedIn and X .
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