Arvinas

Role Description We have an exciting opening for an experienced DMPK scientist. The incumbent will contribute as a DMPK scientist on project teams from drug discovery through all stages of drug development, with a scientific background on key aspects of DMPK science, including but not limited to: - In vitro and in vivo ADME - Animal PK - Toxicokinetics - Drug metabolism - DME- and transporter-based DDI - 14C-ADME studies - QWBA - Human PK prediction This position reports to the Head of Nonclinical Sciences and may be based at our headquarter location in New Haven, CT or a remote role based within the U.S. Principal Responsibilities - Serve as a project DMPK scientist and advise discovery teams on strategies for early ADMET profiling up to the selection of lead candidate into preclinical development. - Represent DMPK function on company-wide development teams to support the advancement of preclinical and clinical development assets. - Contribute to the in vitro DDI and other in vitro/in vivo DMPK assessment for individual preclinical drug candidates and ensure timely availability of key data as part of the IND enabling activities. - Recommend stage appropriate clinical DDI strategy to the clinical pharmacology function. - Contribute to outsource of DMPK studies and ensure timely and high quality conduct of in vitro and in vivo ADMET studies. - Partner with key CROs to develop and customize ADMET assays to support PROTAC drug discovery and development. - Contribute to the preparation of DMPK component of regulatory documents such as IND, IB, or other documents. - Stay up to date with the scientific advance and regulatory landscape for DMPK science in drug discovery and development. Qualifications - In-depth knowledge or expertise on one or several aspects of DMPK science in drug discovery and/or development, such as biotransformation, bioanalysis, pharmacokinetics, toxicokinetics, DME- and transporter-based drug-drug interaction, PBPK or PK/PD modeling, human PK prediction. - General knowledge of drug discovery and development process. - Experience in representing DMPK function on discovery and development teams. - Ability to integrate DMPK knowledge of individual drugs and prepare DMPK components of regulatory documents. - Hands-on experience and proficiency in PK analysis with PK or modeling software such as Phoenix. - Knowledge of relevant regulatory guidance in areas such as drug-drug interaction, bioanalysis, and GLP. Requirements - Ph.D. in pharmaceutical science, chemistry, biochemistry, or related scientific discipline with ten-plus years of relevant experience in DMPK in the biopharmaceutical industry or CROs supporting pharmaceutical development, preferably with a focus on small molecules. - Direct experience with PROTAC, molecular glue, or ADC highly desirable. - Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for a current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of lab and home office environments. - Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. Benefits - Competitive package of base and incentive compensation. - Comprehensive benefits program designed to support the health, wellness and financial security of employees and their families. - Group medical, vision and dental coverage. - Group and supplemental life insurance. - And much more. Company Description Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. For more information about Arvinas, please visit www.arvinas.com and connect on LinkedIn and X .

Role Description This is a senior executive role responsible for all CMC activities from preclinical to product launch and leadership of an established Technical Operations group. The role has oversight of drug substance (API) and drug product (DP) development and production for preclinical, clinical, and commercial requirements. It is responsible for development, scale-up, analytical testing of API and DP. The role has oversight of identification, on-boarding, and management of external vendors and CMO’s. The incumbent is responsible for representing Arvinas CMC function in meetings with regulatory authorities and review of CMC documentation consistent with relevant regulations and guidelines. The role is responsible for higher level integration of Technical Operations activities with key stakeholders such as discovery chemistry, quality, clinical, and regulatory groups. This role is a key member of the Executive Committee Portfolio team, Development Governance, and reports to the Chief Financial Officer. The role can be remote, hybrid, or located at our headquarters in New Haven, CT. Principal Responsibilities - Leadership of the Technical Operations group which incorporates exploratory pharmaceutics, API, DP and Analytical Development, supply chain planning, and CMC authoring. - Ensuring product supply from pre-clinical development through clinical to commercialization. - Providing strategic direction and planning of the technical development and manufacturing of clinical/commercial products with attention to quality, robust and reliable supply, cost-effectiveness and efficient scaling. - Continuing a Technical Operations approach that establishes fast-to-clinic and fast-to-commercial as primary objectives in support of the Arvinas pipeline. - Responsible for establishing and managing the relationships with contract manufacturers, to assure that commercial and clinical production needs are met cost-effectively and in compliance with all GMP regulations and regulatory standards. - Establishing partnerships with Discovery, Clinical, Quality, Regulatory and Commercial to ensure a rapid and successful progression of assets to the commercial market. - Developing and managing annual expense budgets with accurate forecasting based on strategic objectives and prudent decisions regarding expenditures. - Interfacing with senior management to reach decisions that provide best opportunity for organizational success. - Leading the compilation and review of technical sections for Module 2/3 in INDs, IMPDs, NDAs, and MAAs. - Acting as a key executive interface with FDA and EMA for quality sections in INDs, NDAs, IMPDs, and MAAs. - Building a high performing team ensuring that organizational depth is maintained for all key positions. Qualifications - A minimum of 20 years experience working within areas of medicinal chemistry, chemical development, pharmaceutical development, and/or analytical development. - At least 10 years’ experience in a small/medium biotech environment with substantial CMC area leadership responsibilities. - Expertise in small molecule synthesis and process development, pre-formulation/formulation development, and analytical development of the same is required. - Expert-level understanding of API/DP process development and scale-up. - Expert-level understanding of analytical methods and instrumentation used to characterize reactions, material properties, APIs, and drug products. - Experience with and understanding Design of Experiments (DOE), Quality by Design (QbD), Process Analytical Technology (PAT), scale up, formulation and process technologies. - Demonstrated success in advancing a molecule from drug discovery to commercialization. - Demonstrated success in drafting module 2/3 sections of INDs, IMPDs, NDAs, and MAAs. - Extensive working knowledge of GxP practices, ICH guidelines, and other regulatory practices as applied to phase-appropriate applications. - Strong leadership and management abilities. - Critical analysis and strategic thought embedded within exceptional decision-making abilities. - Excellent communication, problem-solving and organizational skills applicable in a cross-functional team environment. - Extensive knowledge of scientific literature and of emerging research areas of pharmaceutical science. Requirements - Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for a current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of office, lab and home office environments. - Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. Education - Ph.D. in organic/medicinal chemistry or pharmaceutics. A combination of relevant education, demonstrated subject matter expertise, and applicable job experience may be considered in lieu of the degree. Benefits - Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. - Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. Company Description Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins.

Title: Senior Medical Director Clinical Development Neuroscience Location: Remote, Hybrid, New Haven - CT Job Description: Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC® Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC® targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. Arvinas is currently progressing multiple investigational drugs through clinical development programs, including ARV-102, targeting LRRK2 for neurodegenerative diseases; ARV-806, targeting KRAS G12D for mutated cancers, including pancreatic, colorectal, and non-small cell lung cancers; ARV-393, targeting BCL6 for relapsed/refractory non-Hodgkin Lymphoma; ARV-027, targeting the polyglutamine-expanded androgen receptor, or polyQ-AR, in skeletal muscle; and vepdegestrant, targeting the estrogen receptor for patients with locally advanced or metastatic ER+/HER2- breast cancer. On August 8th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant. In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC® androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. Arvinas is headquartered in New Haven, Connecticut. For more information about Arvinas, visit www.arvinas.com and connect on LinkedIn and X. Position Summary Arvinas is looking for an experienced Senior Medical Director with the passion and creativity to develop great medicines for neuromuscular and neurodegenerative diseases. The ideal candidate is a physician with experience in global drug development and filing, who is enthusiastic about applying their knowledge to improve the lives of patients with neurological diseases. This individual has excellent management and leadership capabilities and is motivated to participate in and lead an innovative drug development team. Reporting to the Executive Medical Director of Clinical Research, Neuroscience, the Senior Medical Director will be primarily responsible for the development, oversight, and execution of clinical research and development programs, including pivotal trials and filing activities. This position will serve as a key liaison between company and clinical investigators and establish credible relationships with opinion leaders, regulatory officials and other key stakeholders and partners. The successful candidate will be ready for a career defining experience and have the passion to drive several therapeutics for serious debilitating diseases to final approval. This role can be located at our headquarters in New Haven, CT or work with a hybrid or remote work arrangement from a location within the U.S. Principal Responsibilities Key responsibilities of this role include, but are not limited to: - Partner with discovery and biology leadership and provide clinical input and guidance to develop the neuroscience corporate strategy. - Design Phase I/II/III research trials targeting neurologic diseases, requiring expertise and stewardship in the areas of CNS/Neurology - Monitor the safety of patients enrolled in clinical studies - Provide medical and scientific input in review of clinical data, patient medical safety data, and laboratory values, maintaining an ongoing assessment of the safety profile, and efficacy data, as appropriate. - Work closely with all functions of the organization and external partners to manage trial execution and investigators’ engagement. - Collaborate in developing global regulatory plans and play a key role in regulatory meetings in partnership with regulatory affairs. - Identify, develop, and maintain relationships with external experts to better understand the candidate drug’s effects and gain strategic insights to strengthen the program. - Provide clinical assessments of potential in-licensing assets, identifying novel therapeutics opportunities as well as critical study design and execution challenges. - Lead the interpretation and summary of clinical trial data, including the preparation of study reports, integrated summaries, and clinical portions of package inserts and other product labeling. - Provide input on and review of various reports, applications, and publications - Ensure consistent practices with the highest ethical standards in compliance with internal SOPs, local regulations, and laws. Additional Responsibilities, including but not limited to: - Participate in the selection of clinical investigators - Provide guidance to study investigators - Provide medical support to Clinical Operations in the oversight of contract research organizations - Provide medical and scientific input on clinical data, patient medical safety data, and laboratory values, maintaining an ongoing assessment of the safety profile, and efficacy data, as appropriate. - Contribute to the overall strategy for drug development - Collaborate on the preparation and submission of IND, CTA, and NDA documents, and safety reports. - Support the clinical aspects of interactions with regulatory agencies worldwide - Participate in the planning, writing, and review of Clinical Study Reports, regulatory updates, and submissions. - Analyze and interpret study data for abstracts or publication as required. - Assist in the evaluation of scientific opportunities by contributing to due diligence activities, including critical assessment of clinical and translational data. - Provide medical expertise to support corporate partnering and business development efforts, including active participation in partnership committees and cross-functional task groups. - Collaborate with senior leadership and cross-functional teams to inform overall company strategy and contribute to the identification, evaluation, and in-licensing of new programs. - Work with the financial group as needed to assist with the production of budgets and timelines for the clinical development team. - Ensure that medical activities in clinical trials are conducted in compliance with Good Clinical Practice standards. Qualifications - A minimum of 5 years (7+ years strongly preferred) of biotech/pharma experience in neurological disease clinical drug development - Experience across multiple stages of clinical development, from IND to NDA / BLA. - Global clinical development experience is required, and global filing experience is preferred. - Technical (Medical and Scientific) experience evaluating targets/agents for in-licensing or internal development. - Experience supervising physicians and/or scientific staff in a management or team leader capacity is highly desirable. - Excellent interpersonal and public speaking skills are required for this high visibility position. - Demonstrated ability to work in a matrix environment with cross-functional teams. - Must be legally authorized to work in the US without the need for employer sponsorship now or at any time in the future. - The duties of this role are generally conducted in a home office environment. Employees must be able, with or without accommodation, to use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. Education - M.D. or equivalent degree is required. - Formal training in Neurology and professional board certification are highly preferred. INSERT JOB DESCRIPTION HERE Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations. On August 8th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant. In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. For more information, please visit www.arvinas.com. Position Summary We are seeking an experienced Director of Clinical Operations with deep expertise in neuroscience drug development to lead the global execution of early- and mid-stage clinical trials. This role will focus on Phase I/II (including Phase 1b) studies in neurodegenerative diseases, including Parkinson’s Disease (PD), atypical parkinsonism (e.g., PSP), SBMA, and related indications. This is a critical leadership role for a hands-on clinical operations expert with a proven track record in designing, operationalizing, and executing complex neuroscience trials. The ideal candidate brings deep experience overseeing CROs and external vendors, ensuring delivery of studies with operational excellence, high quality, and inspection readiness. The Director will be responsible for translating clinical development strategy into seamless, high-quality execution, from IND-enabling activities through early clinical development, ensuring studies are delivered on time, within budget, and in compliance with GCP, ICH guidelines, and company SOPs. This individual will also play a key role in building and scaling clinical operations infrastructure, processes, and teams to support a growing neuroscience pipeline. This position reports to the Executive Director, Clinical Operations and may be based remotely within the U.S. Principal Responsibilities Key responsibilities include, but are not limited to: - Lead end-to-end clinical operations for global early-phase neuroscience trials, ensuring delivery against timelines, budget, quality, and enrollment targets. - Serve as the primary operational lead for CRO oversight, driving accountability, performance, and partnership to ensure execution excellence and high-quality data delivery. - Provide strategic and technical leadership in the planning and execution of complex neuroscience studies, including dose-escalation, cohort expansion, and rare disease trial designs. - Translate clinical development strategy into operational plans, ensuring alignment across cross-functional stakeholders and external partners. - Build, lead, and develop a high-performing clinical operations team, including hiring, training, and resource prioritization aligned with program needs. - Establish and optimize clinical operations infrastructure, including SOPs, systems, processes, and KPIs to support scalable and compliant trial execution. - Oversee vendor selection, contracting, and management, including CROs and specialty vendors; ensure performance metrics are defined and met. - Proactively identify and mitigate operational risks, particularly for early-phase and rare disease studies. - Partner cross-functionally with Clinical Development, Medical, Regulatory, Biometrics, CMC, Supply Chain, Legal, IT, and Finance to ensure integrated execution. - Collaborate with key opinion leaders (KOLs) and investigators to inform protocol design and feasibility. - Ensure studies are conducted in compliance with GCP, ICH guidelines, and regulatory requirements, maintaining inspection readiness at all times. - Oversee clinical documentation and deliverables, including protocols, IBs, DSURs, and study reports, in collaboration with medical writing and clinical teams. - Monitor and report on clinical trial performance metrics (KPIs), including enrollment, quality, timelines, and budget. - Foster a collaborative, accountable, and execution-focused culture within the clinical operations function and across stakeholders. Qualifications - 12+ years of clinical operations experience, with significant hands-on leadership of early-phase clinical trials, including Phase I/II studies. - Deep expertise in neuroscience clinical trials, particularly in neurodegenerative diseases (e.g., PD, PSP, SBMA, ALS). - Demonstrated success in CRO oversight and vendor management, with a strong ability to drive performance, accountability, and quality. - Proven experience advancing programs from preclinical/IND-enabling through early clinical development. - 5+ years of people management experience, with the ability to build and lead high-performing teams. - Strong understanding of GCP, ICH guidelines, and global regulatory requirements. - Experience in biotech or fast-paced clinical-stage environments, with the ability to operate with agility and accountability. - Excellent strategic thinking, problem-solving, and risk management skills. - Strong communication and stakeholder management skills, with the ability to influence at senior levels. - Demonstrated ability to manage budgets, timelines, and competing priorities across multiple programs. - Experience with INDs and early clinical development is highly preferred. - Clinical pharmacology and/or dose-escalation study experience is desirable. - Willingness to travel as needed. - Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of company office and home office environments. Employees must be able, with or without an accommodation use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. Preferred Experience - Experience in Parkinson’s Disease, PSP, SBMA, ALS, or related neurodegenerative disorders. - Experience with rare disease trials, including patient recruitment challenges and innovative trial designs. - Familiarity with decentralized trial elements and digital health technologies. - Experience with patient registries and natural history studies. - Prior experience building or scaling clinical operations infrastructure in a growing biotech. Education - Bachelor’s degree in Life Sciences, Pharmacy, or related field required; advanced degree preferred. Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations. On August 8th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant. In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. For more information, please visit www.arvinas.com. Position Summary Our Bioinformatics and Proteomics team is looking for a highly motivated individual to explore tools and approaches to optimize computational processes. There may be additional opportunities to aid in application development to allow the team to leverage both internal and external data to support our drug development programs. The intern will present results at team meetings and will summarize their work as a talk or poster at Arvinas at the conclusion of the internship. This position reports to the Senior Research Investigator, Bioinformatics and can be located remotely within the U.S. Principal Responsibilities Key responsibilities of this role include, but are not limited to: - Help identify and process high dimensional data sets for analysis - Utilize state of the art tools to help optimize code, workflows, or applications to analyze and visualize biological data - Prepare and present results at an internal Arvinas function at the conclusion of the internship. Qualifications - Proficiency in Python and/or R programming required; experience with Linux and AWS is a plus - Knowledge and experience with data analysis & visualization, modeling, and machine learning methods and tools - Knowledge and experience with AI tools for code and process optimization - Experience working on neurobiology or cancer biology projects is desirable. - Must be able to work effectively in both independent and team contexts. - Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of company office and home office environments. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. EDUCATION - Computational Biology, Bioinformatics, Computer Science or related major; candidates should be at least a rising junior/senior undergraduate or Master’s program student - Completed coursework related to neuroscience or cancer biology preferred Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations. On August 8th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant. In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. For more information, please visit www.arvinas.com. Position Summary We are seeking a highly motivated Manager, Clinical Biomarker Assays, Translational Sciences, Neuroscience with biomarker expertise to lead and execute clinical biomarker assay development, validation and implementation activities to support our neuroscience clinical programs. This individual will perform as the Clinical Biomarker Assay Lead within Translational Sciences to support Neuroscience programs, and will be responsible for clinical biomarker CROs evaluation and oversight, clinical biomarker assay development and validation, clinical sample testing execution, and high-quality biomarker data generation and transfer to support assessment of,pharmacodynamics including target engagement, patient stratification, and disease progression. The successful candidate will combine strong scientific rigor with cross-functional leadership and a track record of overseeing development of biomarker assays for utilization in clinical studies. This position reports to Director, Translational Sciences – Neuroscience and can be located at our headquarters in New Haven, CT or work remotely from a location within the U.S. Principal Responsibilities Key responsibilities of this role include, but are not limited to: - Conduct scientific and operational due diligence and selection of external biomarker CROs and assay platforms, leading vendor due diligence processes including, but not limited to assessment of biomarker technology, evaluations of biomarker assay feasibility, analytical performance and validation characteristics, and overall technical capability. - Lead and oversee development, qualification, and validation of clinical biomarker assays (e.g., ELISA, Simoa, MSD, LC-MS/MS, Olink/SomaScan, NGS etc) in collaboration with internal teams and CROs, including review of assay analytical validation plans, biomarker reports, and technical documentation to ensure timely clinical biomarker assay deliverables and biomarker assay performance meets regulatory and industry standards for clinical use (e.g., GCLP, CLIA, CAP as applicable). - Oversee external CROs/labs performing clinical biomarker testing, including vendor management. assay transfer and clinical sample testing. Ensure high-quality biomarker data generation, QC, and timely data transfer - Cross-functional collaboration with Translational Sciences Lead, Clinical Operations, Biosample Operations, Data Management, and external vendors to ensure execution of biomarker readouts in our clinical studies. Qualifications Required Qualifications - 5+ years (industry preferred) in clinical biomarker assay development and/or bioanalytical sciences. - Demonstrated experience managing external CROs and central laboratories - Demonstrated experience with protein biomarkers (such as fluid (including CSF) and tissue biomarkers, blood-based biomarkers), and genomic platforms (e.g., Simoa, MSD, Olink, mass spectrometry, NGS) - Experience with neuroimaging biomarkers (e.g., PET, MRI) and/or digital biomarkers preferred. - Familiarity with clinical data standards and biomarker data transfer processes. - Experience working in neuroscience and/or rare diseases such as Parkinson’s disease, PSP, Alzheimer’s disease, or related disorders preferred - Experience supporting IND-enabling or early-phase clinical trials preferred - Demonstrated success in working cross-functionally within multidisciplinary teams. - Excellent communication, organizational, and problem-solving skills, with the ability to operate independently in a matrixed environment. - Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of company office and home office environments. Employees must be able, with or without an accommodation use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. Education - D. in Neuroscience, Neurobiology, Molecular Biology, Pharmacology, or a related life science field. #LI-Remote Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.

Role Description The Senior Director, Clinical Operations provides strategic and operational leadership for assigned oncology clinical programs, with a strong focus on first-in-human (FIH) and dose-escalation studies. This role is accountable for end-to-end execution, ensuring studies are delivered with high quality, regulatory compliance, and speed. The position requires demonstrated leadership in CRO and vendor management, cross-functional decision-making, and risk mitigation in complex global trials. This role may oversee one or more studies or programs and serves as a key operational partner to Clinical Development, Regulatory, Biometrics, Quality, and Sourcing. This position reports to senior Clinical Operations leadership and may be remote, hybrid, or based in New Haven, CT. Principal Responsibilities - Leadership Expectations: - This role is expected to operate as a leader, anticipating issues, driving alignment, and holding teams and vendors accountable for delivery. - Strategic and Leadership Responsibilities: - Provide operational leadership and accountability for oncology clinical trials, including FIH and dose-escalation studies. - Translate asset and governance decisions into executable operational plans, timelines, and resourcing strategies. - Lead and influence cross-functional teams to drive timely decision-making. - Lead operational planning and execution of Clinical Pharmacology studies (e.g., FIH, SAD/MAD, food effect, DDI, QTc, bioavailability studies). - Develop and maintain the study operational plan, timelines, and cross-functional deliverables in collaboration with Clinical Pharmacology, Data Management, Biostats, Safety, and Regulatory. - Coordinate study start-up, site readiness, and operational oversight, including monitoring enrollment, dosing milestones, and data delivery timelines. - Lead cross-functional study team meetings, track risks and issues, and ensure timely resolution to maintain study timelines. - Ensure Trial Master File (TMF) completeness and inspection readiness throughout the study lifecycle. - Provide regular study status updates to program leadership, highlighting progress, risks, and mitigation strategies. - Study Execution and Oversight: - Lead the end-to-end operational execution of assigned studies from startup through close-out. - Own study timelines, deliverables, and operational KPIs; proactively identify and mitigate risks. - Oversee FIH dose-escalation execution, including cohort management and safety review coordination. - Drive feasibility, country and site strategy, and global startup execution. - Ensure investigator meetings, SIVs, and training strategies are aligned with study complexity. - CRO and Vendor Management: - Provide strong oversight and governance of CROs and vendors. - Partner with Sourcing and Finance on CRO selection, contracting, change orders, and budget oversight. - Ensure CRO execution aligns with sponsor expectations for speed, accountability, and quality. - Lead regular vendor governance and performance reviews. - Compliance and Quality: - Ensure studies are conducted in accordance with ICH/GCP, FDA, EMA, and global regulations. - Partner with QA to ensure readiness inspection. - Oversee monitoring strategies, data review cadence, and clinical data quality oversight. - Cross-Functional Collaboration: - Act as a key operational partner to Clinical Development, Regulatory Affairs, Biometrics, Data Management, and QA. - Provide clear communication on progress, risks, and decisions. Qualifications - 15+ years of clinical operations experience in drug development. - Demonstrated leadership in oncology clinical trials, including FIH and dose-escalation studies. - Proven experience leading global studies and managing CROs and vendors. - Experience in fast-paced early development environments. Skills and Competencies - Strong leadership, judgment, and decision-making skills. - Ability to balance speed and accountability. - Excellent stakeholder management and communication skills. - Deep understanding of clinical trial operations and regulatory requirements. Education - Bachelor’s degree in a clinical or science-based field required; advanced degree preferred. Benefits - Competitive package of base and incentive compensation. - Comprehensive benefits program designed to support health, wellness, and financial security. - Group medical, vision, and dental coverage. - Group and supplemental life insurance. - And much more. Company Description Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins.

• Explore state of the art tools for protein structure prediction and ternary complex modeling. • Collect and prepare a comprehensive dataset of published ternary complex X-ray and cryo-EM structures. • Rigorously evaluate the performance of different ternary complex modeling approaches. • Prepare and present results at an internal Arvinas function at the conclusion of the internship.

Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs currently enrolling: ARV-102 for the treatment of patients with neurodegenerative disorders,ARV-393 for the treatment of patients with relapsed/refractory non-Hodgkin Lymphoma and potentially other lymphomas, and ARV-806, a KRAS G12D PROTAC for the treatment patients with solid tumors with KRAS G12D mutations. On August 8th 2025, the U.S. Food and Drug Administration (FDA) accepted the New Drug Application (NDA) for vepdegestrant- an investigational, orally bioavailable PROTAC estrogen receptor degrader- for its use as a monotherapy in the treatment of adults with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2-), ESR1-mutated advanced or metastatic breast cancer previously treated with endocrine-based therapy. In September 2025, Arvinas and Pfizer announced their plan to jointly select a third party for the out-licensing and commercialization of vepdegestrant. In April 2024, Arvinas entered into a transaction with Novartis, including a global license agreement for the development and commercialization of the clinical stage PROTAC androgen receptor protein degrader ARV-766 for the treatment of prostate cancer. The transaction closed in May 2024. #TeamArvinas is made up of passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. For more information, please visit www.arvinas.com. Position Summary The internship project will explore approaches to ternary complex modeling and have a focus on evaluating internal, commercial, and literature workflows and tools. Collaborating closely with members of the Arvinas CADD team, the intern will configure, run, and benchmark ternary complex modeling workflows. The intern will present results at CADD team meetings and will summarize their work as a talk or poster at Arvinas at the conclusion of the internship. This position reports to the Senior Research Investigator, Computational Chemistry and can be located remotely within the U.S. Principal Responsibilities Key responsibilities of this role include, but are not limited to: - Explore state of the art tools for protein structure prediction and ternary complex modeling. - Collect and prepare a comprehensive dataset of published ternary complex X-ray and cryo-EM structures. - Rigorously evaluate the performance of different ternary complex modeling approaches. - Prepare and present results at an internal Arvinas function at the conclusion of the internship. Qualifications - Experience using protein structure predictions methods (AlphaFold, RoseTTAFold, Boltz, etc.) is required. - Experience with a cheminformatics toolkit (RDKit, OpenEye, Schrodinger, etc.) is required. - Proficiency in Python programming required. - Experience using version control (GitHub, GitLab, Bitbucket, etc.) required. - Knowledge of and experience with at least one ML framework (TensorFlow, PyTorch or Keras) is desirable. - Experience working on medicinal chemistry projects is desirable. - Must be able to work effectively in both independent and team contexts. - Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of company office and home office environments. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours. EDUCATION - Computational Chemistry/Biology, Chemistry, Biology, or Computer Science major. - Completion of classes in Computational Chemistry, Chemistry, and/or Molecular Biology & Biophysics strongly preferred. - Preference for doctoral graduate students nearing degree completion. #LI-Remote Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com Arvinas is an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identify, national origin, disability or protected veteran status.

This description is a summary of our understanding of the job description. Click on 'Apply' button to find out more. Role Description Arvinas has an excellent opportunity for a summer internship in our Clinical Operations function to gain exposure, training, and experience supporting the following activities: - Assist with study documentation and maintenance of trial master files (TMF) - Support coordination with study sites, CROs, and cross-functional teams - Help track study timelines and key deliverables This position reports to the Clinical Operations Lead and can be remote, hybrid, or located at our headquarters in New Haven, CT. Qualifications - Strong interest in clinical research; prior experience not required - Detail-oriented with good organizational skills - Strong communication and teamwork abilities - Proficiency in Microsoft Office - Eager to learn in a fast-paced environment Requirements - Arvinas will not be providing VISA sponsorship for this position now or in the future. You must have the ability to work without a need for current or future VISA sponsorship. - The duties of this role are generally conducted in a combination of company office and home office environments. - Employees must be able, with or without an accommodation, to lift/carry 15/30 pounds unassisted/assisted. - Work comfortably in a controlled environment with and around biological, infectious, and hazardous materials. - Gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging. - Engage in problem solving, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. Benefits - Competitive package of base and incentive compensation - Comprehensive benefits program designed to support health, wellness, and financial security - Group medical, vision, and dental coverage - Group and supplemental life insurance - And much more