• Oversee end-to-end delivery of all Fractional COO, Fractional CFO, and Bookkeeping engagements, ensuring methodology consistency and client satisfaction across the portfolio. • Directly manage, coach, and develop team leads and individual team members when needed; conduct regular 1:1s, performance reviews, and capacity planning. • Work with the COO to build, refine, and enforce standardized financial frameworks including P&L management, cash flow forecasting, and balance sheet review for client engagements. • Serve as escalation point for complex client financial situations; provide hands-on fractional support when required. • Collaborate with the COO and senior leadership on fractional service product development, pricing, and operational scalability. • Maintain business operating rhythms and systems within the fractionals team including scorecards and quarterly rock/boulder planning.

• Own and drive Evidence Action's approach to new program evaluation • Develop and maintain centralized MLE systems for sharing, tracking, and applying evidence internally and externally • Lead the development of Evidence Action's learning agenda • Provide strategic MLE oversight for new program development and accelerator processes • Identify and address cross-program monitoring blind spots and systemic risks • Champion the strategic use of data, technology, and AI

Role Description Centessa is growing its clinical development organization. Reporting to the SVP, Clinical Development, the Executive will provide medical leadership and oversight to Centessa’s programs and associated clinical trials. The role requires leadership and contributions both at a strategic level and hands-on project level work. The Executive Director will have prior experience in the biotech/pharma industry, in neurodegenerative/neuropsychiatric therapeutic areas and across the development cycle of an asset (early to late phase). - Primary point of contact for clinical development activities with willingness to work strategically and hands on at the program and clinical trial levels. - Accountable for the oversight, monitoring and surveillance of overall risk, safety, benefit/efficacy to patients as well as compliant trial execution and optimal integrity of data. - Responsible for establishing relationships and communication with KOLs, investigators and relevant site medical (or other supportive roles) personnel. - Lead the clinical development strategy and innovative approaches for the overall clinical pathway for the asset. - Key clinical development contributor to publication strategy and planning, authoring of publications, posters, etc., and present or support presentations, posters, etc., in conferences and meetings. - Play a key role in regulatory and health authority interactions. - Lead clinical development contributor to regulatory activities, submissions, and clinical sections of regulatory/health authority pre-meeting packages and initial applications, routine annual reports, ad hoc safety reports (SUSARs), interim and final CSRs, etc. - Author asset and clinical trial level plans, charters, documents. - Determine optimal clinical trial design options that are innovative, patient centric, cost efficient, and enable meeting business goals. - Responsible for review, analysis and interpretation of all clinical trial data including assessment of protocol deviations. - Lead asset level clinical sub-teams and play key leadership role on program team for clinical development. - Lead asset level and trial level medical forums as needed (safety review committee, ad board, KOL meetings, medical review/discussions of patient cases, cohort review meetings, etc.). - Attend and present as needed at core team meetings, investigator meetings, site visits, etc. - Liaise with cross functional partners, vendors, and CROs to ensure the progression of clinical studies within the expected time frame. - Provide clinical evaluation and interpretation of pre-clinical results. - Remain current on the development of orexin agonists and the relevant therapeutic areas through review of the scientific literature, interactions with KOLs and other external experts and attendance at relevant scientific meetings, to provide input and guidance for the strategic direction of Centessa clinical stage programs. Qualifications - MD required, MD/PhD strongly preferred (includes internationally recognized equivalent) - Minimum 10 years of overall experience (academia, clinical practice, pharma/biotech industry, etc.) - Minimum 5 years of pharmaceutical/biotech industry experience, including managing clinical development and clinical science teams, clinical development programs and clinical trials - Prior pharma/biotech and line management experience – Required - CNS therapeutic area (particularly neurodegenerative/neuropsychiatric) experience- Required - Willingness to deliver project and tactical level work - Excellent working knowledge of regulations across various agencies (FDA, EMA, etc.) and GCP, & ICH guidelines. Knowledge or experience supporting regulatory or health authority inspections a plus. - Experience leading and authoring clinical development inputs into regulatory submissions (IND, CTAs, NDA/BLAs, designation applications, etc.) and representing clinical development in agency interactions. - Experience authoring and guiding teams with key asset and clinical trial level plans and documents. - Strong knowledge in clinical development strategy, clinical trial design, regulatory pathways, biostatistics methodologies, and ability to analyze and interpret translational medicine, clinical, and research data as it relates to an asset, patients, etc. - Possess excellent written and oral communication skills with internal and external stakeholders - Proven ability to work collaboratively, take initiative, solve complex issues, and deliver results in a fast-paced, team-based matrix environment - Demonstrate sound judgement in handling complex, confidential, and highly regulated information - Ability and willingness to travel as required. Benefits - The annual base salary range for this level is $300,000.00 to $375,000.00. Individual compensation within this range will be determined based on a variety of factors, including qualifications, skills, relevant experience, and job knowledge. - In addition to base pay, this role is eligible for a discretionary annual bonus. - Centessa also offers a comprehensive benefits package, which includes: - 401(k) plan - Company-sponsored medical, dental, vision, and life insurance - Generous paid time off - Health and wellness program Work Location The Executive Director, Clinical Development role is a remote role based in the US, with occasional travel. EEOC Statement Centessa Pharmaceuticals believes in a diverse environment and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion, or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Centessa Pharmaceuticals will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Assistant Director of Product Management, Digital Experience - Product Management/Product Ownership - Regular Full-Time - United States; Des Moines, Iowa; Charlotte, North Carolina; Raleigh, North Carolina - Remote: Yes - H567000-Customer Experience We’re looking for an Assistant Director of Product Management to join our Digital Experience team. In this role, you’ll lead and evolve our enterprise web experience, optimizing customer-facing digital journeys at scale while coaching product managers and partnering closely with UX and technology.   You'll focus on: - Product Strategy: Define and lead the product strategy for a portion of the enterprise digital experience, focused on optimizing web‑facing customer and employer journeys through data, customer insights, and cross‑functional alignment - Product Discovery: Ensure effective discovery practices that inform decision‑making and facilitate collaborative solutioning to improve experience and efficiency - Product Delivery: Be accountable for successful delivery across the product family, partnering closely with engineering and UX in an Agile environment and clearly communicating plans and releases - Product Assessment: Maintain insight into product health, outcomes, and investment effectiveness, using data‑informed storytelling to guide trade‑offs and strategic adjustments - Stakeholder Management & Communication: Serve as a trusted partner across business, technology, and UX teams by proactively communicating strategy, priorities, and outcomes to drive alignment and value realization - Product Leadership: Lead, coach, and develop Product Managers while balancing hands‑on product leadership with people management and continuously strengthening product management practices Operating at the intersection of financial services and technology, Principal builds financial tools that help our customers live better lives. We take pride in being a purpose-led firm, motivated by our mission to make financial security accessible to all. Our mission, integrity, and customer focus have made us a trusted leader for more than 140 years. Who You Are - 8+ years of business, technology, or product management experience; or equivalent demonstrated through the following: work experience, military experience, or education. - 5+ years working in a highly collaborative, fast-paced product environment - 2+ years of informal or formal leadership experience - Proven success establishing product strategy across multiple products and aligning it to enterprise priorities - Strong background of stakeholder management and cross-functional collaboration, especially partnering with UX/design and engineering - Experience using data and insights to drive decisions and communicate outcomes through clear, structured storytelling - Demonstrated understanding of modern product discovery and product delivery practices and the ability to coach others on those practices - Excellent communication skills, including the ability to establish relationships and influence business partners Skills That Will Help You Stand Out - Experience leading enterprise web experiences across multiple lines of business or customer segments - Experience improving digital journeys through analytics, experimentation, and iterative optimization Salary Range Information Salary ranges below reflect targeted base salaries. Non-sales positions have the opportunity to participate in a bonus program. Sales positions are eligible for sales incentives, and in some instances a bonus plan, whereby total compensation may far exceed base salary depending on individual performance. Actual compensation for all roles will be based upon geographic location, work experience, education, licensure requirements and/or skill level and will be finalized at the time of offer. Salary Range (Non-Exempt expressed as hourly; Exempt expressed as yearly) $127000 - $171000 / year Time Off Program Flexible Time Off (FTO) is provided to salaried (exempt) employees and provides the opportunity to take time away from the office with pay for vacation, personal or short-term illness. Employees don’t accrue a bank of time off under FTO and there is no set number of days provided. Pension Eligible Yes Travel Ability to travel up to quarterly as needed; travel is not routine but flexibility to travel is required. Work Environments This role offers in-office, hybrid (blending at least three office days in a typical workweek), and remote work arrangements (only if residing more than 30 miles from Des Moines, IA, Charlotte, NC, and Raleigh, NC). You’ll work with your leader to figure out which option may align best based on several factors.