• Define and drive the organization’s public cloud strategy and modernization roadmap aligned to business objectives • Lead the design, engineering, and optimization of scalable, resilient, and secure cloud platforms • Manage end-to-end delivery of cloud programs, including planning, execution, governance, and reporting • Build, mentor, and lead high-performing cloud and engineering teams; manage strategic vendors and partners • Partner with security teams to ensure cloud security, compliance, audit readiness, and risk mitigation • Oversee incident management, disaster recovery, and business continuity for cloud platforms • Collaborate with senior stakeholders to ensure stakeholder satisfaction, transparency, and delivery excellence • Drive continuous improvement through standardized frameworks, metrics, and best practices.

Role Description The Senior Medical Science Liaison (Sr MSL) is a therapeutic and disease area scientific expert for investigational and approved gene therapy clinical programs. They demonstrate leadership in field medical excellence and coaching as well as medical and scientific support with national level strategic planning in the Eastern Territory of the United States. As a field-based member of the medical affairs team, the Sr MSL will be responsible for developing and enhancing professional relationships with external thought leaders involved in all phases of the clinical development process through a fair-balanced and high-value exchange of clinical and scientific information. In addition to these typical MSL responsibilities, the Sr MSL will develop strategy, serve as a team mentor, and lead national level initiatives. Key Responsibilities - Identify, build and maintain collaborative partnerships with healthcare providers (HCP’s) and key external experts such as KOL’s and academic institutions to become a trusted scientific partner. - Provide timely, audience-appropriate information and updates to enhance the understanding of the scientific and medical value of Orchard’s programs. - Maintain training records and deliver training updates to ensure all personnel in assigned Qualified Treatment Centers are appropriately trained according to Orchard’s SOPs and the latest Product Manual. - Develop a territory profile including Centers of Excellence, key expertise, newborn screening approaches and leaders, and market access pathways to inform medical strategy and tactical planning. - Gather insights from the field on data, therapeutic area, and competitive intelligence to help inform company strategies and evidence generation plans. - Build thorough operational understanding to ensure excellence in execution balanced with risk management within the boundaries of all governance processes. - Review and oversee Investigator-Sponsored Trial (IST) requests and Early Access Program (EAP) requests throughout the internal review process and any follow up requests for information. - Build effective internal partnerships through communication and collaboration across the organization. - Ensure compliance with internal and external regulatory and legal guidelines. - Maintain clinical, scientific, and technical expertise in therapeutic area. - Develop strategic initiatives to support departmental goals from a field medical excellence perspective. - Successfully manage at least two large cross-functional projects with demonstrated leadership and collaboration skills. - Proactively seek out and demonstrate successful peer coaching of other team members. - Develop US field resource materials specific to stakeholder group, disease state, and technology. - Provide strategic insights by maintaining expertise in the therapeutic area and related fields. - Monitor the competitive environment for advances and trends in the therapeutic area. - Serve as peer leader to mentor and coach new or junior MSLs, supporting onboarding, training, and field excellence. Qualifications - Advanced Scientific / Healthcare Degree (PhD, PharmD, MD, NP, DVM, CGC or similar preferred; RN, MS, or similar with substantial experience considered). - Minimum of 5 years of experience in a scientific, clinical or MSL role within the biotech or pharmaceutical industry. - Extensive experience as an MSL supporting post-approval commercial products in the field. - Ability to lead and motivate team members without a direct reporting relationship. - Track record of successfully establishing relationships with health care provider thought leaders. - Understanding of US government and industry guidelines, regulations, laws, etc. - Experience and relevant knowledge in one or more key therapeutic areas: hematopoietic stem cell transplantation, gene therapy, and neurology/genetics. - Experience in developing and delivering effective scientific educational materials and programs. - Strong knowledge and established network with health care providers and industry experts. - Fluency in both spoken and written English. - Excellent communication and presentation skills. - Effective interpersonal skills and awareness of inward and outward emotional intelligence. - Ability to apply technical expertise and solutions to diverse/individualized situations. - Experience in achieving results, generating ideas and influencing outcomes through collaboration. - Highly effective in building close working relationships with cross-functional partners. - Growth mindset – curious by nature, proactive in keeping abreast of key scientific developments. - Valid US Driver’s License and clean driving record. - Ability to travel frequently (75%), often overnight. Salary Range The anticipated salary for this position will be $170,000 - $225,000. The actual salary offered for this role at commencement of employment may vary based on several factors including but not limited to relevant experience, skill set, qualifications, education, job-based knowledge, location, and other business and organizational needs. Company Description Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSCs). Orchard has its global headquarters in London, England, and its U.S. headquarters in Boston, Massachusetts.

• Owns the review of business opportunities to optimize the product portfolio through analysis and understanding of targeted markets, segmentation efforts, market trends, new technology, and competitive environment. • Working closely with Managed Services delivery teams, creates product roadmaps to deliver on the product vision, to optimize service margins and create customer value. • The role is responsible for translating business and customer needs into clear, actionable product requirements that guide an offshore development team of 8 individuals. • Own and maintain a well-groomed product backlog with clear user stories, acceptance criteria, and business context. • In combination with the BAs, leads sprint planning, backlog grooming, and regular check-ins across time zones. • Manages a team of business analysts across both NA and India. • Collaborates with other stakeholders to define product roadmaps and go to market strategies that enable achievement of revenue goals and competitively position the solution for future growth. • Manages product line life cycle from strategic planning to tactical activities and serves as an internal voice for the customer on new or already existing products throughout the product lifecycle. This includes understanding how customers are using our services today, where value is generated and how they should evolve. • This role owns the GTM process from a services perspective, service pricing, operational design, operational modelling and scaling. • Monitors and analyzes how well a GHX product is performing, to include product profitability, actual to planned revenue, customer satisfaction, and retention/renewals. • Reviews internal metrics to determine how the product impacts the company operations. • Reviews areas that may impact product profitability, to include product life cycle, quality, technical support, marketing programs, and sales support. • Manages a group of products and services that meet market needs; assesses the health of the portfolio and how components contribute to corporate strategy. • Creates product roadmaps illustrating the vision for the product. Describes the idea or stereotypical users that represent the programming targets. • Writes scenarios for user personas to describe instances of market problems or situations that illustrate why the product requirement is necessary. • Reviews the release plan with periodic checkpoints of progress in each of the operational groups.

• Assess and diagnose current seller compensation plans. • Partner with Partner Development, Finance, People, and Legal during diligence and deal structuring to design aligned compensation approaches. • Model compensation scenarios and clearly articulate tradeoffs and considerations. • Ensure compensation commitments made during negotiations are deliberate, documented, and operationally feasible post-close. • Own and maintain clear, scalable compensation frameworks for M&A, including standard models, transition approaches, and exception criteria. • Define governance for bespoke arrangements, including tracking, sunset provisions, and conversion to standard plans. • Create repeatable playbooks, tools, and documentation used by deal teams, People Partners, Rewards, and Finance. • Develop clear education materials for incoming partners explaining Mercer’s compensation philosophy, programs, and what to expect over time. • Translate specific compensation commitments into Mercer’s compensation cycle. • Manage phased transitions, including multi-year or multi-cycle transitions. • Ensure accuracy and alignment across Compensation, Legal and Finance. • Act as the escalation owner for M&A compensation issues post-close. • Maintain a centralized, living repository of all M&A compensation commitments. • Serve as the single source of truth for historical M&A compensation decisions. • Build and maintain deep industry expertise in wealth management compensation practices, including advisor, partner, and leadership pay models. • Interact directly with sellers, acting as a credible, trusted partner. • Represent Mercer’s culture of collaboration, professionalism, and long-term partnership in all seller interactions. • Partner seamlessly internally, presenting a unified and collaborative front to sellers.