BridgeBio Pharma is on a mission quickly and safely discover, develop, and deliver breakthrough medicines to patients with genetic diseases. To reach this goal,
Senior Manager - Associate Director, Drug Substance
Location
California
Posted
54 days ago
Salary
$175K - $185K / year
Seniority
Lead
Job Description
Senior Manager - Associate Director, Drug Substance
BridgeBio Pharma
Title: Sr. Manager / Associate Director, Drug Substance; Hypopara Location: San Francisco United States Job Description: When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a "moneyball for biotech" approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation-including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work. Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on In 2015, we pioneered a "moneyball for biotech" approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible. Together we define white space, push boundaries and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. What You'll Do Senior Scientist / Associate Director, Drug Substance Development and Manufacturing will support Calcilytix Therapeutics, a subsidiary of BridgeBio Pharma. This position will be responsible for managing outsourced drug substance process development and manufacturing activities at contract suppliers, including manufacture of raw materials and drug substance for clinical studies, process validation, commercial launch, and tech transfer to new vendors to build and maintain the commercial supply chain throughout product lifecycle. The position will also support submission of global marketing authorization applications and responses to health agency queries. Responsibilities - Manage multiple CMOs and CROs to deliver bulk starting materials, intermediates, and drug substance of sufficient quality and quantity to meet corporate and regulatory requirements. Maintain in-depth knowledge of chemical steps, manufacturing processes, and quality controls. - Establish and maintain business relationships with CROs and CMOs appropriate for performing process validation and commercial supply requirements. - Lead early to mid-stage process development and manufacturing to support clinical studies. - Lead validation and commercial-scale manufacturing. - Identify and lead key process problem resolution activities and process improvement initiatives. - Work closely with Quality Assurance function to develop and operate appropriate cGMP procedures, and to ensure product meets established quality standards. - Create and disseminate technical transfer information required by CROs and CMOs to develop and scale up chemical processes and develop and validate analytical methods. - Support authorship, review, and response to queries on all Module 3 drug substance development sections of CTD. Contribute to the overall regulatory control strategy. - Support a culture of continuous improvement and high-performance teamwork. Where You'll Work This is a hybrid role and requires in-office collaboration 2-3x per week in our San Francisco Office. Fully remote could be considered for the right candidate. Who You Are - Minimum of PhD (ideally chemistry or chemical engineering) with 7+ years relevant experience, or BS/MS with 10+ years relevant experience. - Demonstrated chemical development at industrial scale. - Demonstrated experience in managing drug substance chemical development, process validation and manufacturing in support of marketing applications and commercial production. - Strong aptitude and demonstrated experience in synthetic organic chemistry. - Working knowledge of analytical method development and validation. - Familiarity with FDA and ICH guidelines for INDs/NDAs/MAAs. Thorough understanding of cGMP, quality and regulatory requirements for drug substance manufacturing. - Ability to effectively interface with and/or manage highly skilled internal staff. - Ability to work independently as well as in a team. Ability to build good work relationships. Strong attention to detail and time management skills. Excellent oral and written communication skills. - Up to 20% travel may be required. Rewarding Those Who Make the Mission Possible We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return. Financial Benefits: - Market leading compensation - 401K with 100% employer match on first 3% & 50% on the next 2% - Employee stock purchase program - Pre-tax commuter benefits - Referral program with $2,500 award for hired referrals Health & Wellbeing: - Comprehensive health care with 100% premiums covered - no cost to you and dependents - Mental health support via Spring Health (6 therapy sessions & 6 coaching sessions) - Hybrid work model - employees have the autonomy in where and how they do their work - Unlimited flexible paid time off - take the time that you need - Paid parental leave - 4 months for birthing parents & 2 months for non-birthing parents - Flex spending accounts & company-provided group term life & disability - Subsidized lunch via Forkable on days worked from our office Skill Development & Career Paths: - People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility - We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, Spring Health & BetterUp Coaching - We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states. Salary $175,000 - $185,000 USD As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return. For USA based roles: Financial & Rewards - Market-leading compensation - 401(k) with employer match - Employee Stock Purchase Program (ESPP) - Pre-tax commuter benefits (transit and parking) - Referral bonus for hired candidates - Subsidized lunch and parking on in-office days Health & Well-Being - 100% employer-paid medical, dental, and vision premiums for you and your dependents - Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA) - Fertility & family-forming benefits - Expanded mental health support (therapy and coaching resources) - Hybrid work model with flexibility - Flexible, "take-what-you-need" paid time off and company-paid holidays - Comprehensive paid medical and parental leave to care for yourself and your family Skill Development & Career Paths: - People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility - We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching - We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities
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Associate Director, Government Affairs
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Director, Esports
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Sr Dir, Global Partnerships and Channels, Asia
ServiceNowServiceNow provides cloud-based services that automate enterprise information technology operations. As an employer, ServiceNow offers a challenging, collaborat
Company Description It all started in sunny San Diego, California in 2004 when a visionary engineer, Fred Luddy, saw the potential to transform how we work. Fast forward to today - ServiceNow stands as a global market leader, bringing innovative AI-enhanced technology to over 8,100 customers, including 85% of the Fortune 500®. Our intelligent cloud-based platform seamlessly connects people, systems, and processes to empower organizations to find smarter, faster, and better ways to work. But this is just the beginning of our journey. Join us as we pursue our purpose to make the world work better for everyone. Job Description What you get to do in this role: The successful applicant will lead and manage the partner and channel ecosystem across Southeast Asia (SEA) and Hong Kong/Taiwan (HK/TW) markets. This is a senior leadership role with full accountability for driving growth, ecosystem health, and customer success outcomes across the territory. 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Used under license.
Role Description At Leading Educators, we're seeking a strategic financial steward who will transform our grant management from a reactive process to a proactive, risk-mitigating powerhouse. This is not just a job—it's a critical mission to protect and professionalize our financial operations as our grant portfolio becomes increasingly complex. - Own the post-award financial lifecycle of our grants. - Design systems that eliminate manual work, reduce organizational risk, and position us for future funding opportunities. - Create financial resilience that supports our broader mission of educational excellence. - Transform how we manage multi-year, multi-funder grants with precision and strategic insight. Qualifications - Bachelor's degree in Accounting, Finance, Business, Public Administration, or related field. - 5+ years of nonprofit finance or advanced grants management experience. - Proven track record of managing multi-year, multi-funder grants. - Demonstrated ability to independently design and implement financial systems. - Strong technical proficiency with financial systems like SageIntacct and Salesforce. - Exceptional ability to communicate complex financial information clearly. Requirements - Ability to work remotely with occasional national travel (1-3 trips per year). - Experience reading and managing grant agreements independently. - Background in audit, government, or nonprofit compliance preferred. Benefits - 100% paid medical, dental, and vision coverage for individual employees. - Additional premium costs are covered 60% by Leading Educators for partners and dependents on medical, dental, and vision plans. - 4% matching 401k plan. - Flexible Spending Accounts for medical, childcare, and commuter expenses. - Employee Assistance Program (EAP). - Benefits are valued at or above $9,000 for employees. - First three years of employment, full-time staff accrue 22 days a year. - Five additional days are accrued after the third and sixth year of employment. - 16 additional paid days off for various holidays, including three floating holidays staff may use at their discretion.

