BridgeBio Pharma

Title: Head of Procurement and Sourcing Location: San Francisco, CA US Job Description: Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on   In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.    Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work. Position Summary BridgeBio is building a dedicated Strategic Procurement function and we are looking for a Director to lead it. This is a build role: the Director will stand up the team, establish sourcing strategy and governance, and take ownership of procurement across BridgeBio's non-clinical spend categories — IT, Travel & Expense (T&E), Sales & Marketing (S&M), and G&A. The Director will own the full, end-to-end procurement lifecycle: defining category strategy; running competitive sourcing events (RFI/RFP/RFQ) and leading contract negotiations; implementing contract lifecycle management; and building a supplier performance management program with KPI tracking and business reviews. Reporting to the Executive Director, FP&A, the Director will be accountable for delivering measurable savings against an approximately $500M annual addressable spend base, and for building the team, processes, and infrastructure needed to sustain that performance over time. Key Responsibilities Organizational Build-Out & Team Leadership - Stand up and lead the Strategic Procurement team, including direct management of a Sr. Manager, Strategic Sourcing and two Buyer (contractor) resources. - Recruit, onboard, and develop procurement talent as the function scales; define roles, workflows, and performance expectations for the team. Category Management (Non-Clinical Scope) Own strategic sourcing and vendor management across four in-scope categories: · IT — software, hardware, SaaS, telecom, and vendor contracts · T&E — corporate travel, hotel and airline programs · S&M — agencies, events, market research, promotional spend · G&A — IT enterprise services, company-wide events, professional services, facilities, office and MRO supplies Strategic Sourcing & Savings Delivery - Develop and execute category sourcing strategies against ~$500M in addressable non-clinical spend. - Deliver a savings target of 2–4% of addressable spend annually (approximately $5M–$10M), representing a 5x–10x return on the team's total cost. - Build the pipeline, tracking, and reporting needed to validate savings and hold the function accountable to target. Vendor & Contract Management - Lead RFP processes, vendor negotiations, and contract structuring across in-scope categories. - Establish ongoing vendor performance management and contract renewal governance. Cross-Functional Partnership - Partner closely with Finance, IT, Sales & Marketing, G&A, and Legal stakeholders to align sourcing strategy with business needs. - Act as the primary point of contact for procurement matters with the Executive Director, FP&A and other senior stakeholders. Process, Governance & Reporting - Establish procurement policies, approval workflows, and procure-to-pay processes for a newly formed function. - Build dashboards and reporting to track savings, spend under management, and team performance; present results to Finance leadership. Qualifications - Bachelor's degree required; MBA preferred. - 10+ years of progressive experience in procurement or strategic sourcing, including experience leading a team; biotech, pharma, or life sciences industry experience strongly preferred. - Demonstrated experience building or scaling a procurement function, ideally in a growth-stage or resource-conscious environment. - Category expertise across some combination of IT, corporate travel, marketing/agency spend, and G&A services. - Track record of delivering measurable, validated cost savings. - Strong contract negotiation and vendor management skills. - Excellent executive communication and stakeholder management skills, given regular visibility with senior Finance leadership. - Analytical and comfortable operating with limited infrastructure in a fast-paced environment. Success Metrics - Procurement team built out and operating to plan. - 2–4%+ annual savings delivered against addressable spend ($5M–$10M). - 5x–10x return on total team investment. - Sourcing governance, contract management, and reporting processes established across all four in-scope categories. At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states. Salary: $220,000 - $252,000 USD As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return. For Full-Time U.S Based Roles: Financial & Rewards - Market-leading compensation - 401(k) with employer match - Employee Stock Purchase Program (ESPP) - Pre-tax commuter benefits (transit and parking) - Referral bonus for hired candidates - Subsidized lunch and parking on in-office days Health & Well-Being - 100% employer-paid medical, dental, and vision premiums for you and your dependents - Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA) - Fertility & family-forming benefits - Expanded mental health support (therapy and coaching resources) - Hybrid work model with flexibility - Flexible, “take-what-you-need” paid time off and company-paid holidays - Comprehensive paid medical and parental leave to care for yourself and your family Skill Development & Career Paths: - People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility - We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching - We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities

Title: Senior/Executive Director, Business Operations Location: San Francisco - 1800 Owens Job Description: Mavericks Wanted When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on   In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.    Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work. What You'll Do As the Senior/Executive Director, Business Operations, you will play a key role in shaping the future direction of our Encaleret program. You will lead strategic planning efforts and provide critical insights that influence high-impact decisions. Your expertise will help guide commercial launch readiness, modeling & forecasting, preparation of corporate materials intended for presentation, corporate development, and strategic activities. You will also partner closely with cross-functional teams, including supply chain and operations, to ensure strategic alignment. Your analytical skills and industry experience will directly contribute to the company's long-term success. Responsibilities Strategic Planning and Execution - Shape and communicate the company's strategic direction through well-structured presentations that guide prioritization and resource allocation - Lead strategic analyses for program evaluation, including discounted cash flow modeling, and secondary research (e.g., analogs research, epidemiology, claims data analysis) - Prepare a strategy to guide the successful US commercialization of encaleret Stakeholder Communication - Develop and deliver executive-level presentations that effectively communicate strategic insights, corporate initiatives, and market analyses - Create high-quality visual materials for partnership dialogue, Board of Directors meetings, investor discussions & communications, and internal alignment efforts - Ensure presentations are tailored to the audience, synthesizing technical and business content into clear, concise, and actionable messaging - Present and discuss findings of strategic analyses to a variety of audiences, including the Calcilytix team, leadership, and investors - Support corporate development and partnering strategy to ensure that Encaleret can be accessed by eligible patients worldwide Operational Excellence - Oversee budget planning initiatives and ownership of long-term lifecycle planning Cross-functional Partnership - Collaborate with R&D, Regulatory, Finance, Commercial, and Operations to ensure holistic strategy development - Collaborate with functional experts as a strategic partner to support the clinical and commercial success of Encaleret - Collaborate with the BridgeBio commercial team and oversee research in pricing and reimbursement - Lead or contribute to special initiatives involving product lifecycle planning, global expansion, or operational efficiency Where You'll Work This role requires in-office collaboration at least 3-4x per week in our San Francisco or Palo Alto Office. Who You Are - A higher degree or equivalent, such as an M.B.A., M.D., or Ph.D., is preferred - 2-5 years of professional experience in management consulting (life sciences preferred), post-Series A investing, investment banking, venture capital, equity research, and/or corporate role in a therapeutics company - Prior experience contributing to new product commercialization is a plus - Proven scientific acumen, communication skills, and an analytical mindset - A passion for helping patients - Proficiency in financial modeling, particularly DCF models - Tenure-appropriate understanding of the drug development life science and operating model. Understands how value is created across the lifespan of a molecule from discovery to commercial execution - Tenure-appropriate understanding of the biotech landscape - - Exceptional written communication and presentation skills At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states. Salary $249,000—$330,000 USD As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return. For Full-Time U.S Based Roles: Financial & Rewards - Market-leading compensation - - 401(k) with employer match - - Employee Stock Purchase Program (ESPP) - - Pre-tax commuter benefits (transit and parking) - - Referral bonus for hired candidates - - Subsidized lunch and parking on in-office days - Health & Well-Being - 100% employer-paid medical, dental, and vision premiums for you and your dependents - - Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA) - - Fertility & family-forming benefits - - Expanded mental health support (therapy and coaching resources) - - Hybrid work model with flexibility - - Flexible, “take-what-you-need” paid time off and company-paid holidays - - Comprehensive paid medical and parental leave to care for yourself and your family - Skill Development & Career Paths: - People are part of our growth and success story - from discovery to active drug trials and FDA pipelines, there are endless opportunities for skill development and internal mobility - - We provide career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching - - We celebrate strong performance with financial rewards, peer-to-peer recognition, and growth opportunities

Role Description The Skeletal Dysplasia Account Manager is a high-impact, community-focused role central to BridgeBio’s commercial success. This individual will drive the launch of Infigratinib—a first-in-class therapy for achondroplasia—bringing deep clinical acumen, urgency, and a passion for partnering with providers and families. Location: Central Region ~ Multiple territories covering the following areas: - Chicago - Minneapolis - Indianapolis - Cincinnati - Detroit - Kansas City Responsibilities - Develop and execute a dynamic territory business plan targeting geneticists, pediatric endocrinologists, orthopedic specialists, pediatricians, and multi-disciplinary skeletal dysplasia clinic teams to meet and exceed sales goals. - Demonstrate deep expertise in Infigratinib, achondroplasia, and the broader skeletal dysplasia landscape; engage HCPs in clinically relevant, compliant discussions. - Use sales and target data to identify growth opportunities and address territory challenges proactively. - Anticipate potential business challenges, adjust priorities as needed, demonstrate flexibility, and develop solutions to address challenges. - Partner compliantly with Field Medical Directors, Field Reimbursement Managers, Family Account Managers, and the HUB to maximize customer and family satisfaction. - Build and maintain relationships with KOLs in partnership with Marketing and Medical Affairs to expand advocacy for Infigratinib and BridgeBio. - Operate with an “One Bridge” mindset—collaborating across the organization to execute company initiatives and represent BridgeBio with integrity. - Maintain an exceptional level of proficiency in selling skills, clinical, market and product knowledge, and the business environment of the territory. - Ensure all activities comply with applicable regulations, company policies, and Pharma guidelines. Critical Capabilities - Competitive Mindset - Business Acumen & Results Orientation: Balances priorities and leverages available resources to drive results; applies strong analytical skills to surface opportunities in the skeletal dysplasia market. - Resilience & Confidence: Hunter’s mentality with the resilience to identify and support families living with achondroplasia across geographically dispersed centers of care. - Customer Focus - Build Trusting Relationships: Trusted advisor who anticipates and addresses the needs of skeletal dysplasia providers, genetic counselors, and families. - Clinical Acumen & Learning Agility: Continuously deepens clinical knowledge of achondroplasia; sought out as a condition and product expert by HCPs and their teams. - Key Account Success - Influence with Impact: Engages multidisciplinary care teams—from geneticists to orthopedic specialists to community advocacy groups—with credible, complex influence strategies. - Teamwork and Coordination: Prioritizes the community and business while collaborating closely with the Regional Sales Director and cross-functional partners to execute a successful launch. Qualifications - 8–10 years in pharmaceutical or biotech; 4+ years in rare disease, genetic disease, or skeletal dysplasia required. Achondroplasia or pediatric rare disease experience highly preferred. - BS/BA required, MBA a plus. - Willingness to travel extensively. - Product/indication launch experience: Proven record of accomplishment launching products into competitive or new markets, including creating demand through disease-state and stakeholder education. - Account management: Success analyzing complex accounts, building strategy, and driving implementation to deliver measurable impact. - Leadership & communication: Effective communication skills and influence, both internally and externally—with high accountability, sound judgment, and excellent organizational skills. - AI fluency: Demonstrated curiosity and adaptability with AI-powered tools and technologies. - Integrity: Commitment to BridgeBio’s ethical standards and compliance culture. Benefits - Market-leading compensation - 401(k) with employer match - Employee Stock Purchase Program (ESPP) - Pre-tax commuter benefits (transit and parking) - Referral bonus for hired candidates - Subsidized lunch and parking on in-office days - 100% employer-paid medical, dental, and vision premiums for you and your dependents - Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA) - Fertility & family-forming benefits - Expanded mental health support (therapy and coaching resources) - Hybrid work model with flexibility - Flexible, “take-what-you-need” paid time off and company-paid holidays - Comprehensive paid medical and parental leave to care for yourself and your family - Career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching - Celebration of strong performance with financial rewards, peer-to-peer recognition, and growth opportunities

• Meeting and/or exceeding sales goals in an assigned territory by developing, implementing, and executing an integrated territory business plan encompassing key customer targets • Demonstrating subject matter expertise concerning scientific and clinical information for Acoramidis • Taking a customer centric-approach and engaging customers in clinically relevant discussions utilizing approved materials • Effectively analyzing sales data to identify opportunities for business growth or areas of concern in their territory • Being responsible for territory business planning and execution of key company initiatives • Adhering to company guidelines and demonstrating honesty, integrity, trust, respect, and accountability while performing all responsibilities in accordance with company policies and procedures and applicable state and federal rules and regulations • Compliantly partnering with Medical Science Liaisons, Field Reimbursement, Patient Access, HUB, and other key cross-functional team members to develop strategies to ensure a high level of customer satisfaction • Developing and implementing a dynamic territory business plan by analyzing the business, competitive landscape, and territory market to drive business, maintaining professional relationships with targeted KOLs including physicians, medical staff, and hospital personnel • Navigating the hospital formulary process and developing and implementing strategies to ensure successful product positioning and availability • Anticipating potential business challenges, adjusting priorities as needed, and developing solutions to address challenges • Maintaining an exceptional level of proficiency in selling skills, clinical, market and product knowledge, and the business environment of the territory • Collaborating with peers and company personnel to ensure corporate objectives and initiatives are achieved • Effectively planning and organizing schedule to ensure maximum efficiency and use of time to accomplish goals and objectives • Acting as an ambassador on behalf of the company, presenting a professional image and representing the company, products, and people with integrity and respect • Completing tasks and projects assigned by Sales Leadership • Ensuring that all activities are following applicable regulations, compliance, and Pharma guidelines

• Serve as the Ad Promo regulatory lead for assigned products (commercial and/or pipeline). • Provide proactive guidance on promotional strategy, claims development, and risk positioning. • Partner with Commercial, Medical, Legal, and Clinical teams to align messaging with labeling and data. • Interpret and apply FDA regulations, OPDP guidance, enforcement trends, and industry standards to business initiatives. • Assess regulatory risk and recommend clear, practical mitigation strategies. • Lead review and approval of promotional materials through the Medical, Legal and Regulatory review committee (MLR). • Ensure materials are accurate, balanced, and supported by substantial evidence. • Provide strategic direction on disease awareness, HCP and patient materials, digital content, and launch campaigns. • Support advisory boards, speaker programs, and field training materials as needed. • Contribute to development and refinement of internal SOPs and review processes. • Partner with Regulatory Labeling to ensure promotional claims align with approved labeling and clinical data. • Anticipate labeling implications for promotional planning, especially during launch readiness. • Support development of core claims documents and messaging frameworks. • Monitor FDA enforcement actions and emerging trends. • Support responses to OPDP inquiries or regulatory questions related to promotional materials. • Contribute to inspection readiness activities related to promotional review processes.

• Develop and execute a dynamic territory business plan targeting geneticists, pediatric endocrinologists, orthopedic specialists, pediatricians, and multi-disciplinary skeletal dysplasia clinic teams to meet and exceed sales goals. • Demonstrate deep expertise in Infigratinib, achondroplasia, and the broader skeletal dysplasia landscape; engage HCPs in clinically relevant, compliant discussions. • Use sales and target data to identify growth opportunities and address territory challenges proactively. • Anticipates potential business challenges, adjusts priorities as needed, demonstrates flexibility, and develops solutions to address challenges. • Partners compliantly with Field Medical Directors, Field Reimbursement Managers, Family Account Managers, and the HUB to maximize customer and family satisfaction. • Build and maintain relationships with KOLs in partnership with Marketing and Medical Affairs to expand advocacy for Infigratinib and BridgeBio. • Operate with an “One Bridge” mindset—collaborating across the organization to execute company initiatives and represent BridgeBio with integrity. • Maintains an exceptional level of proficiency in selling skills, clinical, market and product knowledge and the business environment of the territory. • Ensure all activities comply with applicable regulations, company policies, and Pharma guidelines.

• Develop and execute a dynamic territory business plan targeting geneticists, pediatric endocrinologists, orthopedic specialists, pediatricians, and multi-disciplinary skeletal dysplasia clinic teams to meet and exceed sales goals. • Demonstrate deep expertise in Infigratinib, achondroplasia, and the broader skeletal dysplasia landscape; engage HCPs in clinically relevant, compliant discussions. • Use sales and target data to identify growth opportunities and address territory challenges proactively. • Anticipates potential business challenges, adjusts priorities as needed, demonstrates flexibility, and develops solutions to address challenges. • Partners compliantly with Field Medical Directors, Field Reimbursement Managers, Family Account Managers, and the HUB to maximize customer and family satisfaction. • Build and maintain relationships with KOLs in partnership with Marketing and Medical Affairs to expand advocacy for Infigratinib and BridgeBio. • Operate with an “One Bridge” mindset—collaborating across the organization to execute company initiatives and represent BridgeBio with integrity. • Maintains an exceptional level of proficiency in selling skills, clinical, market and product knowledge and the business environment of the territory. • Ensure all activities comply with applicable regulations, company policies, and Pharma guidelines.

• Develop and execute a dynamic territory business plan targeting geneticists, pediatric endocrinologists, orthopedic specialists, pediatricians, and multi-disciplinary skeletal dysplasia clinic teams to meet and exceed sales goals. • Demonstrate deep expertise in Infigratinib, achondroplasia, and the broader skeletal dysplasia landscape; engage HCPs in clinically relevant, compliant discussions. • Use sales and target data to identify growth opportunities and address territory challenges proactively. • Anticipates potential business challenges, adjusts priorities as needed, demonstrates flexibility, and develops solutions to address challenges. • Partners compliantly with Field Medical Directors, Field Reimbursement Managers, Family Account Managers, and the HUB to maximize customer and family satisfaction. • Build and maintain relationships with KOLs in partnership with Marketing and Medical Affairs to expand advocacy for Infigratinib and BridgeBio. • Operate with an “One Bridge” mindset—collaborating across the organization to execute company initiatives and represent BridgeBio with integrity. • Maintains an exceptional level of proficiency in selling skills, clinical, market and product knowledge and the business environment of the territory. • Ensure all activities comply with applicable regulations, company policies, and Pharma guidelines.

• Develop and execute a dynamic territory business plan targeting geneticists, pediatric endocrinologists, orthopedic specialists, pediatricians, and multi-disciplinary skeletal dysplasia clinic teams to meet and exceed sales goals. • Demonstrate deep expertise in Infigratinib, achondroplasia, and the broader skeletal dysplasia landscape; engage HCPs in clinically relevant, compliant discussions. • Use sales and target data to identify growth opportunities and address territory challenges proactively. • Anticipates potential business challenges, adjusts priorities as needed, demonstrates flexibility, and develops solutions to address challenges. • Partners compliantly with Field Medical Directors, Field Reimbursement Managers, Family Account Managers, and the HUB to maximize customer and family satisfaction. • Build and maintain relationships with KOLs in partnership with Marketing and Medical Affairs to expand advocacy for Infigratinib and BridgeBio. • Operate with an “One Bridge” mindset—collaborating across the organization to execute company initiatives and represent BridgeBio with integrity. • Maintains an exceptional level of proficiency in selling skills, clinical, market and product knowledge and the business environment of the territory. • Ensure all activities comply with applicable regulations, company policies, and Pharma guidelines.

• Develop and execute a dynamic territory business plan targeting geneticists, pediatric endocrinologists, orthopedic specialists, pediatricians, and multi-disciplinary skeletal dysplasia clinic teams to meet and exceed sales goals. • Demonstrate deep expertise in Infigratinib, achondroplasia, and the broader skeletal dysplasia landscape; engage HCPs in clinically relevant, compliant discussions. • Use sales and target data to identify growth opportunities and address territory challenges proactively. • Anticipates potential business challenges, adjusts priorities as needed, demonstrates flexibility, and develops solutions to address challenges. • Partners compliantly with Field Medical Directors, Field Reimbursement Managers, Family Account Managers, and the HUB to maximize customer and family satisfaction. • Build and maintain relationships with KOLs in partnership with Marketing and Medical Affairs to expand advocacy for Infigratinib and BridgeBio. • Operate with an “One Bridge” mindset—collaborating across the organization to execute company initiatives and represent BridgeBio with integrity. • Maintains an exceptional level of proficiency in selling skills, clinical, market and product knowledge and the business environment of the territory. • Ensure all activities comply with applicable regulations, company policies, and Pharma guidelines.