• Design, build, and deploy machine learning solutions for audience targeting, lookalike generation, and individual propensity scoring • Own the complete ML lifecycle - from exploratory analysis and experimentation all the way through production deployment and operational monitoring • Develop and ship production ML systems spanning self-supervised representation learning, vector similarity search, and supervised classifiers • Leverage distributed computing (Spark/Databricks) and cloud data platforms (AWS, Snowflake) to build and run production ML pipelines at scale • Ensure model quality through rigorous evaluation practices: from embedding validation and retrieval quality to supervised model calibration and production monitoring • Engineer features at scale from demographic, behavioral, and identity data — including handling missing values, encoding strategies, and pipeline-level data quality validation • Contribute ML logic directly into shared production services, working alongside data engineering, software engineering, and product teams

eClinical Solutions helps life sciences organizations around the world accelerate clinical development initiatives with expert data services and the elluminate Clinical Data Cloud – the foundation of digital trials. Together, the elluminate platform and digital data services give clients self-service access to all their data from one centralized location plus advanced analytics that help them make smarter, faster business decisions. eClinical Solutions is committed to driving innovation in clinical trials through a better approach to data management and data analytics. We use the eClinical Solutions technology platform, elluminate, throughout the data management process to accelerate timelines for our clients and automate manual processes. We believe in a more agile approach to data management using our core technology elluminate - enabling our life sciences clients to proactively manage their clinical programs and make decisions. You will make an impact: As a Senior Clinical Data Manager (Sr. CDM) you will independently act as a study lead and are responsible for the oversight, maintenance, and management of clinical trial database(s) for assigned projects through the full data management process life cycle. You are viewed as the CDM expert and will serve as the primary liaison between eClinical personnel and Sponsor personnel. You will create and oversee the database design specifications, validation, maintenance/data cleaning, and closeout activities of project-specific clinical trial databases. As a Senior Clinical Data Manager, you may delegate tasks/responsibilities to multiple team members in multiple projects. You will provide ongoing project oversight to ensure proper planning and timely completion of high-quality Sponsor deliverables. Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. Your day to day: - Primary representative for eClinical Solutions and sponsor data management interaction - Responsible for monitoring and ensuring adherence to study timelines and deliverables - Accountable for the overall quality of data management activities and deliverables at the study or program level - Ensure efficiency and consistency for data management tasks across programs - Communicate with global study teams - Participate in client study kickoff and closeout/lessons learned meetings - Create materials for and present at Investigator Meetings - Develop content and deliver Sponsor CRA and/or site training - Delegate tasks, support and provide guidance to study data management team - Oversee and/or develop data management documents including DMPs, eCRF Completion Guidelines, CRFs, and Help Text - Oversee and/or Develop Internal System Testing (IST) plan for database/user roles/edit check specifications - Participate in Internal System Testing (IST) on the database/user roles/edit check specifications - Assist with preparation for implementation of a centralized data management platform for strategic data cleaning and reporting - Utilization of centralized data management platform including graphical patient profiles and operational analytics - Compile the sponsor UAT package - Oversee and/or perform data review as documented in the Data Management Plan and Data Validation Specifications - Oversee and/or perform manual review/QC checks as listed in the Data Validation Specifications exception listings and reporting tools - Oversee and/or perform data review for overall consistency and accuracy - Oversee and/or perform vendor data reconciliation (e.g., IVRS, laboratory data) with the clinical database - Oversee and/or perform query processing/resolution - Provide ongoing data management reports and metrics - Oversee and/or develop specifications and collaborate with programming for programming and QC of manual listings, external data reconciliation, metrics and custom reports as needed throughout the study - Define and develop specifications for database, programming and/or edit check changes as needed throughout the study - Track data management issues and ensure follow up to resolution - Identify data issues and/or data trends, communicate to the Clinical Data Management team and Sponsor, assist with development and implementation of action plan - Maintain data management study documentation - Perform steps pertaining to database freeze/lock and coordinate all related activities - Ongoing evaluation of process and participate in process improvement - Assist in the creation and review of SOPs, WIs, and training materials - Mentor junior level staff and peers on all associated tasks within a study - Participate in proposal defenses - Perform other duties as requested by management Take the first step towards your dream career. Here is what we are looking for in this role. Qualifications: - Bachelor’s degree in Pharmaceutical/Biotechnology or higher in health-related field preferred - 8+ years in Clinical Data Management experience preferred - Knowledge of ICH/GCP guidelines, 21 CFR Part 11, clinical trial methodology - Strong project management experience and project team leadership skills including work planning and work delegation - Experience with EDC and performing data management activities - Excellent verbal and written communication skills - Proficiency in Microsoft Office Applications, specifically MS Project and MS Excel - Experience with EDC and Clinical Data Management Systems  Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours! eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/ eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here! We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need. Pay Range US Pay Ranges $100,000—$125,000 USD

be part of a team that values safety, inclusion, and excellence we are one of the largest U.S. railroads transporting the nation’s freight across 28 western states and 3 Canadian provinces. as a member of our team, you will play a role in supporting the movement of essential products and materials that help feed, clothe, supply, and power communities throughout America and the world. bnsf | tech: innovating and transforming the future of freight rail bnsf | tech is the technology division making BNSF the preeminent freight and mobility company in north america. are you ready to drive change? if you are passionate about making a difference and eager to advance your career in a dynamic and supportive environment, we want you on our team! join us in reshaping the future of freight rail and discover a fulfilling career where your contributions matter. we are committed to a culture where all employees are included, belong, and have equal opportunity to achieve their full potential. Come make a difference with us! learn more about BNSF and our Benefits Job Location: Remote US Anticipated Start Date: 01/01/2026 The US base salary range for this full-time position is provided below: Salary Range: $165,000-$300,000 L5: $165,000 - $220,00 L6: $225,000 - $300,000 The range represents the amount bnsf | tech reasonably expects to pay for the position based on the level, scope, and responsibilities of the role.  Individual compensation and level of position offered is determined by the hiring location and additional factors including but not limited to job-related skills, experience, and relevant education or training. In addition to base pay and bonus eligibility, BNSF offers a comprehensive benefits package. This is a full-time remote position. Employees may work from anywhere within the contiguous 48 states of the United States Travel is up to 20%. Employees will be required to occasionally travel to our corporate headquarters in Fort Worth, TX for in person meetings. Travel expenses for business needs will be covered by BNSF This position is open to candidates who are currently authorized to work in the United States. We are also open to sponsoring H-1B transfers, TN nonimmigrant status, and STEM OPT candidates with at least 2 years of remaining eligibility. Apply early as this job may be removed or filled prior to the closing date, which is approximately seven (7) days after the posting date. data & ai: lead our charge into the future as an ai company by transforming our data assets into a real time enterprise. Key responsibilities may include: Lead cross-functional collaboration to identify and define analytic initiatives, formulate strategies, and develop solutions to achieve business goals through effective use of data machine learning models. Apply data science skills to analyze large, complex datasets and identify meaningful patterns that lead to actionable insights and data-driven solutions to business problems. Lead the development and deployment of advanced machine learning models to forecast outcomes and optimize workflows. Engage closely with stakeholders to grasp their requirements and deliver actionable insights that drive strategic decision-making. Design and present compelling visualizations and reports to effectively communicate analytical findings. Oversee the maintenance and enhancement of data pipelines to uphold data quality and precision. Keep abreast of emerging trends and breakthroughs in data science and machine learning fields. Proficiently extract, aggregate, and transform data from SQL and NoSQL databases, leveraging languages like R, Python, or other relevant tools for analysis and modeling. Build, test, and validate statistical, and machine learning models and analyses using Python, R, or other appropriate language as part of overall solution development. Lead implementation of analytic solutions into reporting platforms or production systems by leading the solution design, development, testing, and monitoring. The duties and responsibilities in this posting are representative categories to be used in deciding whether to apply for this position. This is not an exhaustive list of the position’s duties. At BNSF Railway, we encourage individuals from all backgrounds to apply, showcasing their skills, experiences and development. We provide resources and tools to help you reach your full potential, fostering a supportive and inclusive environment. Basic Qualifications - Minimum 6 years of experience with building optimization algorithms or relevant experience. - Advanced proficiency in programming languages such as Python, R, SQL, and Java. - Demonstrated expertise in utilizing data visualization tools to communicate insights clearly and effectively. - In-depth experience with data science cloud platforms and their integration into business solutions. - Exceptional intellectual curiosity and a proven ability to thrive in a fast-paced, collaborative team environment. - Track record of rapidly acquiring new technical skills and adapting to cutting-edge technologies. - Strong communication skills to articulate technical concepts to diverse audiences with clarity and professionalism. - Deep understanding and application of statistical analysis and advanced machine learning techniques. - Must understand and have proficiency in the core architecture of LLMs (e.g., transformers and attention mechanisms) - Experience with prompt engineering techniques, including chain-of-thought prompting, Retrieval-Augmented Generation (RAG), fine-tuning of language models, and evaluation methodologies. - Experience with Vector Databases and embeddings. - Experience with Model Fine-tuning. - Experience with GPU optimization. Preferred Qualifications - Bachelor's degree or higher in Operations Research, Computer Science, Industrial Engineering or a related field. Ph.D is a plus. - Knowledge of geospatial analytics, route optimization, and GIS concepts. - Previous hands-on experience with AI/Machine Learning frameworks and tools, showcasing innovative solutions. - Extensive background in Rail, Shipping, Airline, Logistics, Warehousing, Supply Chain, or Transportation industries, or in the High-Tech sector. - Proficiency in leveraging open-source libraries and frameworks to drive data science initiatives. - Seasoned in Agile methodologies like Scrum, Kanban, or SAFe for efficient project management and delivery at a senior level. At BNSF, you will have access to a comprehensive and competitive benefits package including: - An industry-leading 401(k) and renowned Railroad Retirement program. - A range of robust health care options for you and your dependents (including domestic partners), including medical, dental, vision, telemedicine, mental health, cancer support, and high-quality care network options. - Health care spending accounts (HSA) with employer contributions, as well as life and disability insurance, provided at no cost. - Family benefits including parental, pediatric and family building support, adoption and surrogacy reimbursement, and dependent care spending account (with employer match). - Access to discounts on travel, gym memberships, counseling services and wellness support. - Annual bonus (Incentive Compensation Program) - Generous leave / time off policies. - For more information, visit Benefits. Please be aware of potential fraud that can occur when searching for new career opportunities. Please review our FAQ for more information and awareness. All positions require pre-employment background verification. BNSF Railway is an Equal Opportunity Employer, all qualified applicants receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

• Participate in the full modeling lifecycle, from statistical analysis and experimentation to building, validating, and iterating on machine learning models that address critical business challenges • Own the data foundation by preparing, cleaning and transforming raw, complex data into high-quality features for modeling • Investigate data discrepancies (tracking bugs, ETL errors, definitional issues) and design automated frameworks to ensure data accuracy • Act as a strategic liaison, collaborating with data Engineering and product teams to drive the data strategy