PTC Therapeutics, Inc.

• improve business processes w/ technology and provide local functional & process support • assess & support master data governance for supply chain and manufacturing business processes • support & provide guidance on reporting needs • provide Supply Chain, Manufacturing & Logistics process support, best practices & guidance • ensure timely & complete Change Control documentation

Analyst, Legal Operations remote type Hybrid locations USA - New Jersey - Warren time type Full time job requisition id R3716 Job Description Summary: The Legal Operations Analyst provides day-to-day operational and technical support for the Legal department’s technology and reporting needs, with a focus on the company’s Enterprise Contract Lifecycle Management Tool (CLM), ServiceNow and related legal technology. This role manages the Legal service desk queue, supports end users across multiple channels, and partners with IT and Legal stakeholders to improve service delivery, system adoption, and data-driven insights through dashboards and reporting. Job Description: Responsibilities: Legal Technology Support / Service Desk - Provide day-to-day technical support for Legal technology, including CLM and related Legal applications and workflows. - Support users via phone/email/chat/walk-in/self-service for incidents and service requests. - Manage the ServiceNow ticket queue, including: - Triage, categorize, and prioritize incidents and requests - Route/escalate to IT, vendors, or internal owners as appropriate; track progress and drive timely resolution - Communicate status updates and resolutions; ensure accurate documentation and closure in ServiceNow - Participate in system upgrades, release testing/UAT, service improvement initiatives, and service requests; document changes and support go-live activities. - Maintain and improve knowledge articles/FAQs and standard work instructions to increase self-service resolution and consistent support. Reporting, Metrics, and Analytics - Partner with IT and Legal stakeholders to define KPIs and measurement requirements (e.g., ticket volume, SLA performance, adoption, contract cycle time, data quality). - Support monthly reporting through data/input collection, coordination, and organization, including web-based programs, Excel, and data tracking applications. - Design/build Power BI dashboards and recurring reports; publish insights and highlight trends/opportunities. - Design/build Excel models/tools (templates, trackers, reconciliation tools) to support operational reporting and process monitoring. - Perform basic data validation and quality checks; identify root causes of recurring issues and recommend corrective actions. Training, Enablement, and Process Improvement - Design and deliver end-user trainings and develop training materials (job aids, quick reference guides, videos) for Legal applications and workflows. - Provide best-practice guidance to improve system usage, data quality, and user adoption. - Continuously identify opportunities to streamline intake/support workflows, improve CLM configurations/usage, and enhance reporting automation. Qualifications: - Bachelor’s degree or equivalent relevant experience. - Experience in a service/support, operations, systems, or analytics role (experience supporting business applications preferred). - Demonstrated proficiency with Power BI and Excel (including building repeatable reporting tools). - Strong customer service orientation, communication skills, and ability to translate technical concepts for non-technical users. - Strong organizational skills with the ability to manage priorities in a ticket-queue environment. - Special knowledge or skills and/or licenses or certificates preferred. - Healthcare Compliance Certifications - SQL / databases experience (querying, data extraction, validation) is a plus. - Experience supporting CLM and/or Legal department processes. - Experience using ServiceNow (incident, request, knowledge, reporting). - Programming/scripting experience (Python and/or JavaScript) is a plus (automation, integrations, data transformation). * Travel requirements-0-10% Office-based position with hybrid flexibility. Expected Base Salary Range: $56,400 – 70,900. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity. In addition to base salary, PTC employees are also eligible for short- and long-term incentives. All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans.

Sr. Medical Science Liaison remote type Remote locations Canada (Remote) time type Full time job requisition id R3696 PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture! Site: www.ptcbio.com Job Description Summary: The Senior Medical Science Liaison (Sr MSL) is a field-based position of Medical Affairs that supports and represents PTC and its products with, and to, key opinion leaders (KOLs), clinicians, academic institutions, and professional organizations. The incumbent addresses the specific needs of these clients by responding to unsolicited requests for information about PTC-marketed and developing products. As the clinical and medical expert on the company’s products and therapeutic areas, they build long-term relationships and establishe rapport with clinicians in hospitals, clinics, and academic centers through highly scientific product and disease state discussions that support or expand current therapeutic concepts and ensures safe and effective utilization of products. The incumbent is also a resource to company management regarding market dynamics, business development, and client feedback. The incumbent works cross-functionally with internal departments and external resources on Medical Affairs related issues. The Senior Medical Science Liaison supports adherence to relevant regulatory and compliance requirements and company Standard Operating Procedures (SOPs) as appropriate. Job Description: Responsibilities: - Establishes, manages, and maintains successful relations with relevant health authorities, including but not limited to: KOLs, HCPs, academic institutions, payors, medical societies, and patient organizations, etc. - Delivers, and may develop/design, fair-balanced and objective clinical and scientific presentations to healthcare professionals (HCPs), payors, and patient organizations in response to unsolicited requests for information on the use of company products. - Attends national and regional medical meetings and symposia as a representative of PTC and engages in discussions with attendees as appropriate; attend scientific sessions and poster presentations, gathers information, and summarizes findings; as possible, and when appropriate, cultivates professional relationships from these contacts. - Identifies and trains speakers for advisory boards, symposia, and educational programs with approved materials, slide sets, abstracts, posters, etc. - Identifies, organizes, and executes regional medical initiatives, e.g. advisory boards, as needed. - Provides input to management regarding competitive therapies, business development opportunities/risks, and market insights. - Facilitates the accurate and timely submission of unsolicited applications for unrestricted educational grants or research initiatives and requests for support of studies, per company policy. - Maintains awareness of competitor information relevant to the company’s therapeutic areas, goals/objectives, project activities and /or product team priorities and stays current on therapeutic advances and competing therapies or products; analyzes and applies relevant intelligence findings and communicates and presents insightful data/impact in an efficient format to appropriate internal stakeholders. - Maintains a thorough awareness of medical/clinical, regulatory, compliance, and quality issues and processes as they apply to the PTC therapeutic areas and adheres to, and supports, these standards, and the standards established by the company. - Contributes to the development of national medical strategy - Acts as a mentor to junior team members. Qualifications: - Advanced scientific degree (PhD, PharmD, MD, DNP, MSN, MS, Registered Dietician, or Genetic Counselor) with 3+ years of experience as Medical Science liaison. - Experience in Inborn Errors of Metabolism, genetics, rare diseases, and/or specialty medicine. Experience in Phenylketonuria is preferred. - Experience supporting high-cost products that are distributed through a specialty pharmacy and requires extensive coordination with patient access services. - In-depth, hands-on experience working with KOLs, clinicians, HCPs, and payers, while striving to build strategic, long-term partnerships and developing tailored engagement plans that align with business and medical objectives. - Ability to influence without direct authority. - Excellent verbal and written communication skills, including scientific/technical writing and presentations, with the ability to communicate complex technical information clearly. - Demonstrated success in interpreting scientific data and presenting research information to scientists and HCPs. - Skilled in delivering high-impact presentations to both internal and external stakeholders with confidence. - Ability to identify opportunities for presenting data at local, regional, and national conferences, and effectively present at these events when opportunities arise. - Proven experience in developing and conducting engaging and informative training sessions to provide teams with the latest medical insights and industry best practices. - Strong analytical skills to critically evaluate new data and translate findings into effective field strategies, while identifying data gaps and proactively proposing solutions. - Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines. - Excellent understanding of the pharmaceutical delivery process and the ability to work compliantly/appropriately within the industry. - Excellent planning, organization, and time management skills, including the ability to support and prioritize multiple projects, with experience in working on and leading projects and/or initiatives aligned to US Medical strategy, objectives, and tactics. - Proficiency with Microsoft Office. - Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members. - Must possess a valid driver’s license and a personal automobile with an active vehicle insurance policy. Must be able to travel daily to/from customer accounts and drive and/or fly long distances (distances will vary based upon the size of assigned territory). - This position requires overnight travel, the amount of which will vary based upon the assigned territory. In addition to travel within the territory, overnight and/or weekend travel outside of the assigned territory is required. - Daily entry to hospitals and other medical facilities is required. Many facilities have instituted vendor credentialing policies that require vendors to meet defined training, background checks and proof of immunization requirements as a condition of entry. PTC employees entering these facilities are required to abide by these credentialing requirements. - Must have a valid passport and be able and willing to travel internationally when required. - Fluency in English and French preferred but not required. - Experience supporting an orphan, rare disease and/or specialized drug(s) is preferred.  Travel requirements: 50 – 60% -Domestic and International (Field based position) EEO Statement: PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.

Case Manager, Patient Services -Rare Disease (West Coast Candidates) Remote Remote(US-California) Remote(US-Arizona) Remote(US-Utah) Remote(US-Colorado) Remote(US-Washington) Remote(US-Oregon) Full time R3681 PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. Job Description Summary: The Case Manager will provide personalized assistance to patients/caregivers with complex and rare medical conditions. Reporting to the Team Lead, Patient Services, the Case Manager will navigate patient’s healthcare insurance, perform administrative functions and interact with Patients, Caregivers, HCPs, Field Sales, Payers, Specialty Pharmacies and Patient Engagement. The Case Manager will be the face of PTC to patients and internal/external customers. The Case Manager will serve as a resource to their teammates and Team Lead. Job Description: Responsibilities include, but are not limited to: - Work directly with patients/caregivers to help them obtain access to PTC products. - Quickly build positive working relationships with patients, caregivers, HCPs, patient engagement, and the sales team to collect/share appropriate information and coordinate patient care. - Solve problems with urgency to help patients/caregivers gain access to therapy and maintain adherence. - Communicate with internal and external stakeholders while maintaining the confidentiality of patient health information and acting in compliance with all laws and regulations and facilitating coordination of information/resources. - Navigate the CRM system with ease and rapidly learn internal business rules and processes. - Report Adverse Events and Product Quality Complaints. - Adheres to PTC’s Standard Operating Procedures and Business Rules. - Accurately interprets patient insurance, prescription, and other health-related documentation as needed. - Responsible/Accountable for handling all aspects of patient cases and must be able to complete follow-up promptly and professionally. - Performs clerical and administrative functions such as mailing and faxing. - Acquire/Exhibit/Maintain subject matter expertise in the area of orphan/rare disease, including but not limited to the condition, treatment, community of patients and caregivers, activities and events offered throughout the country, etc., to ensure staff is providing the appropriate support/service (s). - Applies subject matter expertise to drive positive patient outcomes. Qualifications: Bachelor’s degree with 3 to 5 years of Case Management or recognized equivalent of education and experience with orphan/rare disease biotech environment experience. Rare disease experience required. - Case Management experience demonstrating strong problem-solving and solution skills. - Must have hands on experience with in pharmacy billing, prior Authorization, appeals, and peer-to-peer review. - Ability to anticipate patients' needs and respond quickly, flexibly and creatively to solve problems. - Experience working with Sales Reps. - Case Management experience in a rare disease environment. - Ability to work independently and collaboratively in a team environment consisting of internal and external team members. - Proficiency with Microsoft Office. - Excellent verbal and written communication skills. - Excellent organization and time management skills including the ability to support and prioritize multiple tasks. - Ability to enter data quickly and accurately into CRM. - Speak clearly and pleasantly. - Active listening skills. - Adapt to a quickly changing environment. Special knowledge or skills and/or licenses or certificates preferred. - Bilingual/Spanish Speaking is a plus. - Pharmacy Technician. - HCP Office Management. - Registered Dietitian License preferred but not required. Expected Base Salary Range: $75,100 - $96,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity. In addition to base salary, PTC employees are also eligible for short- and long-term incentives. All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans.

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture! Site: www.ptcbio.com Job Description Summary: The Scientific Engagement Specialist plays a key role in supporting Medical Affairs, Patient Engagement, and cross‑functional teams through the development of high‑quality scientific materials, patient‑friendly content, and strategic initiatives across rare disease programs. This role contributes to medical training, scientific communications, and community‑facing resources—ensuring complex data is translated into clear, meaningful information tailored for healthcare professionals, payers, patients, and advocacy groups. The Scientific Engagement Liaison supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate. Job Description: Responsibilities: - Contribute to the development of the Medical Affairs clinical presentations for HCPs, Payers, etc. and other scientific writing initiatives as needed - Attend internal scientific & business meetings and contribute through brainstorming and discussions - Creation of plain language summaries for publications across disease states - Contribute to PTC Marketing Initiatives (insights, ACMG patient friendly PKU guidelines, Marketing communications, etc.) - Build out rare disease and/or disease specific related resources for patients/families and assess any gaps or opportunities to connect with the community - Contribute to patient/community educational program planning and execution with patient engagement liaison teams - Work closely with patient engagement teams on internal support and operations initiatives in support of PTC patient/family/community programs, including site reviews, contracting and internal tracking - Review and provide input on local/regional/global brand plans regarding strategic & operational elements for launch readiness - Develop & contribute to patient facing materials for rare disease communications (including social media & community outreach) - Work across the US Functions (Medical, Patient Engagement, Operations, etc.) with Project Leads on key initiatives, as identified Qualifications: Bachelor’s degree in scientific discipline (including genetics) or a related field and a minimum of 1 year of relevant experience in a pharmaceutical, biotechnology or similar environment - Deep understanding of the rare disease market - Excellent written, verbal, communication and interpersonal skills. - Proficiency in Microsoft Office suite with strong working knowledge of excel, including writing Macro’s and data manipulation - Superb attention to detail. - Strong leadership skills. - A positive attitude and willingness to learn. - Excellent time management skills. Travel requirements: Up to 20% Expected Base Salary Range: $84,700 – $107,000. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity. In addition to base salary, PTC employees are also eligible for short- and long-term incentives. All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans. EEO Statement: PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. Click here to return to the careers page

• Define GMA vision and strategies for PKU • Collaborate with Regional Directors to meet global strategies • Lead scientific communication for Sepiapterin • Develop relationships with PKU KOLs and stakeholders • Represents GMA at scientific congresses • Develop evidence generation and publication strategies

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture! Site: www.ptcbio.com Job Description Summary: The Patient Success Liaison at PTC supports rare disease patients (e.g., PKU) through focused case management for pediatric patients and their caregivers, as well as adult patients enrolled in PTC Cares. This role supports coordination of therapy initiation, managing patient-level logistical needs in collaboration with the Sales, Patient Engagement, and Case Manager teams, promoting long-term treatment adherence, and navigating life-stage transitions (e.g., childhood to adolescence, transition to adult care). The Patient Success Liaison also serves as a PKU subject matter resource for the Patient Services team to promote consistent, high-quality patient support. This role does not provide medical advice but focuses on product training, adherence, and logistical responsibilities using approved materials. The Patient Success Liaison supports adherence to relevant regulatory and compliance requirements and company Standard Operating Procedures (SOPs) as appropriate. Job Description: Responsibilities: - Educate patients and caregivers on disease state, medication safety, administration and storage via phone/video and other approved channels. - Work hand-in-hand with Sales, Patient Engagement, and Case Manager teams with the assigned Case Manager, Patient Engagement and Sales to coordinate therapy initiation and ongoing patient support, align on patient-level logistical needs, and ensure a seamless experience for patients enrolled in PTC Cares. - Utilizes resources to empower patients and improve treatment compliance. - Identify and address adherence barriers (diet fatigue, taste preferences, social pressure, school/work constraints, access challenges, psychosocial factors). - Provide proactive follow-up based on program triggers, risk, missed check-ins, or patient-reported concerns. - Support transition milestones (e.g., increasing adolescent independence, transition to adult care teams, major life events that affect dietary adherence). - Coordinate with caregivers and healthcare providers, as appropriate and permitted, to reinforce plans and continuity of care. - Escalate urgent concerns, clinical red flags, or safety issues per program guidance and required reporting procedures. - Act as the PKU resource for Patient Services staff—answer questions, support complex cases, and provide coaching on patient communication approaches. - Contribute to the development and refinement of PKU-specific workflows, scripts, and patient education tools. - Share themes and insights with leadership (e.g., common adherence barriers by age group) to improve services and patient experience. - Document all patient interactions accurately and in a timely manner in approved systems. - Maintain compliance with HIPAA/privacy requirements and PTC Cares program standards. - Participate in quality improvement initiatives and support adherence/outcome tracking as defined by the program. Qualifications: - Bachelor’s Degree and 5+ years of clinical nutrition/nursing and/or patient counseling experience with demonstrated adherence/behavior change support skills. Active, Dietitian/Nursing license and/or Master’s degree preferred. - PKU nutrition and/or nursing expertise with practical, real-world application across life stages. - Ability to drive sustained adherence through individualized coaching and barrier resolution. - High-quality documentation, organization, and follow-through. - Collaborative, consultative approach—trusted resource to the Patient Services team. - Experience with PKU and/or inherited metabolic disorders across pediatric and adult populations. - Strong competency in patient education, motivational interviewing, and coaching (including video/telephone delivery). - Strong interpersonal and communication skills to interact with patients, families, and HCPs. - High proficiency in handling patient logistics and tracking therapy adherence. - Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines. - Excellent understanding of the pharmaceutical delivery process and the ability to work compliantly/appropriately within the industry. - Excellent planning, organization, and time management skills, including the ability to support and prioritize multiple projects. - Proficiency with Microsoft Office. - Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members. ​Special knowledge or skills and/or licenses or certificates preferred. - Active, Dietitian/Nursing license and/or master’s degree. - Experience in rare disease patient services, hub services, specialty pharmacy, or patient support programs. - Familiarity with EMR/CRM documentation and metric-driven patient outreach. - Bilingual (as aligned with patient population needs). Travel requirements: Up to 50% Expected Base Salary Range: $97,100 - $122,200. The base salary offered will be contingent on assessment of candidate education level, background, and experience relative to the requirements of the position they are being considered for, as well as review of internal equity. In addition to base salary, PTC employees are also eligible for short- and long-term incentives. All eligible employees may also enroll in PTC’s medical, dental, vision, and retirement savings plans. EEO Statement: PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination. 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• Develops and leads global medical affairs activities related to PKU • Drives communication and collaboration across teams • Acts as the PKU subject matter expert in Global Medical Affairs • Builds relationships with key opinion leaders and stakeholders • Develops evidence generation and publication strategies

• Provide personalized assistance to patients/caregivers with complex medical conditions • Work directly with patients/caregivers to access PTC products • Build positive relationships with various stakeholders • Solve problems to help patients gain therapy access • Communicate confidentially with stakeholders while complying with laws • Navigate CRM system and learn internal processes • Report Adverse Events and Product Quality Complaints • Interpret patient insurance and health-related documentation • Perform administrative functions • Maintain subject matter expertise in rare diseases