Scientist/Sr. Scientist, Oligo Biology – In Vitro
Location
California
Posted
6 days ago
Salary
$115K - $175K / year
Seniority
Senior
Job Description
Scientist/Sr. Scientist, Oligo Biology – In Vitro
Korsana Biosciences
• Design molecular and cellular biology experiments in close collaboration with internal bioinformatics and chemistry teams to support robust in vitro and in vivo screening campaigns. • Manage external CROs, including experimental design, priority setting, technical oversight, data review, timeline management, and proactive troubleshooting to ensure high-quality, timely project execution. • Design and optimize siRNAs, ASOs, PMOs, and other novel nucleotide modalities to enhance therapeutic profiles. • Generate and interpret structure-activity relationships (SAR) to guide lead optimization and candidate selection. • Maintain thorough technical documentation using Electronic Lab Notebooks (ELNs) and effectively communicate experimental strategies, results, and recommendations to multidisciplinary scientific audiences. • Actively evaluate emerging technologies and scientific literature to identify innovative approaches that enhance oligonucleotide potency, extrahepatic delivery, durability, and safety.
Job Requirements
- Ph.D. in biology, pharmaceutical sciences, or related discipline with 0-6 years of relevant industry experience, OR M.S. with 2-8 years of industry experience in oligonucleotide therapeutic development.
- Deep understanding of siRNA and ASO design principles, cellular mechanisms of action, and chemical modification strategies.
- Familiarity with state-of-the-art oligonucleotide delivery technologies, including GalNAc conjugates, lipid conjugates, peptide/antibody-oligonucleotide conjugates (AOCs), or other targeted delivery methods.
- Hands-on experience with mammalian cell culture, diverse transfection methodologies.
Benefits
- Eligible for target annual bonus
- Equity-based compensation
- Participation in the company’s benefit programs
Related Guides
Related Categories
Related Job Pages
More Scientist Jobs
Decision Scientist – Product
CVS HealthCVS Health is a leading healthcare company operating CVS Specialty, CVS Pharmacy, CVS MinuteClinic, and CVS Caremark. In 2018, CVS combined forces with healthca
• develop predictive models, risk and profitability logic, and scenario/forecast frameworks that translate claims, contract terms, and market signals into the numbers our deal teams act on • partner with underwriters, pricing actuaries, and finance to translate business questions into testable code — pricing calculators, P&L tools, recurring forecasts, and the rule engines underneath them • balance a long-running model build, a quick-turn analysis for a sales leader, and a recurring reporting cycle in the same week
Field Applications Scientist
Bio-TechneEmpowering scientists & clinicians by providing high-quality reagents, analytical instruments, & precision diagnostics.
• Provide on-field support for pre-and post-sales activities with direct customers and channel partners • Educate, train, and support new and existing customers on Lunaphore instrumentation and data analysis solutions • Collaborate with account managers to expand instrument, software, and consumable sales • Attend scientific meetings, conferences, and trade shows to present company products, applications, and data • Investigate issues relating to hardware, software, and biological assays and develop solutions to address them • Report and present feedback from the field through thorough and detailed presentations • Develop multiplex staining assays and evaluate stained tissues
• Author and coordinate development of clinical pharmacology trial protocols and ensure timely review, approval, and issuance • Perform preliminary, interim, and final PK, PD, and PK/PD analyses using non-compartmental methods • Develop the Clinical Pharmacology Analysis Plan (CPAP) and generate data handling logbooks prior to final NCA • Create tables, listings, and figures and contribute to drafting clinical pharmacology sections of Clinical Study Reports (CSRs) • Conduct QC review of protocols, analyses, datasets, and all deliverables while ensuring compliance with SOPs, ICH-GCP, and regulatory requirements
Pharmacokinetic Scientist
CelerionCelerion Can Take You from First-In-Human through Proof-of-Concept.
• Data analysis and interpretation • Perform PK analyses independently • Assist with PD analyses • Interpret PK and statistical results and findings independently • Perform QC reviews as assigned • Write and review reports as assigned • Prepare PK data/report files for electronic filing of projects for submission to regulatory agencies • Maintain and file all supportive documentation pertaining to the study and ensure proper archiving of projects • Other responsibilities • Interact with clients alongside or under direction of a senior scientist, as needed • Prepare internal presentations



