Korsana Biosciences

• Design and optimize chemically modified oligonucleotides, including siRNAs, ASOs, PMOs, and other emerging modalities. • Develop novel nucleoside analogs, phosphoramidites, backbone chemistries, and oligonucleotide architectures to improve potency, stability, durability, and tissue delivery. • Generate and interpret structure-activity relationships (SAR) to guide lead optimization across oligonucleotide chemistries and modification patterns. • Design oligonucleotide libraries in collaboration with bioinformatics and biology teams to support cellular and in vivo screening campaigns. • Develop synthetic routes for novel oligonucleotide building blocks using modern organic and nucleoside chemistry approaches. • Oversee the synthesis, purification, and analytical characterization of oligonucleotides and intermediates, leveraging both internal capabilities and external CRO partners. • Manage external CROs, including experimental design, prioritization, technical oversight, data review, timeline management, and troubleshooting to ensure high-quality and timely project execution. • Develop and apply analytical methods, including RP-HPLC, IEX, LC-MS, CE, and SEC, to characterize oligonucleotides and support process development. • Partner closely with biology, pharmacology, toxicology, and translational sciences teams to understand how chemical modifications impact biological activity and therapeutic performance. • Contribute to next-generation oligonucleotide platform technologies, including novel chemistries, delivery strategies, and manufacturability improvements. • Evaluate emerging technologies and scientific literature to identify innovative approaches that enhance potency, extrahepatic delivery, durability, and safety. • Maintain thorough technical documentation and effectively communicate experimental strategies, results, and recommendations to cross-functional teams.

• Design molecular and cellular biology experiments in close collaboration with internal bioinformatics and chemistry teams to support robust in vitro and in vivo screening campaigns. • Manage external CROs, including experimental design, priority setting, technical oversight, data review, timeline management, and proactive troubleshooting to ensure high-quality, timely project execution. • Design and optimize siRNAs, ASOs, PMOs, and other novel nucleotide modalities to enhance therapeutic profiles. • Generate and interpret structure-activity relationships (SAR) to guide lead optimization and candidate selection. • Maintain thorough technical documentation using Electronic Lab Notebooks (ELNs) and effectively communicate experimental strategies, results, and recommendations to multidisciplinary scientific audiences. • Actively evaluate emerging technologies and scientific literature to identify innovative approaches that enhance oligonucleotide potency, extrahepatic delivery, durability, and safety.