• Direct the planning, preparation, writing and review of portions of aggregate reports • Organize and direct liaison for activities with affiliates and other internal Amgen partners regarding products • Author Safety Assessment Reports and other safety documents and regulatory responses in collaboration with the GSO • Review and provide input and support on study protocols, statistical analysis plans and other clinical study-related documents • Review of AEs/SAEs from clinical trials as needed • Review standard design of tables, figures, and listings for safety data from clinical studies • Participate in development of safety-related data collection forms for clinical studies • Participate in study team meetings as requested or needed • Perform data analysis to evaluate safety signals and write up analysis results • Search and review adverse event data, literature, and other safety-relevant data for the purpose of signal detection • Prepare presentation of the Global Safety Team’s recommendations on safety issues to the cross-functional decision-making body • Assist GSO in the development of risk management strategy and activities: Provides contents for risk management plans • Develop or update strategy and content for regional risk management plans • Assist GSOs to oversee risk minimization activities including tracking of activities as needed. • Evaluate risk minimization activity • Prepare response to regulatory inquiries related to risk management plans under the guidance of GSO • Support activities related to new drug applications and other regulatory filings • Assist GSO in developing a strategy for safety-related regulatory activities • Provide safety contents for filings • Undertake activities delegated by the QPPV as detailed in the PV System Master File and maintain a state of inspection readiness • Be representative and point of contact for Health Authority Inspection and Internal Process Audits within the remit of role and responsibility

• Provide scientific and technical support for health-related research, programs, and initiatives • Analyze and interpret scientific data • Support research and program activities • Prepare technical documentation • Collaborate with project teams and stakeholders to meet program objectives

• Engage with HCPs, KOLs, authorities, and scientific stakeholders as a peer • Generate, document, synthesize, and compliantly share actionable medical insights from external engagements • Effectively disseminate key scientific insights using omnichannel and digital platforms • Ensure insights are communicated effectively to cluster medical leadership and relevant internal stakeholders • Support the CML in external engagement, acting as a representative of Pfizer Medical

• Provides scientific and technical support for health-related research, programs, and initiatives • Analyzes and interprets scientific data, supporting research and program activities • Prepares technical documentation, and collaborates with project teams and stakeholders to meet program objectives while ensuring compliance with applicable federal requirements