Our Purpose Mastercard powers economies and empowers people in 200+ countries and territories worldwide. Together with our customers, we're helping build a sustainable economy where everyone can prosper. We support a wide range of digital payments choices, making transactions secure, simple, smart and accessible. Our technology and innovation, partnerships and networks combine to deliver a unique set of products and services that help people, businesses and governments realize their greatest potential. Title and Summary Manager, Commercial Strategy & Portfolio Optimization, SME LAC Manager, Commercial Strategy & Portfolio Optimization, SME LAC is a specialist role designed to drive data-led growth opportunities across SME portfolios and elevate the quality and impact of client engagement across Latin America and the Caribbean. This role sits alongside Specialist Sales and Account Management, with a clear mandate: "To translate SME spend data into sharper, highly commercial and regionally relevant client conversations that unlock growth across diverse LAC markets". Acting as a bridge between data, strategy, product, and commercial teams this role will identify insights from SME portfolios and equip frontline teams with clear, actionable narratives to: Drive GDV(Gross Dolar Volume) growth, improve portfolio performance and strengthen client engagement. This is a highly commercial, execution-focused role centered on how we sell, ensuring every client interaction is: insight-led, locally contextualized and tied to measurable outcomes. Key Responsibilities: 1. Insight-Led Client Engagement• Analyze SME customer spend, portfolio performance, and behavioral data across LAC markets to identify growth opportunities and strategic recommendations.• Generate actionable insights tailored to different market dynamics (issuer maturity, acceptance, cross-border flows)• Translate data into clear and compelling client narratives highlighting: Spend activation, Working capital optimization, Cross-border and FX opportunities• Support frontline teams in shaping and delivering high-impact client conversations and Quartile Business Reviews 2. Enabling Sales & Account Teams (Regional + Markets)• Partner with Specialist Sales, Account Management, and Country teams• Embed insight-led selling into day-to-day client engagement• Provide: Structured talking points, Opportunity framing and Value articulation• Support priority client engagements as needed to demonstrate best-in-class conversations 3. Pipeline & Opportunity Identification• Use data-driven insights to proactively identify opportunities across SME portfolios: activation, usage growth, cross-sell / upsell and retention• Support pipeline development aligned with: cluster/country priorities and SME growth targets in LAC• Ensure opportunities are: clearly quantified and linked to GDV and revenue impact 4. Portfolio Optimization (LAC Focus)• Diagnose underperformance across markets (activation gaps, dormancy, low penetration)• Define targeted actions considering LAC-specific constraints (acceptance gaps, product penetration, informality)• Monitor KPIs and trends to assess impact• Support creation of scalable playbooks across clusters (e.g., ChiPeBol, Brazil, Mexico) 5. Cross-Functional Collaboration• Work closely with: SME Product, Data & Analytics, Marketing and Customer Solutions• Ensure insights are aligned with product capabilities and regional priorities• Feed market learnings back into product and proposition development• Support creation of repeatable sales assets and engagement frameworks for LAC Role Impact• Higher quality and consistency of SME client conversations across LAC• Stronger pipeline generation driven by data-led opportunity identification• Increased GDV and revenue via activation and portfolio optimization• Better alignment between product propositions and real SME client needs in LAC All About you:• Experience in payments, banking, product management, business strategy, commercial analytics, or SME-focused roles.• Strong ability to analyze data, identify business opportunities, and translate insights into growth strategies and commercial outcomes.• Experience with portfolio optimization, product performance analysis, • customer analytics, or similar data-driven business initiatives.• Experience partnering with Sales, Account Management, or Product teams to drive client growth and business impact.• Strong understanding of SME markets, payments, and regional dynamics across LAC.• Fluent in English and Spanish (Portuguese is a plus).• Comfortable operating across data, strategy, product, and sales functions.• Available to work from the office at least 3 days per week. Corporate Security Responsibility All activities involving access to Mastercard assets, information, and networks comes with an inherent risk to the organization and, therefore, it is expected that every person working for, or on behalf of, Mastercard is responsible for information security and must: - Abide by Mastercard's security policies and practices; - Ensure the confidentiality and integrity of the information being accessed; - Report any suspected information security violation or breach, and - Complete all periodic mandatory security trainings in accordance with Mastercard's guidelines.

• Identify targets and execute selling strategies through ethical selling practice • Drive sales growth and help derive best practices for targeting and reimbursement • Contribute key learnings to the team to demonstrate understanding of marketplace • Use approved corporate literature and scientific data to engage customers • Provide reporting and tracking of sales activities and territory sales forecasts • Demonstrate understanding of industry products and updates • Ensure compliance with company guidelines and legal standards • Assist with training field Area Managers and mentorship roles as needed

• Identify targets and executing selling strategies based on company direction through ethical selling practice. • Drive sales growth through helping to derive best practices to ensure proper targeting and appropriate reimbursement practices. • Contribute key learnings to the team at ETS to demonstrate key understanding of the marketplace and places of strategic opportunities. • Use approved corporate literature, scientific data and presentations to customer and potential customers. • Provide reporting and tracking of sales activities and territory sales forecasts based on agreed upon timelines. • Demonstrate an understanding of industry products, updates and market knowledge. • Ensure that all activities conform to company guidelines, travel/expense guidelines compliance standards, Code of Ethics and federal/state/local laws. • Assist with training field Area Managers, professional education and mentorship roles as needed. • Other duties as assigned.

Role Description Assess patients’ needs and develop action plans that provide for the initiation and continuation of treatment with Alnylam products while coordinating the exchange of all applicable patient-related information with appropriate internal and external stakeholders. - Develops a comprehensive understanding of the reimbursement process, billing/coding nuances, insurance plans, payer trends, financial assistance programs, patient assistance programs, and related resources. - Assists in obtaining insurance approval for Alnylam products, and proactively plans for maintenance of coverage by working with patients and their caregivers/families, healthcare providers, insurance companies, specialty pharmacies, and Alnylam colleagues. - Understands the resources available in their specific region, and how they can be best employed to support patient care. - Identifies complex patient-specific issues and develops and executes action plans accordingly. - Maintains disease, reimbursement and insurance coverage expertise through continuing medical education and attendance at relevant conferences and other educational opportunities. - Educates patients, caregivers, family members, health care providers, and others regarding insurance options and limitations, including PA and policy requirements necessary to initiate and maintain treatment, patient services’ offerings and relevant disease/product information as necessary. - Fosters collaborative relationships with all internal and external customers including but not limited to Patient Education Liaisons, medical, sales, field reimbursement, corporate accounts, patient advocacy, insurance company case managers, specialty pharmacies, home health agencies, and office coordinators. - Attend patient meetings and represent Alnylam at industry conferences, as needed. - Ensures compliance with all corporate and industry policies in collaboration with Alnylam Legal, Regulatory and Compliance. Qualifications - Bachelor’s Degree required. Health Care/Social Work/Nursing (or related field) a plus. - 3+ years recent case management experience in the healthcare or pharmaceutical/biotech industry. Ultra-rare disease experience a plus. - Experience should include but not be limited to home care management, case management review, utilization review, social service support, insurance reimbursement, patient assistance programs, or billing and coding. - Knowledge of benefit verification and prior authorization process for infused and injectable products. - Knowledge of private payer, Medicare, and Medicaid structure, systems, and reimbursement process required. - Experience and proficiency in working with a Customer Relationship Management System, such as Salesforce.com. - Possess strong written and verbal communication skills, exceptional listening, critical thinking, problem solving, negotiation and mediation skills. - Ability to navigate difficult conversations and handle sensitive issues with opposing opinions. - Ability to work independently and manage competing priorities. - Experience working in cross-functional teams and effective in influencing without authority. - Desire to innovate and work in a fast-paced, flexible, and energetic environment. - Self-starter who is highly passionate about rare disease and Alnylam’s core values: Commitment to People, Innovation and Discovery, Sense of Urgency, Open Culture, and Passion for Excellence. - Ability to travel 5%, including weekends/evenings, as needed. Requirements - U.S. Pay Range: $85,500.00 - $115,600.00 - The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. - This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Benefits - Comprehensive benefits including medical, dental, and vision coverage. - Life and disability insurance. - Lifestyle reimbursement program. - Flexible spending and health savings accounts. - 401(k) with a generous company match. - Paid time off, wellness days, holidays, and two company-wide recharge breaks. - Generous family resources and leave.