Role Description This is a foundational hire at a pivotal moment. As VP of Translational Sciences, you will be the scientific bridge between our discovery engine and clinical programs — owning the strategy and execution that translates CAPAC®-based assets to IND-enabling studies and into first-in-human trials. Reporting to the CEO, this role will partner across our research, clinical, and regulatory teams to build the translational framework that our next wave of programs depends on. This is a high-impact, hands-on role for someone who thrives at the interface of research and the clinic. It also offers the opportunity to build and lead the translational function as our pipeline scales in the future. Responsibilities - Translational Strategy - Accountable for the translational development strategy for pipeline assets from drug candidate through IND submission and Phase 1 entry. - Support translational hypotheses and biomarker strategies that connect preclinical biology to clinical endpoints. - Support indication selection frameworks and biomarker-driven go/no-go criteria that guide program progression decisions. - Support targeted patient stratification and enrichment strategies that inform clinical trial design and improve probability of success. - Identify and prioritize experiments, models, and data packages needed to support regulatory filings and clinical decision-making. - Partner with research and clinical leadership to align translational milestones with overall program strategy. - Characterize drug mechanisms of action and resistance to inform clinical hypotheses, patient selection, and combination strategies. - IND & Regulatory Readiness - Lead the scientific content and coordination of IND-enabling activities, including PK/PD, safety, and biomarker packages. - Author and review translational sections of INDs, investigator brochures, and other regulatory documents. - Serve as the translational science lead in interactions with FDA and other regulatory agencies. - Ensure preclinical-to-clinical bridging is scientifically rigorous and clearly communicated. - Cross-Functional Leadership - Collaborate closely with Research (animal models, PK/PD, efficacy), Clinical Development, Clinical Operations, and CMC to ensure translational readiness at each program gate. - Support clinical protocol development by providing translational rationale for dosing, scheduling, patient selection, and biomarker collection. - Contribute to the design and interpretation of early clinical data to inform go/no-go decisions and Phase 2 design. - Build, mentor, and scale the translational science function as programs grow. - External Partnerships - Identify and manage together with research and clinical leadership, academic collaborators, CROs, and biomarker labs that support translational programs. - Represent Shasqi's translational science at conferences, in publications, and in partnership discussions. - Co-author scientific publications, regulatory documents, and contribute to IP filings that protect and advance Shasqi’s platform. - Articulate Shasqi’s translational strategy and platform differentiation to the board and other external partners/investors as needed. Qualifications - Ph.D., M.D., or M.D./Ph.D. in oncology, pharmacology, cancer biology, or a related field. - 12+ years experience in translational oncology drug development at a biotech or pharma company, including personally leading and advancing at least two programs from preclinical candidates through IND filing and into Phase 1. - Deep understanding of IND-enabling studies and the preclinical data packages required by the FDA and other regulatory agencies. - Hands-on experience with PK/PD, biomarker strategy, and dose selection for oncology programs. - Strong scientific writing skills with experience authoring regulatory documents. - Ability to work at the bench-to-bedside interface in a small, fast-moving team. - Comfort being the most senior translational scientist in the company — supporting the design of studies and authoring regulatory documents directly, with limited support infrastructure and a high tolerance for ambiguity. Preferred Qualifications - Experience with solid tumor indications. - Prior experience at a company transitioning from preclinical to clinical stage. - Comfort working across diverse modality types (small molecules, biologics, ADCs or other targeted therapies) — candidates from a range of therapeutic backgrounds are encouraged to apply. - Experience collaborating with bioinformatics or computational biology teams on biomarker discovery, patient stratification, or translational data analysis. Compensation & Eligibility - Competitive base salary as part of a broader total rewards package. - Equity: Included as part of total compensation. - Comprehensive benefits: medical, dental, vision, 401(k), short- and long-term disability. - Flexible PTO and a WFH stipend to support remote work. - Ongoing opportunities for professional development, growth, and mentorship. - The anticipated base salary range for this role is $300,000 - $325,000 USD, plus annual performance bonus and meaningful equity participation. - Final compensation will depend on location, experience, skills, education, and internal equity. - U.S.-based employees only. Must be authorized to work in the United States. We are not currently sponsoring visas. Other Requirements - Travel: approximately 10% for team meetings, scientific conferences, CRO and collaborator site visits, and regulatory interactions. Company Description Shasqi is a biotech company advancing a new class of targeted cancer therapies, built on Nobel prize-winning technology called click chemistry. Backed by leading biotech investors, we are building a pipeline of first-in-class therapies that are designed to overcome the limitations of ADCs increasing efficacy and limiting toxicities. Our lead asset will be entering the clinic in early 2027.

Role Description The Vice President, Market Access – Payer & Specialty Pharmacy is a senior leader accountable for influencing and executing market access strategies that enable sustainable patient access to Sun Pharma’s portfolio across pharmacy and medical benefit pathways (including Part D and buy-and-bill), encompassing payers, PBMs, specialty pharmacies, and government channels. This role translates payer, reimbursement, specialty pharmacy, and policy dynamics into portfolio-specific access strategies, determining the optimal mix of commercial, federal, state, specialty, or hybrid pathways based on product needs. The VP provides executive leadership for specialty pharmacy strategy, including network design, product access, and programs aligned with Sun Pharma’s access and commercial objectives, while serving as a trusted partner to senior payer, PBM, and specialty pharmacy stakeholders to drive durable access and successful commercialization. Although Sun Pharma's corporate offices are located in Princeton, NJ, this is a field-based role. Key Responsibilities - Payer & PBM Market Access Leadership - Develop and execute comprehensive payer and PBM access strategies that maximize formulary placement, reimbursement, and utilization across national and regional health plans. - Lead engagement and negotiations with national and regional payers, PBMs, and managed care organizations, driving access decisions that support launch excellence and lifecycle management. - Establish and oversee payer contracting and pricing strategies that balance access, affordability, competitiveness, and long-term portfolio value. - Develop customer-specific value propositions that address payer priorities related to clinical value, economics, population management, and outcomes. - Partner closely with HEOR and Medical Affairs to communicate differentiated clinical, economic, and real-world evidence to payer and PBM decision-makers. - Monitor payer trends including utilization management, coverage policy evolution, specialty benefit management, biosimilar strategies, and value-based arrangements to proactively inform access strategy. - Strengthen long-term payer and PBM partnerships through executive-level engagement and consistent delivery against customer commitments. - Specialty Pharmacy & Operations - Influence specialty pharmacy strategy, distribution network design, and channel optimization to support access, speed to therapy, and patient experience. - Oversee negotiations and contracting with specialty pharmacies to drive utilization and operational performance. - Develop and implement innovative specialty pharmacy access strategies that reduce friction across referral, onboarding, reimbursement, and fulfillment, with the goal of improving patient initiation, continuation, and overall access to Sun Pharma products. - Establish performance frameworks and KPIs focused on access rate, HUB utilization, affordability support, adherence, and operational efficiency. - Ensure alignment between specialty pharmacy operations, patient services, HUB, and brand strategies to minimize access friction for patients and providers. - Strategic Market Access Planning & Portfolio Positioning - Lead short- and long-term market access planning across commercial, Medicare, Medicaid, and government channels. - Integrate payer, PBM, and specialty pharmacy insights into launch readiness, indication expansion, and lifecycle planning. - Anticipate shifts in the access landscape and adapt strategies to ensure Sun Pharma’s portfolio is optimally positioned for sustainable growth. - Government Markets & Federal Accounts Leadership - Provide executive oversight for Sun Pharma’s federal and state government market access strategy, including Veterans Administration (VA), Department of Defense (DoD), Indian Health Services (IHS), Medicare, State Medicaid programs, and TRICARE. - Lead and support a team which is responsible for calling on senior-level personnel within federal and state entities to secure formulary access for the Sun Pharma product line. - Support contract negotiations that result in executed agreements enabling access, utilization, and growth within assigned government sectors. - Healthcare Policy & Access Implications - Partner closely with the Government Policy team to understand, anticipate, and engage on federal and state policy developments (e.g., MFN, pricing and reimbursement reforms) that may impact market access and portfolio economics. - Assess the access and commercial implications of policy changes and recommend strategic options to optimize portfolio positioning across commercial, federal, and state channels. - Collaborate with Legal, Compliance, Trade, and other stakeholders to ensure recommended strategies are compliant, executable, and aligned with enterprise priorities. - Cross-Functional & Organizational Leadership - Build, lead, and develop high-performing payer, specialty pharmacy, and government account teams. - Foster a culture of strong payer acumen, customer centricity, and disciplined execution across the Market Access organization. - Partner closely with Sales, Medical Affairs, Commercial Operations, Patient Services, Trade, Legal, Compliance, and Finance to deliver seamless access strategies. - Provide executive leadership with insights on payer trends, access risks, competitive dynamics, and policy-driven implications. Qualifications - Bachelor’s degree required; advanced degree (MBA, MPH, PharmD, JD, or related field) preferred. - 12+ years of progressive experience in pharmaceutical or biotech market access, payer strategy, or managed markets leadership. - Deep expertise in payer and PBM contracting, reimbursement, and specialty pharmacy models. - Demonstrated success negotiating complex payer, PBM, specialty pharmacy, and government contracts. - Demonstrated ability to lead and develop high-performing, complex organizations, with a proven track record of building talent, managing competing priorities, fostering accountability, and inspiring innovation and future leaders within matrixed environments. - Strong executive presence with a track record of influencing senior external stakeholders. - Experience supporting specialty, complex, or chronic disease portfolios preferred. Core Competencies - Payer & PBM Strategy and Negotiation - Specialty Pharmacy Channel Leadership - Market Access & Reimbursement Expertise - Executive Customer Engagement - Contract Strategy & Governance - Healthcare Policy Impact Assessment - Cross-Functional Leadership - Commercial & Financial Acumen - Talent Development & Team Leadership Benefits - The presently-anticipated base compensation pay range for this position is $280,500 to $342,500. - Actual base compensation may vary based on a number of factors, including but not limited to geographical location and experience. - This position is part of the Annual Performance Bonus Plan. - Employees are eligible to participate in Company employee benefit programs which include: - Medical, dental and vision coverage - Life insurance - Disability insurance - 401(k) savings plan - Flexible spending accounts - Employee assistance program - Employees also receive various paid time off benefits, including vacation time and sick time.

• Own the underwriting direction, risk appetite, and portfolio composition of the E&S Property book across all target classes • Set and enforce underwriting standards, pricing guidelines, and coverage parameters consistent with the book's profitability objectives • Lead complex and large-account underwriting decisions; serve as the technical authority and escalation point for the team • Maintain a disciplined approach to accumulation management • Monitor and actively manage loss ratios, combined ratios, and portfolio trends • Partner with actuarial and finance on pricing adequacy, rate monitoring, and reserving inputs • Lead, mentor, and develop a team of 10 property underwriters • Cultivate and deepen relationships with key wholesale broker partners

• Underwrites new and renewal business • Approves policy changes • Maintain workload, and controls written business up to and including the time of binding according to Company guidelines and established CRC procedures • Provides leadership to a production/underwriting team • Provides high quality professional service to Agents and Carrier Partners • Meet or exceed production goals as assigned by manager • Supervise a multi-person team ensuring all pertinent information is communicated • Develop and maintain excellent relationships with clients • Market all products and services to clients • Communicate properly and timely with all producers regarding submissions and decisions for new or renewal business • Approve and disapprove endorsement requests according to internal and Company guidelines • Monitor accounts to ensure compliance with the firm's policies and procedures • Monitor production, hit ratios, renewal retention ratios spread of risk and other production and quality measures to minimize risk and predict future success • Review and handle policy servicing requests (endorsement, audits, Company requests, Certificates, Premium Finance Notices and Cancellations, etc.) appropriately • Review inspection reports and compare to the conditions that were represented at the time of binding and take appropriate or needed actions • Meet or exceed file documentation standards, comply with underwriting authority level standards and pass all audits - both internal and external • Maintain necessary licenses to produce business