Role Description A Sr. Medical Science Liaison at Rapport is more than a scientific expert; they are a connector, collaborator, and trusted partner who helps bridge the external medical community with internal teams. By fostering trusted scientific relationships, generating meaningful insights, and supporting evidence development, the MSL helps shape Medical Affairs strategy while contributing to a team culture where people support one another, learn together, and celebrate shared success. Reporting to the Director, Field Medical, the MSL will support compliant scientific exchange, insight generation, evidence-related activities, and field execution aligned with Medical Affairs strategy. Your day-to-day: - Scientific Exchange & External Engagement - Build, maintain, and serve as a primary scientific contact for peer-to-peer relationships with scientific leaders, investigators, healthcare professionals, and academic centers within the assigned geography. - Conduct compliant, balanced, and evidence-based scientific exchange regarding disease-state science, clinical data, treatment paradigms, safety considerations, and the evolving competitive landscape. - Respond to unsolicited medical inquiries in accordance with company policies and applicable regulations, including inquiries related to clinical data, evidence interpretation, safety, and patient management considerations. - Represent Medical Affairs at medical conferences, scientific congresses, regional society meetings, and advocacy or educational events as appropriate. - Insight Generation & Communication - Gather, document, and synthesize field insights related to clinical practice trends, patient needs, barriers to care, emerging evidence, and competitive intelligence. - Communicate insights to appropriate internal stakeholders to inform medical strategy, evidence generation, scientific communications, lifecycle planning, and field execution. - Identify regional opportunities and challenges that may impact medical education, stakeholder engagement, evidence needs or launch readiness. - Education & Scientific Support - Deliver high-quality scientific presentations to healthcare providers, formulary or decision-making stakeholders, and internal teams, as appropriate. - Contribute to the development or review of scientific materials, including slide decks, FAQs, training resources, congress materials, advisory board content, and standard medical responses, when requested. - Support internal medical training and field readiness activities by sharing scientific expertise, field insights, and external stakeholder perspectives. - Cross-Functional Collaboration - Partner with Medical Affairs colleagues and cross-functional teams, including Medical Science, Clinical Trial Awareness, Regulatory, Safety, Market Access, Corporate Affairs, and Commercial, while maintaining strict compliance boundaries. - Provide scientific input and field perspective to support launch planning, competitive preparedness, medical education, payer-related scientific needs, and patient journey initiatives. - Escalate key scientific, safety, compliance, or reputational issues through appropriate internal channels in a timely manner. Qualifications - Advanced degree in a relevant scientific or clinical discipline required; PharmD, PhD, MD, DO, NP, or equivalent preferred depending on therapeutic area and business needs. - 5+ years of industry experience with at least 3 as an MSL with additional years in clinical, research, or related healthcare experience. - Epilepsy and/or neurology therapeutic area expertise and established network. - Strong understanding of clinical research, evidence generation, medical communications, and compliant scientific exchange. - Demonstrated ability to build credible peer-to-peer relationships with external scientific and clinical stakeholders. - Excellent written, verbal, and presentation skills, with the ability to tailor communication to diverse scientific and healthcare audiences. - Strong organizational skills and ability to manage a field territory, prioritize external engagements, and document insights in a timely manner. Requirements - Collaborative mindset: We are looking for individuals who are humble, curious, generous with their expertise, and committed to helping teammates succeed. We value collaboration over competition and seek people who elevate those around them. - Ability to travel approximately 50% or more depending on geography, business needs, and congress activity. Preferred - Prior experience in field medical affairs, medical communications, clinical development, real-world evidence, or investigator-initiated study support. - Psychiatry therapeutic area expertise. - Experience supporting pre-launch, launch, or post-launch medical activities. - Experience working in emerging biotech environment. Benefits - Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start. - We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities. - Your perspective matters. Stick your neck out, share your ideas – we work as a team. - We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with. - Leadership that CARES – about you, your growth + development. - We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together. - Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more! - You get to be YOU! Show up as you are and make every day count. Your Compensation We get it. Compensation is an important part of your offer. You shouldn’t be surprised at the end of the recruiting process, and you should know that your offer is fair and equitable. How do we do this? We tell you about our hiring range now - we expect the hiring range for the role to be $180,000 to $200,000. Our actual offer will reflect a lot of factors including your relevant skills, experience, location, salary market data, and internal equity. In addition to a competitive salary, we also offer a pretty great benefits package. We don’t stop here - if you join Rapport, we go to the next level. We share our full salary ranges for every level across our company. Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law. Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

• Build trust and credibility for Oura and our products for members, physicians, scientists and health systems. • Collaborate closely with engineering, product, design, data science and algorithm teams to define clinical features aligned with metabolic health, including integrations with continuous glucose monitors (CGM) and laboratory testing, and alignment with related teams such as sleep, activity and women’s health. • Collaborate on clinical feature specifications: Translate your metabolic health knowledge and existing literature into real-world informed performance goals, working closely with science and product teams. • Design and oversee clinical validation studies (feasibility, observational, real-world) to demonstrate product performance and clinical relevance in the metabolic space. • Work with regulatory, quality and clinical outcomes teams to build protocols, drive submissions and ensure compliance in applicable markets, and adapt to the changing regulatory environment in major markets. • Engage cross-functionally: proactively anticipate risks, communicate clearly about challenges, adjust plans, and maintain a collaborative mindset. • Serve as a clinical voice across the organization: staying abreast of the newest and most relevant medical insights, weaving this science into product decisions, translating this into company knowledge and features. • Guide the team on inclusion of appropriate biometrics and ground truth data, clinical endpoints, and study design. Uplevel internal knowledge across teams related to this domain of medicine and science. • Represent Oura externally to scientific audiences, payors, partners, clinicians and health systems.

• Enterprise Health System Engagement — Build executive relationships across major IDNs, AMCs, and specialty health systems, and drive enterprise evaluations through clinical governance and procurement pathways. • Strategic Market Leadership — Shape Heidi's US clinical strategy and track health policy developments (CMS, HIPAA, ONC/TEFCA, AI guidance) to inform commercial direction. • Thought Leadership & National Presence — Represent Heidi at major industry and specialty conferences (HIMSS, HLTH, JPM Healthcare, and more) and publish clinical content that builds national credibility. • Commercial Impact — Actively originate and support enterprise deals, arming health system buyers with clinical narratives, ROI frameworks, and procurement-ready materials. • Clinical Advisory Council — Co-own the US Clinical Advisory Council and manage Heidi's specialty advisor network across Urology, Orthopaedics, Cardiology, and Primary Care. • Product & Workflow Influence — Guide US-specific EHR workflow configuration (Epic, Oracle Health, Athenahealth) and translate regulatory requirements into product specs.

Title: Patient Safety Associate Medical Director Location: Boston, MA Job Description: Job Description General Summary: The Patient Safety Associate Medical Director will provide medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development). This role will optimizes patient safety of Vertex products and maintenance of compliance with the Pharmacovigilance regulations of Regulatory Agencies around the globe, through the effective and timely completion of Safety activities through the product life cycle. Key Duties and Responsibilities: - Provides medical safety expertise, state of the art pharmacovigilance, and safety risk management for assigned products (marketed or in development) - Responsible for the safety assessment activities of assigned products under the supervision of a GPS Disease-area Safety Head - Monitors the benefit risk profile of assigned products/portfolio in an ongoing fashion and in accordance GPS processes and procedures - Leads the safety and risk management processes including chairing assigned Disease-area Safety and Product Safety Teams - Identifies, prioritizes and analyzes clinical safety signals, in accordance with GPS procedures - Performs ongoing review of emerging safety data from various sources including single case reports, published literature, aggregate reports, and other sources - Represents the department as medical safety lead on cross-functional study and program teams for assigned products and studies, providing guidance regarding safety matters and issues - Conducts medical evaluation of relevant safety-related information from Toxicology, Non-Clinical studies, as well as Product Quality complaints, as needed - Participates in protocol development, specifically the monitoring and collection of safety information in clinical trial protocols, as well as statistical analysis plans - Participates in the analysis of safety data from on-going and completed clinical trials and representation in Clinical Study Reports - Contributes to preparation and review of periodic reports (DSUR, PSUR, PADER) contributing medical strategy and expertise to content, authoring applicable analysis and content - Review and provides medical content, as needed, for key study-related documents, e.g. IB, ICF, IDMC Charter - Assists in departmental development activities including SOP and Work Instructions development - Provides guidance to staff regarding optimal practice regarding collection, evaluation and processing of adverse experience reports, from a medical perspective - Provides support in Partner /Affiliate agreements and interactions, as needed - Other activities as needed or as requested by GPS management Knowledge and Skills: - Broad and extensive knowledge of medicine, pharmacovigilance and relevant regulations - Extensive evidence of effective delivery of high quality safety relevant documents. - Broad knowledge of relevant concepts in data management and systems, pharmacoepidemiology and statistics, including the interpretation of complex data and information - Communicates complex issues in an understandable, effective and relevant manner. - Strong influencing skills with the ability to explain and defend positions regarding significant issues in the face of opposition - Strategic focus regarding activities, with proactive planning and prioritization skills. - Takes ownership of appropriate issues and appropriately delegates - Technical expertise in pharmacovigilance and clinical safety - Excellent analytical and problem solving skills, with sound autonomy and applied judgment - Appropriate experience with Regulatory Agency and key stakeholder interactions - Experience with ICSR case review and Aggregate Safety analysis and reports Education and Experience: - MD, DO or equivalent ex-US medical degree - Typically requires 3 years of experience with relevant experience in Safety/Pharmacovigilance, or the equivalent combination of education and experience Pay Range: $200,000 - $300,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com